... dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP)". The Journal of Experimental Medicine ... The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This ... Chen L, Glover JN, Hogan PG, Rao A, Harrison SC (Mar 1998). "Structure of the DNA-binding domains from NFAT, Fos and Jun bound ... "Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets". Journal of ...

One of the nuclear targets for PKA is the transcriptional control protein CREB (cAMP response element binding protein). In ... Kandel identified CREB as being a protein involved in long-term memory storage. One result of CREB activation is an increase in ... Neurotransmitters, second messenger systems, protein kinases, ion channels, and transcription factors like CREB have been ... Kandel, Eric R. (May 14, 2012). "The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB". Molecular Brain. 5 ...

When cAMP levels are increased in neurons, this may trigger activation of cAMP response element-binding proteins (CREB). CREBs ...

"Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating ... "A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR". Cell. 66 ... "Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent ... "Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent ...

"Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating ... Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions ... modulating their activity in the presence of cellular retinoic acid-binding protein II". The Journal of Biological Chemistry. ... "Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone- ...

"Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating ... Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions ... is a nuclear receptor protein that in humans is encoded by the THRB gene. The protein encoded by this gene is a nuclear hormone ... Shuto Y, Wakabayashi I, Amuro N, Minami S, Okazaki T (1992). "A point mutation in the 3,5,3'-triiodothyronine-binding domain of ...

The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). ATF4 is not a ... cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper ... a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding ... The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription ...

It has been shown that associates with Host cell factor C1, CREB binding protein, WDR5, CTBP, MEN1, etc. The rearrangement of ...

"MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein". Molecular and Cellular Biology. 21 (7): 2249- ... "MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein". Molecular and Cellular Biology. 21 (7): 2249- ... "Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein ... "Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein ...

The cellular transcription factor CREB (cAMP response element-binding protein) helps learning and the stabilization and ... While viral CREB reversed the conditioning deficits in CREB knockout animals, additional CREB did not seem to enhance memory of ... When a herpes simplex virus expressing CREB was infused into the amygdala of CREB knockout mice, the expression of CREB in the ... CREB for binding sites in the DNA; the transgenic protein lacks the domains required for making functional complexes. To ...

... and Dach proteins mediated through CREB binding protein". Molecular and Cellular Biology. 22 (19): 6759-66. doi:10.1128/MCB. ... which may be involved both in determining DNA-binding specificity and in mediating protein-protein interactions. Genes in the ... Members of the SIX gene family encode proteins that are characterized by a divergent DNA-binding homeodomain and an upstream ... Homeobox protein SIX1 (Sine oculis homeobox homolog 1) is a protein that in humans is encoded by the SIX1 gene. The vertebrate ...

CREB-binding protein, EP300, IRF4, NFKB1, Nuclear receptor coactivator 1, and SND1. Gene fusion Recurrent somatic fusions of ... STAT6 shares structural similarity with the other STAT proteins and is composed of the N-terminal domain, DNA binding domain, ... NGFI-A-binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been identified in solitary fibrous tumors ... family of proteins. The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene ...

... and Dach proteins mediated through CREB binding protein". Mol. Cell. Biol. 22 (19): 6759-66. doi:10.1128/MCB.22.19.6759- ... Homeobox protein SIX2 is a protein that in humans is encoded by the SIX2 gene. GRCh38: Ensembl release 89: ENSG00000170577 - ... 2000). "Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2". Gene. 247 (1-2): 145-51. ...

"GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin ... GA-binding protein alpha chain is a protein that in humans is encoded by the GABPA gene. This gene encodes one of three GA- ... effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein". The ... binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with ...

Emodin specifically causes phosphorylation of cAMP-responsive element binding protein (CREB), an important molecule in the ... The differentiation of N2a cells is caused by activation of the mitogen-activated protein kinase/extracellular-signal regulated ... kinase (MAPK/ERK) and the phosphoinositide-3-kinase/protein kinase B (PI3K/Akt) signaling pathways. The cells, due to passaging ...

Weaver BK, Kumar KP, Reich NC (1998). "Interferon Regulatory Factor 3 and CREB-Binding Protein/p300 Are Subunits of Double- ... Mach CM, Hargrove BW, Kunkel GR (2002). "The Small RNA gene activator protein, SphI postoctamer homology-binding factor/ ... Morin P, Bragança J, Bandu MT, Lin R, Hiscott J, Doly J, Civas A (2002). "Preferential binding sites for interferon regulatory ... A 2015 study shows phosphorylation of innate immune adaptor proteins MAVS, STING and TRIF at a conserved pLxIS motif recruits ...

... and Dach proteins mediated through CREB binding protein". Mol. Cell. Biol. 22 (19): 6759-66. doi:10.1128/MCB.22.19.6759- ... Homeobox protein SIX4 is a protein that in humans is encoded by the SIX4 gene. GRCh38: Ensembl release 89: ENSG00000100625 - ... Kawakami K, Ohto H, Ikeda K, Roeder RG (1996). "Structure, function and expression of a murine homeobox protein AREC3, a ... preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. 275 (41): 32129-34. doi: ...

