This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, ... binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The ... binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...
The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be ... Like other cyclophilins, PPIA forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ... The PPIA protein is an important apoptotic constituent. During a normal embryologic processes, or during cell injury (such as ... PPIA may also activate Akt and NF-κB signaling, resulting in the upregulation of Bcl-2, an antiapoptotic protein, and thus ...
This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the same protein ... The ATP5F1A protein weighs 59.7 kDa and is composed of 553 amino acids. The protein is a subunit of the catalytic portion of ... "The major protein expression profile and two-dimensional protein database of human heart". Electrophoresis. 16 (7): 1160-9. doi ... Subunits alpha and beta form the catalytic core in F1. Rotation of the central stalk against the surrounding alpha(3)beta(3) ...
Peripheral proteins are unlike integral proteins in that they hold weak interactions with the surface of the bilayer and can ... The hydrophobic core of the phospholipid bilayer is constantly in motion because of rotations around the bonds of lipid tails. ... Integral proteins span the membranes with different domains on either side. Integral proteins hold strong association with the ... Phospholipid bilayers contain different proteins. These membrane proteins have various functions and characteristics and ...
LEAP2 is a cysteine-rich, and cationic protein. LEAP2 contains a core structure with two disulphide bonds formed by cysteine ... Protein pages needing a picture, Antimicrobial peptides, Protein families). ... Protein Sci. 12 (1): 143-52. doi:10.1110/ps.0213603. PMC 2312392. PMID 12493837. This article incorporates text from the public ...
The great majority of PPI interfaces reflects the composition of protein surfaces, rather than the protein cores, in spite of ... complex Protein domain dynamics Protein flexibility Protein structure Protein-protein interaction prediction Protein-protein ... Protein-Protein Interaction Databases Library of Modulators of Protein-Protein Interactions (PPI) Proteins and Enzymes at ... To test protein-protein interaction, the targeted protein cDNA and query protein cDNA were immobilized in a same coated slide. ...
... core protein beta-D-xylosyltransferase, UDP-D-xylose:core protein xylosyltransferase, UDP-D-xylose:proteoglycan core protein ... UDP-xylose-core protein beta-D-xylosyltransferase, uridine diphosphoxylose-core protein beta-xylosyltransferase, and uridine ... proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II". J. Mol. Biol. 304 (4): 517-28. doi:10.1006/ ... In enzymology, a protein xylosyltransferase (EC 2.4.2.26) is an enzyme that catalyzes the chemical reaction in which a beta-D- ...
Therefore, protein folding or secretion is not influenced and usually it does not interfere with protein function. Strep-tag is ... The Strep-tag was originally selected from a genetic library to specifically bind to a proteolytically truncated "core" version ... This not only allows the isolation of sensitive proteins in a native state, but it is also possible to purify intact protein ... The Strep-tag system offers a selective tool to purify proteins under physiological conditions. The proteins obtained are ...
Elongation: The core is used for elongation by addition of actin monomers. Steady state/Annealing: A balance between ... An analogue principle is used by the well-studied capping proteins which are responsible for a natural limiting factor of actin ... Secondly, it is possible to first form the isoindolone core in an intermolecular Diels-Alder reaction and in a second step ... Firstly, it is possible to form the six-membered ring of the isoindolone core and the larger macrocyclic ring simultaneously in ...
This particular heat shock protein is known as a member of hsp60 family of stress proteins, which can be found in both ... In contrast, VP4 is located inside the virus and its function is to anchor the RNA core to the viral capsid. While sharing ... Their icosahedral capsids contain 4 proteins: VP1, VP2, VP3 and VP4. VP1, VP2, and VP3 are located on the surface of the capsid ... Its adhesion proteins attach to tracheal epithelial cells by sialoglycoproteins or sialoglycolipid receptors, which are located ...
Several lines of evidence suggest that it is the 660 nm fluorescence emission band of the APC core which is quenched by OCPR. ... Orange carotenoid protein (OCP) is a water-soluble protein which plays a role in photoprotection in diverse cyanobacteria. It ... Another protein, the fluorescence recovery protein (FRP), interacts with the CTD in OCPR and catalyzes the reaction which ... The OCP participates in key protein-protein interactions that are critical to its photoprotective function. The activated OCPR ...
