Microbicides for sexually transmitted diseases
"VivaGelâ„¢ - Clinical trials Under Way". Star Pharma. Archived from the original on 7 January 2008. Retrieved 1 April 2018. ... World Health Organization (2002). "HIV/AIDS Topics: Microbicides". Geneva: World Health Organization. Retrieved August 28, 2006 ... "Microbicide Clinical Trials". AVAC. Archived from the original on 16 July 2011. Retrieved 1 April 2018. Global Campaign for ... "Ongoing Clinical Trials of Topical Microbicide Candidates (May 2011)". AVAC. Archived from the original on 16 July 2011. ...
Confidentiality
2008). Conducting clinical trials. A theoretical and practical guide. ISBN 978-3-940934-00-0 "Professional Standards Authority ... Mallis, Adam (6 March 2023). "Confidentiality In Healthcare - Medicine Interview Hot Topic Questions". The UKCAT People. ... "Confidentiality breaches in clinical practice: what happens in hospitals?". BMC Medical Ethics. 17 (1): 52. doi:10.1186/s12910- ... States have to maintain confidentiality whenever they gain access to confidential information as a result of the good clinical ...
Hyperpolarized carbon-13 MRI
"Clinical Trials". Lupo JM, Chen AP, Zierhut ML, Bok RA, Cunningham CH, Kurhanewicz J, Vigneron DB, Nelson SJ (February 2010). " ... Topics in Magnetic Resonance Imaging. 25 (1): 31-7. doi:10.1097/RMR.0000000000000076. PMC 4968075. PMID 26848559. " ... The majority of clinical studies utilizing 13C hyperpolarization are currently studying pyruvate metabolism in prostate cancer ...
American Association for Cancer Research
... clinical research including clinical trials; endocrinology; epidemiology and prevention; experimental therapeutics, molecular ... Some of the topics include biochemistry; chemical, physical, and viral carcinogenesis and mutagenesis; ... clinical trials on targeted therapy, and cancer immunotherapy research including immune checkpoint blockade and Chimeric ... Educational Workshops that train early-career investigators in clinical trial design, molecular biology, integrative molecular ...
Imetelstat
2020). "Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials". Current Topics in Medicinal Chemistry. 20 (6 ... The first telomerase inhibitor to enter clinical trials, As of early 2023, it was in Phase 2/3 trials for various cancer types ...
List of vaccine topics
"MERS vaccine shows promise in clinical trial, say researchers". "Developing a vaccine against Nipah virus". ScienceDaily (Press ... "Inferring Reasons for the Failure of Staphylococcus aureus Vaccines in Clinical Trials". Frontiers in Cellular and Infection ... placebo-controlled phase 2 clinical trial". The Lancet. 381 (9871): 1037-1045. doi:10.1016/S0140-6736(12)61764-4. PMID 23352749 ... Current Topics in Microbiology and Immunology. Vol. 325. pp. 361-382. doi:10.1007/978-3-540-77349-8_20. ISBN 978-3-540-77348-1 ...
Paolo Zamboni
On this topic he conducted several randomized clinical trials and published books. The CHIVA and the stripping methods are ... January 2018). "Efficacy and Safety of Extracranial Vein Angioplasty in Multiple Sclerosis: A Randomized Clinical Trial". JAMA ... compression treatment: a randomized clinical trial". European Journal of Vascular and Endovascular Surgery. 25 (4): 313-318. ... "A phase II randomized clinical trial for the treatment of recalcitrant chronic leg ulcers using centrifuged adipose tissue ...
Nausea
... a systematic review of randomized clinical trials". British Journal of Anaesthesia. 84 (3): 367-71. doi:10.1093/oxfordjournals. ... Over 30 definitions of nausea were proposed in a 2011 book on the topic. Nausea is a non-specific symptom, which means that it ... "Bulimia Nervosa-Topic Overview". WebMD. Archived from the original on 25 July 2012. Retrieved 26 July 2012. The dictionary ... a meta-analysis of randomized controlled trials". Acta Anaesthesiologica Scandinavica. 46 (3): 238-44. doi:10.1034/j.1399- ...
Clinical trial naming conventions
... medical or health words that are not related to the topic of the study, such as ALIVE or RESCUE; and other English words not ... Berkwits, Michael (7 November 2000). "CAPTURE! SHOCK! EXCITE! Clinical Trial Acronyms and the "Branding" of Clinical Research ... CALERIE ALMANAC PARAMOUNT trial JUPITER trial PROVE-IT TIMI 22 RECOVERY trial Lowe, Derek (18 July 2019). "Acronym Fever. We ... "Clinical trial names can be quite AMUSING, but they don't include unicorns : Spoonful of Medicine". blogs.nature.com. Retrieved ...
