Mark Bretscher
The presence of cholesterol makes a bilayer thicker: the increasing thickness of the membrane from cis- to trans- leads to a ... This helps keep the level of cholesterol at a high level in the plasma membrane, making it a better barrier for the cell. ... Bretscher, MS; Munro, S (1993). "Cholesterol and the Golgi apparatus". Science. 261 (5126): 1280-1281. Bibcode:1993Sci... ... he proposed that the Golgi apparatus concentrates cholesterol away from the cis-side of the Golgi towards the trans-side. ...
Aseem Malhotra
Demasi, M; Lustig R. H; Malhotra A. (2017). The cholesterol and calorie hypotheses are both dead - it is time to focus on the ... Boseley S (30 October 2018). "Butter nonsense: the rise of the cholesterol deniers". The Guardian. Oury, Jean-Paul (28 August ... Cardiologist Tim Chico commented that "high cholesterol has been proven beyond all doubt to contribute to coronary artery ... "Expert reaction to new report on statins and the cholesterol hypothesis". Science Media Centre. Retrieved 2 December 2018. ...
William Landau
Is cholesterol a risk factor for stroke? Cholesterol-NO. Arch Neuro 1999; 56:1521-1524 Landau WM. "Hypertonus Spasticity, ...
Lipid hypothesis
de Langen showed that the traditional Javanese diet, poor in cholesterol and other lipids, was associated with a low level of ... Too much LDL (called 'bad cholesterol') can lead to fatty deposits building up in the arteries which increases the risk of ... An interpretive history of the cholesterol controversy, part V: the discovery of the statins and the end of the controversy". J ... LaRosa JC (1998). "Cholesterol & atherosclerosis: a controversy resolved". Adv Nurse Pract. 6 (5): 36-37. PMID 9633288. ...
Neurosteroid
Hénin J, Salari R, Murlidaran S, Brannigan G (May 2014). "A predicted binding site for cholesterol on the GABAA receptor". ... October 2013). "The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D- ... Levitan I, Singh DK, Rosenhouse-Dantsker A (2014). "Cholesterol binding to ion channels". Frontiers in Physiology. 5: 65. doi: ... Neurosteroids are synthesized from cholesterol, which is converted into pregnenolone and then into all other endogenous ...
Pfizer
Agovino, Theresa (December 3, 2006). "Pfizer ends cholesterol drug development". The Seattle Times. Associated Press. Tanne, ...
Multiple sclerosis
Chen Y, Popko B (2018). "Cholesterol crystals impede nerve repair". Science. 359 (6376): 635-636. Bibcode:2018Sci...359..635C. ... "Defective cholesterol clearance limits remyelination in the aged central nervous system". Science. 359 (6376): 684-688. Bibcode ... the signs and symptoms of the disease.Cholesterol crystals are believed both to impair myelin repair and aggravate inflammation ...
LRP1
Neurons require cholesterol to function. Cholesterol is imported into the neuron by apolipoprotein E (apoE) via LRP1 receptors ... LRP1 has a cholesterol-independent role in atherosclerosis by modulating the activity and cellular localization of the PDGFR-β ... "Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) ... leading to decreased neuronal cholesterol and increased amyloid beta. LRP1 is also implicated in the effective clearance of Aβ ...
Guggulsterone
In humans, it acts as an antagonist of the farnesoid X receptor, which was once believed to result in decreased cholesterol ... Several studies have been published that indicate no overall reduction in total cholesterol occurs using various dosages of ... "Guggulipid Ineffective for Lowering Cholesterol". JAMA. 290 (6): 765-772. doi:10.1001/jama.290.6.765. PMID 12915429. Sahni, S; ... guggulsterone, and levels of low-density lipoprotein ("bad cholesterol") increased in many people. Nevertheless, guggulsterone ...
John Deanfield
"HEART UK - The Cholesterol Charity". Heartuk.org.uk. "The Somerville Foundation - Adult Congenital Heart Disease Support". The ...
SOAT2
The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol ... This gene is a member of a small family of Acyl-CoA:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme ... Katsuren K; Fukuyama S; Takata K; Ohta T (2003). "Effects of a new single-nucleotide polymorphism in the Acyl-CoA:cholesterol ... Lin S; Lu X; Chang CC; Chang TY (2004). "Human Acyl-Coenzyme A:Cholesterol Acyltransferase Expressed in Chinese Hamster Ovary ...
Pregnenolone
To assay conversion of cholesterol to pregnenolone, radiolabeled cholesterol has been used. Pregnenolone product can be ... Pregnenolone is synthesized from cholesterol. This conversion involves hydroxylation of the side chain at the C20 and C22 ... Hanukoglu I, Jefcoate CR (1980). "Pregnenolone separation from cholesterol using Sephadex LH-20 mini-columns". Journal of ... There are two intermediates in the transformation of cholesterol into pregnenolone, 22R-hydroxycholesterol and 20α,22R- ...
Dali ni horbo
It has 43% less cholesterol. In some cases it is tolerated by individuals who have a cow milk allergy. The Batak boil the milk ...
Terbinafine
In fungi, lanosterol is then converted to ergosterol; in humans, lanosterol becomes cholesterol. However, as fungi and animals ... making it selective for inhibiting ergosterol production in fungi without significantly affecting cholesterol production in ...
SREBP cleavage-activating protein
When cholesterol is present, SCAP undergoes a conformational change that prevents it from activating SREBP and cholesterol ... In cholesterol-depleted cells, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their ... Javitt NB (2002). "Cholesterol, hydroxycholesterols, and bile acids". Biochem. Biophys. Res. Commun. 292 (5): 1147-53. doi: ... Brown MS, Goldstein JL (1999). "A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood". ...
