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*  Etrolizumab
... it is manufactured in CHO cells. As of 2016 it was in phase III studies for induction and maintenance therapy in people with ... Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, ...
*  Pertuzumab
It is manufactured recombinantly in CHO cells. The monoclonal antibody 2C4 appears to have first been published in 1990 by ... sets off signal transduction through several pathways that stimulate cell proliferation and cell growth; if overexpressed it ... Pertuzumab had also been studied in Non-small cell lung cancer but as of 2016 that indication had been discontinued. As of 2016 ... Badache, A; Hynes, NE (April 2004). "A new therapeutic antibody masks ErbB2 to its partners" (PDF). Cancer Cell. 5 (4): 299-301 ...
*  Zeocin
"Phleomycin resistance as a dominant selectable marker in CHO cells". Somatic Cell and Molecular Genetics. 14 (3): 243-52. doi: ... It causes cell death by intercalating into DNA and induces double strand breaks of the DNA. Zeocin is blue in colour due to the ... When zeocin enters a cell, the Cu2+ is reduced to Cu+ and then removed, and zeocin becomes activated and can then bind DNA. ... It is a broad-spectrum antibiotic that is effective against most bacteria, filamentous fungi, yeast, plant, and animal cells. ...
*  Motilin receptor
Thielemans L, Depoortere I, Vanden Broeck J, Peeters TL (2002). "The motilin pharmacophore in CHO cells expressing the human ... 2001). "Demonstration of a functional motilin receptor in TE671 cells from human cerebellum". Brain Res. 895 (1-2): 119-28. doi ...
*  Leukotriene B4 receptor 1
Yokomizo T, Noiri E, Izumi T, Shimizu T (2003). "In vivo chemotaxis using CHO cells expressing human leukotriene B4 receptor". ... Kato K, Yokomizo T, Izumi T, Shimizu T (2000). "Cell-specific transcriptional regulation of human leukotriene B(4) receptor ... "Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells". J Biol Chem. 271 (31): 18363-7. doi:10.1074/jbc ... "Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells". ...
*  Deacetylasperulosidic acid
The clastogen-suppressing effects of Tochu tea in CHO cells and mice". Mutation research. 388 (1): 7-20. doi:10.1016/s1383-5718 ... inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line". Cancer Research. 61 (15): 5749-56. ...
*  Blood vessel epicardial substance
Skalski M, Coppolino MG (Oct 2005). "SNARE-mediated trafficking of alpha5beta1 integrin is required for spreading in CHO cells ... Bves demonstrates dynamic localization, dependent upon cell-cell junction formation. Prior to cell-cell contact, Bves is ... Disruption of Bves results in decreased cell speed and increased cell roundness, which are cell processes modulated by the Rho ... Grossly, cell motility and cell adhesion are impaired. Only recently have the molecular mechanisms underlying the function of ...
*  Glycogen storage disease type II
This was followed by production of clinical grade alpha-glucosidase in Chinese hamster ovary (CHO) cells and in the milk of ... Genzyme also had its own product (Myozyme) grown in CHO cells under development. In November 2001, Genzyme chief executive ... muscle cells) or in white blood cells. The choice of sample depends on the facilities available at the diagnostic laboratory. ... Administration of the enzyme lead to its uptake by the liver and not the muscle cells where it is needed. In the early 1990s ...
*  KiSS1-derived peptide receptor
"Metastin suppresses the motility and growth of CHO cells transfected with its receptor". Biochemical and Biophysical Research ... "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells". The ... Journal of Cell Science. 117 (Pt 8): 1319-28. doi:10.1242/jcs.00971. PMID 15020672. "KiSS1-Derived Peptide Receptors". IUPHAR ... "Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells". The Journal ...
