Marekov LN, Steinert PM (1998). "Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell ...

In enzymology, a sphingomyelin synthase (EC 2.7.8.27) is an enzyme that catalyzes the chemical reaction a ceramide + a ... Ullman MD, Radin NS (1974). "The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver". J. Biol. Chem ... The systematic name of this enzyme class is ceramide:phosphatidylcholine cholinephosphotransferase. Other names in common use ... the two substrates of this enzyme are ceramide and phosphatidylcholine, whereas its two products are sphingomyelin and 1,2- ...

Du W, Gervay-Hague J (May 2005). "Efficient synthesis of alpha-galactosyl ceramide analogues using glycosyl iodide donors". Org ...

The ceramide is transported to the Golgi apparatus where it can be converted to sphingomyelin. Sphingomyelin synthase is ... Studies in the late 1990s had found that ceramide was produced in a variety of conditions leading to apoptosis. It was then ... The sphingosine and fatty acid can collectively be categorized as a ceramide. This composition allows sphingomyelin to play ... The dihydrosphingosine undergoes N-acylation followed by desaturation to yield a ceramide. Each one of these reactions occurs ...

2004). "Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis". J. Biol. Chem. 279 (2): 1281-90 ...

"Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis". The Journal of ...

Ceramide and sphingomyelin have clinical relevance: In patients with major depressive disorder, elevated ASM activity has been ... 2008). "Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis" (PDF). Nat Med ... In cystic fibrosis, accumulation of ceramide can be lowered using FIASMAs such as amitriptyline. Cell culture-based experiments ... where it cleaves sphingomyelin to ceramide and sphingosine, the latter of which is then phosphorylated to sphingosine-1- ...

Dimethylsphingosine Fingolimod Radin N (2003). "Killing tumours by ceramide-induced apoptosis: a critique of available drugs". ... Sphingolipid metabolites, such as ceramides, sphingosine and sphingosine-1-phosphate, are lipid signaling molecules involved in ... acylated to dihydroceramide finally oxidized by FAD to ceramide. Sphingosine is then solely formed via degradation of ...

It is also known as CD77, Gb3, GL3, and ceramide trihexoside. It is one of the few clusters of differentiation that is not a ... "The role of ceramide trihexoside (globotriaosylceramide) in the diagnosis and follow-up of the efficacy of treatment of Fabry ...

It was concluded that using ceramide cleanser and ceramide moisturizing cream caused the favorable tolerability, did not ... Studies show that ceramide-containing moisturizers are important for optimal skin care; they enhance acne therapy adherence and ... Moisturizers, especially ceramide-containing moisturizers, as an adjunct therapy are particularly helpful for the dry skin and ... Zeichner, Joshua A.; Del Rosso, James Q. (December 2016). "Multivesicular Emulsion Ceramide-containing Moisturizers: An ...

1997). "Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis". Science. 277 (5332): 1652-5. doi:10.1126/ ...

Chemically, it is water (80%), lipids (10%) and proteins (10%). The lipids include ceramides, cholesterol, fatty acids, ...

These corneocytes are embedded in a lipid matrix composed of ceramides, cholesterol, and fatty acids. The stratum corneum ... the cell membrane is replaced by a layer of ceramides which become covalently linked to an envelope of structural proteins (the ...

"A PAMPA study of the permeability-enhancing effect of new ceramide analogues". Chemistry & Biodiversity. 6 (11): 1867-74. doi: ...

"Ceramide regulates atypical PKCzeta/lambda-mediated cell polarity in primitive ectoderm cells. A novel function of ...

UDP-N-acetylgalactosamine: (N-acetylneuraminyl)-galactosylglucosyl ceramide N-acetylgalactosaminyltransferase in rat brain". ... ceramide This enzyme catalyses the formation of the gangliosides (i.e. sialic-acid-containing glycosphingolipids) GM2, GD2 and ... ceramide 4-beta-N-acetyl-D-galactosaminyltransferase. This enzyme catalyses the following chemical reaction UDP-N-acetyl-D- ... ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine GM3 N- ...

Yin X, Zafrullah M, Lee H, Haimovitz-Friedman A, Fuks Z, Kolesnick R (2009). "A ceramide-binding C1 domain mediates kinase ... Instead, they interact with other lipids, such as ceramide or phosphatidic acid, and even aid in the recognition of activated ...

Li, Shaojie; Du, Liangcheng; Yuen, Gary; Harris, Steven D. (2006). "Distinct Ceramide Synthases Regulate Polarized Growth in ... to have anti-fungal activity mediated through the disruption of the biosynthesis of Sphingolipid's by targeting a ceramide ...

Qu Y, Zhang HB, Liu JK (2004). "Isolation and structure of a new ceramide from the Basidiomycete Hygrophorus eburneus". ... Additional secondary metabolites discovered in H. eburneus include the ceramide compound named hygrophamide ((2S,3R,4R,2'R)-2-( ...

cite journal}}: Cite journal requires ,journal= (help) Hoekstra, D. (1999). "Ceramide-mediated apoptosis of hepatocytes in vivo ...

November 2001). "Localization of ceramide and glucosylceramide in human epidermis by immunogold electron microscopy". The ...

Han X, Amar S (2004). "Secreted frizzled-related protein 1 (SFRP1) protects fibroblasts from ceramide-induced apoptosis". J. ...

... and biological functions of Fonsecaea pedrosoi ceramide monohexosides". Infection and Immunity. 73 (12): 7860-7868. doi:10.1128 ...

If the ceramide transporter protein is involved, it will go to the TGN to form sphingomyelin. If the vesicles are the ones in ... The ER is the compartment where the synthesis of ceramide is produced. Then, it will move to the Golgi apparatus. ...

Alternatively, fatty acids can be converted to lipid intermediates like diacylglycerol, ceramides and fatty acyl-CoAs. These ...

Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and ...

"Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans". Genes & Development. 15 (2): 201- ...

They consist of a hydrophobic ceramide part and a glycosidically bound carbohydrate part. This oligosaccharide content remains ... a lactose disaccharide that is glycosidically bound to a ceramide. Larger structures are subdivided into different groups by ...

2006). "Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide". Mol. Cell. ...

S1P is formed from ceramide, which is composed of a sphingosine and a fatty acid. Ceramidase, an enzyme primarily present in ... plasma membrane, will convert ceramide to sphingosine. sphingosine is then phosphorylated by sphingosine kinase (SK) isoenzymes ...