Budding of the plasma membrane then occurs, forming a clathrin coated pit.[1] Other receptors can nucleate a clathrin-coated ... Receptor-mediated endocytosis (RME), also called clathrin-mediated endocytosis, is a process by which cells absorb metabolites ... Clathrin-mediated endocytosis of many receptor types begins with the cargo ligands in the luminal compartment of the cell ... Kaksonen M, Roux A (May 2018). "Mechanisms of clathrin-mediated endocytosis". Nature Reviews. Molecular Cell Biology. 19 (5): ...
... interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic". Mol. Biol. Cell. 10 (8): 2687-702. ... Goodman OB, Keen JH (1995). "The alpha chain of the AP-2 adaptor is a clathrin binding subunit". J. Biol. Chem. 270 (40): 23768 ... Kirchhausen T (2000). "Clathrin". Annu. Rev. Biochem. 69: 699-727. doi:10.1146/annurev.biochem.69.1.699. PMID 10966473. ... This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles ...
"Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, ... Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ (Nov 2002). "Clint: a novel clathrin-binding ENTH-domain protein at the ... Kirchhausen T (2000). "Clathrin". Annual Review of Biochemistry. 69: 699-727. doi:10.1146/annurev.biochem.69.1.699. PMID ... Kim YM, Benovic JL (Aug 2002). "Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein- ...
Kirchhausen T (2000). "Clathrin". Annu. Rev. Biochem. 69: 699-727. doi:10.1146/annurev.biochem.69.1.699. PMID 10966473. Geyer M ... 1999). "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin ... 1999). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4". Curr ... Doray B, Kornfeld S (2001). "Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in ...
The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated ... Kirchhausen T (2000). "Clathrin". Annual Review of Biochemistry. 69: 699-727. doi:10.1146/annurev.biochem.69.1.699. PMID ... Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in ... Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in ...
"Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by ... Kirchhausen T (2000). "Clathrin". Annual Review of Biochemistry. 69: 699-727. doi:10.1146/annurev.biochem.69.1.699. PMID ... "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly". Proceedings of the ... "Association and colocalization of Eps15 with adaptor protein-2 and clathrin". The Journal of Cell Biology. 136 (4): 811-21. doi ...
Kirchhausen T (2000). "Clathrin". Annual Review of Biochemistry. 69: 699-727. doi:10.1146/annurev.biochem.69.1.699. PMID ... "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor". ... "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4". Current ... where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic ...
However, in higher eukaryotes there are several conserved motifs such as the clathrin-binding motifs which bind clathrin heavy ... The epsin homologue of C. elegans is EPN-1. EPN-1 conserves the UIM, ENTH domain, and clathrin-binding motif. ... Chen X, Irani NG, Firml, J (2011). "Clathrin - mediated endocytosis: the gateway into plant cells". Current Opinion in Plant ... Epsin 4, which encodes the protein enthoprotin, now known as clathrin interactor 1 (CLINT1), has been shown to be involved in ...
IFNAR1 and IFNAR2 can be internalized through endocytosis in response to agonism through clathrin-dependent and clathrin- ... Electron microscopy experiments show IFNAR receptors concentrated in clathrin-coated pits, and inhibition of clathrin-mediated ... Clathrin-dependent endocytosis[edit]. Following receptor agonism, the C-terminus of IFNAR is phosphorylated, followed by its ... in the presence of stimulation when the clathrin-dependent endocytosis pathway is inhibited with siRNA knockdown of clathrin or ...
Jung N, Haucke V (September 2007). "Clathrin-mediated endocytosis at synapses". Traffic. 8 (9): 1129-36. doi:10.1111/j.1600- ... Long-term depression enacts mechanisms to decrease AMPA receptor density in selected dendritic spines, dependent on clathrin ... Interactions from calcineurin activate dynamin GTPase activity, allowing the clathrin pit to excise itself from the cell ... consisting of a clathrin-coated pit underneath a section of AMPAR-containing plasma membrane and interacting proteins, is the ...
5) In the periactive zone the membrane proteins are sequestered and are endocytosed forming a clathrin coated vesicle. (6) The ... Jung Nadja; Haucke Volker (2007). "Clathrin-Mediated Endocytosis at Synapses". Traffic. 8 (9): 1129-1136. doi:10.1111/j.1600- ... 2010). "Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits". Biochemical and Biophysical Research ... clathrin and endophilin.[17] In Drosophilia the intersectin homolog, Dap160, is located in the periactive zone of the ...
Fölsch H, Pypaert M, Schu P, Mellman I (Feb 2001). "Distribution and function of AP-1 clathrin adaptor complexes in polarized ... Korolchuk VI, Banting G (Jun 2002). "CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles". Traffic. 3 (6 ... Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in ... Hirst J, Robinson MS (Aug 1998). "Clathrin and adaptors". Biochimica et Biophysica Acta. 1404 (1-2): 173-93. doi:10.1016/S0167- ...
1997). "Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain". J. Biol. ... 1998). "Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta ... ter Haar E, Musacchio A, Harrison SC, Kirchhausen T (1998). "Atomic structure of clathrin: a beta propeller terminal domain ... interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin- ...