Discovery and development of beta-blockers
Lechat, P. (2008). "Clinical pharmacology of beta-blockers in cardiology: trial results and clinical applications". Hot Topics ... Clinical trials started in the summer of 1964 and a year later, propranolol was launched under the trade name Inderal, only two ... The launch took place in November 1963 when many small-scale clinical trials had proved their effectiveness in angina and ... Although DCI had no clinical utility, a change in the compound did provide a clinical candidate, pronethalol, which was ...
Allergy
Clinical trials have been initiated to test the effectiveness of certain worms in treating some allergies. It may be that the ... For more information on this topic, see Helminthic therapy. In the initial stages of allergy, a type I hypersensitivity ... The authors concluded that based on rigorous clinical trials of all types of homeopathy for childhood and adolescence ailments ... systematic review of randomized clinical trials". Mayo Clinic Proceedings. 82 (1): 69-75. CiteSeerX 10.1.1.456.5352. doi: ...
Sunnybrook Health Sciences Centre
Various clinical trials are also run out of the centre. Research is conducted through the Odette Cancer Centre research program ... Research spans from the topics of basic genetics, biochemistry and biology of cancer. The program provides critical care and ... "About clinical trials - Odette Cancer Centre - Sunnybrook Hospital". sunnybrook.ca. Retrieved February 14, 2018. "Odette Cancer ...
Alexandre Loupy
These discoveries allow to improve the performance of clinical trials and to consider new therapeutic innovations in ... He is known for his discoveries on the topic of graft rejection.,, Its approach proposing innovative methodological tools has ... and prospects for integrative endpoints for next-generation clinical trials". American Journal of Transplantation. 18 (2): 293- ... Journal of Clinical Investigation, Circulation and Circulation Research. and more specialized peer-reviewed journals such as ...
Pruvanserin
It was in phase II clinical trials in 2008 but appears to have been discontinued as it is no longer in the company's ... Teegarden BR, Al Shamma H, Xiong Y (2008). "5-HT(2A) inverse-agonists for the treatment of insomnia". Current Topics in ... "Efficacy Study of LY2422347 to Treat Insomnia - Full Text View - ClinicalTrials.gov". 24 January 2007. "Eli Lilly and Company ...
Gender bias in medical diagnosis
Schiebinger L (October 2003). "Women's health and clinical trials". The Journal of Clinical Investigation. 112 (7): 973-977. ... This topic alone sparked controversy and brought about question to the medical standard of our time. Popular media has ... "Systematic Review of Gender Bias in the Clinical Trials of New Long-Acting Antipsychotic Drugs". Journal of Clinical ... In 2018 the US FDA released draft guidelines for inclusion of pregnant women in clinical trials. In a 2019 meta-analysis it was ...
Neuroprotection
Importantly, clinical trials for the drug in patients with ischemic stroke show it to be effective as well as noninvasive. ... Glutamate antagonists are a hot topic of research. Below are some of the treatments that have promising results for the future ... Over 150 drugs have been tested in clinical trials, leading to the regulatory approval of tissue plasminogen activator in ... Kaur H, Prakash A, Medhi B (2013). "Drug therapy in stroke: from preclinical to clinical studies". Pharmacology. 92 (5-6): 324- ...
Alexander Kabanov (chemist)
His work led to the first polymeric micelle drug to enter clinical trials and was instrumental in establishment of polymeric ... Zhang, Peng; Wagner, Ernst (April 2017). "History of Polymeric Gene Delivery Systems". Topics in Current Chemistry. 375 (2): 26 ... Self-assembling complexes for gene delivery : from laboratory to clinical trial. Alexander V. Kabanov, Philip L. Felgner, L. W ... From nanoformulation to clinical approval". Advanced Drug Delivery Reviews. 156: 80-118. doi:10.1016/j.addr.2020.09.009. ISSN ...
2-hydroxy-dATP diphosphatase
Karonudib, an MTH1 inhibitor, is currently being evaluated a phase I clinical trial for safety and tolerability. A potent and ... Research into this topic is ongoing. MTH1 is a potential drug target to treat cancer, however there are conflicting results ... This makes it a topic of interest in cancer research, both as a potential method for healthy cells to prevent cancer and a ... "MTH1, A Phase I, Study on Tumors Inhibition, First in Human, First in Class (MASTIFF)". ClinicalTrials.gov. U.S. National ...
Dietary Supplements (database)
... clinical trials; health and adverse effects; fortification; traditional Chinese medicine and other folk/ethnic supplement ... The subset will retrieve dietary supplement-related citations on topics including, but not limited to: chemical composition; ...
