Cholesterol+ester+transfer+proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles with ... Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the ... "Concerted actions of cholesteryl ester transfer protein and phospholipid transfer protein in type 2 diabetes: effects of ... "Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol". The New England Journal of Medicine. 350 (15 ...

The cholesterol ester transfer protein(CETP) helps the transfer of cholesterol esters from lipoproteins to other lipoproteins ... There is a very common pattern of two different cholesterol ester transfer protein gene mutations (D442G, 5.1%; intron 14G:A, ... there is increased coronary heart disease in Japanese American men with a mutation in the cholesterol ester transfer protein ... It plays a fundamental role in the reverse transport of cholesterol to the liver, which is why a mutation in this can lead to ...

... a novel cholesteryl ester transfer protein inhibitor, in individuals with below-average high-density lipoprotein cholesterol ... by inhibiting cholesterylester transfer protein (CETP), which normally transfers cholesterol from HDL cholesterol to very low ... a novel cholesteryl ester transfer protein inhibitor, in individuals with below-average high-density lipoprotein cholesterol ... "Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol". New England Journal of Medicine. 350 (15): ...

Anacetrapib is a cholesteryl ester transfer protein inhibitor that raises high-density lipoprotein (HDL) cholesterol and ... February 2009). "Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and ... One reason for this is that elastin, the principal load-bearing protein present in the wall of the aorta, is reduced in the ... In short, raising HDL cholesterol is beneficial because it induces programmed cell death. The walls of a failing aorta are ...

"Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): A randomised, double- ... CETP inhibitors inhibit cholesterylester transfer protein (CETP), which normally transfers cholesterol from HDL cholesterol to ... A CETP inhibitor is a member of a class of drugs that inhibit cholesterylester transfer protein (CETP). They are intended to ... lower LDL cholesterol, and enhance reverse cholesterol transport.[citation needed] ...

... of high density lipoprotein subfractions in lipid transfer reactions mediated by cholesterol ester transfer protein (CETP)". J ... This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol. GRCh38: ... 2008). "Lipid transfer inhibitor protein (apolipoprotein F) concentration in normolipidemic and hyperlipidemic subjects". J. ... Wang X, Driscoll DM, Morton RE (1999). "Molecular cloning and expression of lipid transfer inhibitor protein reveals its ...

... transfer protein Cholesteryl ester storage disease Acyl CoA cholesteryl acyltransferase (ACAT) Lecithin- ... Cholesteryl ester, a dietary lipid, is an ester of cholesterol. The ester bond is formed between the carboxylate group of a ... Cholesteryl ester is found in human brains as lipid droplets which store and transport cholesterol. Increased levels of ... ISBN 9781608314126.{{cite book}}: CS1 maint: multiple names: authors list (link) Cholesterol+Esters at the U.S. National ...

... and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or ... "Assessment of Clinical Effects of Cholesteryl Ester Transfer Protein Inhibition With Evacetrapib in Patients at a High Risk for ... that inhibits cholesterylester transfer protein (CETP inhibitor). CETP collects triglycerides from very low-density ... Kolata, Gina (3 April 2016). "Dashing Hopes, Study Shows a Cholesterol Drug Had No Effect on Heart Health". New York Times. ...

... cholesterol acyltransferase and cholesteryl ester transfer protein in abnormal high density lipoprotein metabolism in insulin ... that converts free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into ... Lecithin-cholesterol acyltransferase (Thr123----Ile) and lecithin-cholesterol acyltransferase (Thr347----Met)". J. Clin. Invest ... 1992). "Interaction of rat lecithin-cholesterol acyltransferase with rat apolipoprotein A-I and with lecithin-cholesterol ...

The cholesteryl esters can be transferred, with the help of CETP (cholesterylester transfer protein) in exchange for ... The cholesterol is converted to cholesteryl esters by the enzyme LCAT (lecithin-cholesterol acyltransferase). ... Cholesterol from non-hepatic peripheral tissues is transferred to HDL by the ABCA1 (ATP-binding cassette transporter). ... Reverse cholesterol transport is a multi-step process resulting in the net movement of cholesterol from peripheral tissues back ...

StAR-related lipid transfer protein 4 (STARD4) is a soluble protein involved in cholesterol transport. It can transfer up to 7 ... "Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation". Journal of ... "The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 ... "Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory ...

