Corticotropin-like intermediate peptide
Corticotropin-Like+Intermediate+Lobe+Peptide at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Genes on ... Corticotropin-like intermediate [lobe] peptide (CLIP), also known as adrenocorticotropic hormone fragment 18-39 (ACTH(18-39)), ... Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). "Effect of corticotropin-like intermediate lobe peptide on ... "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain". ...
Corticotropic cell
Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). "Effect of corticotropin-like intermediate lobe peptide on ... These peptide hormones are stored within vesicles in the corticotropic cells and are released in response to CRH stimulation ... These peptide hormones are then released into the bloodstream, where they circulate and act on target tissues. ACTH released ... CRH is a 41-amino-acid peptide hormone that is secreted by the parvocellular neurosecretory cells, which are found within the ...
Pituitary gland
... the posterior pituitary lobe, and an intermediate lobe that joins them. The intermediate lobe is avascular and almost absent in ... bombesin-like peptides (gastrin-releasing peptide, neuromedin B and C), and neurotensin, and inhibited by hypothalamic dopamine ... and melanocyte-stimulating hormone are released under the influence of hypothalamic corticotropin-releasing hormone (CRH).: ... In many animals, these three lobes are distinct. The intermediate lobe is present in many animal species, particularly in ...
Hypophyseal portal system
... and capillary shunts exchanging blood between the intermediate and neural lobes. Such microvascular structures indicate moment- ... The peptides released at the median eminence enter the primary plexus capillaries. From there, they are transported to the ... The main hormones transported by the system include gonadotropin-releasing hormone, corticotropin-releasing hormone, growth ... Peptides released near the median eminence from hypothalamic nuclei are transported to the anterior pituitary, where they apply ...
Endocrine gland
The intermediate lobe of the pituitary gland secretes only one enzyme that is melanocyte stimulating hormone. It is linked with ... Examples include the heart (atrial natriuretic peptide); gastrointestinal tract organs (gastrin, secretin, and others); the ... Adrenocorticotropic hormone release is triggered by corticotropin-releasing hormone and inhibited by rising glucocorticoid ...
Proopiomelanocortin
Corticotropin (Adrenocorticotropic Hormone, or ACTH) Corticotropin-like Intermediate Peptide (CLIP) β-Lipotropin (β-LPH) Gamma ... The POMC gene is expressed in both the anterior and intermediate lobes of the pituitary gland. This gene encodes a 285-amino ... POMC is cut (cleaved) to give rise to multiple peptide hormones. Each of these peptides is packaged in large dense-core ... while α-MSH secreted from the intermediate lobe of the pituitary regulates the movement of melanin produced from melanocytes in ...
Adrenocorticotropic hormone
Glucocorticoids may also inhibit the rates of POMC gene transcription and peptide synthesis. The latter is an example of a slow ... POMC, ACTH and β-lipotropin are secreted from corticotropic cells in the anterior lobe (or adenohypophysis) of the pituitary ... Veldhuis JD, Iranmanesh A, Naftolowitz D, Tatham N, Cassidy F, Carroll BJ (November 2001). "Corticotropin secretory dynamics in ... many substances secreted within this axis exhibit slow/intermediate and fast feedback-loop activity. Glucocorticoids secreted ...
Granulocyte
Eosinophils also have kidney-shaped lobed nuclei (two to four lobes). The number of granules in an eosinophil can vary because ... Multiple intermediate cell types exist in this differentiation process, including myeloblasts and promyelocytes. Examples of ... vasoactive intestinal peptide (VIP), vascular endothelial growth factor (VEGF), TNF, prostaglandins, leukotrienes, and ... MCs contain numerous granules and secrete an abundance of prestored mediators such as corticotropin-releasing hormone (CRH), ...
Neuroendocrinology
The pituitary gland is divided into three lobes: the anterior pituitary, the intermediate pituitary lobe, and the posterior ... The peptides secreted by hypothalamic neuroendocrine neurons into the blood proved to be released also into the brain, and the ... "On the presence in hog hypothalamus of 3-corticotropin releasing factor, alpha- and beta-melanocyte stimulating hormones, ... These two neuronal systems project axons to the median eminence, where they release their peptides into portal blood vessels ...