These applications include surgery, radiation therapy, chemotherapy, hormone therapy, immunotherapy and combined treatment ... Can it be a Multifunctional Drug?". Current Drug Metabolism. 21 (7): 512-524. doi:10.2174/1389200221666200610172105. PMID ... Wang, Ye; Liu, Yanfang; Du, Xinyang; Ma, Hong; Yao, Jing (30 January 2020). "The Anti-Cancer Mechanisms of Berberine: A Review ... besides enhancing the efficacy of chemotherapy and radiation therapy". Caloric restriction mimetics, including some present in ...

55-59 Combined modality chemotherapy is the use of drugs with other cancer treatments, such as surgery, radiation therapy, or ... Anti-Cancer Drugs (journal) Antimicrobial chemotherapy Cancer and nausea Cancer-related fatigue Chemo brain Chemotherapy ... 59 Intensification chemotherapy is identical to consolidation chemotherapy but a different drug than the induction chemotherapy ... In regard to the potential benefit that drug-resistant cells can be recruited for effective therapy by combining chemotherapy ...

Rhabdomyosarcoma Ewing's sarcoma Malignant hydatidiform mole Sometimes it will be combined with other drugs in chemotherapy ... Actinomycin D was the first antibiotic shown to have anti-cancer activity. It was first isolated by Selman Waksman and his co- ... and radiation therapy". Cancer. 38 (5): 1925-1930. doi:10.1002/1097-0142(197611)38:5. 3.0.CO;2-J. PMID 991106. Uberti EM, ... "Drugs@FDA: Dactinomycin". FDA. Retrieved 2023-10-15. Toba K, Koike T, Watanabe K, Fuse I, Takahashi M, Hashimoto S, et al. ( ...

Shim JS, Liu JO (2014). "Recent advances in drug repositioning for the discovery of new anticancer drugs". International ... In some of these trials, nelfinavir is used alone in monotherapy fashion, whereas in others it is combined with other modes of ... Antimicrobial Agents and Chemotherapy. 55 (6): 2696-2703. doi:10.1128/AAC.01295-10. PMC 3101462. PMID 21402841. Maxson T, Deane ... cancer therapy, such as well-established chemotherapeutic agents or radiation therapy.[citation needed] As of April 2022[update ...

Most previous chemotherapy drugs for cancer were (relatively) nonselective in their activity. Although their exact mechanisms ... Additionally, SCLC's are typically much more sensitive to chemotherapy and/or radiation therapy than are NSCLC's. Therefore, ... Ansari J, Palmer DH, Rea DW, Hussain SA (June 2009). "Role of tyrosine kinase inhibitors in lung cancer". Anti-Cancer Agents in ... While there have been no randomized clinical trials of targeted agents in combined small-cell lung carcinoma (c-SCLC),[citation ...

... are treated with radiation therapy and cisplatin-based chemotherapy. On 15 June 2006, the US Food and Drug Administration ... There is insufficient evidence whether anticancer drugs after standard care help women with locally advanced cervical cancer to ... More recently, CIN2 and CIN3 have been combined into CIN2/3. These results are what a pathologist might report from a biopsy.[ ... In addition, chemotherapy can be used to treat cervical cancer, and has been found to be more effective than radiation alone. ...

... is a commonly used regimen of breast cancer chemotherapy that combines three anti-cancer agents: cyclophosphamide, methotrexate ... Cyclophosphamide may be also administered intravenously in conjunction with these drugs, or may be taken as an oral tablet, ... followed by radiation for stage III breast cancer: a phase II trial (CALGB 8944)". Breast Cancer Res. Treat. 113 (3): 479-90. ... v t e (Articles with short description, Short description matches Wikidata, Chemotherapy regimens used in breast cancer, All ...

... the drug is released without harmful radiation or relying on a specific chemical reaction to occur and the drug can be ... Agasti SS, Chompoosor A, You CC, Ghosh P, Kim CK, Rotello VM (April 2009). "Photoregulated release of caged anticancer drugs ... A major cause for the ineffectiveness of current chemotherapy treatments is multiple drug resistance which can arise from ... second approach is to attach a chemotherapeutic drug directly to the functionalized surface of the silver nanoparticle combined ...

Delivers chemotherapy or radiation in a targeted manner which allows higher concentrations to be administered Monoclonal ... They can be administered alone or be linked (conjugated) to anticancer drugs, radioisotopes, or other biologic response ... A clinical trial of bortezomib showed that bortezomib alone had no activity in DLBCL, but when combined with chemotherapy, it ... that bortezomib enhances the activity of chemotherapy for ABC but not GCB DLBCL when combined with conventional chemotherapy. ...

... typically combined into a multi-drug chemotherapy regimen. Some are also treated with radiation therapy. In some cases, a bone ... Compared to most anti-cancer drugs, it has relatively few side effects and can be taken orally at home. With this drug, more ... Many different anti-cancer drugs are effective for the treatment of AML. Treatments vary somewhat according to the age of the ... People who are high-risk receive higher drug doses of these drugs, plus additional drugs. CNS prophylaxis (preventive therapy) ...

