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*  Factor XI
... a member of the serine protease inhibitor/serpin class of proteins), which is independent of protein Z (its action on factor X ... Like many other coagulation factors, it is a serine protease. In humans, Factor XI is encoded by the F11 gene. Factor XI (FXI) ... It is an autosomal recessive disorder. There is little spontaneous bleeding, but surgical procedures may cause excessive blood ... Factor XI or plasma thromboplastin antecedent is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade ...
*  Scott syndrome
... syndrome is a rare congenital bleeding disorder that is due to a defect in a platelet mechanism required for blood coagulation ... A candidate protein, scramblase, that may be involved in this process appears to be normal in Scott syndrome platelets. Other ... Scott syndrome: a disorder of platelet coagulant activity (PCA). Sem Hemat 1994; 31:312-319 Zwaal FA, Comfurius P, Bevers EM. ... Deficiency of factor Xa-factor Va binding sites on the platelets of a patient with a bleeding disorder. Blood 1979; 54:1015- ...
*  Factor VIII
The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. ... Defects in this gene result in hemophilia A, a recessive X-linked coagulation disorder. Factor VIII is produced in liver ... GeneReviews/NCBI/NIH/UW entry on Hemophilia A The Coagulation Factor VIII Protein Factor VIII at the US National Library of ... This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which ...
*  Factor V Leiden
May 1994). "Mutation in blood coagulation factor V associated with resistance to activated protein C". Nature. 369 (6475): 64-7 ... It is extremely rare for this disorder to cause the formation of clots in arteries that can lead to stroke or heart attack, ... Activated protein C (aPC) is a natural anticoagulant that acts to limit the extent of clotting by cleaving and degrading factor ... This is done by running two tests simultaneously; one test is run in the presence of activated protein C (APC) and the other, ...
*  Discovery and development of direct thrombin inhibitors
They inhibit thrombin, a serine protease which affects the coagulation cascade in many ways. DTIs have undergone rapid ... It was first introduced in Japan in 1990 for treatment of peripheral vascular disorders. The publication of the NAPAP-fIIa ... such as requiring intravenous administration and having a variable dose-response curve due to substantial protein binding. In ... which help with the coagulation. Given this broad action of thrombin it stands as a good drug target for anticoagulant drugs ...
*  Disseminated intravascular coagulation
Presence of an underlying disorder known to be associated with DIC (no=0, yes=2) Global coagulation results Platelet count (> ... disseminated intravascular coagulation". Pol J Pharmacol. 48 (1): 73-5. PMID 9112631. Smith, OP (1997). "Use of protein-C ... the body is maintained in a finely tuned balance of coagulation and fibrinolysis. The activation of the coagulation cascade ... Recombinant human activated protein C was previously recommended in those with severe sepsis and DIC, but drotrecogin alfa has ...
*  List of MeSH codes (C15)
... coagulation protein disorders MeSH C15.378.100.141.036 --- activated protein c resistance MeSH C15.378.100.141.072 --- ... blood coagulation disorders, inherited MeSH C15.378.100.425.037 --- activated protein c resistance MeSH C15.378.100.425.056 ... disseminated intravascular coagulation MeSH C15.378.925.795 --- protein c deficiency MeSH C15.378.925.800 --- protein s ... protein c deficiency MeSH C15.378.147.890 --- protein s deficiency MeSH C15.378.190.196 --- anemia, aplastic MeSH C15.378. ...
*  Hematologic disease
Thrombocytosis Recurrent thrombosis Disseminated intravascular coagulation Disorders of clotting proteins Hemophilia Hemophilia ... Myeloproliferative disorder Coagulopathies (disorders of bleeding and coagulation) ... C Von Willebrand disease Disseminated intravascular coagulation Protein S deficiency Antiphospholipid syndrome Disorders of ... Hematologic diseases are disorders which primarily affect the blood. Hematology includes the study of these disorders. ...
