Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene. The protein encoded by this gene is ... The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by the alpha subunit as the ... "Entrez Gene: CBFB core-binding factor, beta subunit". The Cancer Genome Atlas Network (2012). "Comprehensive molecular ... the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family ...

... core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and ... The protein is a heterodimer of alpha- and beta-subunits. The alpha-subunit binds DNA as a monomer, and appears to have a role ... In addition to the highly conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has ... highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit ...

... subunit of 150 kDa, a beta prime subunit (β′) of 155 kDa, and a small omega (ω) subunit. A sigma (σ) factor binds to the core, ... RNA polymerase "core" from E. coli consists of five subunits: two alpha (α) subunits of 36 kDa, a beta (β) ... The core enzyme has five subunits (~400 kDa): β′ The β′ subunit is the largest subunit, and is encoded by the rpoC gene. The β ... The ω subunit facilitates assembly of RNAP and stabilizes assembled RNAP. In order to bind promoters, RNAP core associates with ...

This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the ... 1997). "Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1". ... "Entrez Gene: GABPB2 GA binding protein transcription factor, beta subunit 2". Sawada J, Goto M, Watanabe H, et al. (1995). " ... GA-binding protein subunit beta-1 is a protein that in humans is encoded by the GABPB1 gene. ...

A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-YGYGGT-3' found in a ... Core binding factor RUNX1 RUNX2 GRCh38: Ensembl release 89: ENSG00000020633 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Jin YH, Jeon EJ, Li QL, Lee YH, Choi JK, Kim WJ, Lee KY, Bae SC (Jul 2004). "Transforming growth factor-beta stimulates p300- ... Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene. This gene encodes a member of the ...

... a DNA binding CBFα chain (RUNX1 or RUNX2) and a non-DNA-binding subunit called core binding factor β (CBFβ); the binding ... "Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding ... Wang, S, Speck, NA (January 1992). "Purification of core-binding factor, a protein that binds the conserved core site in murine ... Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor ...

The core RNA polymerase (consisting of 2 alpha (α), 1 beta (β), 1 beta-prime (β'), and 1 omega (ω) subunits) binds a sigma ... Due to the higher expression, the factor will bind with a high probability to the polymerase-core-enzyme. Doing so, other ... Instead, it changes its binding with the core during initiation and elongation. Therefore, the sigma factor cycles between a ... Different sigma factors are utilized under different environmental conditions. These specialized sigma factors bind the ...

... a beta, and a beta prime (α, α, β, and β'). A fifth subunit, sigma (called the σ-factor), is only present during initiation and ... The binding of the σ-factor to the promoter is the first step in initiation. Once the σ-factor releases from the polymerase, ... When the σ-factor detaches, it is in core polymerase form. The σ-factor recognizes promoter sequences at -35 and -10 regions ... Bacteria have a σ-factor that detects and binds to promoter sites but eukaryotes do not need a σ-factor. Instead, eukaryotes ...

Transcription factors bind to hypersensitive site cores and cause the LCR to form a loop that can interact with the promoter of ... hemoglobin subunit gamma-1 (fetal) HBD, hemoglobin subunit delta (adult) HBB, hemoglobin subunit beta (adult) There is an opsin ... Transcription factors bind to the LCR to form a complex. The complex moves along the DNA helix until it can bind to the ... Transcription factors bind to DNA from the LCR to the promoter in an orderly fashion using non-DNA-binding proteins and ...

This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that ... pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding ... TFIIA-alpha and beta-like factor is a protein that in humans is encoded by the GTF2A1L gene. The assembly and stability of the ... 2001). "TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general ...

These core binding factors, or nuclear factors (NF-Y), are composed of three subunits - NF-YA, NF-YB, and NF-YC. Whereas in ... This is composed of three alpha-helices separated by two beta strand-loop domains. Similar to NF-YA, NF-YB has been shown to ... It is essential to the transcription that these core binding factors (also referred to as nuclear factor Y or NF-Y) are able to ... the core binding factor (CBF)-DNA complex retains a high degree of conservation within the CCAAT binding motif, as well as the ...

The beta subunits are responsible for binding the RNAP to the DNA, preventing premature dissociation. In Escherichia coli, the ... As noted above in RNA Polymerase and Sigma Factors, the beta clamp proteins within the RNAP complex have a higher initial ... Eubacterial RNAP holoenzymes consist of a core with four major subunits α2 ββ'. In cyanobacteria, β' is formed from two smaller ... In E. coli, a repressor binds the DNA operon and dislodges RNAP due to the loosely bound beta clamp, whereas in Synechocystis, ...

Some of these transcription factors appear to form multi-protein DNA-bound complexes. Phosphorylation of the RHD appears to ... The N-terminal specificity domain resembles the core domain of the p53 transcription factor, and contains a recognition loop ... The RHD is composed of two immunoglobulin-like beta barrel subdomains that grip the DNA in the major groove. ... Biancalana M, Natan E, Lenardo MJ, Fersht AR (September 2021). "NF-κB Rel subunit exchange on a physiological timescale". ...

TFIIB makes protein-protein interactions with the TATA-binding protein (TBP) subunit of transcription factor IID, and the RPB1 ... TFIIB-related factor) which also contains a conserved zinc ribbon and C terminal core. However, the structure diverges in the ... It forms a beta sheet and an ordered loop that helps with the stability of the structure when transcription is initiated. The ... Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II ...

... binds to the beta-propeller of the DDB1 adaptor protein which interacts with numerous DDB1-CUL4-Associated Factors (DCAFs ... CRL4Cdt2 also degrades PCNA-bound PR-Set7/SET8, which is a histone 4 methyltransferase, and the p12 subunit of DNA polymerase δ ... RBX1 is a core component of Cullin-RING ubiquitin ligase (CRL) complexes and functions to recruit E2 ubiquitin conjugating ... Recent reports show that IMiDs bind to CRL4CRBN and promote the degradation of IKZN1 and IKZN3 transcription factors, which are ...

