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*  Low-density lipoprotein receptor gene family
... excess cholesterol in the blood is captured by low-density lipoprotein (LDL) and removed by the liver via endocytosis of the ... Schematic representation of the seven mammalian LDL receptor (LDLR) family members LDL receptor family members LDL Receptors at ... These modules are: LDL receptor type A (LA) repeats of 40 residues each, displaying a triple-disulfide-bond-stabilized ... In addition to these domains which can be found in all receptors of the gene family, LDL receptor and certain isoforms of ...
*  Lipid profile
... the test is mainly concerned with high LDL, or "bad cholesterol" levels). So, while a high total cholesterol level may help ... Total lipids Serum total cholesterol serum HDL cholesterol Total cholesterol/HDL cholesterol ratio Serum triglycerides serum ... someone's total cholesterol may be high, but this may be due to very high HDL ("good cholesterol") cholesterol levels,-which ... VLDL may be defined as the total cholesterol that is neither HDL nor LDL. Then Friedewald's equation mentioned above yields: ...
*  Genetic testing
... elevated LDL cholesterol; premature heart disease Fanconi anaemia Predisposition of acute myeloid leukemia; skeletal ... Apolipoprotein E-associated Elevation of both serum cholesterol and triglycerides; accelerated atherosclerosis, coronary heart ...
*  Oat
"LDL Cholesterol and Oatmeal". WebMD. 2 February 2009. "Title 21--Chapter 1, Subchapter B, Part 101 - Food labeling - Specific ... Its daily consumption over weeks lowers LDL ("bad") and total cholesterol, possibly reducing the risk of heart disease. One ... After reports of research finding that dietary oats can help lower cholesterol, the United States Food and Drug Administration ... Oats are a nutrient-rich food associated with lower blood cholesterol when consumed regularly. Avenins present in oats ( ...
*  Stormie Jones
LDL-cholesterol, from her bloodstream. As a result, her LDL-cholesterol levels became very high and caused her two heart ... was able to clear the LDL-cholesterol from her blood. Indeed, after the transplant, Stormie's LDL-cholesterol declined by 81%- ... The case showed that the liver controls blood cholesterol and that high cholesterol is controllable, and was part of the ... Stormie had a condition which raised her blood cholesterol to 10 times normal levels. The condition, a severe form of familial ...
*  Corpus luteum
Cholesterol is released and stored within the cell as cholesterol ester. LDL is recycled for further cholesterol transport. ... Progesterone is synthesized from cholesterol by both the large and small luteal cells upon luteal maturation. Cholesterol-LDL ... PKA actively phosphorylates steroidogenic acute regulatory protein (StAR) and translocator protein to transport cholesterol ... cholesterol side chain cleavage) system". Arch. Biochem. Biophys. 305 (2): 489-98. doi:10.1006/abbi.1993.1452. PMID 8396893. ...
*  Red yeast rice
As a consequence, circulating total cholesterol and LDL-cholesterol are lowered. In a meta-analysis of 91 randomized clinical ... In the treated group, LDL-cholesterol declined 21%. Two patients dropped out because of myalgia, 1 for diarrhea, and 1 for ... reported LDL-cholesterol lowered by 1.02 mmol/L (39.4 mg/dL) compared to placebo. The incidence of reported adverse effects ... LDL-cholesterol was lowered by 24-49% depending on the statin. Different strains of Monascus fungus will produce different ...
*  Beta-propeller
Betteridge, John (2013). "PCSK9-an exciting target for reducing LDL-cholesterol levels". Nature Reviews Endocrinology. 9: 76-78 ...
*  French paradox
... partly through increasing HDL cholesterol whilst reducing LDL cholesterol. In 1999, Malcolm Law and Nicholas Wald published a ... In his 2009 book Cholesterol and The French Paradox, Frank Cooper argues that the French paradox is due to the lack of ... Second, Law and Wald presented a time-lag hypothesis: if there were a delay in serum cholesterol concentrations increasing and ... Consumption of animal fat and serum cholesterol concentrations increased only recently in France but did so decades ago in ...
*  Trimethylglycine
TMG supplementation lowers homocysteine but also raises LDL-cholesterol. Trimethylglycine can act as an adjuvant of the ...
*  Rosuvastatin
... is approved in the United States for the treatment of high LDL cholesterol (dyslipidemia), total cholesterol ( ... The effects of rosuvastatin on LDL cholesterol are dose-related. Higher doses were more efficacious in improving the lipid ... Meta-analysis showed that rosuvastatin is able to modestly increase levels of HDL cholesterol as well, as with other statins. A ... "FDA Drug Safety Communication: Important safety label changes to cholesterol-lowering statin drugs". "Annual Report and Form 20 ...
*  SEC24A
Male homozygotes had decreased circulating cholesterol and LDL cholesterol levels. "SEC24 family, member A (S. cerevisiae)". ...
*  Hypercholesterolemia
LDL and total cholesterol also increases by very high fructose intake. Glucocorticoids increase cholesterol LDL production by ... Including only hypocaloric diets, the effects of low-fat vs high-fat diets on total cholesterol and LDL cholesterol levels were ... Cholesterol Treatment Trialists' (CTT) Collaborators (2012). "The effects of lowering LDL cholesterol with statin therapy in ... Eating dietary cholesterol causes a small rise in serum cholesterol. Dietary limits for cholesterol were proposed in United ...
*  PCSK9
LDL) receptor and LDL cholesterol". J. Biol. Chem. 279 (47): 48865-75. doi:10.1074/jbc.M409699200. PMID 15358785. Lalanne F, ... and thus excessive removal of the LDL receptor, leaving people carrying the mutations with too much LDL cholesterol. Meanwhile ... "Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates". Proc. ... Variants of PCSK9 can reduce or increase circulating cholesterol. LDL-particles are removed from the blood when they bind to ...
