In constant darkness, ClockΔ19 mice heterozygous for the Clock mutant allele exhibit lengthened circadian periods, while Clock ... indicating that Clock functions as a positive element in the circadian loop. While the mutation affects the circadian clock of ... Clock -/- null mutant mice, in which Clock has been knocked out, display completely normal circadian rhythms. The discovery of ... That showed that "intact CLOCK genes" are necessary for normal mammalian circadian function[how?]. CLOCK protein has been found ...

genome was regulated by a circadian clock. (1) The circadian oscillators in eukaryotes that have been studied function using a ... "Structure and function from the circadian clock protein KaiA of Synechococcus elongatus: a potential clock input mechanism". ... the cyanobacterial clock proteins are the main circadian regulator in cyanobacteria. The cyanobacterial clock proteins comprise ... Garces RG, Wu N, Gillon W, Pai EF (April 2004). "Anabaena circadian clock proteins KaiA and KaiB reveal a potential common ...

She is known for her extensive studies of photic and non-photic effects on the mammalian circadian clocks. Notably, Meijer is ... Specifically, they found that a phase shift in one's circadian clock due to different patterns of light exposure results in ... Meijer is a major contributor to the topic of circadian clocks and neuronal organization. She discovered that synaptic and ... In addition to still unraveling neuronal mechanisms of circadian clocks and their applications to health, Meijer's lab now ...

"Circadian rhythms of locomotor activity in Ansell's mole-rat: are mole-rat's clocks ticking?". Journal of Zoology. 276 (4): 343 ...

... two genes that regulate the mammalian circadian clock. This induction of PER protein can entrain the circadian clock to light/ ... Michael Greenberg first demonstrated the role of CREB in the mammalian circadian clock in 1993 through a series of experiments ... Entrainment of the mammalian circadian clock is established via light induction of PER. Light excites melanopsin-containing ... and genes involved in the mammalian circadian clock (PER1, PER2). CREB is closely related in structure and function to CREM ( ...

August 2009). "Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period". The Journal of ... regulates period length of the mouse suprachiasmatic circadian clock in vitro". PLOS ONE. 5 (4): e10303. Bibcode:2010PLoSO... ... While this research has shown that circadian rhythm is modulated primarily by the alternate isoform CK1-δ rather than CK1-ε, ... August 2010). "Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes". Proceedings of ...

The circadian clock in these insects enforces a daily pattern of emergence by permitting or triggering eclosion during specific ... This technique has been used as recently as 2021 to evaluate how the central circadian clock regulates eclosion by coupling to ... In holometabolous insects, the circadian clock regulates the timing of adult emergence. The daily rhythm of adult emergence in ... Pittendrigh used this model to demonstrate that the circadian clock in drosophila is temperature-compensated (meaning its ...

PER1 and PER2 are necessary for molecular timekeeping and light responsiveness in the master circadian clock in the SCN, but ... It is expressed in a circadian pattern in the suprachiasmatic nucleus (SCN), the primary circadian pacemaker in the mammalian ... Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian ... subtle effects on circadian clock function". Molecular and Cellular Biology. 20 (17): 6269-75. doi:10.1128/MCB.20.17.6269- ...

Space travel can adversely affect the body's natural biological clock (circadian rhythm); sleep patterns causing sleep ...

Many animals depend on such a clock to maintain their circadian rhythm. Animals that use sun compass orientation are fish, ... The experiment implied that the sandhoppers use the sun and their internal clock to determine their heading, and that they had ... Since the Sun moves in the sky, navigation by this means also requires an internal clock. ... which also requires an accurate time-of-day clock. In 2003, the African dung beetle Scarabaeus zambesianus was shown to ...

"Light-independent role of CRY1 and CRY2 in the mammalian circadian clock". Science. 286 (5440): 768-771. doi:10.1126/science. ... neurotransmitter release from synapse and asynchronous release from synapses Role of CRY1 and CRY2 in mammalian circadian clock ... disorders Development of technologies to activate and monitor neuronal activity Regulation of sleep and circadian rhythms The ...