Its main function is inhibition of cholesteryl ester transfer protein (CETP), probably by altering the electric charge of HDL ... cholesterol with an important role in the exchange of esterified cholesterol between lipoproteins and in removal of cholesterol ... When proteins rich in triglycerides like chylomicrons and VLDL are broken down, this apoprotein is transferred again to HDL. It ... C-I accounts for the ability of plasma high density lipoproteins to inhibit the cholesteryl ester transfer protein activity". ...

Ezetimibe is a selective inhibitor of dietary cholesterol absorption. Lomitapide is a microsomal triglyceride transfer protein ... Flaxseed oil Investigational classes of hypolipidemic agents: CETP inhibitors (cholesteryl ester transfer protein), 1 candidate ... Similar to ezetimibe, phytosterols reduce the absorption of cholesterol in the gut, so they are most effective when consumed ... Statins (HMG-CoA reductase inhibitors) are particularly well suited for lowering LDL, the cholesterol with the strongest links ...

... which is mediated by cholesteryl ester transfer protein (CETP).This protein exchanges triglycerides of VLDL against cholesteryl ... "National Reference System for Cholesterol - Cholesterol Reference Method Laboratory Network - HDL Cholesterol Certification ... converts the free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into ... "The target of regulating the ATP-binding cassette A1 protein (ABCA1): promoting ABCA1-mediated cholesterol efflux in different ...

Other medications that are in various stages of development include thyromimetics, cholesterol-ester-transfer protein (CETP ... This size variation at the gene level is expressed on the protein level as well, resulting in apo(a) proteins with 10 to more ... Apo(a) proteins vary in size due to a size polymorphism [KIV-2 VNTR], which is caused by a variable number of kringle IV ... Lp(a) is not fully synthesised until the precursor protein is released from the cell, so the slower rate of production for the ...

It also inhibits HDL-C hepatic uptake by suppressing production of the cholesterol ester transfer protein (CETP) gene. It ... Niacin reduces synthesis of low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), ... participating in many hydrogen transfer processes. NAD is important in catabolism of fat, carbohydrate, protein, and alcohol, ... and raise blood high density lipoprotein cholesterol (HDL-C, often referred to as "good" cholesterol). There are two forms: ...

... is an intracellular protein located in the endoplasmic reticulum that forms cholesteryl esters from cholesterol. Sterol O- ... The role of this enzyme is to transfer fatty acyl groups from one molecule to another. ACAT is an important enzyme in bile acid ... cholesterol acyltransferase. It gives the cholesterol ester cholesterol oleate. from Sigrid Hahn; Hans-Ulrich Klör (2001). ... cholesterol ester Thus, the two substrates of this enzyme are acyl-CoA and cholesterol, whereas its two products are CoA and ...

Huang Z; Inazu A; Nohara A; Higashikata T; Mabuchi H (December 2002). "Cholesteryl ester transfer protein inhibitor (JTT-705) ... The drug was aimed at raising the blood levels of HDL cholesterol. Prevailing observations indicate that high HDL levels ... Changes in inflammation and cholesterol efflux capacity may in part explain the benefits associated with the protective ... "Roche Drops After Halting Cholesterol Drug Development". Bloomberg. Michelle Fay Cortez (November 5, 2012), "Roche's Good ...

MTP is also involved with cholesterol ester and cluster of differentiation 1d biosynthesis. Transferring sphingolipids to apoB- ... and Al-Qarni studied the microsomal triglyceride transfer protein (MTP). MTP is an endoplasmic reticulum resident protein and ... Protein extrusion into a microsome can be described by multiple factors. A protein has been extruded if it is resistant to ... Normally, a secretory protein only has its signal sequence removed if the microsomes are there for protein synthesis due to the ...

... transfers cholesteryl esters to the VLDL in exchange for phospholipids and triglycerides via cholesterylester transfer protein ... Very-low-density lipoproteins transport endogenous triglycerides, phospholipids, cholesterol, and cholesteryl esters. It ... cholesterol, cholesteryl esters, and triglycerides. As it circulates in blood, it picks up apolipoprotein C-II (apoC-II) and ... VLDL now meets back up with HDL where apoC-II is transferred back to HDL (but keeps apoE). HDL also ...

