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"Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site". ... Sheffler DJ, Conn PJ (September 2008). "Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially ... which acts as a selective positive allosteric modulator for the metabotropic glutamate receptor subtype mGluR1. It was derived ... "A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from ...
... the site where the endogenous ligand glutamate binds) at least two distinct allosteric binding sites exist on the mGluR5. A ... "Identification and characterization of a novel splice variant of the metabotropic glutamate receptor 5 gene in human ... Enz R (March 2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS ... Minakami R, Jinnai N, Sugiyama H (August 1997). "Phosphorylation and calmodulin binding of the metabotropic glutamate receptor ...
LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to ... Chi H, Jang JK, Kim JH, Vezina P (October 2006). "Blockade of group II metabotropic glutamate receptors in the nucleus ... Yoon HS, Jang JK, Kim JH (September 2008). "Blockade of group II metabotropic glutamate receptors produces hyper-locomotion in ... O'Neill MF, Heron-Maxwell C, Conway MW, Monn JA, Ornstein P (October 2003). "Group II metabotropic glutamate receptor ...
... a protein that selectively binds metabotropic glutamate receptors". Nature. 386 (6622): 284-288. Bibcode:1997Natur.386..284B. ... Roche KW, O'Brien RJ, Mammen AL, Bernhardt J, Huganir RL (1996). "Characterization of multiple phosphorylation sites on the ... Glutamate receptor 1 is a protein that in humans is encoded by the GRIA1 gene. Glutamate receptors are the predominant ... "Entrez Gene: GRIA1 glutamate receptor, ionotropic, AMPA 1". Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA (June 2004 ...
"Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3". Proceedings of the ... "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. ... "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3". Proceedings of the ... PPM1A has been shown to interact with Metabotropic glutamate receptor 3. In 2006, Dr. Feng found that PPM1A can terminate TGF- ...
"Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a] ... the site where the endogenous ligand glutamate binds) at least two distinct allosteric binding sites exist on the mGluR1. A ... Robbins MJ, Ciruela F, Rhodes A, McIlhinney RA (1999). "Characterization of the dimerization of metabotropic glutamate ... The glutamate receptor, metabotropic 1, also known as GRM1, is a human gene which encodes the metabotropic glutamate receptor 1 ...
October 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". ... Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full ... a protein that selectively binds metabotropic glutamate receptors". Nature. 386 (6622): 284-288. Bibcode:1997Natur.386..284B. ... September 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell. 114 (6): 777- ...
... and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". The Journal of Biological Chemistry. ... "Molecular characterization and localization of human metabotropic glutamate receptor type 3". Brain Research. Molecular Brain ... and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". The Journal of Biological Chemistry. ... Metabotropic glutamate receptor 3 has been shown to interact with: GRIP1, PICK1, and PPM1A. Metabotropic glutamate receptor ...
This domain is responsible for the binding of both Mg2+ATP and aspartate. These two active sites are connected by a tunnel ... Structural characterization of asparagine synthetase from mammalian sources have been difficult due to the low abundance and ... The N-terminal active site catalyzes glutamine hydrolysis to yield glutamate and ammonia. The C-terminal active site catalyzes ... Thus, after being released in, and channeled from, the glutaminase site, the ammonia molecule attacks the bound βAspAMP 1 to ...
... and dextromethorphan bind with higher affinity to the phencyclidine receptor in the absence of magnesium and L-glutamate". ... cloning and pharmacological characterisation of two receptor variants". FEBS Letters. 413 (3): 489-494. doi:10.1016/S0014-5793( ... TCAs are protein bound and become less bound in more acidic conditions, so by reversing the acidosis, protein binding increases ... Plasma protein binding is generally 90% or greater. There are two major groups of TCAs in terms of chemical structure, which ...
1988). "Isolation and characterization of cDNA clones encoding human liver glutamate dehydrogenase: evidence for a small gene ... syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate ... 2002). "Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations". ... Glutamate dehydrogenase pseudogene 5, also known as GLUDP5, is a human gene. "Human PubMed Reference:". National Center for ...
"Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): ... Soloviev MM, Ciruela F, Chan WY, McIlhinney RA (Feb 2000). "Molecular characterisation of two structurally distinct groups of ... a protein that selectively binds metabotropic glutamate receptors". Nature. 386 (6622): 284-8. doi:10.1038/386284a0. PMID ... Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell ...
Like all glutamate receptors, mGluRs bind with glutamate, an amino acid that functions as an excitatory neurotransmitter. The ... Endoh T (October 2004). "Characterization of modulatory effects of postsynaptic metabotropic glutamate receptors on calcium ... The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect ... Metabotropic glutamate receptors are also thought to affect dopaminergic and adrenergic neurotransmission. Like other glutamate ...
... a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding ... pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino- 1a ... Kim J, Lee S, Park H, Song B, Hong I, Geum D, Shin K, Choi S (March 2007). "Blockade of amygdala metabotropic glutamate ... CPCCOEt is a drug used in scientific research, which acts as a non-competitive antagonist at the metabotropic glutamate ...