The holotoxin can be taken up by clathrin-coated pits, as well as by clathrin-independent pathways including caveolae and ... Nichols BJ, Lippincott-Schwartz J (October 2001). "Endocytosis without clathrin coats". Trends Cell Biol. 11 (10): 406-12. doi: ...
P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes". Science. 291 (5506): 1051-5. doi:10.1126/science ... Pearse, B. M. F.; Robinson, M. S. (1990). "Clathrin, Adaptors, and Sorting". Annual Review of Cell Biology. 6: 151-171. doi: ... Pearse first purified coated vesicles; she also discovered the clathrin coat molecule in 1975. Coated pits and vesicles were ... subscription required) Pearse, B. M. (1987). "Clathrin and coated vesicles". The EMBO Journal. 6 (9): 2507-12. PMC 553666 . ...
Byland R, Vance PJ, Hoxie JA, Marsh M (2007). "A Conserved Dileucine Motif Mediates Clathrin and AP-2-dependent Endocytosis of ... One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane ... "Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit". Pearse BM, Smith CJ, Owen DJ (2000). "Clathrin coat ... 2006). "Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2". Virology. 342 (2): 190-200. doi:10.1016/j.virol. ...
Examples include: Archain ARFs Clathrin Caveolin Dynamin and related proteins, such as the EHD protein family Rab proteins ... cis-Golgi Clathrin : trans-Golgi ----> Lysosomes, Plasma membrane ----> Endosomes (receptor-mediated endocytosis) Membrane ...
The clathrin coated pit invaginates into the cytosol and forms a clathrin coated vesicle. The clathrin proteins will then ... The particles are absorbed through the use of clathrin coated pits. These clathrin coated pits are short lived and serve only ... Proteins in the clathrin coat on the plasma membrane have propensity to bind and trap macromolecules or ligands. However, it is ... Clathrin Hydrolase Lysosome Phagocytosis Pinocytosis Rieger, R.; Michaelis, A.; Green, M.M. 1991. Glossary of Genetics. ...
Once the clathrin coat detaches, other proteins can interact directly with the AMPARs using PDZ carboxyl tail domains; for ... The complex, consisting of a clathrin-coated pit underneath a section of AMPAR-containing plasma membrane and interacting ... Long-term depression enacts mechanisms to decrease AMPA receptor density in selected dendritic spines, dependent on clathrin ... Interactions from calcineurin activate dynamin GTPase activity, allowing the clathrin pit to excise itself from the cell ...
The AP2 adaptor complex is a multimeric protein that works on the cell membrane to internalize cargo in clathrin-mediated ... The alpha and beta appendage domains bind to accessory proteins and to clathrin. Their interactions allow the temporal and ... "Clathrin coat construction in endocytosis". Current Opinion in Structural Biology. 10 (2): 220-8. doi:10.1016/S0959-440X(00) ... spatial regulation of the assembly of clathrin-coated vesicles and their endocytosis. The AP-2 complex is a heterotetramer ...
"Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by ... In the brain, its primary function is thought to be the recruitment of dynamin to sites of clathrin-mediated endocytosis. There ... A ubiquitous splice form of amphiphysin 2 that does not contain clathrin or adaptor interactions is highly expressed in muscle ... McMahon HT, Wigge P, Smith C (August 1997). "Clathrin interacts specifically with amphiphysin and is displaced by dynamin". ...
The CLINT1 protein binds to the terminal domain of the clathrin heavy chain and stimulates clathrin cage vesicle assembly. ... Clathrin interactor 1 (CLINT1), also known as EPSIN4, is a protein which in humans is encoded by the CLINT1 gene. ... Clathrin coated vesicles enable neurotransmitter receptors and other proteins to be endocytosed or taken up across neuronal ... 2004). "Clathrin adaptor epsinR is required for retrograde sorting on early endosomal membranes". Dev. Cell. 6 (4): 525-38. doi ...
The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The ... This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in ... Foti M, Mangasarian A, Piguet V, Lew DP, Krause KH, Trono D, Carpentier JL (Oct 1997). "Nef-mediated clathrin-coated pit ... Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in ...
"Dynamics of intracellular clathrin/AP1- and clathrin/AP3-containing carriers". Cell Reports. 2 (5): 1111-9. doi:10.1016/j. ... The involvement of the heterotetramer of COPI is similar to that of the AP/clathrin situation, but the coat of COPI is not ... Cocucci E, Aguet F, Boulant S, Kirchhausen T (August 2012). "The first five seconds in the life of a clathrin-coated pit". Cell ... AP-5 is associated with 2 proteins, SPG11 and SPG15, which have some structural similarity to clathrin, and may form the coat ...
Raiborg C, Bache KG, Mehlum A, Stang E, Stenmark H (2001). "Hrs recruits clathrin to early endosomes". EMBO J. 20 (17): 5008-21 ... "Hrs recruits clathrin to early endosomes". EMBO J. 20 (17): 5008-21. doi:10.1093/emboj/20.17.5008. PMC 125612 . PMID 11532964. ...