Loading...
*  Conserved sequence
Identifying conserved sequences can be used to discover and predict functional sequences such as genes. Conserved sequences ... Sequences may also recombine or be deleted due to chromosomal rearrangements. Conserved sequences are sequences which persist ... Highly conserved DNA sequences are thought to have functional value, although the role for many highly conserved non-coding DNA ... In evolutionary biology, conserved sequences are similar or identical sequences in nucleic acids (DNA and RNA) or proteins ...
*  Conserved non-coding sequence
A conserved non-coding sequence (CNS) is a DNA sequence of noncoding DNA that is evolutionarily conserved. These sequences are ... Conserved non-coding sequences can be important sites of evolutionary divergence as mutations in these regions may alter the ... Jan 2005). "Plant conserved non-coding sequences and paralogue evolution". Trends in Genetics. 21 (1): 60-65. doi:10.1016/j.tig ... Intron sequences may be conserved, often because they contain expression regulating elements that put functional constraints on ...
*  NAPP (Database)
Conserved sequence Ott, Alban; Idali Anouar; Marchais Antonin; Gautheret Daniel (Jan 2012). "NAPP: the Nucleic Acid ... The Nucleic acid phylogenetic profiling (NAPP) is a database of coding and non-coding sequences according to their pattern of ...
*  MMP3
A highly conserved sequence (. . .PRCGXPD. . .) is present in the propeptide. Removal of the propeptide by proteolysis results ... The hemopexin-like domain of MMPs is highly conserved and shows sequence similarity to the plasma protein, hemopexin. The ... Most members of the MMP family are organized into three basic, distinctive, and well-conserved domains based on structural ... the three histidine residues that coordinate with the catalytic zinc are conserved among all the MMPs. Little is known about ...
*  Leader peptidase A
LepA has a highly conserved sequence. LepA orthologs have been found in bacteria and almost all eukaryotes. The conservation in ... The amino acid sequence of LepA indicates that it is a G protein, which consists of five known domains. The first four domains ... However, Domain IV of EF-G has been shown through several studies to occupy the decoding sequence of the A site after the tRNAs ... March PE, Inouye M (November 1985). "GTP-binding membrane protein of Escherichia coli with sequence homology to initiation ...
*  SRNA-Xcc1
The conserved sequence motif 'AUACAAnACCC' was boxed. The phylogenetic tree of sRNA-Xcc1 homologs based on multiple alignments ...
*  Aminoacyl tRNA synthetase
There are two classes of aminoacyl tRNA synthetase: Class I has two highly conserved sequence motifs. It aminoacylates at the 2 ... Class II has three highly conserved sequence motifs. It aminoacylates at the 3'-OH of a terminal adenosine on tRNA, and is ... For instance, one can start with the gene for a protein that binds a certain sequence of DNA, and, by directing an unnatural ... Glycyl and Cysteinyl-tRNA synthetases is known as the DALR domain after characteristic conserved amino acids. Most of the aaRSs ...
*  FluChip
... a Robust Tool for Conserved Sequence Identification". Bioinformatics. 21 (24): 4420-4422. doi:10.1093/bioinformatics/bti719. ... Numerous short DNA capture sequences were designed , and used to both type and subtype influenza A viruses by taking advantage ... Dawson, Erica D.; Rowlen, Kathy L. (February 2010). FluChip: Robust Sequence Selection Method for a Diagnostic Influenza ... "Robust Sequence Selection Method Used To Develop the FluChip Diagnostic Microarray for Influenza Virus". Journal of Clinical ...
*  MADS-box
The MADS box is a conserved sequence motif. The genes which contain this motif are called the MADS-box gene family. The MADS ... The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are ... There is evidence that the MADS domain evolved from a sequence stretch of a type II topoisomerase in a common ancestor of all ... MEF2-like MADS-domain proteins in animals and fungi have the MEF2 domain as a second conserved domain. In plants, the MEF2-like ...
*  CYTL1
Proteins have two conserved sequence motifs: PPTCYSR and DDC. GRCh38: Ensembl release 89: ENSG00000170891 - Ensembl, May 2017 ...
*  Mathieu Blanchette (computational biologist)
"Identification and characterization of multi-species conserved sequences". Genome Research. 13 (12): 2507-18. doi:10.1101/gr. ... His research focuses on developing new algorithms for the detection of functional regions in DNA sequences. Blanchette studied ... His research focuses on developing computational methods for detecting functional regions in DNA sequences. His postdoctoral ... 2003). "Comparative analyses of multi-species sequences from targeted genomic regions". Nature. 424 (6950): 788-93. doi:10.1038 ...
*  Chromosome 6 open reading frame 165
This domain has two conserved sequence motifs: GFC and GLL. The only predicted post-translational modification this protein ... and a protein sequence of 622 amino acids. The C6orf165 gene is conserved in chimpanzee, rhesus monkey, dog, cow, mouse, rat, ... Other known aliases are "dJ382I10.1, UPF0704 Protein C6orf165." In humans, the gene coding sequence is 56,501 base pairs long, ... "Conserved domains on [ Homo sapiens (human) ]". Retrieved 2014-03-09. "post-translational_modification". Retrieved 2014-05-06 ...
