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*  Pfam
Numbers of DUFs are expected to continue increasing as conserved sequences of unknown function continue to be identified in ... For each family, a representative subset of sequences are aligned into a high-quality seed alignment. Sequences for the seed ... The Pfam website allows users to submit protein or DNA sequences to search for matches to families in the database. If DNA is ... Over time both sequence and residue coverage have increased, and as families have grown, more evolutionary relationships have ...
*  SLITRK1
LRR1 is a more conserved sequence and is present as a dimer while LRR2 is a monomer and has a more variable sequence. The ... conserved sequence of LRR1 contains critical binding pockets and specific charged residues that are important for it to carry ... Both LRR sequences are randomly positioned on the protein and contain variable linker regions. The protein also contains a ... In a Japanese study, next-gen sequencing was used to screen 92 TS patients and 361 healthy controls, none of TS patients were ...
*  De novo transcriptome assembly
... or a family or set of genes that share a conserved sequence). Chrysalis then partitions the full read set among these separate ... Whereas high sequence coverage for a genome may indicate the presence of repetitive sequences (and thus be masked), for a ... "DNA Sequencing Costs: Data from the NHGRI Large-Scale Genome Sequencing Program Available at: www.genome.gov/sequencingcosts". ... ABySS is a parallel, paired-end sequence assembler. Trans-ABySS (Assembly By Short Sequences) is a software pipeline written in ...
*  ATP-binding cassette transporter
This histidine contacts residues across the dimer interface in the Walker A motif and the D loop, a conserved sequence ... is located in the cytoplasm and has a highly conserved sequence. The NBD is the site for ATP binding. In most exporters, the N- ... This conserved helix extending from the TMD segments into or near the active site of the NBD is largely responsible for ... It shows significant sequence similarity to human ABC transporters of subfamily B that includes MDR1 and TAP1/TAP2. The ATPase ...
*  SENP1
... which causes hydrolysis peptide bond of SUMO is in a conserved sequence Gly-Gly-,-Ala-Thr-Tyr at the C-terminal to be added to ... although it has been seen that is exported out from the nucleus to the cytosol through a sequence of nuclear export (NES) that ... 1 The seven proteases possess a conserved C-terminal domain which are variable in size, and with a distinct N-terminal domain ...
*  Substitution matrix
... of conserved sequences found in multiple protein alignments. These conserved sequences are assumed to be of functional ... For example, the sequence ALEIRYLRD could mutate into the sequence ALEINYLRD in one step, and possibly AQEINYQRD over a longer ... If we can line up the two sequences using a sequence alignment algorithm such that the mutations required to transform a ... A matrix for more distantly related sequences can be calculated from a matrix for closely related sequences by taking the ...
*  Embryonal fyn-associated substrate
Central "substrate domain" containing multiple repeats of tyrosine residues embedded within specific conserved sequences (YxxP ... is highly conserved between family members at both primary amino acid sequence and predicted fold. All CAS proteins except ... but instead mediates signaling by promoting protein-protein interactions through conserved sequence motifs (Figure 1). An ... The amino acid sequences of the SH3 domains are 70% identical among human EFS, BCAR1, and NEDD9, making this the most highly ...
*  Glycoside hydrolase family 33
... expression in Escherichia coli and identification of conserved sequences in sialidases and other proteins". Mol. Gen. Genet. ... Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). "Conserved catalytic machinery and the prediction of a ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ... Rothe B, Rothe B, Roggentin P, Schauer R (1991). "The sialidase gene from Clostridium septicum: cloning, sequencing, ...
*  Sialidase
... sequencing, expression in Escherichia coli and identification of conserved sequences in sialidases and other proteins". Mol. ...
*  History of RNA biology
The rRNA sequences that make up the ribosomal active site represent some of the most highly conserved sequences in the ... The first comparative sequence analysis was done and revealed that the sequences varied through evolution in such a way that ... Although determining the sequence of proteins was becoming somewhat routine, methods for sequencing of nucleic acids were not ... The genetic code consists of the translation of particular nucleotide sequences in mRNA to specific amino acid sequences in ...
*  Cupiennin
The hydrophobic N-terminal is characterised by six repeats of four amino acids, which are in a conserved sequence: position 1 ... The amino acid sequences of cupiennin 1b, c, and d were obtained by a combination of sequence analysis and mass spectrometric ... They were isolated and identified in 2002 as a family of peptides called cupiennin 1. The sequence was determined by a process ...
*  Suppressor of fused Sufu protein N terminal domain
The human ortholog of Drosophila suppressor of fused, has a conserved sequence, this means that particular amino acids have ...
*  RBPMS
The RRM domain consists of two short stretches of conserved sequence called RNP1 and RNP2, as well as a few highly conserved ...
*  HOXA11-AS1
Of these lncRNAs, HOXA11-AS, is the most conserved sequence in a wide range of organisms, which shows its longevity in the ... LncRNAs are concentrated in the nucleus because these sequences, contained in the intron sequences, are removed from the final ... LncRNAs are able to complementarily hybridize to DNA sequences in the genome, thus targeting sequences and localizing ... Many lncRNAs are sequences that regulate the expression of nearby or distant genes. Common in HOX genes, lncRNAs can either ...
