... is a protein that in humans is encoded by the CCL3 gene. CCL3 is a cytokine belonging to the CC chemokine family that is ... "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3". Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL ... Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) ... Human CCL3 genome location and CCL3 gene details page in the UCSC Genome Browser. Menten P, Wuyts A, Van Damme J (Dec 2002). " ...

Typical inflammatory chemokines include: CCL2, CCL3 and CCL5, CXCL1, CXCL2 and CXCL8. A typical example is CXCL-8, which acts ... C4-CC chemokines), but a small number of CC chemokines possess six cysteines (C6-CC chemokines). C6-CC chemokines include CCL1 ... The third group of chemokines is known as the C chemokines (or γ chemokines), and is unlike all other chemokines in that it has ... CCL1 for the ligand 1 of the CC-family of chemokines, and CCR1 for its respective receptor. The CC chemokine (or β-chemokine) ...

Townson JR, Barcellos LF, Nibbs RJ (2002). "Gene copy number regulates the production of the human chemokine CCL3-L1". Eur. J. ... 1999). "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine ... C-C motif chemokine 4-like is a protein that in humans is encoded by the CCL4L1 gene. This gene is one of several cytokine ... "Entrez Gene: CCL4L1 chemokine (C-C motif) ligand 4-like 1". Retrieved 8 February 2013. Human CCL4L2 genome location and CCL4L2 ...

Townson JR, Barcellos LF, Nibbs RJ (October 2002). "Gene copy number regulates the production of the human chemokine CCL3-L1". ... This protein binds to several chemokine receptors including chemokine binding protein 2 (CCBP2 or D6) and chemokine (C-C motif ... This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines are a family of secreted ... Chemokine (C-C motif) ligand 3-like 1, also known as CCL3L1, is a protein which in humans is encoded by the CCL3L1 gene. ...

The CC chemokines CCL3, CCL5, CCL17 and CCL22 signal through this receptor. CCR5 is expressed on several cell types including ... This receptor has several CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14 and CCL16. CCR6, a ... The CC chemokine receptors all work by activating the G protein Gi. CCR1 was the first CC chemokine receptor identified and ... CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to ...

The biological effect is carried out through ligation of chemokine receptors CCR1 (ligand CCL3) and CCR5 (ligands CCL3 and CCL4 ... December 2010). "Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme". The ... There are two chemokines in the MIP-3 group. MIP-3α (CCL20) and MIP-3β (CCL19). MIP-3α is binding to receptor CCR6. CCL20 is ... The genes for CCL3 and CCL4 are both located on human chromosome 17 and on murine chromosome 11. They are produced by many ...

Certain chemokines are also regulated by T-bet, namely xcl1, ccl3, ccl4 and chemokine receptors cxcr3, ccr5. The expression of ...

The Gp120 envelope protein is a chemokine mimic. Though it lacks the unique structure of a chemokine, it is still capable of ... CCR5's cognate ligands include CCL3, CCL4 (also known as MIP 1α and 1β, respectively), and CCL3L1. CCR5 furthermore interacts ... It is a G protein-coupled receptor which functions as a chemokine receptor in the CC chemokine group. ... C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved ...

... host-derived pro-inflammatory chemokines (e.g. CXCL8, CCL2, CCL3, CCL4, CCL5, CCL11, CXCL10), platelet-activating factor, and ... stimulates their expression the chemokine receptor, CCR5, to inhibit chemokine signaling, enhances their phagocyte activity, ... chemokine receptor-like 1), also termed the ChemR23 or E series resolvin receptor (ERV), is expressed on inflammation- ...

Chemokine-like protein TAFA-5 is a protein that in humans is encoded by the TAFA5 gene. This gene is a member of the TAFA ... These proteins contain conserved cysteine residues at fixed positions, and are distantly related to CCL3, a member of the CC- ... "TAFA5 TAFA chemokine like family member 5 [ Homo sapiens (human) ]". National Center for Biotechnology Information. Retrieved ... chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to ...

C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene. CCR1 has also recently been designated ... The ligands of this receptor include CCL3 (or MIP-1 alpha), CCL5 (or RANTES), CCL7 (or MCP-3), and CCL23 (or MPIF-1). ... "Entrez Gene: CCR1 chemokine (C-C motif) receptor 1". Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, ... This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on ...

Chemokine (C-C motif) ligand 18 (CCL18) is a small cytokine belonging to the CC chemokine family. The functions of CCL18 have ... Because of these pseudo-exons, it is believed that CCL18 arose as a result of a gene fusion event between CCL3-like protein ... It was previously known as Pulmonary and activation-regulated chemokine (PARC), dendritic cell (DC)-chemokine 1 (DC-CK1), ... Chemokines are classed as a special type of cytokine that is involved in immune cell trafficking. CCL18 in particular has some ...