Drug bestows radiation resistance on mice and monkeys". Science. 320 (5873): 163. doi:10.1126/science.320.5873.163. PMID ... Additionally, entolimod may also be developed as an adjuvant to standard radiation and chemotherapy, which will allow using of ... Additionally, entolimod evidences a supportive care benefit in preclinical models when combined with radiation treatment and ... May 2013). "Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist". Proceedings of ...

... after which chemotherapy and radiation therapy are used. The medication temozolomide is frequently used as part of chemotherapy ... Direct nose-to-brain drug delivery is being explored as a means to achieve higher, and hopefully more effective, drug ... More prognostic power can be obtained by combining the mutational status of IDH1 and the methylation status of MGMT into a two- ... However, increasing understanding of the mechanistic basis through which alternating electric field therapy exerts anti-cancer ...

A number of possible chemotherapy agents can be selected, but most involve the platinum-based chemotherapy drug called ... "Percutaneous image-guided thermal ablation and radiation therapy: outcomes of combined treatment for 41 patients with ... Nikolova T, Christmann M, Kaina B (July 2009). "FEN1 is overexpressed in testis, lung and brain tumors". Anticancer Research. ... "Chemotherapy with cetuximab versus chemotherapy alone for chemotherapy-naive advanced non-small cell lung cancer". The Cochrane ...

... acts as an anti-cancer drug by binding to the mRNA initiation site of the clusterin gene, reducing clusterin protein ... The Phase III SYNERGY trial looked into the addition of Custirsen to first-line Docetaxel and Prednisone chemotherapy, ... and radiation therapy. This resistance is caused by the inhibition of the pro-apoptotic BLC2 gene, prevention of protein ... Thrombocytopenia Anaemia Leukopenia Fever Fatigue Rigors Alopecia Anorexia In patients who received combined treatment with ...

All techniques are often combined with radiation or chemotherapy, muddying how much toxicity is the result of those treatments ... March 1987). "Clinical evaluation of total-body hyperthermia combined with anticancer chemotherapy for far-advanced ... Hot chemotherapy drugs are pumped directly into the peritoneal cavity to kill the cancer cells. Whole-body hyperthermia heats ... Normally, chemotherapy drugs are infused at the same time. One specialized type of this approach is continuous hyperthermic ...

Gong, Qian; Gao, Xingxing; Liu, Wenfang; Hong, Tingting; Chen, Chuanpin (2019). "Drug-Loaded Microbubbles Combined with ... Radiation therapy is known to increase BBB permeability, but the temporal characteristics of radiation-induced opening are ... Studies have also shown that FUS can be used to both thermally ablate brain tumors and improve delivery of chemotherapy through ... Expert Review of Anticancer Therapy, 7(sup1), S79-S85. https://doi.org/10.1586/14737140.7.12s.s79. Rubin, P., Gash, D. M., ...

... when combined with temozolomide and radiation therapy and a clinical trial was underway as of August 2015[update]. While the ... "Drug Approval Package: Temodar NDA #022277". U.S. Food and Drug Administration (FDA). 24 November 2009. Archived from the ... Temozolomide, sold under the brand name Temodar among others, is an anticancer medication used to treat brain tumors such as ... March 2006). "Modulation of chemotherapy resistance in regional therapy: a novel therapeutic approach to advanced extremity ...

In certain cases chemotherapy or radiation that has previously not had any effect can be made effective. Hyperthermia alters ... High-energy therapeutic ultrasound could increase higher-density anti-cancer drug load and nanomedicines to target tumor sites ... However, combining the therapy with chemotherapeutic treatments can help to solve this problem. Another strategy is to use ... chemotherapy, radiation, and immunotherapy). However, researchers are still trying to determine whether these treatments are ...

Treatment may include a combination of surgery, radiation therapy, chemotherapy, and targeted therapy. Previous diagnosis and ... Center for Drug Evaluation and Research (2018-11-03). "Nivolumab for SCCHN". FDA. Center for Drug Evaluation and Research (2019 ... The T, N, and M characteristics are combined to produce a "stage" of the cancer, from I to IVB. Survival advantages provided by ... Anticancer Research. 33 (8): 3481-3485. PMID 23898123. Archived from the original on 2016-01-07. Schmitz M, Driesch C, Beer- ...

"Prospects for hypoxia-activated anticancer drugs". Current Medicinal Chemistry. Anti-Cancer Agents. 4 (5): 395-9. doi:10.2174/ ... "Chemotherapy, Tirapazamine, and Radiation Therapy in Treating Patients With Non-Small Cell Lung Cancer" at ClinicalTrials.gov ( ... A new clinical phase I trial of Tirapazamine combined with embolization in liver cancer has been received in June, 2014. This ... Tirapazamine (SR-[[4233]]) is an experimental anticancer drug that is activated to a toxic radical only at very low levels of ...

