In January 2016, Mesoblast released results of a phase 2 clinical trial on 241 children with acute Graft-versus-host disease, ... Hale G, Waldmann H (May 1994). "Control of graft-versus-host disease and graft rejection by T cell depletion of donor and ... Wagner JE, Thompson JS, Carter SL, Kernan NA (2005). "Effect of graft-versus-host disease prophylaxis on 3-year disease-free ... In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis ...
GvL is a part of the reaction of the graft against the host. Whereas graft-versus-host-disease (GvHD) has a negative impact on ... evidence for a graft-versus-tumor effect". Journal of Clinical Oncology. 17 (7): 2044-9. doi:10.1200/jco.1999.17.7.2044. PMID ... Rezvani AR, Storb RF (May 2008). "Separation of graft-vs.-tumor effects from graft-vs.-host disease in allogeneic hematopoietic ... Warren EH, Deeg HJ (April 2013). "Dissecting graft-versus-leukemia from graft-versus-host-disease using novel strategies". ...
"Graft-versus-host disease affecting oral cavity. A review". Journal of Clinical and Experimental Dentistry. 7 (1): e138-e145. ... Graft versus Host Disease: An autoimmune disease developed following bone marrow transplant in which its oral presentation is ... Imanguli, Mm; Alevizos, I; Brown, R; Pavletic, Sz; Atkinson, Jc (July 2008). "Oral graft-versus-host disease". Oral Diseases. ... Mucous Membrane Pemphigoid: Autoimmune disease which affects only mucous membranes with clinical presentation of hard and rigid ...
The clinical presentation is the same as GvHD occurring in other settings, such as bone marrow transplantation. TA-GvHD can ... Transfusion-associated graft-versus-host disease (TA-GvHD) is a rare complication of blood transfusion, in which the ... A Case of Fetal-Induced Graft-versus-Host Disease Fung MK, Grossman BJ, Hillyer CD, Westhoff CM (2014). Technical manual (18th ... Gupta A, Bansal D, Dass R, Das A (December 2004). "Transfusion associated graft versus host disease" (PDF). Indian Pediatrics. ...
"Role of interleukin-18 in acute graft-vs-host disease". The Journal of Laboratory and Clinical Medicine. 141 (6): 365-71. doi: ... IL-18 has also been found to increase the Alzheimer's disease-associated amyloid-beta production in human neuron cells. IL-18 ... Jia H, Liu J, Han B (2018). "Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases". BioMed Research ... Orozco A, Gemmell E, Bickel M, Seymour GJ (July 2007). "Interleukin 18 and periodontal disease". Journal of Dental Research. 86 ...
... is also involved in Graft-versus-host disease (GVHD) and has potential to serve as a diagnostic/prognostic biomarker. ... As a result, tumor vaccine strategies for Hsp70s have been highly successful in animal models and progressed to clinical trials ... and Graft-versus-host disease. This gene encodes a 70kDa heat shock protein and is located in the major histocompatibility ... "Elevated level of HSPA1L mRNA correlates with graft-versus-host disease". Transplant Immunology. 32 (3): 188-94. doi:10.1016/j. ...
"Dermatologic Manifestations of Graft Versus Host Disease: Introduction, Clinical Overview, Pathophysiology". June 10, 2021 - ... Maculopapular rash is seen in graft-versus-host disease (GVHD) developed after a hematopoietic stem cell transplant (bone ... This type of rash is common in several diseases and medical conditions, including scarlet fever, measles, Ebola virus disease, ...
Medicine portal Bone healing CNT Network Bio-Stress Sensors Graft-versus-host disease Hydroxyapatite Oral and Maxillofacial ... In order to make the dentin graft usable and bacteria-free, some companies have developed clinical procedures which include ... when bone grafting is used to treat gum disease. Another common bone graft, which is more substantial than those used for ... Distal femoral bone graft takes up to six months to heal. The most common use of bone grafting is in the application of dental ...
Graft-versus-host disease is an auto- and alloimmune disorder, exhibiting a variable clinical course. It can manifest in either ... Host response is defined as the "response of the host organism (local and systemic) to the implanted material or device". Most ... Velnar, Tomaz; Bunc, Gorazd; Klobucar, Robert; Gradisnik, Lidija (2016). "Biomaterials and host versus graft response: a short ... The interactions between the device upon the host tissue/blood as well as the host tissue/blood upon the device must be ...