*  Sticky platelet syndrome
Among researchers using the term, it has been described as a coagulation disorder that can present in conjunction with protein ... ISBN 0-521-87082-8. Chaturvedi S, Dzieczkowski JS (1999). "Protein S deficiency, activated protein C resistance and sticky ... or if it represents part of the presentation of a more well characterized coagulation disorder. SPS is diagnosed by ... Sticky platelet syndrome is a term used by some to describe a disorder of platelet function. It was first described by Mammen ...
*  Lonomia
... identification of the proteins potentially involved in the coagulation disorder and hemorrhagic syndrome. Gene 355:11-27. ...
*  Coagulopathy
... may be caused by reduced levels or absence of blood-clotting proteins, known as clotting factors or coagulation ... "clotting disorders"; a clotting disorder is a predisposition to clot formation (thrombus), also known as a hypercoagulable ... Genetic disorders, such as hemophilia and Von Willebrand's disease, can cause a reduction in clotting factors. Anticoagulants ... Coagulopathy (also called a bleeding disorder) is a condition in which the blood's ability to coagulate (form clots) is ...
*  Congenital afibrinogenemia
... a blood protein necessary for coagulation. This disorder is autosomal recessive, meaning that two unaffected parents can have a ... Individuals with the disorder have a mutation to their fibrinogen gene that prevents the formation of the protein. In normal ... As this is a disorder that is present in an individual from birth, there are no warning signs to look for. The first symptom ... The newly formed fibrin forms a fiber-rich network that helps trap red blood cells to start the coagulation process and form a ...
*  AT
... a small protein molecule that inactivates several enzymes of the coagulation system Ataxia telangiectasia, an immunodeficiency ... disorder Astatine, a chemical element with symbol At Ampere-turn (symbol At), an International System of Units (MKS) unit of ...
*  Omega loop
A heritable coagulation disorder is caused by a single-site mutation in an omega loop of protein C. Likewise, omega loops play ... Pal, M; Dasgupta, S (1 Jun 2003). "The nature of the turn in omega loops of proteins". Proteins. 51 (4): 591-606. doi:10.1002/ ... Dhar, J; Chakrabarti, P (Jun 2015). "Defining the loop structures in proteins based on composite β-turn mimics". Protein Eng ... Omega loops can contribute to protein function. For example, omega loops can help stabilize interactions between protein and ...
*  Congenital hypofibrinogenemia
... make small amounts of this critical coagulation protein, blood levels of fibrinogen are low, and individuals with the disorder ... This seemingly paradoxical propensity to develop thrombosis in a disorder causing a decrease in a critical protein for blood ... de Moerloose P, Schved JF, Nugent D (2016). "Rare coagulation disorders: fibrinogen, factor VII and factor XIII". Haemophilia ... Individuals with this disorder are usually less symptomatic than patients with other fibrinogen disorders because their ...
*  Bleeding diathesis
There are autoimmune causes of coagulation disorders. They include acquired antibodies to coagulation factors, termed ... Some people lack genes that typically produce the protein coagulation factors that allow normal clotting. Various types of ... Wiskott-Aldrich Syndrome The International Patient Organisation for Primary Immunodeficiencies (IPOPI). Disorders of thrombosis ... a defect in the system of coagulation). Several types are distinguished, ranging from mild to lethal. Also, bleeding diathesis ...
*  Hypertension
... and disseminated intravascular coagulation (a blood clotting disorder). In contrast, gestational hypertension is defined as new ... Additionally, testing of urine samples for protein is used as a secondary indicator of kidney disease. Electrocardiogram (EKG/ ... an endocrine disorder, or the use of birth control pills. Blood pressure is expressed by two measurements, the systolic and ... of the second half of pregnancy and following delivery characterised by increased blood pressure and the presence of protein in ...
*  D-dimer
Coagulation, the formation of a blood clot or thrombus, occurs when the proteins of the coagulation cascade are activated, ... In addition, it is used in the diagnosis of the blood disorder disseminated intravascular coagulation. ... The anti-coagulation medications dabigatran and rivaroxaban decrease D-dimer levels but do not interfere with the D-dimer assay ... It is so named because it contains two D fragments of the fibrin protein joined by a cross-link. D-dimer concentration may be ...
