Type XXVII collagen is related to the "fibrillar" class of collagens and may play a role in development of the skeleton. ... COL27A1 is a type XXVII collagen. It was discovered by James Pace. This gene appears to be turned on in cartilage, the eye, and ... Fibrillar collagens, such as COL27A1, compose one of the most ancient families of extracellular matrix molecules. They form ... Collagen alpha-1 (XXVII) chain (COL27A1) is a protein that in humans is encoded by the COL27A1 gene. ...
"Entrez Gene: COL14A1 collagen, type XIV, alpha 1 (undulin)". "COL14A1 - Collagen alpha-1(XIV) chain precursor - Homo sapiens ( ... 2005). "Collagen types XII and XIV are present in basement membrane zones during human embryonic development". J. Mol. Histol. ... Tono-Oka S, Tanase S, Miike T, Tanaka H (1996). "Transient expression of collagen type XIV during muscle development and its ... Collagen alpha-1(XIV) chain is a protein that in humans is encoded by the COL14A1 gene. It likely plays a role in collagen ...
Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Type-V collagen GRCh38: Ensembl release 89: ... related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type ... Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in ... "Entrez Gene: COL5A1 collagen, type V, alpha 1". Mann K (1992). "Isolation of the alpha 3-chain of human type V collagen and ...
2006). "Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low ... and characterization of the type II enzyme tetramer. The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II) ... The two alternatively spliced types of mRNA correspond to two homologous exons the sequences of which are expressed in a ... a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one ...
This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the ... "Entrez Gene: PRELP proline/arginine-rich end leucine-rich repeat protein". Lewis M (2003). "PRELP, collagen, and a theory of ... 2002). "The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor". J. ... Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome ...
Smith GN, Linsemmayer TF, Newsome DA, Synthesis of type II collagen in vitro by embryonic chick neural retina tissue. Proc Natl ... He also found that the eye's pigmented retina, a type of covering or epithelial tissue, could produce some types of collagen. ... D A Newsome; T F Linsenmayer; R L Trelstad (1976). "Vitreous body collagen. Evidence for a dual origin from the neural retina ... His new observations opened a new field of investigation of the collagen and related structural molecules in the eye and other ...
It is the only type of cartilage that contains type I collagen in addition to the normal type II. The extracellular matrix of ... In cases like this, the body will form a scar in the area using a special type of cartilage called fibrocartilage. ... fibrocartilage is mainly made from type I collagen secreted by chondroblasts. secondary cartilaginous joints: pubic symphysis ... Histology Learning System at Boston University List of distinct cell types in the adult human body Portal: Anatomy (Articles ...
Cartilage is composed of a network of collagen type II held in tension by water-absorbing proteins, hydrophilic proteoglycans. ... The active osteoblast produces substantial collagen type I. About 10% of the bone matrix is collagen with the balance mineral. ... Defects in collagen type I cause the commonest inherited disorder of bone, called osteogenesis imperfecta. Minor, but important ... Almost all of the organic (non-mineral) component of bone is dense collagen type I, which forms dense crosslinked ropes that ...
Type II Collagen is an example of homotrimeric protein, while Type I collagen is an AAB-type heterotrimeric protein. Porins ... When a multimer is formed from polypeptides produced by two different mutant alleles of a particular gene, the mixed multimer ...
The protein encoded by this gene cleaves type II collagen more efficiently than types I and III[citation needed]. It may be ... February 1996). "Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human ... "Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in ... During embryonic development, MMP-13 is expressed in the skeleton as required for restructuring the collagen matrix for bone ...
2006). "Regulation of Type II Collagen Synthesis during Osteoarthritis by Prolyl-4-Hydroxylases : Possible Influence of Low ... II) and characterization of the type II enzyme tetramer. The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha( ... a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one ... 2001). "Characterization of the human and mouse genes for the alpha subunit of type II prolyl 4-hydroxylase. Identification of ...