This results in a condition similar to graft-versus-host disease. Patients often have a refractory disease course but some ... "Clinical presentation and management of thymoma and thymic carcinoma". UpToDate. Nakayama M, Itoh M, Kikuchi S, Tanito K, ... This disease name was coined by Emanual Maverakis and described in detail in 2007 but case reports of graft-versus-host-like ... It has also been referred to in the medical literature as "thymoma-associated graft-versus-host-like disease". Patients with ...
Transfusion-associated graft versus host disease frequently occurs in immunodeficient patients where recipient's body failed to ... July 2012). Clinical Transfusion Medicine Committee of the, AABB. "Red blood cell transfusion: a clinical practice guideline ... July 2015). "A systematic review of transfusion-associated graft-versus-host disease". Blood. 126 (3): 406-414. doi:10.1182/ ... riboflavin and UV light treatment can also replace gamma-irradiation as a method to prevent graft-versus-host disease (TA-GvHD ...
December 2010). "Consensus conference on clinical practice in chronic graft-versus-host disease (GVHD): first-line and topical ... It is recommended only as a third line treatment in graft-versus-host-disease in adults because of lack of efficacy and side ... It is used as a second-line treatment to manage graft versus host disease and aphthous stomatitis in children and has been ... January 2011). "Consensus Conference on Clinical Practice in Chronic GVHD: Second-Line Treatment of Chronic Graft-versus-Host ...
TCD can reduce the risk of graft-versus-host disease (GVHD), which is a common issue in transplants. The idea that TCD of the ... "PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells". Journal of Clinical Investigation ... Soiffer, RJ (1992). "Prevention of graft-versus-host disease by selective depletion of CD6-positive T lymphocytes from donor ... "Low Risk of Chronic Graft Versus Host Disease and Relapse Associated with T-Cell Depleted Peripheral Blood Stem Cell ...
"Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat". Neurobiology of Disease. 43 (3): 552-7. doi: ... Spinner NB (March 2000). "CADASIL: Notch signaling defect or protein accumulation problem?". The Journal of Clinical ... The proteinopathies include such diseases as Creutzfeldt-Jakob disease and other prion diseases, Alzheimer's disease, ... The best known forms of inducible proteopathy are prion diseases, which can be transmitted by exposure of a host organism to ...
In the context of graft versus host disease, caspase-9 can be introduced as an inducible switch. In the presence of a small ... Li P, Zhou L, Zhao T, Liu X, Zhang P, Liu Y, Zheng X, Li Q (April 2017). "Caspase-9: structure, mechanisms and clinical ... Low amounts of caspase-9 leads to cancer and neurodegenerative diseases like Alzheimer's disease. Further alterations at single ... The effects of abnormal caspase-9 levels or function impacts the clinical world. The impact caspase-9 has on the brain can lead ...
"Rapamycin inhibits the generation of graft-versus-host disease- and graft-versus-leukemia-causing T cells by interfering with ... While contrasted results were obtained in clinical trials, pre-clinical studies have shown that Rapamycin can mitigate GVHD by ... Rapamycin has been assessed as prophylaxis or treatment agent of Graft-versus-host disease (GVHD), a complication of ... "Comprehensive analysis of the immunomodulatory effects of rapamycin on human T cells in graft-versus-host disease prophylaxis ...
... a monoclonal antibody administered in first-line treatment for acute graft-versus-host disease". Clinical Pharmacokinetics. 46 ... Inolimomab is a mouse monoclonal antibody developed as an immunosuppressive drug against graft-versus-host disease. Its target ... as treatment for refractory acute graft-versus-host disease". Biology of Blood and Marrow Transplantation. 12 (11): 1135-1141. ...
Many of the early clinical successes using intravenous transplantation came in systemic diseases such as graft versus host ... particularly treating autoimmune diseases, graft versus host disease, Crohn's disease, multiple sclerosis, systemic lupus ... Host Disease (GvHD) and, subsequently, in Japan to treat Crohn's Disease-related fistula. Since then, more than 1,000 clinical ... Clinical studies investigating the efficacy of mesenchymal stem cells in treating diseases are in clinical development around ...
... and cyclosporine in mouse models of host-versus-graft disease and heterotopic heart transplantation". Annals of the New York ... The Journal of Allergy and Clinical Immunology. 108 (2): 275-280. doi:10.1067/mai.2001.116865. PMID 11496246. Mollison KW, Fey ... It has been researched for the treatment of autoimmune diseases and skin diseases, and to prevent rejection after an organ ... Paul C, Graeber M, Stuetz A (January 2000). "Ascomycins: promising agents for the treatment of inflammatory skin diseases". ...