Apolipoprotein E
Apo-E is the principal cholesterol carrier in the brain. Apo-E is required for cholesterol transportation from astrocytes to ... This may be due to their low cholesterol levels. Caucasian and Japanese carriers of two E4 alleles have between 10 and 30 times ... APOE transports lipids, fat-soluble vitamins, and cholesterol into the lymph system and then into the blood. It is synthesized ... In the central nervous system, Apo-E is mainly produced by astrocytes and transports cholesterol to neurons via APOE receptors ...
Steroid
When the two methyl groups and eight carbon side chains (at C-17, as shown for cholesterol) are present, the steroid is said to ... Steroids such as cholesterol decrease membrane fluidity. Similar to lipids, steroids are highly concentrated energy stores. ... Steroid metabolism in humans is also the target of cholesterol-lowering drugs, such as statins. In humans and other animals the ... A steroid (named after the steroid cholesterol which was first described in gall stones from Ancient Greek chole- 'bile' and ...
Pathophysiology of multiple sclerosis
... three of which are cholesterol derivatives Cholesterol crystals are believed to both impair myelin repair and aggravate ... "Cholesterol crystals impede nerve repair". Science. 359 (6376): 635-636. Bibcode:2018Sci...359..635C. doi:10.1126/science. ... "Defective cholesterol clearance limits remyelination in the aged central nervous system". Science. 359 (6376): 684-688. Bibcode ...
Cortisol
It also stimulates the main rate-limiting step in cortisol synthesis, in which cholesterol is converted to pregnenolone and ... Cortisol is synthesized from cholesterol. Synthesis takes place in the zona fasciculata of the adrenal cortex. (The name ... ACTH increases the concentration of cholesterol in the inner mitochondrial membrane, via regulation of the steroidogenic acute ...
Colorimetric analysis
Cholesterol + oxygen --(enzyme cholesterol oxidase)--> cholestenone + hydrogen peroxide Hydrogen peroxide + 4-aminophenazone + ... CHOD = cholesterol oxidase GOD = glucose oxidase GPO = glycerol-3-phosphate oxidase PAP = phenol + aminophenazone (in some ...
Polyunsaturated fat
"Fats explained" (PDF). HEART UK - The Cholesterol Charity. Retrieved 20 February 2019. "Key Recommendations: Components of ...
Ceramide
Aggregation of LDL cholesterol by ceramide causes LDL retention in arterial walls, leading to atherosclerosis. Ceramides cause ... Tippetts TS, Holland WL, Summers SA (2021). "Cholesterol - the devil you know; ceramide - the devil you don't". Trends in ... Together with cholesterol and free fatty acids, ceramides form the lipid mortar, a water-impermeable barrier that prevents ... cholesterol (~ 25% by weight), and free fatty acids (~15% by weight), with smaller quantities of other lipids also being ...
Omelette
An egg white omelette is a variation which omits the yolks to remove fat and cholesterol, which reside exclusively in the yolk ... Brewer, S.; Siple, M. (2011). Low-Cholesterol Cookbook For Dummies. Wiley. p. pt94. ISBN 978-1-119-99679-8. Archived from the ...
Simvastatin
The cholesterol-lowering drug simvastatin can cause severe muscle damage and should not be prescribed in high doses to patients ... A total of 4,444 people with coronary heart disease and blood cholesterol levels from 5.5 to 8.0 mmol/L were randomized to ... It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Simvastatin is ... It is recommended to be used as an addition to a low-cholesterol diet. In heart protection studies, simvastatin showed the ...
Major adverse cardiovascular events
Tippetts TS, Holland WL, Summers SA (2021). "Cholesterol - the devil you know; ceramide - the devil you don't". Trends in ... elevated concentrations of triglycerides and non-HDL cholesterol concentration, reduced HDL concentration and hypertension, as ...
The Rogosin Institute
Wallis, Claudia (10 February 1986). "Medicine: Filtering Out Killer Cholesterol". Time - via content.time.com. "Mouse Cancer ... which led to the adoption of the procedure to treat patients with the genetic form of extremely high cholesterol. Physicians at ... Institute Comprehensive Lipid Control Center is a research and treatment center for adults and children with cholesterol and ...
Dagwood sandwich
ISBN 978-0-7611-7886-6. Annette B. Natow; Jo-Ann Heslin (26 December 2007). The Cholesterol Counter: 7th Edition. Jo Ann Heslin ...
Soup and sandwich
List of sandwiches List of soups Food portal Siple, M. (2009). Low-cholesterol Cookbook for Dummies. For dummies. ...
Scandinavian Simvastatin Survival Study
Before the 4S study, it was not proven that lowering cholesterol could prolong life in people who had CHD. The study concluded ... The objective of the study was to assess the effect of a cholesterol-lowering drug called simvastatin on mortality and ... 2006). Cholesterol, atherosclerosis and coronary disease in the UK, 1950-2000; Wellcome Witnesses to Twentieth Century Medicine ... Thompson, G. R. (1 February 2009). "History of the cholesterol controversy in Britain". QJM: An International Journal of ...
Zena Werb
As cited in: Werb, Zena; Cohn, Zanvil A. (1971). "Cholesterol metabolism in the macrophage. I. The regulation of cholesterol ... "Dynamics of macrophage membrane cholesterol". After graduation she worked at the Strangeways Research Laboratory in Cambridge, ...