*  LDB3
... conserved sequences known as ZASP-like motifs (ZMs); and the four long isoforms have three C-terminal LIM domains. ZASP ... "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain ... "Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing ...
*  VS ribozyme
VS RNA contains many conserved sequence characteristics to group 1 introns. However VS ribozyme splice site is different from ... Basically, VS ribozyme's activity is very dependent on the local sequence of the two three-way junctions. The three-way ...
*  Vasa gene
All DEAD box genes, including Vasa, have 9 conserved sequence motifs. The Vasa gene family evolved from a duplication event ... The conserved domain may act as chaperones by unwinding RNA secondary structures and refolding properly. pre-mRNA splicing, ... Vasa was found to bind RNA in a sequence specific manner. In the Drosophila embryos, Vasa binds the Uracil rich motif of the ... The protein product in humans has 724 amino acids, a molecular mass of 79 kDa and 8 conserved domains in all DEAD-box proteins ...
*  Evolutionary pressure
Fitness (biology) Survival of the fittest Conserved sequences "Natural selection". evolution.berkeley.edu. Retrieved 2017-11-29 ... Lindblad-Toh, Kerstin; members, Broad Sequencing Platform; Wade, Claire M; Mikkelsen, Tarjei S.; Karlsson, Elinor K.; Jaffe, ... David B.; Kamal, Michael; Clamp, Michele; Chang, Jean L. (December 2005). "Genome sequence, comparative analysis and haplotype ...
*  Transfer factor
Kirkpatrick, C. H. (2000). "Transfer factors: Identification of conserved sequences in transfer factor molecules". Molecular ...
*  Satellite DNA
Several RU sequences were cloned and sequenced to reveal conserved regions of conventional DNA sequences interspersed with five ... Conserved sequences showed virtually no differences among cloned RU sequences. Variations among cloned RU sequences were ... The nucleotide sequence of the repeats is fairly well conserved across species. However, variation in the length of the repeat ... One RU sequence was shown to have multiple copies of an Alu sequence element inserted into a region bordered by inverted ...
*  C1orf74
Within this DUF, there are two conserved sequence motifs LLGYP and SFS. The translational start site of C1orf74 is after the ... May 2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315-21. doi:10.1038/ ...
*  HES7 gene
This conserved sequence of four amino acids binds Groucho/TLE family members. Groucho/TLE are transcriptional corepressors. ... Homozygotes for a V2A missense mutation in a conserved vertebrate sequence of HES7 resulted in kinked tails while heterozygotes ... Xu X, Sun X, Hu XS, Zhuang Y, Liu YC, Meng H, Miao L, Yu H, Luo SJ (August 2016). "Whole Genome Sequencing Identifies a ... Xu X, Sun X, Hu XS, Zhuang Y, Liu YC, Meng H, Miao L, Yu H, Luo SJ (August 2016). "Whole Genome Sequencing Identifies a ...
*  Glycoside hydrolase family 14
Three highly conserved sequence regions are found in all known beta-amylases. The first of these regions is located in the N- ... Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). "Conserved catalytic machinery and the prediction of a ... Friedberg F, Rhodes C (1988). "Segments of amino acid sequence similarity in beta-amylases". Protein Seq. Data Anal. 1 (6): 499 ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
*  KEGG
"Modular architecture of metabolic pathways revealed by conserved sequences of reactions". J Chem Inf Model. 53 (3): 613-22. doi ... Several months after the KEGG project was initiated in 1995, the first report of the completely sequenced bacterial genome was ... Foreseeing the need for a computerized resource that can be used for biological interpretation of genome sequence data, he ... 1995). "Whole-genome random sequencing and assembly of Haemophilus influenzae Rd". Science. 269 (5223): 496-512. doi:10.1126/ ...
*  TFAP2A
Human sequence as reference and searched for multispecies conserved sequences (MCSs). Regions contained in introns 5' and 3' ... Its binding site is a GC-rich sequence that is present in the cis-regulatory regions of several viral and cellular genes. AP2- ... Sequencing of candidate genes in that region in 4 additional unrelated BOFS patients revealed 4 different de novo missense ... A search of NSCL/P cases for potential regulatory elements for IRF6 gene was made aligning genomic sequences to a 500 Kb region ...
*  Sucrose-phosphate synthase
This conserved sequence may potentially aid in recognition of a regulatory SPS-kinase. Once phosphorylated, the inactivated ... First, antibodies with high specificities for plant SPS also target the bacterial SPS, indicating the structure is conserved ... Furthermore, genomic studies reveal that closely related plant homologues exhibit up to 54% sequence identities. In the open ...
*  Potocki-Lupski syndrome
This conserved sequence has been exploited to learn more about SMS and PTLS. Through genetic studies on both laboratory mice ...