"The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin". The EMBO Journal. 26 (22): 4670 ... "EPIGENETICS AND SPECIALIZED CHROMATIN". Allshire, Robin C; Gosden, John R; Cross, Sally H; Cranston, Gwen; Rout, Derek; ... insight into how transcription and resulting non-coding RNA might influence the assembly of specialised CENP-A chromatin and ... His research group at the Wellcome Trust Centre for Cell Biology focuses on the epigenetic mechanisms governing the assembly of ...

Chromatin greatly impedes transcription in eukaryotes. Assembly of large multi-protein preinitiation complex is required for ... it causes disassembly of elongation factors and/or an assembly of termination factors that cause conformational changes of the ... The eukaryotic genome is organized into a compact chromatin structure that allows only regulated access to DNA. The chromatin ... Pausing can influence chromatin structure at promoters to facilitate gene activity and lead to rapid or synchronous ...

Keller DM, Lu H (2003). "p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16. ... LeRoy G, Orphanides G, Lane WS, Reinberg D (1998). "Requirement of RSF and FACT for transcription of chromatin templates in ... interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of ... Orphanides G, Wu WH, Lane WS, Hampsey M, Reinberg D (1999). "The chromatin-specific transcription elongation factor FACT ...

Progression requires the disassembly of the MCC, which is found to be mediated by p31-Comet. This is through to occur in part ... Ma HT, Poon RY (February 2016). "TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint". ... San-Segundo PA, Roeder GS (April 1999). "Pch2 links chromatin silencing to meiotic checkpoint control". Cell. 97 (3): 313-24. ... including meiosis G2/Prophase and during the Spindle Assembly checkpoint (SAC). Evidence shows regulation to occur through the ...

This allows chromatin to separate from the nuclear lamina in order to be condensed. As apoptosis continues, cell structures ... During mitosis, lamins are phosphorylated by Mitosis-Promoting Factor (MPF), which drives the disassembly of the lamina and the ... Stuurman, Nico; Heins, Susanne; Aebi, Ueli (1998-01-01). "Nuclear Lamins: Their Structure, Assembly, and Interactions". Journal ... This allows chromatin to condense and the DNA to be replicated. After chromosome segregation, dephosphorylation of nuclear ...

Rapid assembly and disassembly of actin network enables cells to migrate (Cell migration). Actin is extremely abundant in most ... Actin takes part in the regulation of chromatin structure, interacting with RNA polymerase I, II and III. In Pol I ... Once the ring has been constructed the structure is maintained by a continual assembly and disassembly that, aided by the Arp2/ ... Assembly classically occurs in three steps. First, the "nucleation phase", in which two to three G-actin molecules slowly join ...

The outcome of these studies strongly supports the notion that condensins play crucial roles in mitotic chromosome assembly and ... "Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast". Nat Genet. 49 (10): 1553-1557. doi:10.1038/ ... "Mutations in the chromosomal passenger complex and the condensin complex differentially affect synaptonemal complex disassembly ... Condensins also play important roles in chromosome assembly and segregation in meiosis. Genetic studies have been reported in S ...

Keller DM, Lu H (2003). "p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16. ... LeRoy G, Orphanides G, Lane WS, Reinberg D (1998). "Requirement of RSF and FACT for transcription of chromatin templates in ... FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and ... The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional ...

2005). "Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein ... 2002). "Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein ... Nucleosome assembly protein 1-like 1 is a protein that in humans is encoded by the NAP1L1 gene. This gene encodes a member of ... "Entrez Gene: NAP1L1 nucleosome assembly protein 1-like 1". Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human ...

Disassembly of cilia requires the action of aurora kinase A. The current scientific understanding of primary cilia views them ... Johnson KA, Rosenbaum JL (December 1992). "Polarity of flagellar assembly in Chlamydomonas". The Journal of Cell Biology. 119 ( ... "A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility". Cell. 185 (18): 3390-3407.e18. ... Patel, MM; Tsiokas, L (1 November 2021). "Insights into the Regulation of Ciliary Disassembly". Cells. 10 (11): 2977. doi: ...