... identical in amino acid composition to CCL3 and CCL4. This chemokine is expressed in various tissues including spleen, bone ... Chemokine (C-C motif) ligand 14 (CCL14) is a small cytokine belonging to the CC chemokine family. It is also commonly known as ... Human CCL14 is located on chromosome 17 within a cluster of other chemokines belonging to the CC family. Schulz-Knappe et al., ... Naruseet al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics, 1996, 34: 236-240. v t e ...

When the 12-amino acid sequence of 'peptide 3'/CCL2 is aligned with the sequences of the other chemokines CCL3, CXCL8 and ... CCL3, CXCL8 and CXCL12 with roughly equal potency of 10μM, but not migration induced by other non-chemokine chemoattractants ... CCL2, CCL3, CCL5 and CXCL12 with THP-1 monocytes, and vs. CXCL8 with neutrophils. In addition NR58,3-14-3 does not ... In addition Val11 is also present in CCL3 and CXCL8. The corresponding 11th amino acid in CXCL12 is Ile. Ala4 in CCL2 is also ...

Breakthrough infection Broadly neutralizing HIV-1 antibodies Bursa of Fabricius C-C chemokine receptor type 6 C-C chemokine ... CCL1 CCL11 CCL12 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28 CCL3 CCL5 ... CD4 CD4+ T cells and antitumor immunity CD74 CD94/NKG2 Cell-mediated immunity CELSR1 Central tolerance Chemokine Chemokine ... CR6261 CroFab Cross-presentation Cross-reactivity Cryptic self epitopes Cryptotope CX3CL1 CX3CR1 CXC chemokine receptors CXCL1 ...

Activation of dectin-1 also triggers expression of many protecting antifungal cytokines and chemokines (TNF, CXCL2, IL-1β, IL-1 ... α, CCL3, GM-CSF, G-CSF and IL-6) and the development of Th17. Histoplasma capsulatum can evade recognition of β-glucan via ... This transcription factor is responsible for the production of numerous inflammatory cytokines and chemokines such as TNF, IL- ...

In humans, MAIT cells express high levels of CD161, interleukin-18 (IL-18) receptor, and chemokine receptors CCR5, CXCR6, and ... CCL3, CCL4 and CCL20, and the recruitment of neutrophils via CCL2 and CXCL2 in an MR1-dependent manner. Additionally to ... CCL3, HMGB1), proteases (Furin, MMP25), growth factors (GM-CSF, M-CSF, PDGFB, LIF) as well as angiogenic genes (HIF1A, VEGFB). ... proinflammatory response correlating with the production of a broad array of proinflammatory cytokines and chemokines like IL- ...

In addition to other chemokines, such as CCL2, CCL3, and CCL4, the presence of CCL1 has been reported in the development of ... Chemokine (C-C motif) ligand 1 (CCL1) is also known as small inducible cytokine A1 and I-309 in humans. CCL1 is a small ... CCL1 is encoded by CCL1 gene which is one of the several chemokine genes clustered on the chromosome 17q11.2-q12 in humans. It ... July 1998). "The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells". Journal of Immunology. 161 (2 ...

... encoding protein Zinc finger protein 830 Several CC chemokines: CCL1, CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL14, ... C-C motif chemokine ligand 4 like 1 (17q12) DDX52: DExD-box helicase 52 (17q12) ERBB2 loca leukemia viral oncogene homolog 2, ...

The chemokines CCL5/RANTES, CCL3/MIP-1α, CCL4/MIP-1β, all of which bind to CCR5, are inhibitory to HIV-1 replication in ... Chemokines are divided into four main subfamilies: C, CC, CXC, and CX3C. Microglial cells are sources of some chemokines and ... The chemokine receptor, CX3CR1, is expressed by microglia in the central nervous system. Fractalkine (CX3CL1) is the exclusive ... Chemokines are cytokines that stimulate directional migration of inflammatory cells in vitro and in vivo. ...

In maturing of DC production of chemokines have different impact on chemokine receptor function: CCR1 and CCR5 were down- ... CCL4 has been shown to interact with CCL3. CCL4 binds to G protein-Coupled Receptors CCR5 and CCR8. Macrophage inflammatory ... Chemokine (C-C motif) ligands 4 (also CCL4) previously known as macrophage inflammatory protein (MIP-1β), is a protein which in ... Production of chemokines provides DC with the capacity to self-regulate their migratory behavior as well as to recruit other ...

Chemokine ligands CXCL9, CXCL10, and CCL5 that bind to chemokine receptors such as CXCR3 and CCR5, Immune suppressive or ... Antigen-activated T cells secrete CCR5 ligands (CCL2 and CCL3) to recruit natural killer (NK) cells and other innate immune ... These initiate the following cascade: CXCR3 ligand chemokines (CXCL-9, -10 and -11) are produced in response to activated B ... To illustrate, growth factors and chemokines activated in response to injury are recruited by tumour cells, sustaining chronic ...