August 2005). "Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but ... Tyrosine kinases often operate near the plasma membrane and hence control the recruitment of p110δ to the plasma membrane where ... Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform also known as phosphoinositide 3-kinase (PI3K) ... Like the other class IA PI3Ks, p110δ is a catalytic subunit, whose activity and subcellular localisation are controlled by an ...

The class IA PI3K p110α is mutated in many cancers. Many of these mutations cause the kinase to be more active. It is the ... Class I PI3Ks catalyze the conversion of phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) into phosphatidylinositol (3,4,5)- ... The PI3K family is divided into four different classes: Class I, Class II, Class III, and Class IV. The classifications are ... Class II comprises three catalytic isoforms (C2α, C2β, and C2γ), but, unlike Classes I and III, no regulatory proteins. Class ...

Row PE, Prior IA, McCullough J, Clague MJ, Urbé S (May 2006). "The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin ... Janssen JW, Schleithoff L, Bartram CR, Schulz AS (April 1998). "An oncogenic fusion product of the phosphatidylinositol 3- ... D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Critical Reviews in ... kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme". Oncogene. 16 (13): 1767-72. doi:10.1038/sj.onc.1201695 ...

In addition to activating Ras/AKT and ERK/MAP kinase, phosphatidylinositol 3-kinase/AKT pathway and STAT transcription factors ... Wilson IA, Jolliffe LK (Dec 1999). "The structure, organization, activation and plasticity of the erythropoietin receptor". ... Combined Scissor-Like Rotation and Self-Rotation of Receptor Dimer Induced by Class I Cytokine". PLOS Computational Biology. 8 ... Mutations in Jak2 kinases associated with EpoR can also lead to polycythemia vera. Primary role of EpoR is to promote ...

Meinertzhagen IA, O'Neil SD (March 1991). "Synaptic organization of columnar elements in the lamina of the wild type in ... Calcium binds to proteins such as calmodulin (CaM) and an eye-specific protein kinase C (PKC) known as InaC. These proteins ... PLCβ hydrolyzes phosphatidylinositol (4,5)-bisphosphate (PIP2), a phospholipid found in the cell membrane, into soluble ... The y mutation comprises the following phenotypic classes: the mutants that show a complete loss of pigmentation from the ...

Serine/Threonine kinases are also known to reduce the activity of insulin. The structure of the insulin-insulin receptor ... Macdonald IA (November 2016). "A review of recent evidence relating to sugars, insulin resistance and diabetes". European ... Layden BT, Durai V, Lowe WL Jr (2010). "G-Protein-Coupled Receptors, Pancreatic Islets, and Diabetes". Nature Education. 3 (9 ... Phospholipase C cleaves the membrane phospholipid, phosphatidyl inositol 4,5-bisphosphate, into inositol 1,4,5-trisphosphate ...

Hassler M, Shaltiel IA, Kschonsak M, Simon B, Merkel F, Thärichen L, Bailey HJ, Macošek J, Bravo S, Metz J, Hennig J, Haering ... Baretić D, Williams RL (2014). "PIKKs--the solenoid nest where partners and kinases meet". Curr. Opin. Struct. Biol. 29: 134- ... PMID 11416198.{{cite journal}}: CS1 maint: multiple names: authors list (link) Eukaryotic Linear Motif resource motif class LIG ... phosphatidylinositol 3-kinase-related protein kinases) such as ATM (Ataxia telangiectasia mutated) and ATR (Ataxia ...

Hirokawa N, Nitta R, Okada Y (December 2009). "The mechanisms of kinesin motor motility: lessons from the monomeric motor KIF1A ... Karasmanis EP, Phan CT, Angelis D, Kesisova IA, Hoogenraad CC, McKenney RJ, Spiliotis ET (July 2018). "Polarity of Neuronal ... Three MAPs that localize within dendrites, doublecortin (DCX), doublecortin-like kinase-1 (DCLK1), and MAP9, regulate motor ... Klopfenstein DR, Tomishige M, Stuurman N, Vale RD (May 2002). "Role of phosphatidylinositol(4,5)bisphosphate organization in ...

The class IA phospholipid kinase, PI-3 kinase, is activated by the majority of RTKs. Similarly to other SH2 domain-containing ... Valius M, Kazlauskas A (April 1993). "Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of ... Dimerization is a prerequisite for the activation of the kinase. Kinase activation is visualized as tyrosine phosphorylation of ... which in many cases also are substrates for the kinase. The second part of the tyrosine kinase domain in the PDGFβ receptor is ...

Rahman IA, Tsuboi K, Uyama T, Ueda N (August 2014). "New players in the fatty acyl ethanolamide metabolism". Pharmacological ... Soderstrom K (2009). "Lessons from nonmammalian species". In Kendall D, Alexander S (eds.). Behavioral Neurobiology of the ... December 2007). "The endogenous cannabinoid system stimulates glucose uptake in human fat cells via phosphatidylinositol 3- ... kinase and calcium-dependent mechanisms". The Journal of Clinical Endocrinology and Metabolism. 92 (12): 4810-4819. doi:10.1210 ...

Graeff, R; Liu, Q; Kriksunov, IA; Hao, Q; Lee, HC (2006-09-29). "Acidic residues at the active sites of CD38 and ADP-ribosyl ... Their luminal pH is one characteristic that distinguishes a given vesicle class from another: where endosomes are weakly acidic ... Phosphatidylinositol 3,5-bisphosphate, PI(3,5)P2 and also by metabolic state (via ATP and mTOR). This controversy ultimately ... P₂ and multiple protein kinases". EMBO J. 33 (5): 501-11. doi:10.1002/embj.201387035. PMC 3989630. PMID 24502975. Grimm, C; ...