"Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres." ... Furthermore, the intra-chromosomal distribution of telomere length in p-arms versus q-arms can be measured. Data from different ... The slide is then placed into a preheated oven where the chromosomal DNA in the cell is denatured at 80 °C for several minutes ... Telomeres are necessary at chromosome ends to prevent DNA-damage responses as well as genome instability. To this day, the Q- ...

1999). "Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum ...

SIRT2 has been proposed to act as a tumor suppressor by preventing chromosomal instability during mitosis. SIRT2-specific ... thereby regulating chromosomal condensation during mitosis. During the cell cycle, SIRT2 associates with several mitotic ...

"Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia". ...

... chromosomal instability is known to be induced by aromatic amines in urinary bladder cells. Chromosomal instability may lead to ... 2002) and even large scale chromosomal damage was observed in yeast and mammalian cells exposed to o-toluidine in vitro. More ... Research has indicated that o-toluidine is a mutagen and causes oxidative DNA damage and chromosomal damage (Skipper et al. ... chromosomal damage, and cytotoxicity. In the U.S., o-toluidine was first listed in the Third Annual Report on Carcinogens as ' ...

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in ... "Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in ...

On the cellular level, cells of affected individuals exhibit chromosomal abnormalities, genomic instability, and sensitivity to ... Thus, individuals with RecQ-associated PS show an increased risk of developing cancer, which is caused by genomic instability ... Defective homologous recombination can cause mutation and genetic instability. Such defective recombination can introduce gaps ... "Genomic instability in laminopathy-based premature aging". Nat. Med. 11 (7): 780-5. doi:10.1038/nm1266. PMID 15980864. S2CID ...

H2AX is an indicator of melanoma because of its high correlation to chromosomal instability (Warters et al., 2005). When high ... MiR-182 is a member of a miRNA cluster in a chromosomal locus that is most often amplified in melanoma (Segura et al. 2009). It ...

"Fast chromosomal evolution and karyotype instability: recurrent chromosomal rearrangements in the peach potato aphidMyzus ... Lepidoptera indeed tolerate chromosomal variations in view of their holokinetic chromosomes, which facilitate the successful ... In view of their ability to favour the inheritance of chromosomal fragments, holocentrism has been associated to recurrent ... In aphids, holocentric chromosomes have been deeply studied and their ability to stabilize chromosomal fragments has been ...

Some members of this family are associated with genetic disorders with predisposition to malignancy and chromosomal instability ... 1995). "Chromosomal localization of the gene encoding the human DNA helicase RECQL and its mouse homologue". Genomics. 26 (3): ...

Multiple studies have found a correlation between the location of segmental duplications and regions of chromosomal instability ... Regions of the genome which are flanked by repeats represent potential hotspots of genomic instability that are prone to copy- ... Comparison can be made between chromosomes that were positive by FISH and the chromosomal position using BLAST. Scientist have ... Further research identified fifty-one regions displaying genomic instability in the form of copy-number polymorphisms. It was ...

In humans, an MCM8 mutation can give rise to premature ovarian failure, as well as chromosomal instability. Mini Chromosome ... "Exome sequencing reveals MCM8 mutation underlies ovarian failure and chromosomal instability". J. Clin. Invest. 125 (1): 258-62 ... MCM8-deficient mice are defective in gametogenesis and display genome instability due to impaired homologous recombination. ... and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination". Mol. ...

Those that did survive had increased chromosomal instability in a micronucleus test and numerous skeletal abnormalities by ...

FA is regarding chromosomal instability, which is why the cross-linking feature of DEB is useful for diagnosis. Dermatoxin - ...

"SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite ... instability pathway". Proceedings of the National Academy of Sciences of the United States of America. 98 (17): 9719-23. ...

Lastly, chromosomal instability is caused by mutations which disrupt the normal segregation of chromosomes in mitosis or ... Genomic instability, the second error, refers to mutations within the genome which causes errors in the replication or repair ... Polyps Genetic alterations - p53 mutation, micro-satellite instability, E-cadherin gene Previous radiation Pernicious anaemia ...

