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*  Bayesian tool for methylation analysis
Most CpG-poor regions are constitutively methylated while most CpG-rich regions (CpG islands) are constitutively unmethylated. ... CpG versus non-CpG methylation. Gene 289, 41-8 (2002) Vanyushin, B.F. DNA methylation in plants. Current Topics in Microbiology ... is defined as the fraction of DNA molecules hybridizing to probe p that contain the CpG c. Ctot : total CpG influence parameter ... CpG methylation state is generally highly correlated over hundreds of bases, so CpGs grouped together in 50- or 100-bp windows ...
*  CpG island hypermethylation
... called CpG island methylator prototype, or CIMP. Higher levels of CpG island hypermethylation are found in CIMP. The frequent ... the CpG island is hypomethylated, and the rest of the genome is methylated. It is evident that the hypomethylation of the CpG ... A CpG island is a Cytosine and Guanine linked by a phosphate in a repeated sequence. These are genetic hotspots as they are ... Hypermethylated CpG islands also act as biomarkers, as they can help distinguish cancer from normal cells in the same sample. ...
*  Reduced representation bisulfite sequencing
... but RRBS has a greater coverage on CpG islands. One of the other most commonly used techniques for profling methylation is ... Some CpG's will be missed. Missing CpG's can also occur since this protocol is only a representative sampling of the genome. ... DNA fragments of 40-220 base pair are representative of the majority of promoter sequences and CpG islands Bisulfite conversion ... This approach enriches for CpG regions of the genome, so it can decrease the amount of sequencing required as well as decrease ...
*  Cancer epigenetics
... there are about 600 to 800 heavily methylated CpG islands in promoters of genes in the tumors while these CpG islands are not ... The "normal" CpG methylation profile is often inverted in cells that become tumorigenic. In normal cells, CpG islands preceding ... Comparing each tumor type with its corresponding normal tissue, 729 CpG island sites (55% of the 1322 CpG sites evaluated) ... However, in cancer cells, CpG islands preceding tumor suppressor gene promoters are often hypermethylated, while CpG ...
*  Transcription (biology)
In vertebrates, the majority of gene promoters contain a CpG island with numerous CpG sites. When many of a gene's promoter CpG ... For example, in colorectal cancers about 600 to 800 genes are transcriptionally inhibited by CpG island methylation (see ... Retrieved Feb 2012 Saxonov S, Berg P, Brutlag DL (January 2006). "A genome-wide analysis of CpG dinucleotides in the human ...
*  BRCC3
"Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Human Molecular Genetics. 1 (3): ...
*  CLCN4
Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in ...
*  L1TD1
"LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold ...
*  SIM2
Osoegawa K, Okano S, Kato Y, Nishimura Y, Soeda E (Jun 1996). "A 19-kb CpG island associated with single-minded gene 2 in Down ...
*  Werner syndrome helicase
The table shows results of analysis of 630 human primary tumors for WRN CpG island hypermethylation. This hypermethylation ...
*  MORT (long non-coding RNA)
The MORT promoter is located in a CpG island that is shared with the ZNF667 gene; the two genes reside in a head to head ... Analysis shows that the MORT gene expression is silenced by DNA hypermethylation of its CpG island promoter in a majority of ...
*  Ectodysplasin A
... a translocation breakpoint is associated with a CpG island that is transcribed". Am. J. Hum. Genet. 58 (1): 126-32. PMC 1914968 ...
*  TRA (gene)
1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Hum. Mol. Genet. 1 (3): ...
*  MLH1
"CpG island methylation of the MLH1, MGMT, DAPK, and CASP8 genes in cancerous and adjacent noncancerous stomach tissues". ... a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1". Proc. Natl. Acad. Sci. U.S.A. ...
*  Secreted frizzled-related protein 1
In numerous cancers, the CpG islands of selected genes are aberrantly methylated (hypermethylated) which results in ... Epigenetic CpG hypermethylation of the SFRP1 promoter during chronic persistent inflammation and aging leads to the occurrence ... silencing mechanism underlying DNA methylation which is brought about through the hypermethylation of CpG-rich islands present ... Detection and quantification of promoter CpG methylation in body fluid is both feasible and noninvasive. Combined MSP analyses ...
*  Transgenerational epigenetic inheritance
"Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer". Cancer ...
*  Differentially methylated regions
CpG islands appear to be unmethylated in most of the normal tissues, however, are highly methylated in cancer tissues. There ... and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts ... and hypermethylation at conserved tissue-specific CpG island shores". Nature Genetics. 41 (2): 178-86. doi:10.1038/ng.298. PMC ... Note: this is different from histone modification.) DNA is mostly methylated at a CpG site, which is a cytosine followed by a ...
*  SALL3
2009). "SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma". Mol. ...
*  MTCP1
"Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Hum. Mol. Genet. 1 (3): 179-86. ...
*  Behavioral epigenetics
Epigenetic differences in DNA methylation of the CpG islands proximal to the DLX1 gene correlated with the differing behavior. ...
*  DNA mismatch repair
"CpG island methylation of the MLH1, MGMT, DAPK, and CASP8 genes in cancerous and adjacent noncancerous stomach tissues". ...
*  PAR1 (gene)
1995). "Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region". Nat ...
*  DNA-PKcs
... strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island". ...
*  P16
Cancer cells show a significant increase in the accumulation of methylation in CpG islands in the promoter region of p16. This ...
*  MicroRNA
... most were found to be deficient due to epigenetic methylation of the CpG island of the MLH1 gene. However, up to 15% of MLH1- ... strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island". ...
*  ATP6V0C
"CpG island in the region of an autosomal dominant polycystic kidney disease locus defines the 5' end of a gene encoding a ...
*  Epigenetics of neurodegenerative diseases
A cluster of CpG dinucleotides clustered together is called a CpG island, and in mammals, these CpG islands are one of the ... Methylation of CpG dinucleotides and/or islands within gene promoters is associated with transcriptional repression via ... Hypothetically, global hypomethylation should be associated with global increases in transcription, since CpG islands are most ... a CpG transformation technique which is sensitive to CpG methylation status, in which global hypomethylation has been observed ...