Caster, Steven (2016). "Circadian clock regulation of mRNA translation through eukaryotic elongation factor eEF-2". PNAS. 113 ( ... While the basic mechanisms of circadian transcriptional control are known, little is understood about how the clock controls ... Rck-2 is a gene that plays a major role in clock control of translation. Rck-2 protein is a kinase and is rhythmically ... activated through phosphorylation events based on the periodicity of the clock. Rck-2 activation is directly associated with ...

The mammalian circadian clock, composed of a transcription feedback loop tightly regulated to oscillate with a period of about ... November 2013). "RNA-methylation-dependent RNA processing controls the speed of the circadian clock". Cell. 155 (4): 793-806. ... The effects of global methylation inhibition on the circadian period in mouse cells can be prevented by ectopic expression of ... Hastings MH (November 2013). "m(6)A mRNA methylation: a new circadian pacesetter". Cell. 155 (4): 740-741. doi:10.1016/j.cell. ...

... are synchronized with the body's internal circadian clock. The best way to observe the workings of this clock is to ... Because circadian clocks synchronize human sleep-wake cycles to coincide with periods of the day during which reward potential ... Researchers have shown that the 24-hour circadian clock also influences cognitive performance in a wide variety of paradigms, ... Roenneberg, Till; Kumar, C. Jairaj; Merrow, Martha (23 January 2007). "The human circadian clock entrains to sun time" (PDF). ...

Miki T, Zhao Z, Lee CC (July 2016). "Interactive Organization of the Circadian Core Regulators PER2, BMAL1, CLOCK and PML". ... PER2, BMAL1, CLOCK, RING finger domain GRCh38: Ensembl release 89: ENSG00000140464 - Ensembl, May 2017 GRCm38: Ensembl release ...

Ronald M. Evans and Ying-Hui Chen, "Mutagenesis and Mapping of a Mouse Gene, Clock, Essential for Circadian Behavior," Science ... Chang found that evening exposure to eBooks cause phase delays in the circadian clock and suppresses melatonin, affecting sleep ... Christopher A. Bradfield and Steven M. Reppert, "Functional identification of the mouse circadian Clock gene by transgenic BAC ... Clock , Essential for Circadian Behavior". Science. 264 (5159): 719-725. doi:10.1126/science.8171325. ISSN 0036-8075. PMC ...

Plants keep track of the time of day with a circadian clock. This internal clock is synchronized with solar time every day ... The internal clock coupled with the ability to perceive light also allows plants to measure the time of the day and so ... Harmer SL, Panda S, Kay SA (2001). "Molecular bases of circadian rhythms". Annual Review of Cell and Developmental Biology. 17 ... using sunlight, temperature, and other cues, similar to the biological clocks present in other organisms. ...

Taghert and colleagues have identified the ~150 circadian clock neurons in the adult Drosophila melanogaster brain. Two ... Peschel, Nicolai (May 20, 2011). "Setting the clock - by nature: Circadian rhythm in the fruitfly Drosophila melanogaster". ... "Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock". Cell. 109 (3): 307-320. doi:10.1016/S0092-8674( ... Taghert's work involves employing the GAL4 activation and GAL80 inhibition of PDF to study PDF's necessity as a circadian ...

This discovery solidified doubletime as a necessary part of the circadian clock. 1978: Andre and Bella Meyer Foundation ... A 40 Year Journey from Drosophila's Clock Mutants to Human Circadian Disorders (Articles with short description, Short ... "Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock". Science. 271 (5256): 1736-1740. ... The book described biological clocks as the reason why a strange plant he had seen years earlier produced flowers that closed ...

"Stochastic gene expression out-of-steady-state in the cyanobacterial circadian clock". Nature. 450 (7173): 1249-52. Bibcode: ...

... oscillate predictably on a 24-hour timescale and interact with other circadian clock genes to regulate circadian rhythms in ... "VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator". Neuron. 37 (2): 249-61. ... Ohno T, Onishi Y, Ishida N (March 2007). "The negative transcription factor E4BP4 is associated with circadian clock protein ... February 2003). "vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock". Cell. 112 (3): 329-41 ...