The protein, as a component of HDL particles, enables efflux of fat molecules by accepting fats from within cells (including ... Paradoxically, carriers of this mutation have very low HDL-C (HDL-Cholesterol) levels, but no increase in the risk of heart ... Chylomicrons secreted from the intestinal enterocyte also contain Apo-AI, but it is quickly transferred to HDL in the ... which is responsible for the formation of most plasma cholesteryl esters. Apolipoprotein AI has also been isolated as a ...

doi:10.1016/B978-0-444-63772-7.00023-3. Abbey M, Nestel PJ (1994). "Plasma cholesteryl ester transfer protein activity is ... Elaidic acid increases plasma cholesterylester transfer protein (CETP) activity which lowers HDL cholesterol. Oleic acid Tardy ... Its salts and esters are called elaidates. Elaidic acid is an unsaturated trans fatty acid, with code C18:1 trans-9. This ...

Fielding PE, Fielding CJ (June 1980). "A cholesteryl ester transfer complex in human plasma". Proceedings of the National ... "Site-specific detection and structural characterization of the glycosylation of human plasma proteins lecithin:cholesterol ... It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein ... Protein Engineering. 10 (6): 621-5. doi:10.1093/protein/10.6.621. PMID 9278274. Zeng C, Spielman AI, Vowels BR, Leyden JJ, ...

The triglycerides are rebuilt in the enterocytes from their fragments and packaged together with cholesterol and proteins to ... cis and trans-fat-rich meals showed that cholesteryl ester transfer (CET) was 28% higher after the trans meal than after the ... cholesterol) or low levels of high-density lipoprotein (HDL, "good" cholesterol). These parameters in turn are believed to be ... "bad cholesterol"), lowering levels of high-density lipoprotein (HDL, often termed "good cholesterol"), increasing triglycerides ...

... which catalyzes fatty acid transfer between phosphatidylcholine and cholesterol. Pancreatic lipase, also known as pancreatic ... Protein Pept. Sci. 1 (1): 91-103. doi:10.2174/1389203003381487. PMID 12369922. Ranaldi S, Belle V, Woudstra M, Rodriguez J, ... Triglyceride lipases (EC 3.1.1.3) are a family of lipolytic enzymes that hydrolyse ester linkages of triglycerides. Lipases are ... Such a region is also present in lipases of prokaryotic origin and in lecithin-cholesterol acyltransferase (EC 2.3.1.43) (LCAT ...

His group identified Tangier disease (HDL deficiency) and cholesteryl ester storage disease, two inborn errors of cholesterol ... He played a prime role in the identification of several apolipoproteins (proteins that characterise the nature of a blood lipid ... but completed his studies at the University of Michigan after being transferred there by the army. During a cycling trip in the ... Subsequently he spent a year in the laboratory of Ivan Frantz, a cholesterol biochemist, at Massachusetts General Hospital. In ...

Proteins are made from amino acids that have been activated by attachment to a transfer RNA molecule through an ester bond. ... M. tuberculosis can also grow on the lipid cholesterol as a sole source of carbon, and genes involved in the cholesterol-use ... Proteins are made of amino acids arranged in a linear chain joined by peptide bonds. Many proteins are enzymes that catalyze ... The polysaccharides produced can have structural or metabolic functions themselves, or be transferred to lipids and proteins by ...

Their 2002 Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids ... and cholesteryl ester transfer". The American Journal of Clinical Nutrition. 77 (5): 1119-24. doi:10.1093/ajcn/77.5.1119. PMID ... cis and trans fat rich meals showed that cholesteryl ester transfer (CET) was 28% higher after the trans meal than after the ... Cholesterol, Protein, and Amino Acids (Macronutrients). National Academies Press. p. i. Archived from the original on 18 ...

... complexes for signal transduction or signaling Managing protein and lipid interactions Functioning as a substrate Transferring ... of cholesterol. At approximately 8 mol% of cholesterol the start of the liquid-disordered phase begins. This same relationship ... Phospholipids consist of two non-polar hydrocarbon chains with ester or ether bonds to the phosphate group which is also linked ... Initially all the model membranes were organized in a liquid order phase but as the addition of cholesterol increase a liquid- ...

Studies on the distribution of vitamin A as ester and alcohol and of carotenoids in the plasma proteins of several species: J. ... 1961 High cholesterol diet and esterification of cholesterol by the intestinal mucosa of rats: S. K. Murthy, S. Mahadevan and J ... Studies on metabolism of vitamin A: 6. The effect of vitamin A deficiency on the activation of sulphate and its transfer to p- ... 1958 Association of vitamin A ester and vitamin A alcohol with proteins in rat liver: S. Krishnamurthy, S. Mahadevan and J. ...