"CCL21 Chemokine Therapy for Lung Cancer". International Trends in Immunity. 1 (1): 10-15. PMC 4175527. PMID 25264541. Kar UK, ... A vault has been packaged with a chemokine for potential use to activate the immune system to attack lung cancer, and this ... Srivastava MK, Andersson A, Baratelli F, Huang M, Kickhoefer VA, Dubinett SM, Rome LH, Sharma S (May 2011). "Novel CCL21-vault ...

The chemokine CCL21 then binds to its receptor CCR7 expressed on the T cell. This binding induces a conformational change in ... They also secrete the chemokine CCL21. Naïve T cells express CCR7 receptor and adhesion molecules L-selectin and LFA-1. As ...

"CCL21 Chemokine Therapy for Lung Cancer". International Trends in Immunity. 1 (1): 10-15. ISSN 2326-3121. PMC 4175527. PMID ... This vault is packaged with a chemokine and will be used to activate the immune system to attack lung cancer. As of 2012[update ... "Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth". PLOS ONE. 6 (5): e18758. Bibcode:2011PLoSO... ...

C6-CC chemokines). C6-CC chemokines include CCL1, CCL15, CCL21, CCL23 and CCL28. CC chemokines induce the migration of ... The third group of chemokines is known as the C chemokines (or γ chemokines), and is unlike all other chemokines in that it has ... Chemokines of this subfamily usually contain four cysteines (C4-CC chemokines), but a small number of CC chemokines possess six ... CCL1 for the ligand 1 of the CC-family of chemokines, and CCR1 for its respective receptor. The CC chemokine (or β-chemokine) ...

For example, Naive T cells express the CCR7 receptor for the chemokine CCL21. and B cells exhibit CXCR5 receptors for chemokine ... FRCs express chemokines such as CCL21 and CCL19 which assist the movement of T cells and dendritic cells with CCR7 receptors. ... For example, the chemokine CCL21 attaches to the surface of the FRCs through collagen and glycosaminoglycan molecules. FRCs ... In mouse lymph nodes the HECs also express the chemokine CCL21 which will bind its receptor CCR7 on the naive T-cell and ...

Its ligands include the related chemokines CCL19 and CCL21, (previously called ELC and SLC). CCR8 is associated with Th2 ... This molecule was originally designated CCR11 due to its ability to bind several CC chemokines (including CCL19, CCL21 and ... The CC chemokine receptors all work by activating the G protein Gi. CCR1 was the first CC chemokine receptor identified and ... CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to ...

Chemokines influence these movements, especially CCL21, which is bound to lymphatic endothelial cell membranes. The influence ... 2013). Interstitial dendritic cell guidance by haptotactic chemokine gradients. Science, 339(6117), 328-332. doi:10.1126/ ... eosinophils and some T cells are influenced by RANTES chemokines. In the autoimmune disorder rheumatoid arthritis and in ...

In any case, CCL21 binds to C-C chemokine receptor type 7 and chemokine receptor CXCR3 receptors on microglia in the thalamus. ... CCL21). The concentration of this chemokine is increased in the ventral posterolateral nucleus of the thalamus where secondary ... The source of CCL21 is not exactly known, but two possibilities exist. First, it might be made in primary nociceptive neurons ... Both pathways depend on the production of chemokines and other molecules important in the inflammatory response.[citation ...

The source of these cues may include neurons secreting chemokines such as CCL21 and surface immobilized chemokines such as ...

Their activation in peripheral tissues induces CCR7 expression on the cell's surface, which recognize CCL19 and CCL21 produced ... May 1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1 ... July 2000). "Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development ... identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and ...

This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/ ... 2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines ... C-C chemokine receptor type 11 is a protein that in humans is encoded by the CCRL1 gene. The protein encoded by this gene is a ... "Entrez Gene: CCRL1 chemokine (C-C motif) receptor-like 1". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to ...

Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known ... The gene for CCL21 is located on human chromosome 9. CCL21 is classified as a homeostatic chemokine, it is produced ... CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7. The main function of CCL21 is to guide ... Other cells using chemokine CCL21 for the migration to the lymph nodes are B cells. However, they are less dependent on it in ...

The rest starts to express CCR7, which is a receptor for mTEC-generated chemokine CCL21, and migrate after concentration ... mTECsHi reservoir and another part is constituted by mature mTECs which are specialized for expression of chemokine CCL21, ... Lkhagvasuren E, Sakata M, Ohigashi I, Takahama Y (May 2013). "Lymphotoxin β receptor regulates the development of CCL21- ...

The DNA vaccine contained the CCL21 secretory chemokine as a way to enhance the likelihood of eliciting the immune response by ... which co-encoded secretory chemokine CCL21 and survivin protein in C57BL/6J mice, Xiang et al. have been able to elicit an ...

... chemokine receptor which recognizes chemokines CCL19 and CCL21, that are largely produced by mTECs in the medulla, and ... TGFβ or stem cell factor and chemokines CCL25, CXCL12 or CCRL1 etc. Essential part of T cell development forms process called ...

Coiled coil domain-containing protein 180 CCL21: chemokine (C-C motif) ligand 21, SCYA21 CCL27: chemokine (C-C motif) ligand 27 ...

Cathelicidin CC chemokine receptors CCBP2 CCL1 CCL11 CCL12 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18 CCL19 CCL2 CCL20 CCL21 CCL22 ... Breakthrough infection Broadly neutralizing HIV-1 antibodies Bursa of Fabricius C-C chemokine receptor type 6 C-C chemokine ... CD4 CD4+ T cells and antitumor immunity CD74 CD94/NKG2 Cell-mediated immunity CELSR1 Central tolerance Chemokine Chemokine ... CR6261 CroFab Cross-presentation Cross-reactivity Cryptic self epitopes Cryptotope CX3CL1 CX3CR1 CXC chemokine receptors CXCL1 ...

Dock2-dependent chemotaxis has been reported in response to the chemokines CXCL12/SDF-1 in T lymphocytes, CXCL13/BLC in B ... lymphocytes and CCL19/ELC in thymocytes (immature lymphocytes) emigrating from the thymus as well as CCL21/SLC in ex vivo ... 2007). "DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin ...

This chemokine-induced latency model has been used in a comprehensive comparison of in vitro models for evaluating latency ... "CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 ... "Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton". ... cells contribute to the ongoing HIV reservoir and that HIV DNA is preferentially found in CD4 T cells expressing the chemokine ...

This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7. It ... 2004). "CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2". Blood. 103 (5): ... Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ... 2000). "Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and ...