Bartek J, Lukas J (December 2001). "Mammalian G1- and S-phase checkpoints in response to DNA damage". Current Opinion in Cell ... This kinase is a catalytic subunit of the protein kinase complex, important for the G1 phase progression and G1/S transition of ... "Entrez Gene: CDK6 cyclin-dependent kinase 6". Meyerson M, Harlow E (March 1994). "Identification of G1 kinase activity for cdk6 ... Liu J, Kipreos ET (July 2000). "Evolution of cyclin-dependent kinases (CDKs) and CDK-activating kinases (CAKs): differential ...
2009). "Implication of Checkpoint Kinase-dependent Up-regulation of Ribonucleotide Reductase R2 in DNA Damage Response". J. ... 2010). "Expression of nucleoside transporters, deoxycitidine kinase, ribonucleotide reductase regulatory subunits, and ... 340 (2): 428-34. doi:10.1016/j.bbrc.2005.12.019. PMID 16376858. Boukovinas I, Papadaki C, Mendez P, et al. (2008). Ramqvist T ( ... 2 (4): 227-34. doi:10.3109/10425179209020807. PMID 1627826. Lin ZP, Belcourt MF, Cory JG, Sartorelli AC (2004). "Stable ...
Eukaryotic checkpoint proteins are well conserved and involve two phosphatidylinositol 3-kinase-related kinases (PIKKs), ATR ... One kinase is the Cdc7-Dbf4 kinase called Dbf4-dependent kinase (DDK) and the other is cyclin-dependent kinase (CDK). Chromatin ... Dart DA, Adams KE, Akerman I, Lakin ND (April 2004). "Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S ... In order to become fully active, the ATR kinase rely on sensor proteins that sense whether the checkpoint proteins are ...
Diril; Bisteau; Kitagawa (2016). "Loss of the Greatwall kinase weakens the spindle assembly checkpoint". PLOS Genetics. 12 (9 ... Although Mastl kinase is not essential for metaphase entry, it is required for its maintenance by sustaining spindle assembly ... This gene encodes for the protein micro tubule associated serine/threonine kinase and its sub-classes. Micro-tubule-associated ... serine/threonine protein kinase is a mammalian enzyme which was first discovered in Drosophila as an essential kinase (great ...
With the loss of function of Cdc7 in ESCs the S phase is stopped at the G2/M checkpoint. Recombinational repair (RR) is done at ... The Cdc7/Dbf4 kinase complex, along with another serine-threonine kinase, cyclin-dependent kinase (Cdk), phosphorylates the pre ... Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. The Cdc7 kinase is ... The gene, CDC7, is involved in the regulation of cell cycle because of the gene product Cdc7 kinase. The protein is expressed ...
... and spindle assembly checkpoint (SAC), central spindle organization, and cytokinesis. Aneuploidy results from independent and ... Aurora kinase C, also Serine/threonine-protein kinase 13 is an enzyme that in humans is encoded by the AURKC gene. This gene ... Although yeast contain only one Aurora kinase and C. elegans and Drosophila contain only two, mammals have three Aurora kinases ... "Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells". Cell ...
D'Angiolella V, Mari C, Nocera D, Rametti L, Grieco D (October 2003). "The spindle checkpoint requires cyclin-dependent kinase ... CDC20 is also a part of, and regulated by, the spindle assembly checkpoint (SAC). This checkpoint ensures that anaphase ... "p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase". Oncogene. 19 (40): ... "p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase". Oncogene. 19 (40): ...
Chan GK, Jablonski SA, Sudakin V, Hittle JC, Yen TJ (Sep 1999). "Human BUBR1 is a mitotic checkpoint kinase that monitors CENP- ... D'Angiolella V, Mari C, Nocera D, Rametti L, Grieco D (Oct 2003). "The spindle checkpoint requires cyclin-dependent kinase ... Nilsson J, Yekezare M, Minshull J, Pines J (Dec 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 ... This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved ...
... transmits the checkpoint signal by interacting with kinases throughout the cascade. When there is a loss of these kinases (from ... Specifically, they are kinases that are recruited and activated by DNA damage. The stalled replication fork can collapse if ... The results showed that with further loss of checkpoints, replication stress is increased to a higher level. With this change, ... 12 (2): 221-37. doi:10.2217/fon.15.292. PMID 26616915. S2CID 20261656. Kanu N, Cerone MA, Goh G, Zalmas LP, Bartkova J, Dietzen ...
