... is in the alkylating agent family of medications. It works by blocking the formation of DNA and RNA. Chlorambucil ... Chlorambucil was first synthesized by Everett et al. "Chlorambucil". National Cancer Institute. 17 September 2014. Archived ... Chlorambucil is a white to pale beige crystalline or granular powder with a slight odor. When heated to decomposition it emits ... Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, inducing DNA damage via three different methods ...

... chlorambucil prednisolone ester; prednisolone 21-(4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate)) Alestramustine (estradiol 3 ...

A pivotal study of rituximab plus chlorambucil compared with chlorambucil alone (IELSG-19 study, n = 227) demonstrated a ... 50%; p = 0.024) over chlorambucil alone. However, 5-year OS was not improved (88% in both arms). First-line treatment of choice ... Oral alkylating agents such as cyclophosphamide or chlorambucil have been administered for a median duration of 12 months with ... February 2013). "Addition of rituximab to chlorambucil produces superior event-free survival in the treatment of patients with ...

Examples include melphalan and chlorambucil. The following three groups are almost always considered "classical". Nitrogen ... Uramustine or uracil mustard Melphalan Chlorambucil Ifosfamide Bendamustine Nitrosoureas Carmustine Lomustine Streptozocin ...

... alkylating agents such as cyclophosphamides and chlorambucil; and biological drugs such as adalimumab. Most uveitis patients ...

Nitrogen mustards include mechlorethamine, cyclophosphamide, melphalan, chlorambucil, ifosfamide and busulfan. Nitrosoureas ... chlorambucil, and chlormethine. Drugs with medium risk include doxorubicin and platinum analogs such as cisplatin and ...

Barnett, Lois B; Lewis, Susan E (2003). "Chlornaphazine and chlorambucil induce dominant lethal mutations in male mice". ...

December 2000). "Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia". The New England ... Although the purine analogue fludarabine was shown to give superior response rates to chlorambucil as primary therapy, no ...

December 2000). "Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia". The New England ... producing higher response rates than alkylating agents such as chlorambucil alone. Fludarabine is used in various combinations ...

Other nitrogen mustards developed include cyclophosphamide, chlorambucil, uramustine, melphalan, and bendamustine. Bendamustine ...

Chlorambucil, a chemotherapeutic agent, was more effective when conjugated to an SPA than without. In 2012, SPAs were ... SPAs have been paired with the DNA-alkylating moieties cyclopropylpyrroloindole and chlorambucil that were able to damage and ... "DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate". Nucleic Acids Research. 31 (21): 1208- ...

It is the ester formed from two other drugs, prednisolone and chlorambucil. Rarely, it has been associated with myoclonus. List ...

These include: Bleomycin, chlorambucil, cyclophosphamide, cytarabine, doxorubicin, lomustine, mitoxantrone, topotecan, and ...

... chlorambucil, or chlorambucil + rituximab have been used to treat extensive disease with each treatment giving approximately ... chlorambucil), immunotherapy (i.e. rituximab, or a combination (e.g. chlorambucil + rituximab or fludarabine + rituximab or ... Complete responses have been observed in most patients treated with chlorambucil, CHOP regimens, or rituximab but recurrence ... Intravenous rituximab achieves remission rates of 85% in patients that have not received chemotherapy; chlorambucil ...

In November 2013, the US Food and Drug Administration (FDA) approved obinutuzumab in combination with chlorambucil as a first- ... In the clinical trial of obinutuzumab in combination with chlorambucil, participants experienced infusion reactions (69%; 21% ... Obinutuzumab is used in combination with chlorambucil as a first-line treatment for chronic lymphocytic leukemia. It is also ...

... chlorambucil). Remission of the lesions may occur in some cases, but in the others low doses of life-long immunosuppression may ...

The investigation was conducted due to rising prices for five drugs (chlorambucil, melphalan, mercaptopurine, tioguanine and ...

... chlorambucil and chlormethine. Drugs with medium risk include doxorubicin and platinum analogs such as cisplatin and ...

The primary chemotherapeutic plan is combination chemotherapy with chlorambucil or cyclophosphamide, plus a corticosteroid such ... chlorambucil, and various forms of combination chemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisone CHOP, ...

2013: Gazyva (obinutuzumab): For use in combination with chlorambucil to treat patients with previously untreated chronic ...

Gastrointestinal lymphoma has also commonly been treated with a combination of prednisolone and high dose pulse chlorambucil ... Other chemotherapy drugs such as chlorambucil, lomustine (CCNU), cytosine arabinoside, and mitoxantrone are sometimes used in ...

... sometimes in combination with chemotherapeutic drugs such as chlorambucil, cyclophosphamide, or vincristine or with thalidomide ...

... an allele of reeler isolated from a chlorambucil screen, is due to an IAP insertion with exon skipping". Genomics. 42 (3): 479- ...

... chlorambucil and chlormethine. Drugs with medium risk include doxorubicin and platinum analogs such as cisplatin and ...

... chlorambucil (Leukeran) and melphalan (Alkeran). In 1952 the ICR's Eric Boyland had proposed that certain chemicals that cause ...

... or chlorambucil. Treatment is often lifelong, but there is a good prognosis for long-term remission. Alaskan Malamute Collie ...

... combined with either azathioprine of chlorambucil. Very moderate cases may do well by simply avoiding cold exposure. Treatment ...

Their prodrug, which released one equivalent of caffeic acid and chlorambucil upon phototriggering, showed reasonable ...

Likewise chlorambucil and cyclophosphamide are seldom used in the treatment of sarcoidosis due to their high degree of toxicity ... chlorambucil, and cyclosporine), immunomodulatory (pentoxifylline and thalidomide), and anti-tumor necrosis factor treatment ( ...

... chlorambucil). List of anatomical isthmi Saladin, Kenneth (2011-01-13). Anatomy & Physiology: The Unity of Form and Function. p ...