This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that ... Chen Y, Le Cahérec F, Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ... Knight BC, High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation ... Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene. The Sec61 complex is ...

... chimeric transcript that encodes a protein consisting of the first 165 residues from the N-terminus of core-binding factor beta ... Myosin-11 is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light ... 1998). "The chimeric protein, PEBP2 beta/CBF beta-SMMHC, disorganizes cytoplasmic stress fibers and inhibits transcriptional ... chain subunits. It is a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ...

... binds to the beta-propeller of the DDB1 adaptor protein which interacts with numerous DDB1-CUL4-Associated Factors (DCAFs ... The smaller subunit of this Damaged DNA Binding protein complex is known as DDB2 and is able to directly bind DNA lesions ... RBX1 is a core component of Cullin-RING ubiquitin ligase (CRL) complexes and functions to recruit E2 ubiquitin conjugating ... Recent reports show that IMiDs bind to CRL4CRBN and promote the degradation of IKZF1 and IKZF3 transcription factors, which are ...

This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. GRCh38: ... Chen Y; Le Cahérec F; Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ... Knight BC; High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation ... Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene. The protein ...

Ruediger R, Fields K, Walter G (Jan 1999). "Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits ... "Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat ... It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, ... "Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat ...

NusG binds to termination factor Rho and to RNAP. It stimulates the rate of transcription elongation and is required for the ... antitermination change highly conserved amino acids located in a cysteine-rich amino-proximal domain of the RNAP beta' subunit ... The assembly of NusB, S10, and NusG onto the core complex involves nt 2 to 7 of lambda BOXA (CGCUCUUACACA), as well as the ... An additional factor or factors that can be supplied by a cellular extract are required, but their identities are unknown. ...

The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are ... composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase ... It also binds closely to the E3 ubiquitin ligase MDM2, which is a regulator of the degradation of p53 and retinoblastoma ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ...

Elongin A, a subunit of a transcription elongation factor previously known as SIII. It increases the rate of transcription by ... a Kruppel-type zinc finger transcription factor that binds to a 21-bp RE1 silencing element present in over 900 human genes) ... The hydrophobic core residues of helices 2, 3, and 4 are well conserved among TFIIS domains, although helix 1 is less conserved ... Mo X, Kowenz-Leutz E, Xu H, Leutz A (January 2004). "Ras induces mediator complex exchange on C/EBP beta". Molecular Cell. 13 ( ...

4A19 60S subunit viewed from the solvent-exposed side, PDB identifiers 4A17, 4A19 The ribosomal RNA core is represented as a ... and eL40 would be positioned in the decoding site and near the translation factor binding site, respectively. These positions ... and several eukaryotic ribosomal proteins jointly to form inter-protein beta-sheets. Crystal structures of the eukaryotic ... Eukaryotic ribosomes have two unequal subunits, designated small subunit (40S) and large subunit (60S) according to their ...

These subunits are the two elongation factors, EF-Tu & EF-Ts, the ribosomal protein subunit S1, and the RNA dependent RNA ... elongation factor thermo unstable), catalyzing the release of guanosine diphosphate from EF-Tu. This enables EF-Tu to bind to a ... the core domain contains two subdomains, C and N which interact with domains 3 and 1 of EF-Tu respectively. EF-Ts functions as ... EF-Ts comprises the majority of the top portion of the protein, while EF-Tu makes up the bottom half where the beta barrels are ...

It belongs to the thioredoxin superfamily fold which is defined by a beta-sheet core surrounded by alpha-helices. The active ... This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite ... Li S, Rosen BP, Borges-Walmsley MI, Walmsley AR (July 2002). "Evidence for cooperativity between the four binding sites of ... The arsC family also comprises the Spx proteins which are Gram-positive bacterial transcription factors that regulate the ...

Ruediger R, Fields K, Walter G (1999). "Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and ... 1990). "alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure ... Hong Y, Sarge KD (1999). "Regulation of protein phosphatase 2A activity by heat shock transcription factor 2". J. Biol. Chem. ... It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, ...

... one beta (β), one beta prime (β'), and one omega (ω) subunits that make up the core enzyme(~450 kDa). In addition, many ... also known as basal transcriptional factors, are a class of protein transcription factors that bind to specific sites (promoter ... The RNA polymerase core associates with the sigma factor to form RNA polymerase holoenzyme. Sigma factor reduces the affinity ... The core enzyme of RNA polymerase has five subunits (protein subunits) (~400 kDa). Because of the RNA polymerase association ...

Once bound to DNA, the beta subunits can freely slide along double stranded DNA. The beta subunits in turn bind the αε ... MacNeill SA (August 2016). "PCNA-binding proteins in the archaea: novel functionality beyond the conserved core". Current ... DNA clamps also associate with other factors involved in DNA and genome homeostasis, such as nucleosome assembly factors, ... The gamma complex of DNA polymerase III, composed of γδδ'χψ subunits, catalyzes ATP to chaperone two beta subunits to bind to ...

... provides a binding site for the G-protein factors (assists initiation, elongation, and termination), and helps protein folding ... While its core is conserved, it accommodates expansion segments on its periphery. A cryoEM structure of the 50S subunit from ... 5 minutes for beta-galactosidase[citation needed]). Prokaryotic small ribosomal subunit (30S) Ribosomal RNA 23S methyl RNA ... The large ribosomal subunit has a role in protein folding both in vitro and in vivo. The large ribosomal subunit provides a ...