Pierre Gönczy
"SAS-6 defines a protein family required for centrosome duplication in C. Elegans and in human cells". Nature Cell Biology. 7 (2 ... "SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells". Nature Cell Biology. 7 (2 ...
TUBGCP2
It is part of the gamma-tubulin complex, which is required for microtubule nucleation at the centrosome. Tubulin TUBGCP3 ...
Proximal Centriole-Like
The PCL recruits pericentriolar material (PCM) forming a centrosome that acts as a microtubule-organizing center (MTOC). The ...
HBx
... and this interaction dysregulates centrosome dynamics and mitotic spindle formation. It interacts with DDB1 (Damaged DNA ... "Interaction of hepatitis B viral oncoprotein with cellular target HBXIP dysregulates centrosome dynamics and mitotic spindle ...
Golgi apparatus
In mammals, a single Golgi apparatus is usually located near the cell nucleus, close to the centrosome. Tubular connections are ...
Zinc chromate
ISBN 978-1-85957-096-8. Holmes, A.L. (15 February 2011). "Chronic exposure to zinc chromate induces centrosome amplification ...
NUBP2
... and is implicated in the regulation of centrosome duplication". J Cell Sci. 119 (Pt 10): 2035-47. doi:10.1242/jcs.02922. PMID ...
HEPACAM2
Poly (ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome ...
MAPRE1
Immunofluorescence has demonstrated that EB1 localizes to the centrosome, mitotic spindle, and distal tips of cytoplasmic ... is required for the formation and maintenance of a radial microtubule array anchored at the centrosome". Mol. Biol. Cell. 13 ( ...
Polo-like kinase
These include the centrosomes in early M phase, the spindle midzone in early and late anaphase and the midbody during ... During mitosis and cytokinesis, Plks associate with several structures including the centrosome, kinetochores, and the central ... and some proteins such as gamma-tubulin fail to recruit spindle poles in the absence of Plk1 for centrosome maturation. Several ...
JUB (gene)
"LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis". FEBS Lett. 580 ...
Orofaciodigital syndrome 1
OFD1 localizes to both centrosomes and basal bodies within the human genetic cellular structure. This suggests that this ...
Regulator of cell cycle RGCC
The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex ... is located on centrosomes during mitosis and results in G2/M arrest". Oncogene. 26 (8): 1110-21. doi:10.1038/sj.onc.1210148. ...
Cdc14
The nematode Caenorhabditis elegans makes one Cdc14 (CeCdc14), which localizes to the spindle and centrosomes in mitosis, and ... or centrosome behavior. There is evidence that Cdc14 may participate in a DNA damage checkpoint. A novel role for Cdc14 in ... "Xenopus Cdc14 alpha/beta are localized to the nucleolus and centrosome and are required for embryonic cell division". BMC Cell ...
CEP120
This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar ...
NEDD9
However, some of the protein is also cytoplasmic, and small pools localize to the centrosome and the basal body of cilia. At ... NEDD9 binds directly to the Aurora-A mitotic kinase at the centrosome, and promotes its activity, allowing cells to enter ... On the other hand, cells with depleted NEDD9 have prematurely separated centrosomes and are deficient in microtubule organizing ... "The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome". Nat. Cell ...
CASS4
"The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome". Nature ...
Telophase
"GAK is phosphorylated by c-Src and translocated from the centrosome to chromatin at the end of telophase". Cell Cycle. 16 (5): ...
Folliculin
FLCN protein was found to localize on primary cilia, the basal body and centrosome in different cell types. FLCN siRNA ...
Cyclin-dependent kinase 6
When the CDK6 gene is mutated in these developing lines, the centrosomes are not properly divided, this could lead to division ... There is evidence that CDK6 associates with the centrosome and controls organized division and cell cycle phases in neuron ... December 2013). "CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary ...
STIL
PLK4 overexpression also causes centrosome amplification and aneuploidy, which reduce brain volume as a result of cell death . ...
Sema Sgaier
2010). "Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal ... 2010). "Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal ...
Cyclin B1
... association with a detergent-resistant compartment and with the centrosome". J. Cell Sci. 101 (3): 529-45. doi:10.1242/jcs. ...
RINT1
2007). "RINT-1 Serves as a Tumor Suppressor and Maintains Golgi Dynamics and Centrosome Integrity for Cell Survival". Mol. Cell ...
Outline of cell biology
Centrosome - The main microtubule organizing center of animal cells as well as a regulator of cell-cycle progression. Lysosome ... In 1888 identified the centrosome and described it as the 'special organ of cell division.' Peter D. Mitchell - British ...
TUBE1
... two new human centrosomal tubulins reveal new aspects of centrosome structure and function". Nature Cell Biology. 2 (1): 30-5. ... localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome ...
UNC84A
"Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome". ...
TUBD1
... two new human centrosomal tubulins reveal new aspects of centrosome structure and function". Nature Cell Biology. 2 (1): 30-5. ...
Cyclin A2
... association with a detergent-resistant compartment and with the centrosome". J. Cell Sci. 101 (3): 529-545. doi:10.1242/jcs. ...
CHEK2
Tsvetkov L, Xu X, Li J, Stern DF (March 2003). "Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the ...