*  MCFD2
Multiple coagulation factor deficiency protein 2 is a protein that in humans is encoded by the MCFD2 gene. Mutations in MCFD2 ... cause the combined deficiency of factor V and factor VIII (F5F8D), a recessive bleeding disorder. MCFD2 and ERGIC-53 (or LMAN1 ... Zhang B, Kaufman RJ, Ginsburg D (2005). "LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor ... "Entrez Gene: MCFD2 multiple coagulation factor deficiency 2". Nyfeler B, Zhang B, Ginsburg D, et al. (2007). "Cargo selectivity ...
*  Hypoprothrombinemia
This condition is characterized as an autosomal recessive inheritance congenital coagulation disorder affecting 1 per 2,000,000 ... protein C protein S, or protein Z". Thromb Res. 95 (4 Suppl 1): S39-50. doi:10.1016/S0049-3848(99)00083-3. PMID 10499908. J. ... Vitamin K-dependent coagulation factors have a very short half-life, sometimes leading to a deficiency when a depletion of ... This is typically a symptom of the disorder when severe blood loss occurs. Other reported symptoms that are related to the ...
*  Coagulation
Thrombomodulin binds these proteins in such a way that it activates Protein C. The activated form, along with protein S and a ... The best-known coagulation factor disorders are the hemophilias. The three main forms are hemophilia A (factor VIII deficiency ... coagulation involves both a cellular (platelet) and a protein (coagulation factor) component. The system in humans has been the ... as well as Protein S, Protein C and Protein Z. In adding the gamma-carboxyl group to glutamate residues on the immature ...
*  DMOZ - Health: Conditions and Diseases: Blood Disorders: Coagulation Disorders
Blood coagulation disorders are genetic disorders that result in either hypercoagulability (where the blood clots too easily) ... MedlinePlus: Congenital Protein C or S Deficiency Brief information about these hypercoagulability disorders including causes, ... Blood coagulation disorders are genetic disorders that result in either hypercoagulability (where the blood clots too easily) ... Also known as Hageman factor, this is a congenital coagulation disorder that causes prolonged coagulation in a test tube but ...
*  Recombinant DNA
... blood clotting factor VIII A blood-clotting protein that is administered to patients with forms of the bleeding disorder ... hemophilia, who are unable to produce factor VIII in quantities sufficient to support normal blood coagulation. Before the ... Proteins that can result from the expression of recombinant DNA within living cells are termed recombinant proteins. When ... direct the recombinant protein to the proper cellular or extracellular location, and stabilize the protein from degradation. In ...
*  Factor VII deficiency
... a protein that causes blood to clot in the coagulation cascade. After a trauma factor VII initiates the process of coagulation ... It is the most common of the rare congenital coagulation disorders. Symptoms may differ greatly, as apparently modifiers ... Typically this bleeding disorder manifests itself as a tendency to easy bruising, nose bleeding, heavy and prolonged ... Factor VII deficiency is a bleeding disorder characterized by a lack in the production of Factor VII (FVII) (proconvertin), ...
*  Hematology
... disorders of bleeding and coagulation) ...Sickle Cell Anemia ...thalassemia == Blood disorders Hematologists Hematology topics ... blood proteins, bone marrow, platelets, blood vessels, spleen, and the mechanism of coagulation. Such diseases might include ... Hematologists may specialize further or have special interests, for example, in: treating bleeding disorders such as hemophilia ... and treat blood disorders. When applying for this career, most job openings look for first-hand practical experience in a ...
*  Haemophilia A
... while digestive tract and cerebral haemorrhages are also germane to other coagulation disorders.Though typically not life- ... About 5-10% of people with haemophilia A are affected because they make a dysfunctional version of the factor VIII protein, ...
*  Factor X deficiency
... an enzyme protein that causes blood to clot in the coagulation cascade. Produced in the liver FX when activated cleaves ... Factor X deficiency (X as Roman numeral ten) is a bleeding disorder characterized by a lack in the production of factor X (FX ... Typically this bleeding disorder manifests itself as a tendency to easy bruising, nose bleeding, heavy and prolonged ... Blood tests are needed to differentiate FX deficiency from other bleeding disorders. Typical are normal thrombin time, ...