Leitinger B, Kwan AP (2006). "The discoidin domain receptor DDR2 is a receptor for type X collagen". Matrix Biol. 25 (6): 355- ... Leitinger B, Steplewski A, Fertala A (2004). "The D2 period of collagen II contains a specific binding site for the human ... Vogel W, Gish GD, Alves F, Pawson T (1997). "The discoidin domain receptor tyrosine kinases are activated by collagen". Mol. ... In the case of DDR2, the ligand is collagen which binds to its extracellular discoidin domain. This autophosphorylation leads ...
The primary function of MMP-8 is the degradation of type I, II and III collagens. In cancer, loss of MMP-8 in the murine MMTV- ... Neutrophil collagenase, also known as matrix metalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving ... 1993). "Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain". Biochem. J ... one N-and two O-linked carbohydrate chains are located between Kunitz domains 2 and 3 and one N-linked carbohydrate chain is in ...
This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many ... 1998). "Two distinct kerato-epithelin mutations in Reis-Bücklers corneal dystrophy". Am. J. Ophthalmol. 126 (4): 535-42. doi: ... This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The ... 1997). "Characterization of a cartilage-derived 66-kDa protein (RGD-CAP/beta ig-h3) that binds to collagen". Biochim. Biophys. ...
1998). "Complete primary structure of two variant forms of human type XVIII collagen and tissue-specific differences in the ... This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix ... 2002). "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are ... "Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to ...
The annulus fibrosus consists of several layers (laminae) of fibrocartilage made up of both type I and type II collagen. Type I ... The nucleus of the disc acts as a shock absorber, absorbing the impact of the body's activities and keeping the two vertebrae ... The nucleus pulposus consists of large vacuolated notochord cells, small chondrocyte-like cells, collagen fibrils, and aggrecan ... 88 (Suppl 2): 10-4. doi:10.2106/JBJS.F.00019. PMID 16595436. Antoniou, J.; Steffen, T.; Nelson, F.; Winterbottom, N.; Hollander ...
This gene is in between COL2A1, the human type II collagen gene, and VDR, the human Vitamin D Receptor gene. This protein is ... It can be found expressed in many tissues types. Tissue types with high expression included the adrenal gland, eye, ... There are two paralogs for TMEM106C. These paralogs are TMEM106A and TMEM106B. Both genes are found highly conserved in ... Nakai, K. (19 Nov 1999). "PSORT II Prediction". Mitaku Group. "Classification and Secondary Structure Prediction of Membrane ...
The protein made by this gene forms type II collagen, a molecule found mostly in cartilage and in the clear gel that fills the ... Type II collagen is essential for the normal development of bones and other connective tissues (tissues that form the body's ... Mutations in the COL2A1 gene interfere with the assembly of type II collagen molecules, which prevents bones from developing ... types II and XI, and is similar to another skeletal disorder, achondrogenesis type 2, although the spinal changes seen in ...
"Comparative therapeutic efficacy and safety of type-II collagen (UC-II), glucosamine and chondroitin in arthritic dogs: Pain ... "Therapeutic Efficacy and Safety of Undenatured Type II Collagen Singly or in Combination with Glucosamine and Chondroitin in ... ii: 213-227. Ledderhose G (1880). "Über Glykosamin". Zeitschrift für Physiologische Chemie. iv: 139-159. W. N. Haworth; W. H. G ... In the second study, oral glucosamine sulfate capsules (1,500 mg) were given daily for two weeks to 12 people with ...
These include type II collagen in the cartilaginous zones, type III collagen in the reticulin fibres of the vascular walls, ... type IV collagen in the basement membranes of the capillaries, type V collagen in the vascular walls, and type X collagen in ... Although most of a tendon's collagen is type I collagen, many minor collagens are present that play vital roles in tendon ... Fukuta, S.; Oyama, M.; Kavalkovich, K.; Fu, F. H.; Niyibizi, C. (1998). "Identification of types II, IX and X collagens at the ...
