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*  Choline acetyltransferase
In humans, the choline acetyltransferase enzyme is encoded by the CHAT gene. Choline acetyltransferase was first described by ... Choline Acetyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology ... Choline acetyltransferase (commonly abbreviated as ChAT, but sometimes CAT) is a transferase enzyme responsible for the ... Oda Y (2000). "Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system". ...
*  Transferase
Choline acetyltransferase (also known as ChAT or CAT) is an important enzyme which produces the neurotransmitter acetylcholine ... Strauss WL, Kemper RR, Jayakar P, Kong CF, Hersh LB, Hilt DC, Rabin M (Feb 1991). "Human choline acetyltransferase gene maps to ... "Choline O-Acetyltransferase". GeneCards: The Human Gene Compendium. Weizmann Institute of Science. Retrieved 5 December 2013. ... Maselli RA, Chen D, Mo D, Bowe C, Fenton G, Wollmann RL (Feb 2003). "Choline acetyltransferase mutations in myasthenic syndrome ...
*  Vesicular acetylcholine transporter
"Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter". The Journal of Biological ... This gene is located within the first intron of the choline acetyltransferase gene. PET imaging of the VAChT may provide ... Chireux MA, Le Van Thai A, Weber MJ (Mar 1995). "Human choline acetyltransferase gene: localization of alternative first exons ...
*  P19 cell
Differentiated cells also have choline acetyltransferase and acetyl cholinesterase activities. When treated with DMSO, Cardiac ...
*  Cholinergic neuron
The problem with this therapy is that choline acetyltransferase is largely blocked by the blood-brain barrier. PTD-ChAT is a ... It is normal in aging for circadian rhythms to deteriorate as choline acetyltransferase (ChAT) fluctuations change in pattern ... Alzheimer's typically involves a decline in the activity of choline acetyltransferase and acetylcholinesterase, as well as a ... Cholinergic neurons have significantly reduced choline acetyltransferase and acetylcholine activity, which is correlated to the ...
*  Naphthylvinylpyridine
Several NVP derivatives have been synthesized and evaluated for their ability to inhibit choline acetyltransferase and protect ... Haubrich, DR; Goldberg, ME (1975). "Homovanillic acid concentration in the rat brain: Effect of a choline acetyltransferase ... However, NVP's method of acetylcholine (ACh) antagonism involves inhibiting the enzyme choline acetyltransferase. ... "Synthesis of a naphthylvinylpyridine derivative and its use for affinity chromatography of choline acetyltransferase". ...
*  Neuronal lineage marker
There are two key markers in these studies: choline acetyltransferase and tyrosine hydroxylase. Choline acetyltransferase (ChAT ... Choline Acetyltransferase (ChAT) is expressed in cholinergic neurons of both the CNS and PNS. In the CNS, ChAT is expressed in ... "ChAT or Choline Acetyltransferase Antibody". neuromics.com. Retrieved 2014-04-19. Tian, C.; Liu, Q.; Ma, K.; Wang, Y.; Chen, Q ... choline acetyltransferase, parvalbumin, and neurofilament protein. All of these antigens are present in specific neuronal cell ...
*  CEBPB
Robert I, Sutter A, Quirin-Stricker C (October 2002). "Synergistic activation of the human choline acetyltransferase gene by c- ... giving rise to substance P and neurokinin A and the choline acetyltransferase responsible for the biosynthesis of the important ...
*  Bacopa monnieri
In animals, it also inhibits acetylcholinesterase, activates choline acetyltransferase, and increases cerebral blood flow. ...
*  Tricyanoaminopropene
1,1,3 Tricyano-2-amino-1-propene (Triap) stimulates choline acetyltransferase activity in vitro and in vivo. Brain Research. ... It stimulates the action of the enzyme choline acetyltransferase, resulting in increased acetylcholine production. This then ...
*  End-plate potential
"Enhanced acetylcholine secretion in neuroblastoma X glioma hybrid NG108-15 cells transfected with rat choline-acetyltransferase ... Acetylcholine is synthesized in the cytoplasm of the neuron from choline and acetyl-CoA. Choline acyltransferase is the enzyme ...
