... (EC 3.4.21.1, chymotrypsins A and B, alpha-chymar ophth, avazyme, chymar, chymotest, enzeon, quimar, quimotrase, ... Wilcox PE (1970). "[5] Chymotrypsinogens-chymotrypsins". Chymotrypsinogens - chymotrypsins. Methods in Enzymology. Vol. 19. pp ... producing α-chymotrypsin (which is more active and stable than π-chymotrypsin). The resulting molecule is a three-polypeptide ... alpha-chymar, alpha-chymotrypsin A, alpha-chymotrypsin) is a digestive enzyme component of pancreatic juice acting in the ...
Chymotrypsin C, also known as caldecrin or elastase 4, is an enzyme that in humans is encoded by the CTRC gene. Chymotrypsin C ... Brecher AS, Yang MP (1998). "Acetaldehyde inhibits chymotrypsin and serum anti-chymotrypsin activity". J. Investig. Med. 46 (4 ... "Entrez Gene: chymotrypsin C (caldecrin)". Tomomura A, Akiyama M, Itoh H, Yoshino I, Tomomura M, Nishii Y, Noikura T, Saheki T ( ... 2008). "Chymotrypsin C (CTRC) alterations that diminish activity or secretion are associated with chronic pancreatitis". Nat. ...
Chymotrypsin+C at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.4.21). ... Chymotrypsin C (EC 3.4.21.2) is an enzyme. This enzyme catalyses the following chemical reaction: Preferential cleavage: Leu-, ... Folk, J.E. (1970). "Chymotrypsin C (porcine pancreas)". Methods Enzymol. Methods in Enzymology. 19: 109-112. doi:10.1016/0076- ... Wilcox PE (1970). "Chymotrypsinogens - chymotrypsins". Methods Enzymol. Methods in Enzymology. 19: 64-108. doi:10.1016/0076- ...
More generally, he made a study of mechanisms for chymotrypsin catalysis., and in particular the "charge-relay" system as a way ... Bruice, T. C. (1961). "The Mechanisms for Chymotrypsin". Proceedings of the National Academy of Sciences. 47 (12): 1924-1928. ...
When he moved to the University of Cambridge, she joined him, and studied the chymotrypsin inhibitor 2 (CI2). In Cambridge ... Sophie E. Jackson; Alan R. Fersht (1 October 1991). "Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state ... "Effect of cavity-creating mutations in the hydrophobic core of chymotrypsin inhibitor 2". Biochemistry. 32 (42): 11259-69. doi: ...
Tabushi I, Yamada H, Matsuzaki H, Furukawa J (August 1975). "Polyester readily hydrolyzable by chymotrypsin". Journal of ... in the case of α-chymotrypsin) and 1977 (lipase). PET plastic came into widespread use in the 1970s and it has been suggested ...
Chymotrypsin-like protease CTRL-1 is an enzyme that in humans is encoded by the CTRL gene. GRCh38: Ensembl release 89: ... "Entrez Gene: CTRL chymotrypsin-like". Human CTRL genome location and CTRL gene details page in the UCSC Genome Browser. ... Heidtmann HH, Travis J (1994). "A novel chymotrypsin-like serine proteinase from human lung". Biol. Chem. Hoppe-Seyler. 374 (9 ... 1997). "A novel human chymotrypsin-like digestive enzyme". J. Biol. Chem. 272 (12): 8099-104. doi:10.1074/jbc.272.12.8099. PMID ...
Chymotrypsin-like elastase family member 2B is and enzyme that in humans is encoded by the CELA2B gene. Elastases form a ... "Entrez Gene: chymotrypsin-like elastase family". Human CELA2B genome location and CELA2B gene details page in the UCSC Genome ...
Early in his career, Knowles studied α-chymotrypsin and pepsin, which are nonspecific proteases, meaning they accept a broad ... Ingles, DW; Knowles, JR (1967). "Specificity and stereospecificity of α-chymotrypsin". Biochemical Journal. 104 (2): 369-377. ...
Trypsin- and chymotrypsin-inhibitor from soybeans". International Journal of Peptide and Protein Research. 25 (2): 113-31. doi: ...
Gutfreund, H.; Sturtevant, J. M. (1956). "The Mechanism of Chymotrypsin-Catalyzed Reactions". Proceedings of the National ... including chymotrypsin and trypsin, and was especially active in using methods of studying fast reactions to study enzyme ...
1. Chymotrypsin Catalyzed Hydrolysis of p-Nitroanilides of Phenylalanine and Tyrosine Attached to Side-Chains of Copolymers of ... 6. Hydrophilic Gels Cleavable by Chymotrypsin". Biomaterials 3, 150-154 (1982) J. Kopeček, P. Rejmanová, V. Chytrý, "Polymers ...
Hartley, BS; V Massey (1956). "The active center of chymotrypsin: 1. Labelling with a fluorescent dye". Biochimica et ...
It inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. The specificity is similar to the ... Formation and Reactions of Phenylmethanesulfonyl α-Chymotrypsin". Biochemistry. 3 (6): 783-791. doi:10.1021/bi00894a009. PMID ...