*  ERCC4
Wood RD, Burki HJ, Hughes M, Poley A (Feb 1983). "Radiation-induced lethality and mutation in a repair-deficient CHO cell line ... If the stem cells at the base of the crypt express ERCC4 (XPF), generally all several thousand cells of the crypt will also ... Multiple independent complementation groups of Chinese hamster ovary (CHO) cells have been isolated, and this gene restored UV ... Nuclei of cells in the lamina propria, cells which are below and surround the epithelial crypts, largely show hematoxylin blue- ...
*  ERCC1
CHO) cells were isolated, and this gene restored UV resistance to cells of complementation group 1. The human ERCC1 gene ... Wood RD, Burki HJ, Hughes M, Poley A (Feb 1983). "Radiation-induced lethality and mutation in a repair-deficient CHO cell line ... Hayashi T, Takao M, Tanaka K, Yasui A (Jun 1998). "ERCC1 mutations in UV-sensitive Chinese hamster ovary (CHO) cell lines". ... Mammalian cells with mutant ERCC1-XPF are moderately more sensitive than normal cells to agents (such as ionizing radiation) ...
*  Signal peptide
Kober L, Zehe C, Bode J (April 2013). "Optimized signal peptides for the development of high expressing CHO cell lines". ... "Unconventional mechanisms of protein transport to the cell surface of eukaryotic cells". Annual Review of Cell and ... Signal peptides function to prompt a cell to translocate the protein, usually to the cellular membrane. In prokaryotes, signal ... The process by which such secretory proteins gain access to the cell exterior is termed unconventional protein secretion (UPS ...
*  Gene expression
Kober L, Zehe C, Bode J (April 2013). "Optimized signal peptides for the development of high expressing CHO cell lines". ... this gives cells the flexibility to adapt to a variable environment, external signals, damage to the cell, and other stimuli. ... adhesion in tongue squamous cell carcinoma cells". Indian J. Med. Res. 129 (2): 154-63. PMID 19293442. Hanriot L, Keime C, Gay ... In a typical cell, an RNA molecule is only stable if specifically protected from degradation. RNA degradation has particular ...
*  ZP3
2004). "Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells". Biochemistry. 43 ( ... Cell. 143 (3): 404-15. doi:10.1016/j.cell.2010.09.041. PMID 20970175. PDB: 3NK3​ PDB: 3NK4​ Jovine L, Qi H, Williams Z, ... Cell. 143 (3): 404-15. doi:10.1016/j.cell.2010.09.041. PMID 20970175. PDB: 3NK3, 3NK4​ Bansal P, Chakrabarti K, Gupta SK (2009 ... Cell Biol. 4 (6): 457-61. doi:10.1038/ncb802. PMID 12021773. Jovine L, Qi H, Williams Z, Litscher ES, Wassarman PM (2004). "A ...
*  Glutamate aspartate transporter
"Benzodiazepines differently modulate EAAT1/GLAST and EAAT2/GLT1 glutamate transporters expressed in CHO cells". Neurochem. Int ... Cell. Cardiol. 37 (1): 33-41. doi:10.1016/j.yjmcc.2004.04.008. PMID 15242733. Gendreau S, Voswinkel S, Torres-Salazar D, Lang N ... Cell Genet. 69 (3-4): 209-10. doi:10.1159/000133965. PMID 7698014. Shashidharan P, Huntley GW, Meyer T, et al. (1995). "Neuron- ... 2000). "Human T-cell lymphotropic virus type 1-infected T lymphocytes impair catabolism and uptake of glutamate by astrocytes ...
*  Michael Stuart Brown
"Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein". Cell. 87 (3): 415-26. doi: ... Cell. 42 (1): 203-12. doi:10.1016/S0092-8674(85)80116-1. PMID 3860301. Brown MS, Goldstein JL (1985). "Scavenger cell receptor ... a possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells". Cell. 36 (4): 835 ... Sakai J, Duncan EA, Rawson RB, Hua X, Brown MS, Goldstein JL (Jun 1996). "Sterol-regulated release of SREBP-2 from cell ...