There are two upstream checkpoint kinases implicated in regulating Mad1 function through phosphorylation. Mps1 phosphorylates ... Mad1 is a non-essential protein which in yeast has a function in the spindle assembly checkpoint (SAC). This checkpoint ... A spindle assembly checkpoint monitors the status of the spindle and links the metaphase-anaphase transition to proper bipolar ... The spindle assembly checkpoint inhibits the activity of the anaphase promoting complex by preventing degradation of downstream ...
Quinn DI, Lara PN (2015). "Renal-Cell Cancer - Targeting an Immune Checkpoint or Multiple Kinases". N. Engl. J. Med. 373 (19): ... Syn, Nicholas L; Teng, Michele W L; Mok, Tony S K; Soo, Ross A (2017). "De-novo and acquired resistance to immune checkpoint ... 5 (2): 72. doi:10.1016/S1470-2045(04)01368-3. PMID 14974475. Johann, Donald J.; Wei, Bih-Rong; Prieto, Darue A.; Chan, King C ... 3.0.CO;2-G. PMID 9390023. S2CID 34796951. Lauby-Secretan, B; Scoccianti, C; Loomis, D; Grosse, Y; Bianchini, F; Straif, K; ...
... enhanced expression of the receptor tyrosine kinase c-MET, making ASPS sensitive to small-molecule kinase inhibitor such as ... checkpoint inhibitors and cellular immunotherapies in the treatment of ASPS. Researchers at the Huntsman Cancer Institute (HCI ... Current clinical trials are exploring the utility of kinase inhibitors (targeting growth factor pathways and angiogenesis); ... 3.0.co;2-k. PMID 14886902. Ladanyi M, Lui MY, Antonescu CR, Krause-Boehm A, Meindl A, Argani P, et al. (January 2001). "The der ...
... kinase. ATM is a key kinase in the DNA damage checkpoint. Defects in cohesion can increase genome instability, a result ... A similar function-specific alternative RFC (replacing RFC1 with Rad24) plays a role in the DNA damage checkpoint. The presence ... 106 (2): 137-140. doi:10.1016/s0092-8674(01)00439-1. PMID 11511341. Skibbens, Robert V. (2009). "Establishment of Sister ...
Cells utilize various checkpoints as a means of delaying cell cycle progression until it can repair defects. Cdk2 is active ... The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein ... Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the ... Cyclin-dependent kinase 2 is structured in two lobes. The lobe beginning at the N-terminus (N-lobe) contains many beta sheets, ...
Ahonen LJ, Kallio MJ, Daum JR, Bolton M, Manke IA, Yaffe MB, Stukenberg PT, Gorbsky GJ (June 2005). "Polo-like kinase 1 creates ... 14 (2): 131-7. doi:10.1016/j.cub.2003.12.058. PMID 14738735. S2CID 16533093. Bharadwaj R, Qi W, Yu H (March 2004). " ... the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores". Current ...
... activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1". DNA Repair. 8 (9): 996-1003. doi: ... TOPBP1 has been shown to be an activator of ATR, leading to an increase in the kinase activity of ATR. Following instances of ... DNA damage repair is initiated and maintained by two kinases, ataxia-telangiectasia mutated (ATM) and ATR, with ATR proving to ... Ma M, Rodriguez A, Sugimoto K (April 2020). "Activation of ATR-related protein kinase upon DNA damage recognition". Current ...
Likewise, cell cycle checkpoint regulation is ultimately controlled by phosphorylation activity of the ATM kinase, which is ... The MRN complex also participates in activating the checkpoint kinase ATM in response to DNA damage. Production of short single ... has been shown to disrupt the ability of ATM kinase to control the G2-M DNA damage checkpoint, which is required for repair of ... The loss of this checkpoint strips cancer stem cells' ability to repair lethal genetic lesions, making them vulnerable to DNA ...
"GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic ... GADD45G prevents the kinase ability of the cyclin b1/Cdk1 complex in a fashion that does not break apart the complex. It plays ... GADD45G was found to inhibit Cdk1 kinase activity, which would cause disruption of cell growth. It also interacts with CRIF, ... which causes the inhibition of Cdc2-cyclin B1 and Cdk-cyclin E. GADD45 also works with the cyclin-dependent kinase inhibitor ...
Chan GK, Jablonski SA, Sudakin V, Hittle JC, Yen TJ (Sep 1999). "Human BUBR1 is a mitotic checkpoint kinase that monitors CENP- ... Nilsson J, Yekezare M, Minshull J, Pines J (Dec 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 ... "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and ... "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and ...