Chymotrypsin, trypsin and Diclofenac are also recommended. "Osteoarthritis". The Lecturio Medical Concept Library. Retrieved 27 ...
Bernal JD, Fankuchen I, Perutz M (1938). "X-ray study of chymotrypsin and hemoglobin". Nature. 141: 523-524. doi:10.1038/ ... The early crystal structures included chymotrypsin (PDB file 2CHA), chymotrypsinogen (PDB file 1CHG), trypsin (PDB file 1PTN), ... Matthews BW, Sigler PB, Henderson R, Blow DM (1967). "Three-dimensional structure of tosyl-α-chymotrypsin". Nature. 214 (5089 ... comparison with α-chymotrypsin, and implications for zymogen activation". Biochemistry. 9 (9): 1997-2009. doi:10.1021/ ...
TPCK is an irreversible inhibitor of chymotrypsin. Also inhibits some cysteine proteases such as caspase, papain, bromelain or ... as in chymotrypsin, in which it binds to the Histidine-57 residue in the active site). TPCK-treated trypsin is used to improve ...
Fersht AR, Sperling J (February 1973). "The charge relay system in chymotrypsin and chymotrypsinogen". J. Mol. Biol. 74 (2): ...
Postoperative ocular hypertension from use of alpha chymotrypsin. Glaucoma of miscellaneous origin Associated with intraocular ... Drug-induced glaucoma Corticosteroid induced glaucoma Alpha-chymotrypsin glaucoma. ...
Some SSI's also inhibit trypsin, chymotrypsin and griselysin. Commercially, SSI's have huge potential in the commercial market ...
Chymotrypsin-like elastase family member 3B also known as elastase-3B, protease E, or fecal elastase is an enzyme that in ... September 2004). "Fecal chymotrypsin and elastase-1 determination on one single stool collected at random: diagnostic value for ... chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after ... literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin- ...
They inhibit chymotrypsin, a peptidase belong to the S1 family (INTERPRO). Rawlings ND, Tolle DP, Barrett AJ (2004). " ... Pacifastin inhibits the serine peptidases trypsin and chymotrypsin. All pacifastin members that have been characterized at the ...
Bernal, J. D.; Fankuchen, I.; Perutz, MAX (1938). "An X-Ray Study of Chymotrypsin and Haemoglobin". Nature. 141 (3568): 523-524 ... Bernal during which time they examined the structure of chymotrypsin and haemoglobin. He also collaborated with Bernal's ...
Bender, Myron L.; Zerner, Burt (1961). "The formation of the acyl-enzyme intermediate, trans-cinnamoyl-α-chymotrypsin, in the ... Kezdy, Ferenc J.; Bender, Myron L. (1962). "The Kinetics of the α-Chymotrypsin-Catalyzed Hydrolysis of p-Nitrophenyl Acetate". ... Brot, Frederick E.; Bender, Myron L. (1969). "Use of the specificity constant of α-chymotrypsin". Journal of the American ... Philipp, Manfred; Bender, Myron L. (1973). "Is binding the rate-limiting step in acylation of alpha-chymotrypsin by specific ...
The enzymes trypsin and chymotrypsin were first purified in the 1930s. A serine in each of trypsin and chymotrypsin was ... The structure of chymotrypsin was solved by X-ray crystallography in the 1960s, showing the orientation of the catalytic triad ... Blow DM, Birktoft JJ, Hartley BS (1969). "Role of a buried acid group in the mechanism of action of chymotrypsin". Nature. 221 ... The triad is exemplified by chymotrypsin, a model serine protease from the PA superfamily which uses its triad to hydrolyse ...
Genetically engineered mutants of the chymotrypsin serine protease were shown to have some proteinase activity even though ... McLachlan AD (February 1979). "Gene duplications in the structural evolution of chymotrypsin". Journal of Molecular Biology. ...
This mechanism is utilised by the catalytic triad of enzymes such as proteases like chymotrypsin and trypsin, where an acyl- ... For example, the energetics of the covalent bond to the serine molecule in chymotrypsin should be compared to the well- ... Fersht AR, Requena Y (December 1971). "Mechanism of the -chymotrypsin-catalyzed hydrolysis of amides. pH dependence of k c and ... Consider the reaction of peptide bond hydrolysis catalyzed by a pure protein α-chymotrypsin (an enzyme acting without a ...
Additionally, trypsin inhibitor partially interferes with chymotrypsin function. Trypsinogen is an inactive form of trypsin, ... is formed in the pancreas and activated to trypsin with enteropeptidase Chymotrypsinogen is the inactive form of chymotrypsin ...
Purification and properties, and formation of pi-chymotrypsin". The Biochemical Journal. 147 (1): 45-53. doi:10.1042/bj1470045 ...
Stevenson KJ, Gibson D, Dixon GH (February 1974). "Amino acid analyses of chymotrypsin-like proteases from the sea anemone ( ... Gibson D, Dixon GH (May 1969). "Chymotrypsin-like proteases from the sea anemone, Metridium senile". Nature. 222 (5195): 753-6 ...