Chromosomal instability in breast tumors was shown to be associated with mutations in the tumor suppressor gene TP53. After the ... Along with studies on cancer genetics Jórunn studied chromosomal instability in breast tumor tissue using Fluorescence In Situ ... Eyfjord, JE; Bodvarsdottir, SK (2005). "Genomic instability and cancer: networks involved in response to DNA damage". Mutat Res ... "BRCA2 and p53 mutations in primary breast cancer in relation to genetic instability". Cancer Res. 58 (5): 859-62. PMID 9500438 ...

Additionally, she helped to discover the temporal association between high-level chromosomal instability and high-risk human ... February 2004). "Acquisition of High-Level Chromosomal Instability Is Associated with Integration of Human Papillomavirus Type ... Acquisition of High-Level Chromosomal Instability Is Associated with Integration of Human Papillomavirus Type 16 in Cervical ... papillomavirus (HR-HPV) integration, a key step in cervical carcinogenesis, such that integration precedes chromosomal ...

Highly repetitive in nature, human DNA is well known for its extreme instability in multicopy vector systems. It has been found ... The fosmid system is excellent for rapidly creating chromosome-specific mini-BAC libraries from flow-sorted chromosomal DNA. ...

The genetic mutations seen in serous carcinoma are chromosomal instability and mutations in TP53, an important tumor suppressor ... P53 mutations and chromosome instability are associated with serous carcinomas, which tend to resemble ovarian and Fallopian ... In women with Lynch syndrome-associated endometrial cancer, microsatellite instability is common. Development of an endometrial ...

"Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene". Proc ...

He is primarily interested in: Mechanisms Genome instability-Repairs & Spatial dynamics of Chromosomal Territories vis-à- vis ...

... high-level gene amplification by disrupting pre-replication complex bindings in human cancers with chromosomal instability". ... Michaelis C, Ciosk R, Nasmyth K (October 1997). "Cohesins: chromosomal proteins that prevent premature separation of sister ... Numerous recent functional and genomic studies have implicated chromosomal cohesin proteins as critical regulators of ... July 2009). "Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus". Nature. 460 (7253): 410-3 ...

"The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability". Hum Mol Genet. ... 1999). "A selective difference between human Y-chromosomal DNA haplotypes". Curr. Biol. 8 (25): 1391-4. doi:10.1016/S0960-9822( ...

It can directly target the histone H2AX 3'UTR, reduce histone H2AX expression and induce chromosomal instability after DNA ...

... and environmental factors resulting in chromosomal and genomic aberrations and instability. Research has demonstrated that 80- ...

This gene encodes a protein that belongs to the non-histone chromosomal high-mobility group (HMG) protein family. HMG proteins ... These authors noted that repression of ERCC1 (by HGMA2) can reduce DNA repair, leading to increased genome instability. ERCC1 ... The truncated mRNAs may arise from a chromosomal translocation that results in loss of a portion of the HMGA2 gene. ... Overexpression of HMGA2 alone was sufficient to induce chromosomal aberrations, a hallmark of deficiency in NHEJ-mediated DNA ...

The events that lead to genome instability occur in the cell cycle prior to mitosis, specifically in the S phase. Disturbance ... to this phase can generate negative effects, such as inaccurate chromosomal segregation, for the upcoming mitotic phase. The ... Normal replication stress occurs at low to mild levels and induces genomic instability, which can lead to tumorigenesis and ... Burhans WC, Weinberger M (2007). "DNA replication stress, genome instability and aging". Nucleic Acids Research. 35 (22): 7545- ...

If these structures are manipulated incorrectly, through processes known as chromosomal instability and translocation, the cell ... Chromosomal aberrations are disruptions in the normal chromosomal content of a cell and are a major cause of genetic conditions ... Chromosomal recombination during meiosis and subsequent sexual reproduction play a significant role in genetic diversity. ... Governini L, Guerranti C, De Leo V, Boschi L, Luddi A, Gori M, Orvieto R, Piomboni P (November 2015). "Chromosomal aneuploidies ...

April 2008). "Chromosomal instability in gastric mucosa-associated lymphoid tissue lymphomas: a fluorescent in situ ... Currently, this type of analysis will only detect gains and losses of chromosomal material and will not detect balanced ... FISH is used by examining the cellular reproduction cycle, specifically interphase of the nuclei for any chromosomal ... due to subtle chromosomal features; FISH can elucidate these differences. FISH can also be used to detect diseased cells more ...