Many animals depend on such a clock to maintain their circadian rhythm. Animals that use sun compass orientation are fish, ... The butterflies that had their biological clocks set to the natural fall cycle (lights turned on at 7:00 am) tried to fly to ... The experiment implied that the sandhoppers use the sun and their internal clock to determine their heading, and that they had ... Animals associate the sun azimuth with time of day provided by their internal clock and a reference direction provided by their ...

It is regulated by circadian clocks. The circadian rhythm can further be broken down into routine cycles during the 24-hour day ... In some cases, multi-trophic systems may exhibit rhythms driven by the circadian clock of one of the members (which may also be ... The term circadian comes from the Latin circa, meaning "around" and dies, "day", meaning "approximately a day." ... Refinetti, Roberto (2006). Circadian Physiology. CRC Press/Taylor & Francis Group. ISBN 0-8493-2233-2. Lay summary Society for ...

It is believed that the heterochronic pathway represents an evolutionarily conserved predecessor to circadian clocks. Some ... homologs of core circadian clock genes". Developmental Cell. 8 (2): 287-95. doi:10.1016/j.devcel.2004.12.006. PMID 15691769. ...

The search for circadian clock components in humans: new perspectives for association studies. Allebrandt KV, Roenneberg T. ... The MCTQ samples sleep and circadian rhythm data from more than 25,000 participants. Questions about work day and free day ... This Chronotype Questionnaire is important because it delves into the social aspects of circadian rhythms. By testing behavior ... may relate to genetic predispositions of circadian rhythms. "MCTQ - Main Page". WeP Project. Retrieved 2018-05-03. ...

Her focus is on the circadian clock in Neurospora and its application to the genetic mechanisms of the clock in other organisms ... This in turn provided the tool to distinguish between oscillators not directly in the clock and the circadian clock itself. ... 2015). "Around the Fungal Clock: Recent Advances in the Molecular Study of Circadian Clocks in Neurospora and Other Fungi". ... 1 May 2006). "Transcriptional and Post-transcriptional Regulation of the Circadian Clock of Cyanobacteria and Neurospora". ...

Depression may be related to abnormalities in the circadian rhythm, or biological clock. A well synchronized circadian rhythm ... Satyanarayanan, Senthil Kumaran; Su, Huanxing; Lin, Yi-Wen; Su, Kuan-Pin (19 October 2018). "Circadian Rhythm and Melatonin in ... Adverse changes and alterations in the circadian rhythm have been associated various neurological disorders and mood disorders ... Germain, Anne; Kupfer, David J. (6 December 2016). "Circadian rhythm disturbances in depression". Human Psychopharmacology. 23 ...

... and circadian rhythms impact the human metabolome. Archer, Simon N, et al. "A Length Polymorphism in the Circadian Clock Gene ... "Role of the clock gene Period3 in the human cell-autonomous circadian clock". Genes to Cells: Devoted to Molecular & Cellular ... In the early 2000s, her team discovered that administering melatonin can entrain the circadian clock that is normally free- ... One area is understanding how circadian clocks, sleep, and metabolism relate to each other within people with dysfunctional ...

Ikegami, K; Iigo, M; Yoshimura, T (2013). "Circadian clock gene Per2 is not necessary for the photoperiodic response in mice". ... Circadian rhythms Light information received by the eyes is transmitted to the pineal gland via the circadian pacemaker (the ...

There is a strong circadian rhythm of sleep in mammals. The "master clock" for circadian rhythms in mammals is the ... Lesions of the dorsomedial nucleus almost completely eliminate the circadian rhythm of sleep. GABAergic neurons in the ... Saper, Clifford B.; Scammell, Thomas E.; Lu, Jun (2005). "Hypothalamic regulation of sleep and circadian rhythms". Nature. 437 ... "Critical Role of Dorsomedial Hypothalamic Nucleus in a Wide Range of Behavioral Circadian Rhythms". The Journal of Neuroscience ...