ACER3
Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and ...
Maurizio Del Poeta
"Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans". Genes & Development. 15 (2): 201- ...
Glycosphingolipid
They consist of a hydrophobic ceramide part and a glycosidically bound carbohydrate part. This oligosaccharide content remains ... a lactose disaccharide that is glycosidically bound to a ceramide. Larger structures are subdivided into different groups by ...
SGPP1
2006). "Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide". Mol. Cell. ...
Sphingosine-1-phosphate
S1P is formed from ceramide, which is composed of a sphingosine and a fatty acid. Ceramidase, an enzyme primarily present in ... plasma membrane, will convert ceramide to sphingosine. sphingosine is then phosphorylated by sphingosine kinase (SK) isoenzymes ...
Ceramidase
... (EC 3.5.1.23, acylsphingosine deacylase, glycosphingolipid ceramide deacylase) is an enzyme which cleaves fatty ... Ceramide, SPH, and S1P are bioactive lipids that mediate cell proliferation, differentiation, apoptosis, adhesion, and ... regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta. 1781 ... acids from ceramide, producing sphingosine (SPH) which in turn is phosphorylated by a sphingosine kinase to form sphingosine-1- ...
Lipid
... ceramide phosphocholines), whereas insects contain mainly ceramide phosphoethanolamines and fungi have phytoceramide ... Ceramides (N-acyl-sphingoid bases) are a major subclass of sphingoid base derivatives with an amide-linked fatty acid. The ... Hinkovska-Galcheva V, VanWay SM, Shanley TP, Kunkel RG (November 2008). "The role of sphingosine-1-phosphate and ceramide-1- ... These include sphingosine-1-phosphate, a sphingolipid derived from ceramide that is a potent messenger molecule involved in ...
ACER2
Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and ...
ENPP7
Animal studies showed that supplement of SM or ceramide in the diet may inhibit the development of colon cancer. Of particular ... Recent studies on ENPP7 knockout mice clearly showed that digestion of sphingomyelin and generation of ceramide is severely ... ENPP7 may have important roles in preventing tumorigenesis in the intestinal tract, as ceramide, the product of sphingomyelin ... Recent studies further showed that formation of ceramide by ENPP7 in the gut enhanced sphingomyelin-induced inhibition of ...
Progressive symmetric erythrokeratodermia
This gene encodes 3-ketodihydrosphingosine reductase, an enzyme in the ceramide synthesis pathway. The authors also reported ...
Sortilin 1
"Sortilin drives hypertension by modulating sphingolipid/ceramide homeostasis and by triggering oxidative stress". The Journal ...
Farber disease
When the enzyme is deficient, this leads to an accumulation of fatty material (called ceramide) in the lysosomes of the cells, ... Acid ceramidase is responsible for breaking down ceramide into sphingosine and fatty acid. ...
Starfish
Various ceramides are also known from starfish and a small number of alkaloids have also been identified. The functions of ...
Lipid droplet
Alternatively, fatty acids can be converted to lipid intermediates like diacylglycerol (DAG), ceramides and fatty acyl-CoAs. ...
Palmitoyl-CoA
"Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum". FEBS Letters. 416 (2): ...
Lipid raft
2006). "Effects of ceramide on liquid-ordered domains investigated by simultaneous AFM and FCS". Biophysical Journal. 90 (12): ... An alternative receptor for HIV-1 envelope glycoprotein on epithelial cells is glycosphingolipid galactosyl-ceramide (GalCer), ...
Perilipin-5
PLIN5-knockout diabetic mice might avoid excess accumulation of lipotoxic molecules such as DAG and ceramide, a common problem ... The built up of DAG and ceramide disrupts several signaling pathways, including PKC pathway. However, in humans, the ...
Protein kinase, AMP-activated, alpha 1
Blázquez C, Geelen MJ, Velasco G, Guzmán M (2001). "The AMP-activated protein kinase prevents ceramide synthesis de novo and ...
Intramuscular fat
Instead, IMTG metabolites, such as diacylglycerol and ceramide are responsible for the insulin resistance. Studies ...
ABCA12
2009). "Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes". J ...
Ganglioside galactosyltransferase
Other names in common use include UDP-galactose-ceramide galactosyltransferase, uridine diphosphogalactose-ceramide ... UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceram ide galactosyltransferase in rat brain". ... galactosyl-glucosyl-ceramide galactosyltransferase, UDP-galactose-GM2 ganglioside galactosyltransferase, and GM1-synthase. This ... galactosyltransferase, UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase, UDP-galactose-GM2 galactosyltransferase, ...
GM1
... consists of a sialic acid-containing oligosaccharide covalently attached to a ceramide lipid. The A1 subunit of this toxin ...
Glucosylceramide beta-1,4-galactosyltransferase
This enzyme catalyses the following chemical reaction UDP-alpha-D-galactose + beta-D-glucosyl-(1<->1)-ceramide ⇌ {\displaystyle ... Chatterjee S, Ghosh N, Khurana S (April 1992). "Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 ... ceramide beta-1,4-galactosyltransferase) is an enzyme with systematic name UDP-alpha-D-galactose:beta-D-glucosyl-(1<->1)- ... glucosyl ceramide beta 1-4 galactosyltransferase, UDP-Gal:glucosylceramide beta1->4galactosyltransferase, GalT-2, UDP-galactose ...
Nicotinamide
Tanno O, Ota Y, Kitamura N, Katsube T, Inoue S (September 2000). "Nicotinamide increases biosynthesis of ceramides as well as ... Niacinamide increases the biosynthesis of ceramides in human keratinocytes in vitro and improves the epidermal permeability ...
SPTLC2
Epidermal ceramides are critical for normal skin barrier function and SPTLC2 is differentially expressed across body sites to ... Sphingosine is also a substrate for the synthesis of various other molecules including, ceramides, sphingomyelin, cerebrosides ... SPTLC2 is highly upregulated in psoriasis and is likely responsible for some of the epidermal ceramide alterations seen in ... regulate epidermal ceramide composition. In particular, SPTLC2 is upregulated in acral granular layer keratinocytes. SPTLC2 is ...
Fatty acid
Together with cholesterol and ceramides, free fatty acids form a water-impermeable barrier that prevents evaporative water loss ... Generally, the epidermal lipid matrix is composed of an equimolar mixture of ceramides (about 50% by weight), cholesterol (25 ...
SOCS3
Yang G, Badeanlou L, Bielawski J, Roberts AJ, Hannun YA, Samad F (2009). "Central role of ceramide biosynthesis in body weight ... SOCS3 contributes to both leptin resistance and insulin resistance as a result of increased ceramide synthesis. For that reason ...
Mucositis
This results in the upregulation of pro-inflammatory cytokines, ceramide, nitric oxide and matrix metalloproteinases. The ...
Sphingomyelin phosphodiesterase
The activation of SMase has been suggested as a major route for the production of ceramide in response to cellular stresses. ... Hannun YA, Obeid LM (July 2002). "The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the ... The phosphate then reforms its tetrahedral conformation and results in the products ceramide and phosphocholine. In 2016 a ... lysosomal acidic SMase and the magnesium-dependent neutral SMase are considered major candidates for the production of ceramide ...
Helga (Elga) De Vries
... ceramide, alter disease processes. She found that in the brains of MS patients, astrocytes were the main producers of ceramide ... "Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes ...