Loading...
*  Genome instability
Durkin, Sandra G.; Glover, Thomas W. (Dec 2007). "Chromosome Fragile Sites". Annual Review of Genetics. 41 (1): 169-192. doi: ... These sites are called fragile sites, and can occur commonly as naturally present in most mammalian genomes or occur rarely as ... Rare fragile sites can lead to genetic disease such as fragile X mental retardation syndrome, myotonic dystrophy, Friedrich's ... Although, seemingly harmful, these common fragile sites are conserved all the way to yeast and bacteria. These ubiquitous sites ...
*  Chromosomal fragile site
"Heritable fragile sites on human chromosomes. V. A new class of fragile site requiring BrdU for expression". American Journal ... "Heritable fragile sites on human chromosomes. X. New folate-sensitive fragile sites: 6p23, 9p21, 9q32, and 11q23". American ... The FRAXA site is perhaps most famous for its role in Fragile X syndrome, but fragile sites are clinically implicated in many ... Based on their frequency, fragile sites are classified as "common" or "rare". To date, more than 120 fragile sites have been ...
*  WWOX
"Effect of exogenous E2F-1 on the expression of common chromosome fragile site genes, FHIT and WWOX". Biochem. Biophys. Res. ... Ramos D, Aldaz CM (2007). "WWOX, a chromosomal fragile site gene and its role in cancer". Adv. Exp. Med. Biol. 587: 149-59. doi ... Ludes-Meyers JH, Bednarek AK, Popescu NC, Bedford M, Aldaz CM (2004). "WWOX, the common chromosomal fragile site, FRA16D, ... "Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and ...
*  Minisatellite
... s have been associated with chromosome fragile sites and are proximal to a number of recurrent translocation ... Minisatellites are prominent in the centromeres and telomeres of chromosomes, the latter protecting the chromosomes from damage ... which protect the ends of a chromosome from deterioration or from fusion with neighbouring chromosomes. ... In humans, 90% of minisatellites are found at the sub-telomeric region of chromosomes. The human telomere sequence itself is a ...
*  DIP2B
"CGG-Repeat Expansion in the DIP2B Gene is Associated with the Fragile Site FRA12A on Chromosome 12q13.1". The American Journal ... This gene is located near a folate-sensitive fragile site. Model organisms have been used in the study of DIP2B function. A ... as well as AMP-binding sites. The presence of these sites suggests that DIP2B may participate in DNA methylation. ... A member of the disco-interacting protein homolog 2 protein family, it contains a binding site for the transcriptional ...
*  DIP2A
2007). "CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1". Am. J. Hum. ... Gardiner K, Slavov D, Bechtel L, Davisson M (2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene ...
*  FHIT
The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations ... spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract ... Bis(5'-adenosyl)-triphosphatase also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by ... Zanesi N, Pekarsky Y, Croce CM (December 2005). "A mouse model of the fragile gene FHIT: From carcinogenesis to gene therapy ...
*  ZNF44
"Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". Genomics. 13 ( ... 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635-48. doi:10.1016/ ...
*  ZBTB17
"Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". Genomics. 13 ( ...
*  BCL6B
"Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". Genomics. 13 ( ... to human chromosome 17p13.1 by in situ hybridization". Cytogenetics and Cell Genetics. 89 (3-4): 218-9. doi:10.1159/000015617. ...
*  ZNF19
"Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". Genomics. 13 ( ... This gene is located in a region next to ZNF23, a gene also encoding a zinc finger protein, on chromosome 16. GRCh38: Ensembl ...
*  ZNF71
1992). "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". ... 2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529-35. doi:10.1038/nature02399. PMID ... "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2 ...
*  ZNF436
1992). "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". ... 2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315-21. doi:10.1038/nature04727 ...
*  ZNF22
1992). "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". ... Gao Y, Kobayashi H, Ganss B (2004). "The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the ... 1992). "A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10". Genomics. 13 (3 ... "Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering". ...
*  HOXD8
"Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1". Cytogenet. Cell Genet. 90 (1-2 ... This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD ... Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of ...
*  HOXD1
"Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1". Cytogenet. Cell Genet. 90 (1-2 ...
*  HOXD9
"Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1". Cytogenet. Cell Genet. 90 (1-2 ... This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD ... Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of ...
*  HOXD12
"Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1". Cytogenet. Cell Genet. 90 (1-2 ... This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD ... Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of ... end of HOX4 locus on chromosome 2". Genomics. 10 (1): 43-50. doi:10.1016/0888-7543(91)90482-T. PMID 1675198. McAlpine PJ, Shows ...
*  HOXD3
"Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1". Cytogenetics and Cell ... This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD ... Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of ... "Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13". American Journal of Human ...
*  HOXD10
"Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1". Cytogenetics and Cell ... It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence- ...
*  R. Ellen Magenis
Heritable Fragile Site on Chromosome 16: Probable Localization of Haptoglobin Locus in Man by R. Ellen Magenis, Frederick Hecht ... Magenis's first major research project involved a heritable fragile site on the long (q) arm of chromosome 16. She traced this ... 16q fragile site through a multigenerational family and, together with Hecht and Everett Lovrien, she linked the 16q fragile ... Her special interest continues to be in human chromosome mapping. Magenis died on February 4, 2014, after a long illness. Ellen ...
*  List of MeSH codes (G14)
... chromosome fragile sites MeSH G14.340.024.220 --- dna, intergenic MeSH G14.340.024.220.150 --- dna, satellite MeSH G14.340. ... x chromosome MeSH G14.162.865.982.500 --- chromosomes, human, x MeSH G14.162.865.983 --- y chromosome MeSH G14.162.865.983.500 ... chromosomes, human, pair 2 MeSH G14.162.520.300.235.250 --- chromosomes, human, pair 3 MeSH G14.162.520.300.280 --- chromosomes ... chromosomes, human, pair 12 MeSH G14.162.520.300.325.680 --- chromosomes, human, x MeSH G14.162.520.300.370 --- chromosomes, ...
*  Mitotic recombination
In the simple crossover model, the two homologous chromosomes overlap on or near a common Chromosomal fragile site (CFS). This ... In another model, two overlapping sister chromosomes form a double Holliday junction at a common repeat site and are later ... The net effect of this would be one heterozygous chromosome and one homozygous chromosome. Mitotic crossover is known to occur ... In either model, the chromosomes are not guaranteed to trade evenly, or even to rejoin on opposite sides thus most patterns of ...
*  Genotoxicity
Some chemicals have the ability to induce fragile sites in regions of the chromosome where oncogenes are present, which could ... Regions sensitive to breakage, called fragile sites, may result from genotoxic agents (such as pesticides). ... Also, chromosomes' integrity may be altered through chromosome loss and clastogenic lesions causing multiple gene and ... To further analyze the site of lesion, it was observed that polymerase stopped at the site and adenine was inappropriately ...
*  DAB1
2008). "Disabled-1 is a large common fragile site gene, inactivated in multiple cancers". Genes Chromosomes Cancer. 47 (2): 165 ... 2006). "Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E ...
*  Fragile mental retardation 2
... is a gene (FMR2: synonym AFF2), located on the human X chromosome. Mutations in this gene are ... subnuclear structures considered to be storage/modification sites of pre-mRNA splicing factors) and are able to bind RNA with a ... This gene is located on the long arm of chromosome X (Xq27.3-Xq28) It has 22 exons spanning at least 500 kb. Alternative ... The other members of this family have been reported to form fusion genes as a consequence of chromosome translocations and are ...