Loading...
*  Choline kinase
... (also known as CK,ChoK and choline phosphokinase) is an enzyme which catalyzes the first reaction in the choline ... which showed for the first time that choline kinase α can act as a protein chaperone (Asim et al., 2016 ;JNCI "Choline kinase ... Peisach, D; Gee, P; Kent, C; Xu, Z (2003). "The Crystal Structure of Choline Kinase Reveals a Eukaryotic Protein Kinase Fold". ... A related enzyme, ethanolamine kinase, tends to co-purify with choline kinase leading to a suggestion that the two activities ...
*  Choline/ethanolamine kinase family
In molecular biology, the choline/ethanolamine kinase family includes choline kinase(EC 2.7.1.32) and ethanolamine kinase (EC ... Ethanolamine kinase has no choline kinase activity and its activity is inhibited by ADP. Inositol supplementation represses ... Kim KH, Voelker DR, Flocco MT, Carman GM (March 1998). "Expression, purification, and characterization of choline kinase, ... There are two putative choline/ethanolamine kinases (C/EKs) in the Trypanosoma brucei genome. ...
*  CHKA
Spanner S, Ansell GB (1979). "Choline kinase and ethanolamine kinase activity in the cytosol of nerve endings from rat ... Choline kinase alpha is an enzyme that in humans is encoded by the CHKA gene. The major pathway for the biosynthesis of ... 2002). "Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and ... "Entrez Gene: CHKA choline kinase alpha". Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using ...
*  CHKB (gene)
Choline kinase beta is a protein encoded by the CHKB gene. This gene is found on chromosome 22 in humans. Choline kinase (CK) ... The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function ... "Entrez Gene: CHKB choline kinase beta". Human CHKB genome location and CHKB gene details page in the UCSC Genome Browser. Human ... Ishidate K (1997). "Choline/ethanolamine kinase from mammalian tissues". Biochim. Biophys. Acta. 1348 (1-2): 70-8. doi:10.1016/ ...
*  RALGDS
Ramírez de Molina A, Penalva V, Lucas L, Lacal JC (2002). "Regulation of choline kinase activity by Ras proteins involves Ral- ... a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase ... Li W, Han M, Guan KL (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex ... "Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras". Cell. 89 (3): 457-67 ...
*  Miltefosine
2007). "Inhibition of Plasmodium falciparum choline kinase by hexadecyltrimethylammonium bromide: a possible antimalarial ...
*  Phosphocholine
... is made in a reaction, catalyzed by choline kinase, that converts ATP and choline into phosphocholine and ADP. ... Alkylphosphocholines Choline Phosphoethanolamine Lovell TM, Woods RJ, Butlin DJ, et al. (September 2007). "Identification of a ...
*  CHKB
... may refer to: Choline kinase beta, a human gene Christian Historical Voters' League, a Dutch conservative protestant ...
*  List of EC numbers (EC 2)
... glycerone kinase EC 2.7.1.30: glycerol kinase EC 2.7.1.31: glycerate kinase EC 2.7.1.32: choline kinase EC 2.7.1.33: ... subunit kinase EC 2.7.11.24: mitogen-activated protein kinase EC 2.7.11.25: mitogen-activated protein kinase kinase kinase EC ... EC 2.7.1.71: shikimate kinase EC 2.7.1.72: streptomycin 6-kinase EC 2.7.1.73: inosine kinase EC 2.7.1.74: deoxycytidine kinase ... NAD+ kinase EC 2.7.1.24: dephospho-CoA kinase EC 2.7.1.25: adenylyl-sulfate kinase EC 2.7.1.26: riboflavin kinase EC 2.7.1.27: ...
*  List of MeSH codes (D08)
... adenosine kinase MeSH D08.811.913.696.620.155 --- choline kinase MeSH D08.811.913.696.620.175 --- deoxycytidine kinase MeSH ... map kinase kinase kinases MeSH D08.811.913.696.620.682.700.559.100 --- map kinase kinase kinase 1 MeSH D08.811.913.696.620.682. ... map kinase kinase kinase 2 MeSH D08.811.913.696.620.682.700.559.300 --- map kinase kinase kinase 3 MeSH D08.811.913.696.620.682 ... map kinase kinase kinase 4 MeSH D08.811.913.696.620.682.700.559.500 --- map kinase kinase kinase 5 MeSH D08.811.913.696.620.682 ...
*  CDP-choline pathway
Mst other cells will phosphorylate choline by the enzyme choline kinase, the first committed step of CDP-choline pathway. ... Under normal circumstances, choline kinase is not the rate-limiting step of the CDP-choline pathway. However in rapidly ... Choline kinase (CK) is a cytosolic protein that catalyzes the following reaction: choline + ATP ⇌ phosphocholine + ADP In ... The first enzymatic reaction is catalyzed by choline kinase (CK) and involves the phosphorylation of choline to form ...
*  Amifampridine
... particularly those with defects in choline acetyltransferase, downstream kinase 7, and those where any kind of defect causes " ...
*  Ethanolamine kinase
Sung CP, Johnstone RM (1967). "Phosphorylation of choline and ethanolamine in Ehrlich ascites-carcinoma cells". Biochem. J. 105 ... In enzymology, an ethanolamine kinase (EC 2.7.1.82) is an enzyme that catalyzes the chemical reaction ATP + ethanolamine ⇌ {\ ... Other names in common use include ethanolamine kinase (phosphorylating), and ethanolamine phosphokinase. This enzyme ...