... and Dach proteins mediated through CREB binding protein". Mol. Cell. Biol. 22 (19): 6759-6766. doi:10.1128/MCB.22.19.6759- ... which form an α/β structure similar to that found in the winged helix/forkhead subgroup of DNA binding proteins. This protein ... and the basal transcription apparatus through binding to the co-integrator protein CA150. Curiously, DACH1 selectively bound to ... DACH1 binds directly with a Forkhead-like DNA sequence to restrain oncogenic signals from a subset of FKHR proteins. Dach1 ...

"DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in ... CREB-binding protein, and tuberous sclerosis protein 2. GRCh38: Ensembl release 89: ENSG00000150907 - Ensembl, May 2017 GRCm38 ... Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by ... protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein ...

Activators of CREB phosphorylation, for instance forskolin and KSHV binding to endothelial cell targets, can also enhance miR- ... In this instance, the target of translational suppression appears to be p300, a protein that associates with CREB and is an ... Vo N, Klein ME, Varlamova O, Keller DM, Yamamoto T, Goodman RH, Impey S (2005). "A cAMP-response element binding protein- ... The transcription of this cluster was found to be enhanced by the transcription factor CREB (cAMP-response element binding ...

... using a mechanism that activates the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB ... Yang S, Alkayed NJ, Hurn PD, Kirsch JR (March 2009). "Cyclic adenosine monophosphate response element-binding protein ... 4-PPBP is a neuroprotective cyclic amine which binds to sigma receptors. 4-PPBP decreases neuronal nitric oxide synthase (nNOS ... Neuroprotection that is associated with 4-PPBP increases Bcl-2 expression; Bcl-2 expression is regulated by CREB. 3-PPP Yang S ...

... of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein". Nat. Genet. 14 (1): 33-41. doi: ... of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein". Nat. Genet. 14 (1): 33-41. doi: ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... The KAT6A protein contains two nuclear localization domains, a C2HC3 zinc finger and an acetyltransferase domain. This ...

GSK-3β inhibits the transcription factors β-catenin and cyclic AMP (cAMP) response element binding protein (CREB), by ... One of the leading causes of Alzheimer's is the hyperphosphorylation of the tau protein by the enzyme GSK-3, which leads to the ... It is hypothesized that the dual effects of lithium are due to the inhibition of G-proteins that mediate cyclic AMP production ... Lithium treatment alters the function of certain subunits of the dopamine associated G-protein, which may be part of its ...

... has been shown to interact with: ANKRD2, CREB-binding protein, Cyclin T1, Death associated ... Doucas V, Tini M, Egan DA, Evans RM (March 1999). "Modulation of CREB binding protein function by the promyelocytic (PML) ... is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of ... PML contains a SUMO-binding domain necessary for its interaction with other SUMOylated proteins such as itself and many others ...

... it phosphorylates the CREB protein (adds a high energy phosphate group) and activates it. The CREB protein binds to cAMP ... CREB (cAMP response element binding protein) belongs to a family of transcription factors and is positioned in the nucleus of ... a GTP molecule binds to the free nucleotide-binding pocket, and the G protein becomes active. A Gα(GTP) complex is formed, ... and the nucleotide-binding pocket is closed off inside the protein complex. However, upon ligand binding, the receptor switches ...

"CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate ... proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity. ... NFIA+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ... Diversity in this protein family is generated by multiple genes, differential splicing, and heterodimerization.[supplied by ...

Cux1 (CUTL1, CDP, CDP/Cux) has been shown to interact with: CREB binding protein, Retinoblastoma protein, and SATB1 These ... "Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein ( ... "Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein ( ... The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It regulates gene expression, ...

Also, 3C and 2A are responsible for down-regulation of cyclic AMP responsive element binding protein (CREB), a cellular ... binding protein, PABP. This disruption of this binding domain results in down regulation of the initiation of cap dependent ... P1 encodes for a proteins (VP1, VP2, VP3, and VP4) that make the capsid proteins. P2 and P3 proteins assist in infectivity of ... Polioviruses' protease 3C is responsible for host cell transcription shut off by cleaving the TATA-binding protein and other ...

This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear ... PPARG coactivator 1 alpha is a protein that in humans is encoded by the PPARGC1A gene. The protein encoded by this gene is a ... This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. ... This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the ...

CREB binding protein interaction interface and its importance for the function of SRC1". Molecular and Cellular Biology. 21 (1 ... "Entrez Gene: DBI diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)". Kos M, Reid G, Denger ... March 2000). "Tamoxifen-bound estrogen receptor (ER) strongly interacts with the nuclear matrix protein HET/SAF-B, a novel ... March 2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N- ...