... tertiary protein structure) as well as between two cysteine residues in two separated protein subunits (quaternary protein ... Sulfur is one of the core chemical elements needed for biochemical functioning and is an elemental macronutrient for all living ... In general disulfide bonds are necessary in proteins functioning outside cellular space, and they do not change proteins' ... Formation of this geometry is performed in a process called protein folding, and is provided by intra- and inter-molecular ...
Hereafter, the polypeptide chain is fed into the central chamber of the 20S core region that contains the proteolytically ... The Vpu protein of HIV-1 is a protein on the ER membrane and targets newly made CD4 in the endoplasmic reticulum for ... However, HIV produces the membrane protein Vpu that binds to CD4. The Vpu protein mainly retains the CD4 in the ER by SCFβ-TrCP ... Not only membrane proteins surviving the first checkpoint are controlled for their luminal domains, also soluble proteins are ...
The ECALPS is not only attached to a lipid but also an LPS core. The final type of ECA is ECACYC, which is different from the ... The most significant overlap is the use of the WzxE and the WzzE proteins. The mechanism by which ECACYC is made is largely ... The reported values are a combined titer of the ECA antibodies as well as the antibodies that are bound to protein antigens ... To make ECALPS, WaaL, takes the ECA polysaccharide from the isoprenoid carrier and gives it to the core oligosaccharide of LPS ...
DBDs C, D, and E make up the trimerization core of the protein with flexible linker regions connecting them all together. Due ... Single-stranded binding protein Replication protein A1 Replication protein A2 Replication protein A3 Wold MS (1997). " ... Protein-protein interactions between RPA and other proteins happen at the N-terminal of RPA1, specifically DBD F, along with ... Replication protein A (RPA) is the major protein that binds to single-stranded DNA (ssDNA) in eukaryotic cells. In vitro, RPA ...
Studies on the protein of E. coli are the main source of information about the human ClpX protein. In E. coli, the ClpX protein ... The ClpP protease core can partner with different chaperones, namely ClpA, ClpC, ClpE, and ClpX, to form active chaperone- ... This protein is a member of the family of AAA Proteins (AAA+ ATPase) and is to form the protein complex of Clp protease ( ... ClpX and ClpP are two proteins that work together in the ClpXP complex, which is a major protein degradation system in bacteria ...
OEC is surrounded by 4 core proteins of photosystem II at the membrane-lumen interface. The mechanism for splitting water ... Along with the role of Ca+2, Cl−1, and the membrane proteins surrounding the metal cluster not being well understood. Much of ... This cluster is coordinated by D1 and CP43 subunits and stabilized by peripheral membrane proteins. Other characteristics of it ...
The core RNA polymerase (consisting of 2 alpha (α), 1 beta (β), 1 beta-prime (β'), and 1 omega (ω) subunits) binds a sigma ... A sigma factor (σ factor or specificity factor) is a protein needed for initiation of transcription in bacteria. It is a ... Due to the higher expression, the factor will bind with a high probability to the polymerase-core-enzyme. Doing so, other ... Thus, the sigma factor would cycle from one core to another. However, fluorescence resonance energy transfer was used to show ...
... contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may ... The core protein of GPC3 may serve as a co-receptor or a receiver for Wnt. A cysteine-rich domain at the N-lobe of GPC3 has ... Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable ... The protein core of GPC3 consists of two subunits, where the N-terminal subunit has a size of ~40 kDa and the C-terminal ...
The core protein of lumican (like decorin and fibromodulin) is horseshoe shaped. This enables it bind to collagen molecules ... There are four N-linked sites within the leucine-rich repeat domain of the protein core that can be substituted with keratan ... core proteins". Experimental Eye Research. 56 (6): 635-48. doi:10.1006/exer.1993.1081. PMID 8595806. Hillier LD, Lennon G, ... Lumican, also known as LUM, is an extracellular matrix protein that, in humans, is encoded by the LUM gene on chromosome 12. ...