*  3q29 microdeletion syndrome
These include transferrin receptor, choline-phosphate cytidylyltransferase A, RNF168, serine/threonine-protein kinase, nuclear ...
*  CDKN3
It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase ... Niculescu MD; Yamamuro Y; Zeisel SH (2004). "Choline availability modulates human neuroblastoma cell proliferation and alters ... Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene. The protein encoded by this gene ... 2000). "Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed ...
*  Phospholipase D
TYK and controls the signalling indicating that PLD is activated by these kinases. As choline is very abundant in the cell, PLD ... Phosphatidyl choline Phosphatidate Choline Phospholipase cleavage sites Jenkins GM, Frohman MA (October 2005). "Phospholipase D ... As choline has little second messenger activity, PLD activity is mostly transduced by the production of PA. PA is heavily ... Paruch S, El-Benna J, Djerdjouri B, Marullo S, Périanin A (January 2006). "A role of p44/42 mitogen-activated protein kinases ...
*  PLD2
Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled ... catalyze the hydrolysis of PC to produce phosphatidic acid and choline. ... "Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells". J. Biol ... "Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells". J. Biol ...
*  Phospholipase D1
A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis. PC- ... EC 3.1.4.4 catalyze the hydrolysis of PC to produce phosphatidic acid and choline. ... Protein kinase N1 RALA, and RHOA. VU-0359595: 1,700-fold selective versus phospholipase D2, IC50 = 3.7nM. GRCh38: Ensembl ... regulation by protein kinase Calpha and caveolin-1". Biochemistry. 38 (12): 3763-9. doi:10.1021/bi982478+. PMID 10090765. Kim Y ...
*  Phosphatidic acid
... to produce PA and choline. By the phosphorylation of diacylglycerol (DAG) by DAG kinase (DAGK) By the acylation of ... Because choline is very abundant in the cell, PLD activity does not significantly affect choline levels; and choline is ... October 2004). "Sphingosine kinase 1 is an intracellular effector of phosphatidic acid". J. Biol. Chem. 279 (43): 44763-74. doi ... This will show whether the phosphate group is newly derived from the kinase activity or whether it originates from the PC. ...
*  X chromosome
... encoding enzyme Choline-phosphate cytidylyltransferase B PIN4: encoding enzyme Peptidyl-prolyl cis-trans isomerase NIMA- ... encoding protein Ribosomal protein S6 kinase, 90kDa, polypeptide 6 RRAGB: encoding protein Ras-related GTP-binding protein B ... encoding enzyme Nik-related protein kinase OTUD5: encoding protein OTU deubiquitinase 5 PASD1: encoding protein PAS domain- ...
*  Cholinergic neuron
The problem with this therapy is that choline acetyltransferase is largely blocked by the blood-brain barrier. PTD-ChAT is a ... It should also be noted that memantine is able to inhibit the truncation of glycogen synthase kinase-3 (triggered by activated ... It is normal in aging for circadian rhythms to deteriorate as choline acetyltransferase (ChAT) fluctuations change in pattern ... Alzheimer's typically involves a decline in the activity of choline acetyltransferase and acetylcholinesterase, as well as a ...
*  List of biomolecules
K252a K252b KT5720 KT5823 Keratin Kinase For substances with an l- or L- prefix such as L-alanine or DL-alanine, please see the ... Cholesterol Choline Chondroitin sulfate Cinnamaldehyde Citral Citric acid Citrinin Citronellal Citronellol Citrulline Cobalamin ... Cortisol Creatine Creatine kinase Crystallin α-Cyclodextrin Cyclodextrin glycosyltransferase Cyclopamine Cyclopiazonic acid ... superoxide T2 Toxin Tannic acid Tannin Tartaric acid Taurine Tetrodotoxin Thaumatin Topoisomerase Tyrosine kinase Testosterone ...
*  Phosphatidylethanolamine N-methyltransferase
While the CDP-choline pathway, in which choline obtained either by dietary consumption or by metabolism of choline-containing ... phosphorylated AMP-activated protein kinase (AMPK), and serine-307-phosphorylated insulin receptor substrate 1 (IRS1-s307), ... PC made via the PEMT pathway can be degraded by phospholipases C/D, resulting in the de novo formation of choline. Thus, the ... This is one of several examples of the reciprocal regulation of PEMT and CT in the PEMT and CDP-choline pathways. Estrogen has ...
*  PAWR
Xie J, Guo Q (Jul 2004). "Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma ... Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and ... PAWR has been shown to interact with: Apoptosis antagonizing transcription factor, DAPK3, Protein kinase Mζ, SLC5A1, THAP1, and ... interacts selectively with the atypical isoforms of protein kinase C". Cell. 86 (5): 777-86. doi:10.1016/s0092-8674(00)80152-x ...
*  SLC44A1
"Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 ... phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C". ... "Differential expression and regulation of the high-affinity choline transporter CHT1 and choline acetyltransferase in neurons ... Choline transporter-like protein 1 is a protein that in humans is encoded by the SLC44A1 gene. Cluster of differentiation ...
*  Enzyme inhibitor
Protein kinases can also be inhibited by competition at the binding sites where the kinases interact with their substrate ... acetate and choline. This is somewhat unusual among neurotransmitters as most, including serotonin, dopamine, and ... As a consequence, if two protein kinase inhibitors both bind in the active site with similar affinity, but only one has to ... For example, some protein kinase inhibitors have chemical structures that are similar to adenosine triphosphate, one of the ...