"SAS-6 defines a protein family required for centrosome duplication in C. Elegans and in human cells". Nature Cell Biology. 7 (2 ... "SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells". Nature Cell Biology. 7 (2 ...
It is part of the gamma-tubulin complex, which is required for microtubule nucleation at the centrosome. Tubulin TUBGCP3 ...
The PCL recruits pericentriolar material (PCM) forming a centrosome that acts as a microtubule-organizing center (MTOC). The ...
... and this interaction dysregulates centrosome dynamics and mitotic spindle formation. It interacts with DDB1 (Damaged DNA ... "Interaction of hepatitis B viral oncoprotein with cellular target HBXIP dysregulates centrosome dynamics and mitotic spindle ...
In mammals, a single Golgi apparatus is usually located near the cell nucleus, close to the centrosome. Tubular connections are ...
ISBN 978-1-85957-096-8. Holmes, A.L. (15 February 2011). "Chronic exposure to zinc chromate induces centrosome amplification ...
... and is implicated in the regulation of centrosome duplication". J Cell Sci. 119 (Pt 10): 2035-47. doi:10.1242/jcs.02922. PMID ...
Poly (ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome ...
Immunofluorescence has demonstrated that EB1 localizes to the centrosome, mitotic spindle, and distal tips of cytoplasmic ... is required for the formation and maintenance of a radial microtubule array anchored at the centrosome". Mol. Biol. Cell. 13 ( ...
These include the centrosomes in early M phase, the spindle midzone in early and late anaphase and the midbody during ... During mitosis and cytokinesis, Plks associate with several structures including the centrosome, kinetochores, and the central ... and some proteins such as gamma-tubulin fail to recruit spindle poles in the absence of Plk1 for centrosome maturation. Several ...
"LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis". FEBS Lett. 580 ...
OFD1 localizes to both centrosomes and basal bodies within the human genetic cellular structure. This suggests that this ...
The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex ... is located on centrosomes during mitosis and results in G2/M arrest". Oncogene. 26 (8): 1110-21. doi:10.1038/sj.onc.1210148. ...
The nematode Caenorhabditis elegans makes one Cdc14 (CeCdc14), which localizes to the spindle and centrosomes in mitosis, and ... or centrosome behavior. There is evidence that Cdc14 may participate in a DNA damage checkpoint. A novel role for Cdc14 in ... "Xenopus Cdc14 alpha/beta are localized to the nucleolus and centrosome and are required for embryonic cell division". BMC Cell ...
This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar ...
However, some of the protein is also cytoplasmic, and small pools localize to the centrosome and the basal body of cilia. At ... NEDD9 binds directly to the Aurora-A mitotic kinase at the centrosome, and promotes its activity, allowing cells to enter ... On the other hand, cells with depleted NEDD9 have prematurely separated centrosomes and are deficient in microtubule organizing ... "The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome". Nat. Cell ...
"The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome". Nature ...
"GAK is phosphorylated by c-Src and translocated from the centrosome to chromatin at the end of telophase". Cell Cycle. 16 (5): ...
FLCN protein was found to localize on primary cilia, the basal body and centrosome in different cell types. FLCN siRNA ...
When the CDK6 gene is mutated in these developing lines, the centrosomes are not properly divided, this could lead to division ... There is evidence that CDK6 associates with the centrosome and controls organized division and cell cycle phases in neuron ... December 2013). "CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary ...
PLK4 overexpression also causes centrosome amplification and aneuploidy, which reduce brain volume as a result of cell death . ...
2010). "Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal ... 2010). "Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal ...
... association with a detergent-resistant compartment and with the centrosome". J. Cell Sci. 101 (3): 529-45. doi:10.1242/jcs. ...
2007). "RINT-1 Serves as a Tumor Suppressor and Maintains Golgi Dynamics and Centrosome Integrity for Cell Survival". Mol. Cell ...
Centrosome - The main microtubule organizing center of animal cells as well as a regulator of cell-cycle progression. Lysosome ... In 1888 identified the centrosome and described it as the 'special organ of cell division.' Peter D. Mitchell - British ...
... two new human centrosomal tubulins reveal new aspects of centrosome structure and function". Nature Cell Biology. 2 (1): 30-5. ... localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome ...
"Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome". ...
... two new human centrosomal tubulins reveal new aspects of centrosome structure and function". Nature Cell Biology. 2 (1): 30-5. ...
... association with a detergent-resistant compartment and with the centrosome". J. Cell Sci. 101 (3): 529-545. doi:10.1242/jcs. ...
Tsvetkov L, Xu X, Li J, Stern DF (March 2003). "Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the ...