... under control of the collagen type II promoter, was used to make a perlecan transgenic mouse. The collagen type II promoter ... "Regulation of vascular proteoglycan synthesis by angiotensin II type 1 and type 2 receptors". J. Am. Soc. Nephrol. 12 (12): ... In tissue engineered heart valves created by seeding myofibroblasts onto collagen type I followed by endothelial cells, heparan ... March 1995). "Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3". ...
... is a 28 kDa fragment cleaved from collagen type IV There are two subsegments of the peptide that are active; T3 ... The two proteins share 14% amino acid identity, making them very similar in structure. It has been proven to inhibit many types ... Type-IV collagen is present in the basement membrane within normal lungs, and this is reduced in asthmatic patients. There are ... There are two activation sites on the tumstatin fragment. One is at the N-terminus and is responsible for inhibiting ...
... a collagen type II receptor), and integrin receptors (of which there exist several types on chondrocytes). Using the integrin- ... These processes include the synthesis of matrix proteins (type II collagen and proteoglycans), proteases, protease inhibitors, ... Integrins have been identified on the upper shaft of the cilium, acting as anchors to the collagen matrix around it. Recent ... The balance that is struck between anabolic and catabolic processes is strongly influenced by the type of loading that ...
Hyaline cartilage matrix is primarily made of type II collagen and chondroitin sulphate, both of which are also found in ... Articular cartilage development begins with interzone condensation of a Collagen II positive limb bud at the future joint site ... the superficial zone consists mostly of collagen II fibers aligned parallel to the articular surface to resist shear forces, ... lying in groups of two or more in a granular, or almost homogeneous matrix. When arranged in groups of two or more, the ...
... to type II and X collagen and to chondrocalcin (C-propeptide of type II collagen). Implications for anchoring function between ... Kaplan R, Jaye M, Burgess WH, Schlaepfer DD, Haigler HT (Jun 1988). "Cloning and expression of cDNA for human endonexin II, a ... Schlaepfer DD, Mehlman T, Burgess WH, Haigler HT (Sep 1987). "Structural and functional characterization of endonexin II, a ... 149 (2): 253-60. doi:10.1016/0378-1119(94)90157-0. PMID 7958998. Annexin+A5 at the U.S. National Library of Medicine Medical ...
This is a receptor for collagen type I and IV. It consists of two subunits (α2 and β1). The α2 subunit includes a domain ... Glycoprotein VI is one of the immunoglobulin superfamily type I transmembrane glycoproteins. It is an important collagen ... integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem. (United States) 276 (31): 29368-74. DOI: ... The interaction with collagen leads to stabilization of the platelets. The surface expression of this complex shows high ...
Collagenopathy, types II and XI Connective tissue disease Coburn, Alvin (1974). Commitment Total. United States of America: ... Collagen disease is a term previously used to describe systemic autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus ... "collagen disease" was coined by Dr. Alvin F. Coburn in 1932, on his quest to discover streptococcal infection as the cause for ... Collagen disease entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public domain material ...
Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene". The EMBO Journal. 17 (19 ... Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". ... 3 (2): 167-70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848. Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A ( ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Lefebvre V, Li P, de Crombrugghe B (Oct 1998). "A new long ...
... and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene". The EMBO Journal. 17 (19 ... 357 (2): 383-390. doi:10.1016/j.bbrc.2007.03.133. PMID 17433257. SOX6+protein,+human at the U.S. National Library of Medicine ... 39 (2): 486-501. doi:10.1093/nar/gkq819. PMC 3025548. PMID 20852263. Cantù C, Ierardi R, Alborelli I, Fugazza C, Cassinelli L, ... 265 (1-2): 157-164. doi:10.1016/S0378-1119(01)00346-8. PMID 11255018. "Entrez Gene: SOX6 SRY (sex determining region Y)-box 6 ...
This downregulation sees the removal of post-transcriptional repression of TGF-β1 and TGF-β receptor type II (TGF-βRII), and ... consequent collagen production. miR-590 downregulation has further been shown to be mediated by activation of alpha-7 nicotinic ...