Methyl-CpG-binding domain protein 2, Nuclear receptor co-repressor 2, OGT, PHF12, Promyelocytic leukemia protein, RBBP4, RBBP7 ... Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene. The protein encoded by this ... Yao YL, Yang WM (October 2003). "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone ... It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate ...
Scott KL, Plon SE (2005). "CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor". Gene. ... Forkhead box protein N3 is a protein that in humans is encoded by the FOXN3 gene. This gene is a member of the forkhead/winged ... CHES1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ... FOX proteins GRCh38: Ensembl release 89: ENSG00000053254 - Ensembl, May 2017 "Human PubMed Reference:". National Center for ...
García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts ... García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts ... The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large ... "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor". Molecular and Cellular ...
"Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins". Mol. Cell. Biol. 25 (18): 8334-43 ... FUS-interacting serine-arginine-rich protein 1 is a protein that in humans is encoded by the SFRS13A gene. This gene product is ... which are important in mediating association with other cellular proteins. This protein can influence splice site selection of ... "TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins". Mol. Cell. Biol. 20 (10): 3345-54 ...
MDM2 is a repressor of protein 53, which itself is a tumor suppressor. On negative diagnosis it was decided to release a ... a repressor group. Fluorescence is only active if the molecules of the substrate are cut in half. The DNA enzymes simulate ...
RAP1 (Repressor / Activator Protein 1): RAP1 is a stabilizing protein associated with TRF2. RAP1 inhibits DNA repair. POT1 ( ... Protein complexes, Telomere-binding proteins, Telomere-related proteins). ... and TRF2-Interacting Nuclear Protein 2) TIN2 is a stabilizing protein that binds to the TRF1, TRF2, and the TPP1-POT1 complex. ... TPP1 (ACD (gene)): TPP1 is a protein associated with POT1. The loss of TPP1 leads to impaired POT1 function. When telomeres are ...
... is a transcriptional repressor that is specifically expressed during S phase of the cell cycle. The protein is implicated ... MXD3 is a basic helix-loop-helix protein belonging to a subfamily of MAX-interacting proteins. This protein competes with MYC ... "Entrez Gene: MXD3 MAX dimerization protein 3". Fox EJ, Wright SC (February 2003). "The transcriptional repressor gene Mad3 is a ... MAX dimerization protein 3 is a protein that in humans is encoded by the MXD3 gene located on Chromosome 5. ...
... the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals ... Homeobox protein TGIF1 is a protein that, in humans, is encoded by the TGIF1 gene. Alternative splicing has been observed at ... The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains ... It has also been associated with risk of otitis media (inflammation of the middle ear) Homeobox protein TGIF1 has been shown to ...
This is when a substrate binds a repressor protein and causes it to undergo a conformational change. If the repressor is bound ... These auxin response factors are repressed by Aux/IAA repressors. In the presence of auxin, these Aux/AII proteins undergo ... Mutations in PSEN1 decrease its production or ability to cleave proteins. This derepresses the CBP proteins, and allows them to ... Certain RNA binding proteins have been shown to target untranslated regions of the mRNAs and upregulate the translation ...
TFIIIA and similar proteins bind to specific DNA sequences and enhance the reading of corresponding target genes. Repressors ... large protein complexes that provide a bridge between the activators and repressors and the RNA polymerases and other ... 1979-1980: The development of cell-free systems leads to the identification of complex sets of proteins called accessory ... He discovered three distinct nuclear RNA polymerases in 1969 and characterized many proteins involved in the regulation of ...
The Ribose repressor (RbsR) is a bacterial DNA-binding transcription repressor protein and a member of the LacI/GalR protein ... "Structural homology between rbs repressor and ribose binding protein implies functional similarity". Protein Science. 1 (7): ... an allosteric effector of the related LacI/GalR protein Catabolite Control Protein A (CcpA). RbsR in EcoGene RbsR in EColiWiki ... v t e (Orphaned articles from February 2016, All orphaned articles, Bacterial proteins, Gene expression, All stub articles, ...
... is a powerful transcriptional repressor, at least in CpG dense contexts. Transcriptional repression of protein- ... methylated DNA may be bound by proteins known as methyl-CpG-binding domain proteins (MBDs). MBD proteins then recruit ... MethylCpG Binding Proteins (MBPs) and fusion proteins containing just the Methyl Binding Domain (MBD) are used to separate ... DNMT3L is a protein that is homologous to the other DNMT3s but has no catalytic activity. Instead, DNMT3L assists the de novo ...
One of the genes regulated by trp repressor, trpR, codes for the tryptophan repressor protein itself. This is a form of ... If there isn't enough tryptophan, the repressor protein breaks off from the operator (where the repressor is normally bound) ... The (tryptophan) repressor is a 25 kD protein homodimer which regulates transcription of the tryptophan biosynthetic pathway in ... Tryptophan repressor (or trp repressor) is a transcription factor involved in controlling amino acid metabolism. It has been ...
IrrE is a metalloprotease that cleaves repressor protein DdrO". Molecular Microbiology. 94 (2): 434-449. doi:10.1111/mmi.12774 ... RecAC and RecAP are functional proteins that allow repair of massive DNA damage after exposure of D. deserti to high doses of ... A total of 341 protein N termini were confidently identified in the D. deserti TMPP-labeled proteome. Among these, 63 were not ... This database comprised 65,801 hypothetical protein sequences with a large fraction of short ORFs (68% of the ORFs have less ...
