More recently he has been an important figure in the new field of click chemistry. This involves a set of highly selective, ... Modular click chemistry , ScienceWatch , Thomson Reuters. ScienceWatch. Retrieved on 2014-06-16. K. Barry Sharpless at The ... He continued his studies at Dartmouth College earning a B.A. in 1963 and a Ph.D in chemistry from Stanford University in 1968. ... In 2001 he won a half-share of the Nobel Prize in Chemistry for his work on chirally catalysed oxidation reactions (Sharpless ...
"Thiol-Ene Click Chemistry". Angewandte Chemie International Edition. 49: 1540-1573. doi:10.1002/anie.200903924. [3] Saharil, ... The OSTE resins are cured via a rapid thiol-ene "Click" reaction between thiols and allyls. The thiols and allyls react in a ... MicroTAS 2013 Freiburg, (2013) Hoyle, Charles E. (2004). "Thiol-enes: Chemistry of the past with promise for the future". ... Saharil, Farizah; Carlborg, Carl Fredrik; Haraldsson, Tommy; van der Wijngaart, Wouter (2012). "Biocompatible "click" wafer ...
... relative to all other metal-free click chemistry probes. See also "copper-free click chemistry". Commercial use of BCN is ... BCN, also known as bicyclo[6.1.0]nonyne, is a copper-free click chemistry probe that enables highly efficient and completely ... Bioconjugate Chemistry. 26: 2233-42. doi:10.1021/acs.bioconjchem.5b00224. PMID 26061183. Debets; et al. (September 2011). " ...
Click chemistry, MALDI-TOF Calibrants, Thiol-ene Click and semiconductor materials. Polymer Factory was founded in 2005.[ ... bifunctional dendrimers prepared by click chemistry". Chemical Communications (46): 5775-7. doi:10.1039/B512021G. PMID 16307142 ... and molecular weight in the formation of tailor-made ultrathin multilayers using dendritic macromolecules and click chemistry ... Journal of Materials Chemistry. 18 (22): 2545. doi:10.1039/b802197j. Malkoch, M; Hallman, K; Lutsenko, S; Hult, A; Malmström, E ...
T. Fekner; X. Li; M. M. Lee & M. K. Chan (2009). "A Pyrrolysine Analogue for Protein Click Chemistry". Angew. Chem. Int. Ed. 48 ... R. A. Evans (2007). "The Rise of Azide-Alkyne 1,3-Dipolar 'Click' Cycloaddition and its Application to Polymer Science and ... In particular, it participates in the aptly named click reaction with alkynes. Bioconjugation involves the labeling of certain ...
Fekner, T; Li, X; Lee, M. M.; Chan, M. K. (2009). "A pyrrolysine analogue for protein click chemistry". Angewandte Chemie ... Chemistry & Biology. 11 (9): 1317-24. doi:10.1016/j.chembiol.2004.07.011. PMID 15380192. Li, W. T.; Mahapatra, A; Longstaff, D ... Journal of Biological Chemistry. 280 (21): 20740-20751. doi:10.1074/jbc.M501458200. PMID 15788401. Zhang, Y; Gladyshev, V. N. ( ... The Journal of Biological Chemistry. 280 (44): 36962-36969. doi:10.1074/jbc.M506402200. PMID 16096277. Gaston, Marsha A.; Zhang ...
This reaction is very popular in click chemistry. Another azide regular is tosyl azide here in reaction with norbornadiene in a ... Inorganic Chemistry (Fifth Edition). W. H. Freeman and Company, New York, pp 382. M. S. Alfred Hassner (1986). "Synthesis of ... They are also popular for their participation in the "click reaction" and in Staudinger ligation. These two reactions are ... Greenwood, Norman N.; Earnshaw, Alan (1997). Chemistry of the Elements (2nd ed.). Butterworth-Heinemann. p. 433. ISBN 0-08- ...
Franc, Grégory; Kakkar, Ashok K. (2009). "Diels-Alder "Click" Chemistry in Designing Dendritic Macromolecules". Chemistry: A ... The functional group on the surface of PAMAM dendrimers is ideal for click chemistry, which gives rise to many potential ... Dendrimers have been prepared via click chemistry, employing Diels-Alder reactions, thiol-ene and thiol-yne reactions and azide ... Franc, Grégory; Kakkar, Ashok (2008). "Dendrimer design using CuI-catalyzed alkyne-azide "click-chemistry"". Chemical ...