*  Human bocavirus
Replication results in the creation of a series of circular head to tail sequences. A sequence conserved among the Parvoviridae ... Four conserved sequence motifs in are found in SF3 helicases (A, B, B′, and C). These motifs form the nucleoside triphosphate ... Incomplete sequences of bocaviruses have been obtained from wild chimpanzees. These sequences phylogenetically lie within the ... Zeng S, Wang D, Fang L, Ma J, Song T, Zhang R, Chen H, Xiao S (2011). "Complete coding sequences and phylogenetic analysis of ...
*  Genomics of domestication
Since core genes are conserved between and among species, examining DNA sequences for these genes in multiple individuals of a ... The Potato Genome Sequencing Consortium (July 2011). "Genome sequence and analysis of the tuber crop potato". Nature. 475 (7355 ... allows researchers to compare DNA across multiple species and examine conserved sequences. In 2011, researchers at the Potato ... By comparing the sequence of a previously isolated section of chromosome 8 in rice between fragrant and non-fragrant varietals ...
*  Deletion (genetics)
Recent work suggests that some deletions of highly conserved sequences (CONDELs) may be responsible for the evolutionary ... Other computation methods were selected to discover DNA sequencing deletion errors such as end-sequence profiling. Indel ... "End-sequence profiling: Sequence-based analysis of aberrant genomes". Proceedings of the National Academy of Sciences. 100 (13 ... Shmilovici, A.; Ben-Gal, I. (2007). "Using a VOM Model for Reconstructing Potential Coding Regions in EST Sequences" (PDF). ...
*  Group III intron
Similarities between group III and nuclear introns include conserved 5' boundary sequences, lariat formation, lack of internal ... Their conserved sequences proximal to the splicing sites have similarities to those of group II introns, but have fewer ... They do not map into the conserved secondary structure of group II introns. (Indeed, Christopher and Hallick were unable to ... Montandon PE, Stutz E (September 1983). "Nucleotide sequence of a Euglena gracilis chloroplast genome region coding for the ...
*  XMAP215-Dis1 family
These domains are highly conserved monomeric sequences. The second group consists of only the Caenorhabditis elegans protein ... Thorough analysis of the TOG3 domain in zyg-9 provides a basic understanding of this domain that is conserved throughout all ... The XMAP215/Dis1 family is a highly conserved group of microtubule-associated proteins (MAPs) in eukaryotic organisms. These ... Cullen, C. Fiona; Peter Deák; David Glover; Hiroyuki Ohkura (September 1999). "A Gene Encoding a Conserved Microtubule- ...
*  Trimeric autotransporter adhesin
The head domain is connected to the stalk by a short, highly conserved sequence, which is often called the neck, or ... It contains sequence motifs, of which there is a strong similarity with other TAA heads. This indicates that there is a lot of ... The GIN domain is a head domain named after its sequence motif GIN (Glycine-Isoleucine-Aspargine) motif. It has an all-beta ... It also contains a coiled-coil stalk and the typically conserved TAA C terminal membrane anchor. The BadA protein is another ...
*  Riboswitch
Many of the earliest riboswitches to be discovered corresponded to conserved sequence "motifs" (patterns) in 5' UTRs that ... "Computational identification of riboswitches based on RNA conserved functional sequences and conformations". RNA. 15 (7): 1426- ... These data included conserved RNA secondary structures often found in the untranslated regions (UTRs) of the relevant genes and ... Miranda-Ríos J, Navarro M, Soberón M (August 2001). "A conserved RNA structure (thi box) is involved in regulation of thiamin ...
*  CBS domain
It was first identified as a conserved sequence region in 1997 and named after cystathionine beta synthase, one of the proteins ... CBS domains are always found in pairs in protein sequences and each pair of these domains tightly associate in a pseudo dimeric ... "The structure of the cytoplasmic domain of the chloride channel ClC-Ka reveals a conserved interaction interface". Structure. ... CBS domains within the molecule and are traditionally numbered according to the CBS domain that contains each of the conserved ...
*  Paul M. Bingham
... ancient protein family sharing a highly conserved sequence motif with the prp21 family of constitutive splicing proteins". ... He was part of a collaborative team that discovered of the parasitic DNA sequence element, the P element transposon This ... Searles, L. L.; Jokerst, R. S.; Bingham, PM; Voelker, RA; Greenleaf, AL (1982). "Molecular-Cloning of Sequences from a ... Evidence for Higher-Order Domains of Defined DNA-Sequence". Cell. 16 (4): 797-806. doi:10.1016/0092-8674(79)90095-3. PMID ...
*  SWAP protein domain
SWAP proteins share a colinearly arrayed series of novel sequence motifs. This means that they have been conserved over time. ... mRNA splicing helps to remove these sequences, leaving a more favourable sequence. mRNA splicing is an essential event in the ... ancient protein family sharing a highly conserved sequence motif with the prp21 family of constitutive splicing proteins". ... The SWAP protein in different organisms share some similarity in terms of sequence and may have been related at some point in ...
*  Thimet oligopeptidase
... s are M3 peptidases that possess the conserved sequence His-Glu-X-X-His in the amino acid sequence (as ... TOP1 and TOP2 are more similar to the mouse TOP with 28% similarity in the amino acid sequence, whereas TOPL is more similar to ... Unlike TOP1, TOP2 does not contain an N-terminal serine-rich region in its sequence. Based on the localization within the cell ... TOP1 and TOP2 are considered homologs with a 93% similarity in the protein sequence. Their structures have two domains. However ...