*  SLC1A2
"Benzodiazepines differently modulate EAAT1/GLAST and EAAT2/GLT1 glutamate transporters expressed in CHO cells". Neurochem. Int ... J. Physiol., Cell Physiol. 281 (6): C1964-70. PMID 11698255. Tozaki H, Kanno T, Nomura T, Kondoh T, Kodama N, Saito N, Aihara H ... Cell. Neurosci. 19 (2): 152-64. doi:10.1006/mcne.2001.1066. PMID 11860269. Reye P, Sullivan R, Fletcher EL, Pow DV (2002). " ... Cell. Neurosci. 19 (2): 152-64. doi:10.1006/mcne.2001.1066. PMID 11860269. Fontana AC (June 20, 2015). "Current approaches to ...
*  SREBP cleavage-activating protein
"Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein". Cell. 87 (3): 415-26. doi: ... In cholesterol-depleted cells, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their ... V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA ... Brown MS, Goldstein JL (1999). "A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood". ...
*  Nociceptin receptor
"Agonist-induced internalization and desensitization of the human nociceptin receptor expressed in CHO cells". Cellular and ... "The effect of nociceptin on Ca2+ channel current and intracellular Ca2+ in the SH-SY5Y human neuroblastoma cell line". British ... "Activation of phospholipase A2 by the nociceptin receptor expressed in Chinese hamster ovary cells". Journal of Neurochemistry ... receptor mRNA in activated human peripheral blood lymphocytes and lymphocytic cell lines". Brain Research. Molecular Brain ...
*  Mir-345 microRNA precursor family
"Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7". Journal of Biotechnology. 151 (2 ... "Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin". ... a methylation-sensitive microRNA is involved in cell proliferation and invasion in human colorectal cancer". Carcinogenesis. 32 ... cellular motility and oxidative phosphorylation in neural precursors derived from human umbilical cord mesenchymal stem cells ...
*  Mir-489 microRNA precursor family
"Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7". Journal of Biotechnology. 151 (2 ... "Functional Profiling Reveals Critical Role for miRNA in Differentiation of Human Mesenchymal Stem Cells". PLoS ONE. 4 (5): ... "Differences in osteoblast miRNA induced by cell binding domain of collagen and silicate-based synthetic bone". Journal of ... "MiR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC)". British Journal of ...
*  Proxyfan
Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. BMC Pharmacology. 2008 ...
*  Zygosity
"Evidence obtained by segregation analysis for functional hemizygosity at the Emtr locus in CHO cells". Cell. 14: 1007-1013. doi ... In cultured mammalian cells, such as the Chinese hamster ovary cell line, a number of genetic loci are present in a functional ... A diploid organism is heterozygous at a gene locus when its cells contain two different alleles of a gene. The cell or organism ... The cell or organism is called a hemizygote. Hemizygosity is also observed when one copy of a gene is deleted, or in the ...
*  VUF-5681
"Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells". BMC Pharmacology. 8: 9 ...
*  Theodore Puck
He developed the CHO cell line from Chinese hamster ovarian cells for this work. These cells are still widely utilized in the ... Puck was an early pioneer of "somatic cell genetics" and single-cell plating ( i.e. "cloning" .) This work allowed the genetics ... Puck with the assistance of Philip I. Marcus, successfully cloned a HeLa cell in 1955. Puck made many basic discoveries in ... Gordon Sato & colleagues, In Vitro Cell. Devel. Biol-Animal, 2006 The Official Site of Louisa Gross Horwitz Prize Theodore Puck ...
*  New Delhi metallo-beta-lactamase 1
Yong D, Toleman MA, Giske CG, Cho HS, Sundman K, Lee K, Walsh TR (December 2009). "Characterization of a new metallo-beta- ... a class of beta-lactam antibiotics that are capable of killing most bacteria by inhibiting the synthesis of one of their cell ...