Brajesh Lal
He delivered the Clemens Lecture at Yale School of Medicine on this topic. He is now conducting clinical trials to test whether ... He is now leading the world's largest randomized clinical trial to help determine whether blockages in the carotid artery are ... This trial is being conducted across 170 medical centers in the United States, Canada, Israel, Spain, and Australia. He has ... Lal, Brajesh K.; Meschia, James F.; Brott, Thomas G. (March 2017). "Clinical need, design, and goals for the Carotid ...
Pharmacovigilance
... whereas a clinical trial case will typically be assessed for causality by the clinical trial investigator and/or the license ... The CIOMS, a part of the WHO, is globally oriented think tank that provides guidance on drug safety related topics through its ... The variables in a clinical trial are specified and controlled, but a clinical trial can never tell you the whole story of the ... Also known as AE (adverse event) or SAE (serious AE) reporting from clinical trials, safety information from clinical studies ...
Gail Rosseau
Her current research funding is for clinical trials in breast cancer metastasis and idiopathic normal pressure hydrocephalus. ... She is the author of dozens of papers, invited lectures and courses in these topics, including a co-authored white paper with ... She writes and speaks often in the U.S. and abroad on neurosurgical topics. Her most frequent subjects include innovative ... Gail Linskey Rosseau (born c. 1956) is Clinical Professor of Neurosurgery at George Washington University School of Medicine ...
Nanoneuroscience
... is also a popular topic of research and has led to several stage III clinical trials. Invasiveness is not an issue here because ... Because of this, only 3.6% of clinical trials in this field have progressed to stage III since the concept of gene therapy was ... This proves further long term in vivo studies are needed to gain enough understanding to allow for successful clinical trials. ...
Statin
These rates, which are much higher than those seen in randomized clinical trials have been the topic of extensive debate and ... The author of one study argued that adverse events are more common in clinical practice than in randomized clinical trials. A ... A Cochrane meta-analysis of statin clinical trials in primary prevention found no evidence of excess adverse events among those ... Norata GD, Tibolla G, Catapano AL (October 2014). "Statins and skeletal muscles toxicity: from clinical trials to everyday ...
Hantavirus vaccine
In addition to Hantavax three more vaccine candidates have been studied in I-II stage clinical trials. They include a ... However, their prospects are unclear List of vaccine topics Seoul virus Gou virus Vaccine-naive Schmaljohn, C. S. (2012). " ... Field trial of an inactivated vaccine against hemorrhagic fever with renal syndrome in humans. Arch Virol. 1990;1(Suppl):35-47 ... "Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever". ClinicalTrials.gov. ...
National Institute for Health and Care Excellence
They work together to assess the evidence for the guideline topic (e.g. clinical trials of competing products) before preparing ... the Advisory Committee on Topic Selection (ACTS) draws up a list of potential topics of clinical significance for appraisal. ... It was set up as the National Institute for Clinical Excellence in 1999, and on 1 April 2005 joined with the Health Development ... The idea of what was originally termed a National Institute for Clinical Excellence took root when Labour came to power in 1997 ...
Phytosterol
Reviewing clinical trials involving phytosterol supplementation, the FDA concluded that when consumed in the range of 1 to 3 ... Patterson, CA (July 2006). "Phytosterols and stanols: Topic 10075E" (PDF). Agriculture and Agri-Food Canada, Government of ... Plant sterols and stanols, when compared head-to-head in clinical trials, have been shown to equally reduce cholesterol levels ... Trials looking at high doses (> 4 g/day) of plant sterols or stanols are very limited, and none have yet to be completed ...
Withings
... and Withings products have been involved in numerous clinical trials. Connected health Quantified Self Brown, Aaron (12 January ... The Institute has published several research papers on various topics, ...
Society for Research on Biological Rhythms
A variety of approaches are explored by the journal including: genetic, behavioral, modeling, and clinical trials. In 2015 SAGE ... Webarchive template wayback links, Articles with topics of unclear notability from April 2017, All articles with topics of ... The JBR publishes scholarly articles, original research, and reviews on a variety of topics all centering around periodicity in ... unclear notability, Company articles with topics of unclear notability, Articles lacking reliable references from April 2017, ...
Change control
From the information technology perspective for clinical trials, it has been guided by another U.S. Food and Drug ... In a good manufacturing practice regulated industry, the topic is frequently encountered by its users. Various industrial ... "Guidance for Industry - COMPUTERIZED SYSTEMS USED IN CLINICAL TRIALS". U.S. Food and Drug Administration. April 1999. Retrieved ...
Mary Ethel Florey
This is where she ran the first clinical trials of penicillin in 1941 along with her lab partner and husband Howard Walter ... The first volume is dedicated to Penicillin and her research on that topic. The British Journal of Surgery published a review ... Starting in 1941, she was part of the team working on clinical trials at the Radcliffe Infirmary, military hospitals and the ... She worked along with Howard Walter Florey and carried out the first clinical trials of penicillin in 1941 at the Radcliffe ...