"Exploring Isonitrile-Based Click Chemistry for Ligation with Biomolecules". Organic & Biomolecular Chemistry. 9 (21): 7303-7305 ... doi:10.1016/S0065-3055(08)60404-9 Bassett, J.M.; Barker, G.K.; Green, M.; Howard, J.A.; Stone, G.A.; Wolsey, W.C. "Chemistry of ... Ivar Karl Ugi states that "The development of the chemistry of isocyanides has probably suffered only little delay through the ... New Journal of Chemistry. 36 (5): 1137-1340. doi:10.1039/C2NJ40050B. Stephany, R. W.; de Bie, M. J. A.; Drenth, W. (1974). "A ...
... "click chemistry." Dr. K. Barry Sharpless, who was awarded the 2001 Nobel Prize in Chemistry, pioneered this set of powerful and ... "The growing impact of click chemistry on drug discovery". Drug Discov. Today. 8 (24): 1128-37. doi:10.1016/S1359-6446(03)02933- ... Lexicon uses solution-phase chemistry to generate diverse libraries of optically pure compounds that are built using highly ... Lexicon's campus in Princeton, New Jersey is the home of Lexicon's small molecule medicinal chemistry and preclinical ...
Click chemistry is well suited to fill this niche, since click reactions are, by definition, rapid, spontaneous, selective, and ... Azide Click Chemistry". Bioconjugate Chemistry. 21 (10): 1912-6. doi:10.1021/bc100272z. PMC 3014321 . PMID 20886827. Agard NJ, ... Kolb HC, Finn MG, Sharpless KB (June 2001). "Click Chemistry: Diverse Chemical Function from a Few Good Reactions". Angew. Chem ... Bioorganic & Medicinal Chemistry - The Tetrahedron Journal for Research at the Interface of Chemistry and Biology ChemBioChem ...
... of click chemistry and "the premier example of a click reaction." In the reaction above azide 2 reacts neatly with alkyne 1 to ... H. C. Kolb, M. G. Finn and K. B. Sharpless (2001). "Click Chemistry: Diverse Chemical Function from a Few Good Reactions". ... CS1 maint: Uses authors parameter (link) Kolb, H.C.; Sharpless, B.K. (2003). "The growing impact of click chemistry on drug ... "Click-chemistry as an efficient synthetic tool for the preparation of novel conjugated polymers". Chemical Communications. 34 ( ...
... of click chemistry and "the premier example of a click reaction." Condensation reactions are another route to the formation of ... Kolb, H. C.; Finn, M. G.; Sharpless, K. B. (2001). "Click Chemistry: Diverse Chemical Function from a Few Good Reactions". ... Kolb, H. C.; Sharpless, B. K. (2003). "The Growing Impact of Click Chemistry on Drug Discovery". Drug Discovery Today. 8 (24): ... In organic chemistry, the term aromaticity has come to refer to cyclic (ring-shaped), planar (flat) organic compounds with a ...
"Copper-free click chemistry for dynamic in vivo imaging". Proc. Natl. Acad. Sci. USA. 104 (43): 16793-16797. Bibcode:2007PNAS.. ... In organic chemistry, a cycloalkyne is the cyclic analog of an alkyne. A cycloalkyne consists of a closed ring of carbon atoms ... Topics in Current Chemistry. 109: 189-233. doi:10.1007/BFb0018059. Adams, Richard D.; Chen, Gong; Qu, Xiaosu; Wu, Wengan; ... the utility of strained cycloalkynes in both total synthesis of complex natural products and bioorthogonal chemistry. Angle ...
Kolb, H. C.; Finn, M. G.; Sharpless, K. B. (2001). "Click Chemistry: Diverse Chemical Function from a Few Good Reactions". ... "Copper-free click chemistry in living animals". Proceedings of the National Academy of Sciences. 107 (5): 1821. Bibcode: ... One strategy is to first install a unique functional group onto a protein, and then a bioorthogonal or click type reaction is ... Tilley, S. D.; Joshi, N. S.; Francis, M. B. (2008). "Proteins: Chemistry and Chemical Reactivity". Wiley Encyclopedia of ...
The compound has been investigated as a click chemistry mediator. "AC1L1QCE - Compound Summary". PubChem Compound. USA: ... a small and fast click-chemistry multitalent". Chem. Commun. doi:10.1039/C1CC12161H. ... COD reacts with borane to give 9-borabicyclo[3.3.1]nonane, commonly known as 9-BBN, a reagent in organic chemistry used in ... Shriver, D.; Atkins, P. (1999). Inorganic Chemistry. New York: W. H. Freeman and Co. [ISBN missing] Schiffer, Thomas; Oenbrink ...
