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*  Carmofur
However, carmofur is a highly potent acid ceramidase (AC) inhibitor. Ceramide influences cancer cell survival, growth and death ... "Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity". Scientific Reports. 3 ( ...
*  Ceramidase
Presently, 7 human ceramidases encoded by 7 distinct genes have been cloned: acid ceramidase (ASAH1) - cell survival neutral ... Ceramidase at the US National Library of Medicine Medical Subject Headings (MeSH) EC 3.5.1.23 Molecular and Cellular Biology ... Ceramidase (EC 3.5.1.23, acylsphingosine deacylase, glycosphingolipid ceramide deacylase) is an enzyme which cleaves fatty ... UT Southwestern researchers showed that introducing ceramidase in diabetic mice returned their insulin sensitivity to normal. ...
*  ASAH2
Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene. GRCh38: Ensembl release 89: ENSG00000188611 - ... 2004). "Neutral ceramidase gene: role in regulating ceramide-induced apoptosis". Gene. 315: 113-22. doi:10.1016/S0378-1119(03) ... 2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... A novel but highly conserved gene family of neutral/alkaline ceramidases". J. Biol. Chem. 275 (15): 11229-34. doi:10.1074/jbc. ...
*  ASAH1
2000). "Human acid ceramidase is overexpressed but not mutated in prostate cancer". Genes Chromosomes Cancer. 29 (2): 137-46. ... 2001). "Human acid ceramidase: processing, glycosylation, and lysosomal targeting". J. Biol. Chem. 276 (38): 35352-60. doi: ... The ASAH1 gene encodes in humans the acid ceramidase enzyme. This gene encodes a heterodimeric protein consisting of a ... 2003). "Mutation analysis of the acid ceramidase gene in Japanese patients with Farber disease". J. Inherit. Metab. Dis. 25 (7 ...
*  ACER3
Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene. GRCh38: Ensembl ... Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and ... "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide". J. Biol. ...
*  ASAH2C
Neutral ceramidase C also known as N-acylsphingosine amidohydrolase 2C or non-lysosomal ceramidase C or ASAH2C is a ceramidase ... Hwang YH, Tani M, Nakagawa T, Okino N, Ito M (May 2005). "Subcellular localization of human neutral ceramidase expressed in ... Choi MS, Anderson MA, Zhang Z, Zimonjic DB, Popescu N, Mukherjee AB (October 2003). "Neutral ceramidase gene: role in ... "Identification of a novel amidase motif in neutral ceramidase". The Biochemical Journal. 393 (Pt 3): 687-95. doi:10.1042/ ...
*  ASAHL
2005). "Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain". Eur. J. Neurosci. 20 (12): 3489- ... This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript ... "Entrez Gene: ASAHL N-acylsphingosine amidohydrolase (acid ceramidase)-like". Human NAAA genome location and NAAA gene details ... Schulze H, Schepers U, Sandhoff K (2008). "Overexpression and mass spectrometry analysis of mature human acid ceramidase". Biol ...
*  ACER2
Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene. The ACER2/ ... Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates ... 2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys ...
*  Lipid signaling
Sphingosine (Sph) is formed by the action of ceramidase (CDase) enzymes on ceramide in the lysosome. Sph can also be formed in ... The low levels of Sph and their increase in response to stimulation of cells, primarily by activation of ceramidase by growth- ... 2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... Ceramide can also be broken down by enzymes called ceramidases, leading to the formation of sphingosine, Moreover, a phosphate ...
*  ACER1
Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene. ACER1 mediates ... "Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal ... Ito M, Okino N, Tani M, Mitsutake S, Mori K (Mar 2002). "[Molecular evolution of neutral ceramidase: signalling molecule and ... "Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates ...
*  IRF8
In chronic myelogenous leukemia (CML), IRF8 regulates acid ceramidase to mediate CML apoptosis. IRF8 is highly expressed in ... "IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia". Cancer Res. 71 (8): 2882- ...
*  Sphingolipid
Finally, ceramide may be broken down by a ceramidase to form sphingosine. Sphingosine may be phosphorylated to form sphingosine ...
*  Farber disease
Normally, the enzyme ceramidase breaks down fatty material in the body's cells. In Farber Disease, the gene responsible for ... Farber disease (also known as Farber's lipogranulomatosis, ceramidase deficiency, "Fibrocytic dysmucopolysaccharidosis," and " ... autosomal recessive lysosomal storage disease marked by a deficiency in the enzyme ceramidase that causes an accumulation of ...
*  Sphingosine-1-phosphate
Sphingosine can be released from ceramides, a process catalyzed by the enzyme ceramidase. Phosphorylation of sphingosine is ...
*  ENPP7
... neutral ceramidase, and sphingolipid metabolites". Pediatr. Res. 61 (1): 61-6. doi:10.1203/01.pdr.0000250534.92934.c2. PMID ...
*  Roivant Sciences
One of its treatments is a version of ceramidase being developed as treatment for Farber disease. Another was licensed from ...
*  N-acylethanolamine acid amide hydrolase
NAAA's primary structure is nearly identical to that of acid ceramidase (AC), whose only difference is the substitution of Leu ... It does have 30% homology with acid ceramidase, sharing a significant portion of its amino acid sequence. NAAA was discovered ... While it was discovered within the last decade, its structural similarity to the more familiar acid ceramidase (AC) and ... a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase". The ...
*  Fumonisin B1
... de formation via de novo sphinganine and fatty acyl-CoA and via sphingosine produced by the breakdown of ceramide by ceramidase ...
*  Juvenile idiopathic arthritis
... genetic lysosomal disorder caused by a deficiency of the enzyme acid ceramidase. It has symptoms similar to JIA including ...
*  Ceramide
... can be further hydrolyzed by acid ceramidase to form sphingosine and a free fatty acid, both of which are able to ... Anandamide Ceramidase Inhibitors Chemotherapeutic agents Fas ligand Endotoxin homocysteine heat gamma interferon ionizing ...
*  Hugo Moser (scientist)
... and they identified acid ceramidase as the enzyme deficient in Farber's disease. In 1964, Moser returned to the Joseph P. ...
*  ASAH2B
Neutral ceramidase B also known as non-lysosomal ceramidase B or N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B ... or ASAH2B is a ceramidase enzyme which in humans is encoded by the ASAH2B gene. ASAH2B shows reduced expression with increasing ...
*  List of diseases (C)
Ceramidase deficiency Ceramide trihexosidosis Ceraunophobia Cerebellar agenesis Cerebellar ataxia areflexia pes cavus optic ...
*  Daniele Piomelli
Acid Ceramidase inhibitors). Daniele Piomelli is scientific cofounder of Kadmus Pharmaceuticals and Thesan Pharmaceuticals. Di ... "Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity". Science Reports 3:1035. ...
*  ASAH
... acid ceramidase), an enzymatic product of ASAH1, gene mutated in Farber disease. ...