*  SLC44A1
"Differential expression and regulation of the high-affinity choline transporter CHT1 and choline acetyltransferase in neurons ... "Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 ... Choline transporter-like protein 1 is a protein that in humans is encoded by the SLC44A1 gene. Cluster of differentiation ... Traiffort E, Ruat M, O'Regan S, Meunier FM (March 2005). "Molecular characterization of the family of choline transporter-like ...
*  Hemicholinium-3
... by the action of choline acetyltransferase (ChAT). Thus, decreasing the amount of choline available to a neuron will decrease ... Hemicholinium-3 (HC3), also known as hemicholine, is a drug which blocks the reuptake of choline by the high-affinity choline ... The reuptake of choline is the rate limiting step in the synthesis of acetylcholine; hence, hemicholinium-3 decreases the ... Neurons affected by hemicholinium-3 must rely on the transport of choline from the soma (cell body), rather than relying on ...
*  Acetyl-CoA
Choline, in combination with acetyl-CoA, is catalyzed by the enzyme choline acetyltransferase to produce acetylcholine and ... This acetylation is catalyzed by acetyltransferases. This acetylation affects cell growth, mitosis, and apoptosis. Allosteric ...
*  Tubocurarine chloride
Acetylcholine is produced in the body of the neuron by choline acetyltransferase and transported down the axon to the synaptic ...
*  Acetylcholine
... is synthesized in certain neurons by the enzyme choline acetyltransferase from the compounds choline and acetyl- ... Following the evolution of choline transporters, the abundance of intracellular choline paved the way for choline to become ... which causes dysfunction of the enzyme choline acetyltransferase. This inhibition may lead to acetylcholine deficiency, and can ... Acetylcholine is a choline molecule that has been acetylated at the oxygen atom. Because of the presence of a highly polar, ...
*  Neuromuscular junction disease
... type of congenital myasthenia gravis can affect the junction presynaptically by a mutation in the gene encoding choline acetyl transferase ... This protein is an enzyme that is responsible for catalyzing the reaction that combines acetyl-coenzyime A with choline, ...
*  Acetylcholinesterase
... by the pre-synaptic neuron and ACh is synthesized by combining with acetyl-CoA through the action of choline acetyltransferase ... The hydrolysis reaction of the carboxyl ester leads to the formation of an acyl-enzyme and free choline. Then, the acyl-enzyme ... AChE is a hydrolase that hydrolyzes choline esters. It has a very high catalytic activity - each molecule of AChE degrades ... It is an enzyme that catalyzes the breakdown of acetylcholine and of some other choline esters that function as ...
*  Bifemelane
Egashira, T; Takayama, F; Yamanaka, Y (1996). "Effects of bifemelane on muscarinic receptors and choline acetyltransferase in ...
*  Amacrine cell
These amacrine cells are usually characterised by their expression of choline acetyltransferase, or ChAT and are known to play ...
*  Synaptosome
Particles containing acetylcholine and its synthesizing enzyme choline acetyltransferase were originally isolated by Hebb and ... Hebb CO, Whittaker VP (1958). "Intracellular distributions of acetylcholine and choline acetylase". J Physiol. 142: 187-96. doi ...
*  Nucleus basalis
... of the basal forebrain which has wide projections to the neocortex and is rich in acetylcholine and choline acetyltransferase. ...
*  Edinger-Westphal nucleus
... that contain choline acetyltransferase, neurons of the non-preganglionic Edinger-Westphal nucleus contain various neuropeptides ...
*  List of enzymes
EC 2.3.1 Aminolevulinic acid synthase EC 2.3.1.37 Choline acetyltransferase EC 2.3.1.6 Category:EC 2.3.2 Factor XIII EC 2.3. ...
*  HSD2 neurons
... choline acetyltransferase, nitric oxide synthase, cholecystokinin, neurotensin, neuropeptide FF, substance P, somatostatin, ...
*  Carnitine O-palmitoyltransferase
PDOC00402 - Acyltransferases ChoActase / COT / CPT family in PROSITE Choline/Carnitine o-acyltransferase family[permanent dead ... "Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport". Cell. ...