Alleyne, Richard (28 September 2005). "Chemistry as Silverton clicks with new partner". Daily Telegraph. London. Retrieved 27 ...
"Super-resolution optical DNA Mapping via DNA methyltransferase-directed click chemistry". Nucleic Acids Research. 42 (7): e50- ...
Another Good Reaction for Click Chemistry". Angewandte Chemie International Edition. 53: 9430-9448. doi:10.1002/anie.201309399 ... Sulbaek Andersen, M.P., D.R. Blake, F.S. Rowland, M.D. Hurley, and T.J. Wallington, Atmospheric Chemistry of Sulfuryl Fluoride ... Inorganic Chemistry, 13 (4), 837-841, 1974. doi:10.1021/ic50134a016 Dong, J.; Krasnova, L.; Finn, M. G.; Sharpless, K. B. (2014 ... "Inorganic Chemistry" Academic Press: San Diego, 2001. ISBN 0-12-352651-5. Seel, F. "Potassium Fluorosulfite" Inorganic ...
... cell-compatible click chemistry with copper-chelating azides for biomolecular labeling". Angew. Chem. Int. Ed. Engl. 51 (24): ... "Site-specific protein labeling using PRIME and chelation-assisted click chemistry". Nat Protoc. 8 (8): 1620-34. doi:10.1038/ ... 2011). Advanced fluorescence reporters in chemistry and biology. Heidelberg: Springer. ISBN 978-3-642-18034-7. Liu DS, ...
This method has become more popular with the rise of click chemistry. A high yield chemical reaction called atom transfer ... Polymer Chemistry. 45 (9): 1653-1660. Bibcode:2007JPoSA..45.1653T. doi:10.1002/pola.21932. Dhiman, Poonam K.; Kaur, Inderjeet; ... Polymer Chemistry. 31 (2): 527-533. Bibcode:1993JPoSA..31..527H. doi:10.1002/pola.1993.080310225. Grutke, Stefan; Hurley, James ... Macromolecular Chemistry and Physics. 195 (8): 2875-2885. doi:10.1002/macp.1994.021950817. Eisenbach, Claus D.; Heinemann, T. ( ...
The reaction is so versatile that it is termed the "Click" chemistry. Although copper(I) is toxic, many protective ligands have ... Padwa, Albert (1983). 1,3-Dipolar Cycloaddition Chemistry. General Heterocyclic Chemistry Series. 1. United States of America: ... Concerted nature of 1,3-dipolar cycloadditions and the question of diradical intermediates". Journal of Organic Chemistry. 41: ... Fireston, R (1968). "Mechanism of 1,3-dipolar cycloadditions". Journal of Organic Chemistry. 33: 2285-2290. doi:10.1021/ ...
The resulting alkynes are used for a variety of applications including click chemistry. Illustrating the Sonogashira cross ... Organocopper compounds in organometallic chemistry contain carbon to copper chemical bonds. Organocopper chemistry is the ... Chemistries of carbon with other elements of the periodic table: Gary H. Posner (1980). An introduction to synthesis using ... They are reagents in organic chemistry. The first organocopper compound, the explosive copper(I) acetylide Cu2C2 (Cu-C≡C-Cu), ...
Johnson, J. A.; Baskin, J. M.; Bertozzi, C. R.; Koberstein, J. T.; Turro, N. J. (2008). "Copper-Free Click Chemistry for the In ... Houlihan, F. M.; Shugard, A.; Gooden, R.; E. (1988). "An Evolution of Nitrobenzyl Ester Chemistry for Chemical Amplification ... Houlihan, F. M.; Shugard, A.; Gooden, R.; Reichmanis, E. (1988). "An Evaluation of Nitrobenzyl Ester Chemistry for Chemical ... Ssolid-State Behavior". Journal of Polymer Science: Polymer Chemistry Edition. 23 (1): 1-8. Bibcode:1985JPoSA..23....1R. doi: ...
"Convergent synthesis of PAMAM dendrimers using click chemistry of azide-functionalized PAMAM dendrons". Tetrahedron. 62 (39): ... In the future, as synthetic control over dendrimer surface chemistry becomes more robust, PAMAM and other dendrimer families ... Polymer Chemistry. 41 (8): 1047-58. Bibcode:2003JPoSA..41.1047H. doi:10.1002/pola.10643. Rittner, K; Benavente, A; Bompard- ... Bioconjugate Chemistry. 4 (5): 372-9. doi:10.1021/bc00023a012. PMID 8274523. Kolhatkar, Rohit B.; Kitchens, Kelly M.; Swaan, ...
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