Dynamic instability refers to the coexistence of assembly and disassembly at the ends of a microtubule. The microtubule can ... RAN-GTP associates with chromatin during mitosis to create a gradient that allows for local nucleation of microtubules near the ... However, the GTP bound to β-tubulin may be hydrolyzed to GDP shortly after assembly. The assembly properties of GDP-tubulin are ... which is the steady state concentration of dimers at which there is no longer any net assembly or disassembly at the end of the ...

Part of the assembly process includes a compaction step, in which ULF tighten and assume a smaller diameter. The reasons for ... Vimentin heads are able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease ... During mitosis, lamins are phosphorylated by MPF, which drives the disassembly of the lamina and the nuclear envelope. Beaded ... Lee CH, Kim MS, Chung BM, Leahy DJ, Coulombe PA (June 2012). "Structural basis for heteromeric assembly and perinuclear ...

... leading to the disassembly of the lamina and hence the envelope membranes into small vesicles.Electron and fluorescence ... a mesh of intermediate filaments which stabilizes the nuclear membrane as well as being involved in chromatin function. It is ... "Inner/Outer Nuclear Membrane Fusion in Nuclear Pore Assembly". Molecular Biology of the Cell. 21 (23): 4197-4211. doi:10.1091/ ...

018244 Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III ... "Transcription initiation patterns indicate divergent strategies for gene regulation at the chromatin level". PLOS Genetics. 7 ( ... beta polypeptide WDR1 actin disassembly? A specialized form of cell signaling BLOC1S1 BLOC1S2NM_173809 BLOC1S3NM_212550 ...

Based on chromatin immunoprecipitation (ChIP) experiments, ParB has the ability to bind not only to high-affinity parS sites ... Sanchez, A; Cattoni, DI; Walter, JC; Rech, J; Parmeggiani, A; Nollmann, M; Bouet, JY (2015). "Stochastic Self-Assembly of ParB ... "Movement and equipositioning of plasmids by ParA filament disassembly". Proceedings of the National Academy of Sciences of the ...

Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates. Cell 139, 957 ... This was followed by identifying novel functions for p97, including removal of proteins from chromatin as part of the DNA ... Cell 3, 129-142 Deshaies, R.J., Sanders, S., Feldheim, D., and Schekman, R. (1991). Assembly of yeast Sec proteins involved in ... Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. Cell 153, 206-215 Verma, R., Chen, S ...

The chromosomes uncoil back into chromatin. Cytokinesis, the pinching of the cell membrane in animal cells or the formation of ... Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes". Science. 348 (6239): ... and is marked by decondensation and lengthening of the chromosomes and the disassembly of the spindle. Nuclear envelopes re- ... "Self-organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytes". Cell. 130 ...

11,183,530-11,382,580 in the GRCh37 assembly, or 6:11,183,298-11,382,348 in the GRCh38 assembly. The gene is on the minus ... Pugacheva EN, Jablonski SA, Hartman TR, Henske EP, Golemis EA (2007). "HEF1-dependent Aurora A activation induces disassembly ... "The transcription factor PAX5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells". EMBO ...

... a role in cytoskeletal assembly". The Journal of Cell Biology. 119 (4): 893-903. doi:10.1083/jcb.119.4.893. PMC 2289706. PMID ... "Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly". Molecular and Cellular Biology. 20 ... which involves contracting the cortical actin ring and is followed by chromatin condensation and nuclear fragmentation. ... "Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts". The Journal ...

Finally, phosphorylation by M cyclins (e.g., Clb1, 2, 3 and 4) in complex with Cdk1 leads to spindle assembly and sister ... This destruction of M cyclins leads to the final events of mitosis (e.g., spindle disassembly, mitotic exit). Given its ... "Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein". J. Biol. ...

Maruta H, Greer K, Rosenbaum JL (1986). "The acetylation of alpha-tubulin and its relationship to the assembly and disassembly ... Among these proteins, chromatin proteins and metabolic enzymes are highly represented, indicating that acetylation has a ... "NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility". Proc Natl Acad Sci U S A ...