The interaction between connexin 43 and PTPmu increases gap junction communication. PTPµ is expressed in human umbilical cord ... Giepmans BN, Feiken E, Gebbink MF, Moolenaar WH (2003). "Association of connexin43 with a receptor protein tyrosine phosphatase ... PTPmu also dephosphorylates another cell junction protein, connexin 43. ... GJA1 connexin43 (gap junction protein, alpha 1), IQGAP1, PVRL3 (nectin3), PIPKIγ90, PRKCD (PKCδ), and PLCG1 (PLCγ1). GRCh38: ...
... acts at connexins, preferentially to connexin 43 (Cx43). Treatment with rotigaptide has been shown to activate ... Each connexon is made up of 6 functional units (connexins) that associate together to form a channel between adjacent cells. ... increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin 43. British Journal ... Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide ...
Connexin-43 is a 43.0 kDa protein composed of 382 amino acids. GJA1 contains a long C-terminal tail, an N-terminal domain, and ... The connexin-43 internal ribosome entry site is an RNA element present in the 5' UTR of the mRNA of GJA1. This internal ... Gap junction alpha-1 protein (GJA1), also known as connexin 43 (Cx43), is a protein that in humans is encoded by the GJA1 gene ... GJA1 is the most ubiquitously expressed connexin and is detected in most cell types. It is the major protein in heart gap ...
"Entrez Gene: CSNK1D casein kinase 1, delta". Cooper, Cynthia D; Lampe Paul D (Nov 2002). "Casein kinase 1 regulates connexin-43 ...
Shore L, McLean P, Gilmour SK, Hodgins MB, Finbow ME (July 2001). "Polyamines regulate gap junction communication in connexin ... 43-expressing cells". Biochem. J. 357 (Pt 2): 489-95. doi:10.1042/0264-6021:3570489. PMC 1221976 . PMID 11439099. Herberg LJ, ...
It has been found in seronegative NMO and some MS patients Finally, other proteins under study are Connexin 43 and anti-AQP1 ... Masaki, Katsuhisa (October 2015). "Early disruption of glial communication via connexin gap junction in multiple sclerosis, ... of the cases Connexin-43 NMO Aquaporin-1 associated NMO Idiopatic NMO, defined by the absence of all previous antibodies Cassie ... "Connexin 43 astrocytopathy linked to rapidly progressive multiple sclerosis and neuromyelitis optica". PLOS ONE. 8 (8): e72919 ...
It is generally believed to be caused by a mutation in the gene GJA1, which codes for the gap junction protein connexin 43. ... 2003). "Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia". Am. J. Hum. Genet. 72 (2 ... "A nonsense mutation in the first transmembrane domain of connexin 43 underlies autosomal recessive oculodentodigital syndrome ... 43 (7): e37. doi:10.1136/jmg.2005.037655. PMID 16816024. Jones KL, Smith DW, Harvey MA, Hall BD, Quan L (1975). "Older paternal ...
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of ... 2003). "Comparison of connexin 43, 40 and 45 expression patterns in the developing human and mouse hearts". Cell Commun. Adhes ... Gap junction gamma-1 protein (GJC1), also known as gap junction alpha-7 protein (GJA7) and connexin 45 (Cx45) - is a protein ... "Entrez Gene: GJA7 gap junction protein, alpha 7, 45kDa". Andrew L Harris; Darren Locke (2009). Connexins, A Guide. New York: ...
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of ... Gap junction alpha-5 protein (GJA5), also known as connexin 40 (Cx40) - is a protein that in humans is encoded by the GJA5 gene ... 2003). "Comparison of connexin 43, 40 and 45 expression patterns in the developing human and mouse hearts". Cell Commun. Adhes ... 2002). "Connexin expression in Huntington's diseased human brain". Cell Biol. Int. 22 (11-12): 837-47. doi:10.1006/cbir. ...
2013). "Connexin 43 Astrocytopathy Linked to Rapidly Progressive Multiple Sclerosis and Neuromyelitis Optica". PLoS ONE. 8 (8 ... being linked to Connexin 43 autoantibodies with pattern III lesions (distal oligodendrogliopathy) and being responsive to ...
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF (1998). "Regulation of connexin-43 gap junctional intercellular communication by ... "Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ ... "Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein". J. ...
WH Connexin channels, connexin mimetic peptides and ATP release - Le "Informa's global locations". informa.com. Archived from ... An update on connexin genes and their nomenclature in mouse and man - Sohl, G; Willecke, K Idenfitication of cells expressing ... Connexin-43 interactions with ZO-1 and alpha-and beta-tubulin - Giepmans, BNG; Verlaan, I; Moolenaar, ...
Genetic loci associated with HLHS include GJA1 (connexin 43), HAND1, NKX2.5, 10q22, and 6q23. There is a slight risk of ... "Identification of connexin43 (alpha1) gap junction gene mutations in patients with hypoplastic left heart syndrome by ...
One connexin protein has four transmembrane domains 6 Connexins create one Connexon (hemichannel). When different connexins ... By study of connexins still in membranes lipids associated with the connexins have been studied. It was found that specific ... Connexin proteins expressed in neuronal gap junctions include: mCX36 mCX57 mCX45 with mRNAs for at least five other connexins ( ... Though differing in sequence to connexins, innexins are similar enough to connexins to state that innexins form gap junctions ...