Enz R (Mar 2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS Letters ... characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4". ... "Entrez Gene: GRM4 glutamate receptor, metabotropic 4". Chaudhari N, Landin AM, Roper SD (Feb 2000). "A metabotropic glutamate ... "Molecular characterization and localization of human metabotropic glutamate receptor type 4". Brain Research. Molecular Brain ...
To remain open, glutamate and glycine must bind to the NMDA receptor. An NMDA receptor that has glycine and glutamate bound to ... "Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 ... binding to neurotransmitter glutamate sites; glycine antagonists blocks, binding to glycine sites; noncompetitive antagonists ... Aptiganel (Cerestat, CNS-1102): binds the Mg2+ binding site within the channel of the NMDA receptor. HU-211: an enantiomer of ...
Specifically, the catalytic residue has been identified on the PDHB subunit, the 89th residue, which is a glutamate. In forming ... Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length- ... Korotchkina LG, Patel MS (Feb 2008). "Binding of pyruvate dehydrogenase to the core of the human pyruvate dehydrogenase complex ... Fang R, Nixon PF, Duggleby RG (Oct 1998). "Identification of the catalytic glutamate in the E1 component of human pyruvate ...
... and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". The Journal of Biological Chemistry. ... Schulz HL, Stohr H, Weber BH (June 2002). "Characterization of three novel isoforms of the metabotrobic glutamate receptor 7 ( ... Metabotropic glutamate receptor 7 is a protein that in humans is encoded by the GRM7 gene. L-glutamate is the major excitatory ... Enz R (March 2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS ...
"Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3". Proceedings of the ... Traiffort E, Ruat M, O'Regan S, Meunier FM (March 2005). "Molecular characterization of the family of choline transporter-like ... "Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells ...
2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". ... Teyssier C, Belguise K, Galtier F, Chalbos D (2001). "Characterization of the physical interaction between estrogen receptor ... and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221-4. doi: ... Glutamate receptor-interacting protein 1 is a protein that in humans is encoded by the GRIP1 gene. GRIP1 (gene) has been shown ...
The S-adenosylhomocysteine-binding site is formed mainly by the large domain, with contributions from residues within the N- ... Burgess-Cassler A, Ullah AH, Ordal GW (1982). "Purification and characterization of Bacillus subtilis methyl-accepting ... protein L-glutamate ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + protein L-glutamate methyl ester Thus, ... The C-terminal domain has the characteristics of a nucleotide-binding fold, with an insertion of a small anti-parallel beta- ...
Based on functional characterization, there are two known gating mechanism: protopore and common gating. The protopore gating, ... When the presynaptic neuron releases neurotransmitters at the end of an action potential, they bind to ligand-gated ion ... also known as fast gating, is associated with occlusion of the pore via side-chain of conserved glutamate. While the common ...
The bound BIM1 inhibitor blocks the ATP-binding site and puts the kinase domain into an intermediate open conformation. The ... The PKCiota-BIM1 complex interacts with the zinc finger of lambda/iota PKC characterization of lambda-interacting protein (LIP ... involved in this phenomenon mimic glutamate and can adopt two limiting diastereomeric (syn and anti) conformation ... The bound BIM1 inhibitor blocks bilobal interactions, the ATP-binding site, features an ATP-competitive inhibitor, 2-methyl-1H- ...
Ly CD, Roche KW, Lee HK, Wenthold RJ (2002). "Identification of rat EMAP, a delta-glutamate receptor binding protein". Biochem ... 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40-5. doi:10.1038/ ...
September 2003). "Cloning and characterization of a rat brain receptor that binds the endogenous neuromodulator gamma- ... glutamate. The benzamide antipsychotics-amisulpride, nemonapride, etc.-have been shown to bind to these GHB-activated receptors ... It is a precursor to GABA, glutamate, and glycine in certain brain areas. It acts on the GHB receptor and is a weak agonist at ... GHB has at least two distinct binding sites in the central nervous system. GHB acts as an agonist at the inhibitory GHB ...
"Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing". Proceedings of ... Blanco J, Valenzuela A, Herrera C, Lluís C, Hovanessian AG, Franco R (July 2000). "The HIV-1 gp120 inhibits the binding of ... Lai F, Chen CX, Carter KC, Nishikura K (May 1997). "Editing of glutamate receptor B subunit ion channel RNAs by four ... This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination ...
... and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". The Journal of Biological Chemistry. ... March 2003). "Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain". Journal of ... and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". The Journal of Biological Chemistry. ... Glutamate receptor 4 is a protein that in humans is encoded by the GRIA4 gene. This gene is a member of a family of L-glutamate ...
... functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2". The European ... Rabies virus can bind to mGLuR2 directly and the virus-receptor complex is internalized into the cell together. The complex is ... "New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective ... Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in humans, is encoded by the GRM2 gene. mGluR2 is a G protein- ...
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major ... Garcia EP, Mehta S, Blair LA, Wells DG, Shang J, Fukushima T, Fallon JR, Garner CC, Marshall J (October 1998). "SAP90 binds and ... 1992). "Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit". Mol. ... "Entrez Gene: GRIK5 glutamate receptor, ionotropic, kainate 5". Mehta S, Wu H, Garner CC, Marshall J (May 2001). "Molecular ...