Combining DNA damaging therapies such as chemotherapy or radiation treatment with Chk1 inhibition enhances targeted cell death ... Tao ZF, Lin NH (July 2006). "Chk1 inhibitors for novel cancer treatment". Anti-Cancer Agents in Medicinal Chemistry. 6 (4): 377 ... drugs". Molecular Oncology. 5 (4): 368-73. doi:10.1016/j.molonc.2011.07.002. PMC 3590794. PMID 21820372. Chen Z, Xiao Z, Gu WZ ... Cancer therapies utilize DNA damaging therapies such as chemotherapies and ionizing radiation to inhibit tumor cell ...

Some of the factors that have posed challenges for the development of preventive measures and anti-cancer drugs and therapies ... radiation, and chemotherapy. Cancer surveillance experts have reported a 15.8 percent decrease in the age-standardized death ... A 2010 report from the American Cancer Society found that death rates for all cancers combined decreased 1.3% per year from ... The drug Gleevec now cures most CML patients, compared to previous therapy with interferon, which extended life for ...

Radiotherapy therefore can only be given up to a certain level of radiation exposure. Combining radiation therapy with PARP ... Chemotherapy and radiation therapy attempt to kill cancer cells by inducing high levels of DNA damage. By inhibiting PARP1 DNA ... Drugs that inhibit PARP1 cause multiple double strand breaks to form in this way, and in tumours with BRCA1, BRCA2 or PALB2 ... "Today's anti-cancer tools are ever better wielded". The Economist. Retrieved 2017-09-30. Rajman L, Chwalek K, Sinclair DA ( ...

Treatment options include watchful waiting, radiation aimed directly at the affected lymph nodes, chemotherapy, and ... Treatments include rituximab, either alone or combined with chemotherapy; obinutuzumab; combination immunotherapy with ... and adverse drug reactions. It takes six years on average from disease onset to confirmation of diagnosis. Marginal zone ... Expert Review of Anticancer Therapy. 15 (5): 531-544. doi:10.1586/14737140.2015.1023712. ISSN 1473-7140. PMC 4698971. PMID ...

Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J ... His research has affected the following areas: Hong and his colleagues demonstrated the efficacy of combined chemotherapy and ... "HEALTH; Scientists Say an Acne Drug Can Prevent a Type of Cancer. The New York Times, September 20, 1990. "VITAL SIGNS: ... including the Raymond Bourgine Award and the Claude Jacquillat Award from the International Congress on Anti-Cancer Treatment ( ...

It is also common to combine radiation therapy with surgery, chemotherapy, hormone therapy, immunotherapy or some mixture of ... A third technique is to enhance the radiosensitivity of the cancer by giving certain drugs during a course of radiation therapy ... Studies in people having pelvic radiotherapy as part of anticancer treatment for a primary pelvic cancer found that changes in ... Stereotactic radiation is a specialized type of external beam radiation therapy. It uses focused radiation beams targeting a ...

... s are anti-cancer drugs that act on tumours with variations of anaplastic lymphoma kinase (ALK) such as an EML4- ... Some make use of SBRT (stereotactic body radiation therapy), a very precise radiation technique able to provide high doses with ... It demonstrated a clear benefit against both first-line chemotherapy and first-line crizotinib. This was based on the phase 3 ... Currently, solid preclinical studies have been carried out with second-generation inhibitors combined with afatinib, erlotinib ...

Delivering chemotherapy to brain cancer cells and various drugs to other tissues is called acoustic targeted drug delivery ( ... Ultrasound has been used to trigger the release of anti-cancer drugs from delivery vectors including liposomes, polymeric ... This is based on the acoustic radiation force which causes particles to be attracted to either the nodes or anti-nodes of the ... treatment that involves the use of ultrasound combined with medication gels and will utilize ultrasound waves to enhance drug ...

Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 15 (5-6): 249-257. doi:10.1016/ ... Combining multiple chemotherapeutic drugs into one treatment helps overcome the problem of drug resistance. Furthermore, ... involved-field radiation for children and adolescents with favorable, early-stage Hodgkin's disease: results of a prospective ... VAMP regimen or VAMP chemotherapy is a four-drug combination chemotherapy regimen, used today in the treatment of Hodgkin ...

Cancer treatment used to be focused on killing or removing cancer cells and tumours, with chemotherapy or surgery or radiation ... Hoos A (April 2016). "Development of immuno-oncology drugs - from CTLA4 to PD1 to the next generations". Nature Reviews. Drug ... Pento JT (November 2017). "Monoclonal Antibodies for the Treatment of Cancer". Anticancer Research. 37 (11): 5935-5939. doi: ... Low-Dose Combined Vitamin D/Dexamethasone Promotes IL-10 Production and Atheroprotection in Dyslipidemic Mice". Frontiers in ...