48:457-476, 2005 Ohara PT, Vit JP, Bhargava A, Jasmin L (December 2008). "Evidence for a role of connexin 43 in trigeminal pain ...
Intercalated disc architecture was severely impaired and connexin 43-resident gap junctions were markedly reduced. ... 5 (3): 533-43. doi:10.1016/S1097-2765(00)80447-5. PMID 10882138. Sampietro J, Dahlberg CL, Cho US, Hinds TR, Kimelman D, Xu W ( ... 31 (2): 333-43. doi:10.1006/jmcc.1998.0886. PMID 10093046. Yoshida M, Ohkusa T, Nakashima T, Takanari H, Yano M, Takemura G, ... 20 (17): 4935-43. doi:10.1093/emboj/20.17.4935. PMC 125268 . PMID 11532957. Taya S, Yamamoto T, Kanai-Azuma M, Wood SA, ...
Oxford EM, Musa H, Maass K, Coombs W, Taffet SM, Delmar M (September 2007). "Connexin43 remodeling caused by inhibition of ... including connexin 43, the major component of cardiac gap junctions; the voltage-gated sodium channel Na(V)1.5 and its ... Decreased expression of plakophilin-2 via siRNA leads to a decrease in and redistribution of connexin 43 protein, as well as a ... and Connexin43 at the cardiac intercalated disc". Circulation Research. 109 (2): 193-201. doi:10.1161/CIRCRESAHA.111.247023. ...
Negoro, Hiromitsu (2012). "Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal ... Anatomy photo:43:07-0100 at the SUNY Downstate Medical Center - "The Female Pelvis: The Urinary bladder" ...
Rosselló, RA; Wang, Z; Kizana, E; Krebsbach, PH; Kohn, DH (2009). "Connexin 43 as a signaling platform for increasing the ...
Hatakeyama T, Dai P, Harada Y, Hino H, Tsukahara F, Maru Y, Otsuji E, Takamatsu T (2013). "Connexin43 functions as a novel ... Hatakeyama T, Dai P, Harada Y, Hino H, Tsukahara F, Maru Y, Otsuji E, Takamatsu T (2013). "Connexin43 functions as a novel ... 3 (9): 839-43. doi:10.1038/ncb0901-839. PMID 11533664. Zhang B, Rong R, Li H, Peng X, Xiong L, Wang Y, Yu X, Mao H (2015). " ... 22 (8): 2536-43. doi:10.1128/MCB.22.8.2536-2543.2002. PMC 133739 . PMID 11909948. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann ...
Borke JL, Yu JC, Isales CM, Wagle N, Do NN, Chen JR, Bollag RJ (November 2003). "Tension-induced reduction in connexin 43 ...
In the mink, the presence of the connexin-43 protein that is functional in gap junctions, correlates to prolactin secretory ... When prolactin secretion is highest in the spring there is the highest abundance of connexin-43 gap junctions; prolactin ... 92 (1): 43-45. ISSN 0301-5564. PMID 2670846. Marin, F.; Boya, J.; Lopez-Carbonell, A. (1989). "Immunocytochemical localization ...
PKCε modulates the interaction between subunit Kir6.1 of mitoK(ATP) and connexin-43, whose interaction confers cardioprotection ... 270 (43): 25445-54. doi:10.1074/jbc.270.43.25445. PMID 7592712. Burkart EM, Sumandea MP, Kobayashi T, Nili M, Martin AF, ... Crossing PKCε transgenic mice with mutant cTnI mice lacking PKCε phosphorylation sites (Serine-43/Serine-45 mutated to Alanine ... showing that in vitro phosphorylation of cTnI by PKCε or Serine-43/45 mutation to Glutamate to mimic phosphorylation ...
Research Interest Basic Science: Gap junction physiology, cell-to-cell communication modulated by connexin protein, tissue ... Regulation of Cell-Cell Communication Mediated by Connexin 43 in Rabbit Myometrial Cells, Biology of Reproduction 50, 377-889 ( ...
The decrease in expression and instability of connexin-43 may be due to the down regulation of tubulin and kinesin genes, and ... down regulation of these growth factors may also contribute to the reduced expression and instability of connexin-43. DEHP has ... is observed in conjunction with a significant decrease in the amount of expression and instability of gap junctional connexin ... proteins, specifically connexin-43, in cardiomyocytes treated with DEHP. ...
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions (Ca2+) into the cell upon membrane polarization (see membrane potential and calcium in biology).[7] The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta and beta subunits in a 1:1:1 ratio. The S3-S4 linkers of Cav1.2 determine the gating phenotype and modulated gating kinetics of the channel.[8] Cav1.2 is widely expressed in the smooth muscle, pancreatic cells, fibroblasts, and neurons.[9][10] However, it is particularly important and well known for its expression in the heart where it mediates L-type currents, which causes calcium-induced calcium release from the ER Stores via ryanodine receptors. It depolarizes at -30mV and helps define the shape of the action potential in cardiac and smooth muscle.[8] The protein encoded by this gene ...