... conversely silencers bind repressor proteins and make the DNA less available for RNA polymerase. The mature messenger RNA ... A typical protein-coding gene is first copied into RNA as an intermediate in the manufacture of the final protein product.: 6.1 ... The structure of a protein-coding gene consists of many elements of which the actual protein coding sequence is often only a ... From DNA to Protein 6.1: DNA to RNA 6.2: RNA to Protein Ch 7: Control of Gene Expression 7.1: An Overview of Gene Control 7.2: ...
"Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1". Nucleic Acids Res. 24 ... Protein Dr1 is a protein that in humans is encoded by the DR1 gene. This gene encodes a TBP- (TATA box-binding protein) ... The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...
"Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex". The EMBO Journal. ... Ccr4-Not complex plays an important role in mRNA decay and protein quality control in the cytoplasm. The human CCR4-Not complex ...
This would increase the affinity of repressor for O1. The repressor is an allosteric protein, i.e. it can assume either one of ... Joung J, Ramm E, Pabo C (2000). "A bacterial two-hybrid selection system for studying protein-DNA and protein-protein ... The second gene, crp, encodes a protein called catabolite activator protein (CAP) or cAMP receptor protein (CRP). However the ... The protein that is formed by the lacI gene is known as the lac repressor. The type of regulation that the lac operon undergoes ...
C2H2-type zinc finger proteins, such as ZNF238, act on the molecular level as transcriptional activators or repressors and are ... Zinc finger protein 238 (also known as RP58 or ZBTB18) is a zinc finger containing transcription factor that in humans is ... ZNF238+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ... "Entrez Gene: ZNF238 zinc finger protein 238". Fuks F, Burgers WA, Godin N, Kasai M, Kouzarides T (May 2001). "Dnmt3a binds ...
"Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1". Nucleic Acids ... Nuclear factor, interleukin 3 regulated, also known as NFIL3 or E4BP4 is a protein which in humans is encoded by the NFIL3 gene ... Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory ...
During normal growth, the SOS genes are negatively regulated by LexA repressor protein dimers. Under normal conditions, LexA ... The system involves the RecA protein (Rad51 in eukaryotes). The RecA protein, stimulated by single-stranded DNA, is involved in ... The activated form of RecA interacts with the LexA repressor to facilitate the LexA repressor's self-cleavage from the operator ... SulA stops cell division by binding to FtsZ, the initiating protein in this process. This causes filamentation, and the ...
This gene encodes a transcriptional repressor that interacts with several members of the BCL-2 family of proteins. ... Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein ... a Novel Death-Promoting Transcriptional Repressor That Interacts with Bcl-2-Related Proteins". Mol Cell Biol. 19 (6): 4390-404 ... Liu H, Lu ZG, Miki Y, Yoshida K (2007). "Protein Kinase C δ Induces Transcription of the TP53 Tumor Suppressor Gene by ...
... a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein". J. Biol. Chem ... The human DEK gene encodes the DEK protein. This gene encodes a protein with one SAP domain. The protein binds to cruciform DNA ... PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein DEK v t e (Articles with ... Alexiadis V, Waldmann T, Andersen J, Mann M, Knippers R, Gruss C (2000). "The protein encoded by the proto-oncogene DEK changes ...
Arora T, Liu B, He H, Kim J, Murphy TL, Murphy KM, Modlin RL, Shuai K (2003). "PIASx is a transcriptional co-repressor of ... androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability ... E3 SUMO-protein ligase PIAS2 is an enzyme that in humans is encoded by the PIAS2 gene. Protein inhibitor of activated STAT2 has ... protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional ...
2001). "Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins". J. Biol. Chem. 276 (28): 25834 ... CtBP1 is one of two CtBP proteins, the other protein being CtBP2. The CtBP1 protein was originally identified as a human ... "C-Terminal Binding Protein Is a Transcriptional Repressor That Interacts with a Specific Class of Vertebrate Polycomb Proteins ... 1999). "hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation". J. Biol. ...
... a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins". Molecular and Cellular Biology. ... "Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo". Proceedings of ... "Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo". Proceedings of ... "Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R ...
The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin ... "Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells". The Journal of Biological Chemistry. ... "Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells". Biochemical ... Zinc finger protein SNAI2 is a transcription factor that in humans is encoded by the SNAI2 gene. It promotes the ...
This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to ... TCIM is a protein that in humans is encoded by the TCIM gene. This gene encodes a small, monomeric, predominantly unstructured ... "TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer". Cancer Research. 64 (8): 2766-73. ... protein (106 amino acids, 12.3 kDa, isoelectric point 9.39). It is a positive regulator of the Wnt / beta-catenin signaling ...
"CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter". Journal of Biological ... and were later found to be involved also in protein-protein interactions. In addition to these conserved domains, the n- ... The C1C2 protein displayed very rapid "on" and "off" DNA binding rates, whereas any combination of a Cut domain with the Cut ... p200 CUX1 is a very abundant protein that binds to DNA with extremely fast kinetics (rapid "on" and "off" rates). This is not ...
Both of these proteins co-function with adapter proteins that facilitate their transition to the basal cortex during Mitosis. ... A previously described transcription factor in GMCs is Prospero or Pros, a transcriptional repressor. It down-regulates cell ... The proteins (with the exception of aPKC) form a ternary complex at the apical cortex independent of the proteins that ... When experimentally knocking out proteins such as Numb or the tumor suppressing protein Brat the entire larval brain results in ...