A podosome consists of a core rich in actin surrounded by adhesion and scaffolding proteins. The actin filaments within these ... To distinguish podosomes from others types of cellular adhesions, the protein Tks5 and WASP (Wiskott-Aldrich syndrome protein) ... an actin core and a ring complex. Within the core, coordinators of actin nucleation are found. Specifically, the Arp2/3 complex ... Later in 1985, it was shown using the same cells that these protein clusters were localized to protrusions in the ventral ...
The core promoter marks the start site for transcription by binding RNA polymerase and other proteins necessary for copying DNA ... For example, some repressor proteins can bind to the core promoter to prevent polymerase binding. For genes with multiple ... which translates the protein-coding region into a string of amino acids that fold to form the final protein product. In the ... The core promoter of prokaryotic genes, conversely, is sufficient for strong expression and is regulated by repressors. An ...
Many of these units then are assembled into a core-shell spheroid by FUS proteins. Core proteins SFPQ, NONO and PSPC1 tightly ... Paraspeckles are organised into core-shell spheroidal structures; seven proteins on a scaffold of lncRNA NEAT1 (the 23kb ... seem to function through sequestering other proteins and both have distinct core or shell regions with predictable localised ... This reduces nucleoplasmic protein availability. It was noted in their study that this has an impact on the role of free ...
11 of the 35 families form the cas core, which includes the protein families Cas1 through Cas9. A complete CRISPR-Cas locus has ... Cas1 proteins have diverse amino acid sequences. However, their crystal structures are similar and all purified Cas1 proteins ... Most CRISPR-Cas systems have a Cas1 protein. The phylogeny of Cas1 proteins generally agrees with the classification system, ... This interference mechanism is modulated by a modulatory protein, PtiM, binds to one of the interference-mediating proteins, ...
The pgRNA has another function of being translated into the viral polymerase and core proteins). HBV core protein dimers are ... v t e (Protein articles without symbol, Protein pages needing a picture, Viral nonstructural proteins, Hepatitis B virus, All ... Hepatitis B virus DNA polymerase is a hepatitis B viral protein. It is a DNA polymerase that can use either DNA or RNA ... The hepadnaviral P protein is organized into three domains: an N-terminal domain (InterPro: IPR000201) covering the terminal ...
... cores from the active sites of ferredoxin proteins". Journal of the American Chemical Society. 97 (2): 463-464. doi:10.1021/ ... Que, L.; Bobrik, M. A.; Ibers, James A.; Holm, R. H. (1974). "Synthetic analogs of the active sites of iron-sulfur proteins. ... where he studied iron-sulfur clusters in proteins and the synthesis of model clusters. He then was a postdoctoral fellow with ... "Synthetic analogs of the active sites of iron-sulfur proteins. IX. Formation and some electronic and reactivity properties of ...
These complexes directly bind to and inhibit the core circadian transcription factor, CLOCK:BMAL1. As PERIOD proteins are ... Conversely, SasA proteins compete with KaiB proteins for the binding of the KaiC hexamer when the concentration of SasA exceeds ... Similarly, Partch's second publication on sperm-specific proteins which interact with A-kinase anchoring proteins showcases ... "Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II ...
These two proteins homeostatically control miRNA biogenesis by an auto-feedback loop. A 2nt 3' overhang is generated by Drosha ... The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus. The ... Recently, proteins like Drosha have been found significant in cancer prognosis and HIV-1 replication. Members of the ... This can be shown by the knockdown of two important miRNA processing proteins, Drosha and Dicer, which leads to a significant ...
All VKORs are transmembrane proteins with at least three TM helices at the catalytic core. The quinone to be reduced is bound ... Its partner is a redox protein with an unknown identity, probably a thioredoxin-like protein located in the ER lumen such as ... they relay electrons with a redox protein (or in the case of the bacterial homolog, its own fused domain). The human gene for ... relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein ...
The encoded protein is found in the nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein ... RNA-binding protein 39 is a protein that in humans is encoded by the RBM39 gene. The protein encoded by this gene is an RNA ... "Entrez Gene: RBM39 RNA binding motif protein 39". Jung DJ, Na SY, Na DS, Lee JW (Jan 2002). "Molecular cloning and ... with high sequence similarity to this protein suggest that this protein may act as a transcriptional coactivator for JUN/AP-1 ...