Chronic graft-versus-host disease The history of preceding hematopoietic cell transplant is helpful for diagnosis Psoriasis ... OLP may occur as a sole manifestation of the disease or in conjunction with other clinical manifestations of LP, including ... They can also occur in association with graft versus host disease.: 258 Lichen planus lesions are so called because of their " ... Vargas-Díez E, García-Díez A, Marín A, Fernández-Herrera J (May 2005). "Life-threatening graft-vs-host disease". Clinics in ...
He also worked on the phenomenon known as runt disease (graft versus host disease). Although Woodruff had been productive in ... In his clinical role, Woodruff started a vascular surgery program and worked with the use of immunotherapy as a cancer ... He took advantage of this access and his wife's skills as a lab assistant to investigate in utero grafts (tissue grafts ... Woodruff found two volunteers with identical blood antigens and arranged for them to exchange skin grafts. When the grafts were ...
... and oncology known for his role in developing consensus guidelines for clinical trials in chronic Graft-versus-host disease ( ... chronic Graft-versus-host disease (GVHD) and transplantation for autoimmune disease, with a particular interest in addressing ... Currently, he is the Head of the Graft-versus-host disease (GVHD) and Autoimmunity Unit and Senior Clinician at the ... He is the chief editor of the first textbook on GVHD entitled "Chronic Graft Versus Host Disease: Interdisciplinary Management ...
Lee SJ, Wegner SA, McGarigle CJ, Bierer BE, Antin JH (April 1997). "Treatment of chronic graft-versus-host disease with ... Bezerra EL, Vilar MJ, da Trindade Neto PB, Sato EI (October 2005). "Double-blind, randomized, controlled clinical trial of ... The Kv1.3 blocker clofazimine has been reported to be effective in the treatment of chronic graft-versus-host disease, ... "Potassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease". Journal of Alzheimer's Disease. 44 (3 ...
It is being investigated as a potential therapy in the treatment of HIV infection, graft versus host disease (NCT02737306) and ... These findings supported further clinical development of INCB009471 and they have since progressed to phase IIb clinical trials ... HIV enters host cells in the blood by attaching itself to receptors on the surface of the CD4+ cell. Viral entry to the CD4+ ... Phase I clinical trial of vicriviroc gave promising results, so a phase II study in the treatment of naïve patients was ...
... randomized clinical trial of ABX-CBL versus ATG as secondary therapy for steroid-resistant acute graft-versus-host disease". ... antibody intended for use as an immunosuppressive biologic treatment of glucocorticoid-resistant graft versus host disease. It ...
Use of equine ALG was also found to be efficacious in preventing acute graft-vs.-host-disease in patients' post-allogeneic bone ... and Mathe et al., resulted in promising data for the clinical use of ALG for preserving short-term and long-term kidney ... Thymoglobulin is also an effective agent for preventing graft-vs.-host disease in patients receiving haematopoietic stem cell ... such as graft-vs.-host disease and aplastic anemia. As an rATG, thymoglobulin consists of polyclonal antibodies, which, unlike ...
Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: ... It is currently undergoing a Phase III clinical trial to determine efficacy and clinical usefulness. TK is currently being ... Inhibition of graft-versus-host disease. Use of a T cell-controlled suicide gene". J Immunol 1997;158(11):5079-82. Official ... reaction known as graft-versus-host disease. Activation of the cell suicide system is obtained by the administration of ...
... which have lower rates of graft-versus-host disease. Antibodies are used to quantify and purify hematopoietic progenitor stem ... Due to these historical and clinical associations, CD34 expression is almost ubiquitously related to hematopoietic cells; ... December 2019). "Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia ... Injection of CD34+ hematopoietic stem cells has been clinically applied to treat various diseases including spinal cord injury ...
Besides, it has been shown that the adoptive transfer of alloreactive NK cells does not cause graft-versus-host disease (GVHD ... and persistence in large numbers in the host. Clinical use of allogeneic NK cells is promising for the treatment of leukemia. ... The clinical application of NK cells with memory-like properties can significantly increase the efficiency of these cells and ... pave the way for the new NK cell-based clinical approaches for the cancer treatment. Adaptive NK cells can mediate the enhanced ...
Graft-versus-host disease (GVHD) is often a side effect of allogeneic hematopoietic stem cell transplantation (HSCT), driven by ... So A, Thorens B (June 2010). "Uric acid transport and disease". The Journal of Clinical Investigation. 120 (6): 1791-9. doi: ... "Phase I study of urate oxidase in the reduction of acute graft-versus-host disease after myeloablative allogeneic stem cell ... donor T cells destroying host tissue. Uric acid has been shown to increase T cell response, so clinical trials have shown that ...