"Targeting Focal Adhesion Kinase Renders Pancreatic Cancers Responsive to Checkpoint Immunotherapy". Nature Medicine. 22 (8): ... The defective BCR-ABL gene makes it possible to manufacture an abnormal version of an enzyme of the Tyrosine Kinase type ... 104 (2): 321a. Bibcode:2013BpJ...104..321P. doi:10.1016/j.bpj.2012.11.1779. Fuhrmann, A; Staunton, J R; Nandakumar, V; Banyai, ... 13 (2): 124-125. doi:10.1038/nmeth.3744. ISSN 1548-7105. PMC 4861038. PMID 26820546. Pickup, Michael W.; Mouw, Janna K.; Weaver ...
"The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1". Biochemical and Biophysical Research ... Mitotic checkpoint protein BUB3 is a protein that in humans is encoded by the BUB3 gene. Bub3 is a protein involved with the ... Sudakin V, Chan GK, Yen TJ (September 2001). "Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of ... Sudakin V, Chan GK, Yen TJ (September 2001). "Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of ...
Sauer K, Liou J, Singh SB, Yablonski D, Weiss A, Perlmutter RM (November 2001). "Hematopoietic progenitor kinase 1 associates ... and regulation of the pre-B cell checkpoint. The acidic region of BLNK contains several inducibly phosphorylated tyrosine ... A mechanism for negative signaling by the Lyn tyrosine kinase". The Journal of Biological Chemistry. 277 (35): 31703-31714. doi ... Evidence suggests that BLNK is phosphorylated by the tyrosine-protein kinase Syk after B cell receptor activation. ...
2004). "The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway". J. ... Mitogen-activated protein kinase 12 (MAP kinase 12), also known as extracellular signal-regulated kinase 6 (ERK6) or stress- ... Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal ... 2008). "Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection ...
"Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex". The ... DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. The DNA-Pkcs protein is a serine/threonine ... September 1995). "DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia ... "Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit". The Journal of ...
Some of her studies have identified BRD4, as a kinase that regulates early transcription, linking mitosis and transcription and ... TAF7 as a checkpoint regulator of early transcription. Singer's research program was focused on interrogating the regulatory ... to expand serological testing capacity and research to characterize the immune responses elicited by the SARS-CoV-2 viral ...
The CHEK1 (checkpoint kinase 1) gene, located at chromosome position 11q24.2, is responsible for encoding the protein kinase ... 1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science ... 17 (2): 215-20. doi:10.1038/cdd.2009.69. PMID 19498445. Guo CJ, Pan Q, Li DG, Sun H, Liu BW (April 2009). "miR-15b and miR-16 ... 17 (2): 215-20. doi:10.1038/cdd.2009.69. PMID 19498445. Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, et al. ( ...
"DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells ... Liu ST, Chan GK, Hittle JC, Fujii G, Lees E, Yen TJ (Apr 2003). "Human MPS1 kinase is required for mitotic arrest induced by ... Martin-Lluesma S, Stucke VM, Nigg EA (Sep 2002). "Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of ... 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986. Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, ...
Therefore, cancer cells with uncontrolled growth and improper G2/M checkpoints lack KAT5 regulation by cyclin dependent kinase ... protein kinase. ATM protein kinase phosphorylates and therefore activates proteins involved in DNA repair. However, to be ... Lack of KAT5 suppresses ATM protein kinase activity and reduces the ability of a cell to correct its DNA. KAT5 also works later ... Gavaravarapu S, Kamine J (Mar 2000). "Tip60 inhibits activation of CREB protein by protein kinase A". Biochemical and ...
These checkpoints' cell cycle blocks at both the G1/S and G2/M checkpoints are consistent with the inhibition profile of the ... In the cyclin-dependent kinase (CDK) family or CDK, Cyclin, and CKIs, serine/threonine kinases play an integral role in ... A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein which inhibits the enzyme cyclin- ... Seven cyclin-dependent kinase inhibitor proteins have been identified. They are p15, p16, p18, p19, p21, p27, and p57. These ...
Also, 14-3-3ΞΆ can negatively regulate the G2-M phase checkpoint by binding and sequestering the cyclin-dependent kinases to the ... Powell DW, Rane MJ, Chen Q, Singh S, McLeish KR (June 2002). "Identification of 14-3-3zeta as a protein kinase B/Akt substrate ... Birkenfeld J, Betz H, Roth D (January 2003). "Identification of cofilin and LIM-domain-containing protein kinase 1 as novel ... Gannon-Murakami L, Murakami K (June 2002). "Selective association of protein kinase C with 14-3-3 zeta in neuronally ...
Shieh SY, Ahn J, Tamai K, Taya Y, Prives C (2000). "The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate ... Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory ... "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature. 411 (6833): 102-7. Bibcode:2001Natur. ... Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene. ...