*  Asymmetric dimethylarginine
Boger RH, Sydow K, Borlak J, Thum T, Lenzen H, Schubert B, Tsikas D, Bode-Boger SM (21 July 2000). "LDL cholesterol upregulates ... ADMA concentrations are substantially elevated by native or oxidized LDL cholesterol. Thus a spiralling effect occurs with high ... Statins, as well as affecting circulating cholesterol levels, also increase nitric oxide levels and so have a direct effect on ... endothelial LDL levels causing greater ADMA values, which in turn inhibit NO production needed to promote vasodilation. The ...
*  Simvastatin
Statins are more effective than other lipid-regulating drugs at lowering LDL-cholesterol concentration, but they are less ... Pedersen, TR (2010). "Pleiotropic effects of statins: Evidence against benefits beyond LDL-cholesterol lowering". American ... or stroke but having relatively low LDL cholesterol. In this trial, which lasted 5.4 years, overall mortality was reduced by 13 ... simvastatin reduced overall mortality in people with existing cardiovascular disease and high LDL cholesterol by 30% and ...
*  Niacin
It reduces secondary outcomes associated with atherosclerosis, such as low density lipoprotein cholesterol (LDL), very low- ... LDL) or "bad" cholesterol. Decrease in free fatty acids also suppress hepatic expression of apolipoprotein C3 (APOC3) and PPARg ... but results after three months at 1500 mg/day showed no trend for improvements in total cholesterol, LDL-C, HDL-C or ... very low levels of LDL cholesterol, and cardiovascular events". The New England Journal of Medicine. 357 (13): 1301-10. doi: ...
*  Low-carbohydrate diet
... as well as an increase in high-density lipoprotein cholesterol (HDL). Low-density lipoprotein cholesterol (LDL) and creatinine ... These diets are generally associated with higher intakes of total fat, saturated fat, and cholesterol because the protein is ... Potential favorable changes in triglyceride and high-density lipoprotein cholesterol values should be weighed against potential ... unfavorable changes in low-density lipoprotein cholesterol and total cholesterol values when low-carbohydrate diets to induce ...
*  Kathryn Uhrich
... the anionic polymer only targets the bad cholesterol LDL particles and not the good cholesterol HDL. The delivery of these ... Also, the anionic (negatively charged) scorpion-like molecules inhibit cellular uptake of oxidized LDL, the 'bad' cholesterol ... This type of LDL is usually incorporated in macrophages, resulting in foam cell formation and formation of an atherosclerotic ... "Nanoscale Anionic Macromolecules Can Inhibit Cellular Uptake of Differentially Oxidized LDL". Biomacromolecules. 7 (2): 597-603 ...
*  Deep ocean minerals
... cholesterol (LDL-C) was also decreased by DOM. Further, total cholesterol levels of subjects in the DOM group were ... The plasma LDL cholesterol level was lower in the DOW group than in the surface seawater group. Glutathione peroxidase (GPx) ... In 2004, the same group also published new findings showing changes to LDL cholesterol in dietary induced hyperlipidemia ... and it was found that reduction of the LDL cholesterol level and enhancement of (GPx) activity were involved in these effects. ...
*  Tomatine
Friedman, M., Fitch, T.E., Yokoyama, W.E.; Lowering of plasma LDL cholesterol in hamsters by the tomato glycoalkaloid tomatine ... The amount of plasma LDL cholesterol (low-density lipoprotein) decreases as the amount of dietary tomatine increases. The LD50 ... Cholesterol seems to protect the erythrocytes. Intraperitoneal injection of tomatine results in a decrease of diuresis in rats ... These compounds consist of an aglycon, which is a cholesterol derivative, and a carbohydrate chain, which in the case of α- ...
*  Bezafibrate
It helps to lower LDL cholesterol and triglyceride in the blood, and increase HDL. Bezafibrate was first introduced by ... "Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: the ... The combination of a cholesterol-lowering drug, bezafibrate, and a contraceptive steroid, medroxyprogesterone acetate, could be ... Bezafibrate improves markers of combined hyperlipidemia, effectively reducing LDL and triglycerides and improving HDL levels. ...
*  Low-fat diet
Saturated fat has been shown to raise total and LDL cholesterol in a large number of studies and has also been correlated with ... Decrease in saturated fat intake was only marginally related to decrease in LDL cholesterol. The meta-analysis concluded that ... of total calories has been shown to decrease total and LDL cholesterol by 10 to 20%; however, most of this decrease is due to a ... and high-fat diets showed low-fat diets decreased total cholesterol and LDL, but these decreases were not found when only ...
*  Cocoa bean
Short-term benefits in LDL cholesterol levels from dark chocolate consumption have been found. The addition of whole milk to ...
*  MYLIP
Pharmacologic inhibition of IDOL could reduce plasma LDL cholesterol by increasing plasma LDL receptor density. The ERM protein ... MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation. The ... Increased Degradation of LDL Receptor Protein (IDOL) is a ubiquitin ligase that ubiquinates LDL receptors in endosomes and ... "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor". Science. 325 (5936): 100-4. doi: ...
*  Apolipoprotein C4
2008). "Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of ... 2008). "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or ... 2006). "Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in ... 2010). "No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels". Atherosclerosis. 211 (2): ...
*  Pinto bean
Studies have indicated pinto beans can lower the levels of both HDL and LDL cholesterol. Pinto beans have also been shown to ...