A tubulin-like protein, FtsZ plays a critical role in formation of a contractile ring for the cell division. Cell division in ... In metaphase, the centromeres of the chromosomes align themselves on the metaphase plate (or equatorial plate), an imaginary ... One of these proteins that is broken down is securin which through its breakdown releases the enzyme separase that cleaves the ... This process is evidenced to be caused in a large part by the highly conserved Spo11 protein through a mechanism similar to ...

Detailed analysis of protein expression in Dictyostelium has been hampered by large shifts in the protein expression profile ... leading researchers to believe it serves as centromeres. The repeats correspond to repeated sequences of amino acids and are ... The role of the RER in the intracellular infection is not known, but the RER is not required as a source of proteins for the ... Defects in DNA repair lead to devastating human cancers, so the ability to study human repair proteins in a simple tractable ...

This protein is also predicted as a DNA binding protein. The protein may assume a tertiary structure of a coiled coil. ... 14 is a gene of uncertain function located at 3p14.2 near fragile site FRBA3-which falls between this gene and the centromere. ... protein name). The mRNA is composed of 6 exons, and encodes a 15007.84 kD protein known as HT021. This protein has a pre- ... Its protein is expected to localize to the nucleus and bind DNA. Orthologs have been identified in all of the major animal ...

... generates a nuclear protein responsible for oestrogen receptor associated protein repression. Gene expression of stem ... similar regions of disrupted growth and four regions of enhanced growth starting from the telomere and ending at the centromere ... Articles with short description, Short description matches Wikidata, Genes on human chromosome 8, Protein pages needing a ...

Protein Mis18-alpha is a protein that in humans is encoded by the MIS18A gene. GRCh38: Ensembl release 89: ENSG00000159055 - ... Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C, Yanagida M (Jan 2007). "Priming of centromere for CENP-A ... "P5644 interacts with phosphatidylinositol-4-phosphate adaptor protein-1 associated protein-1". Molecular and Cellular ... "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins ...

... protein - protein biosynthesis - Protein Data Bank - protein design - protein expression - protein folding - protein isoform - ... centromere - centrosome - chaperone - chelation - chemical biology - chemical bond - chemical compound - conformation - ... protein P16 - protein P34cdc2 - protein precursor - protein structure prediction - protein subunit - protein synthesis - ... proto-oncogene protein C-kit - proto-oncogene proteins c-abl - proto-oncogene proteins c-bcl-2 - Proto-oncogene proteins c-fos ...

CLIP-associated proteins like CLASP1 in humans have also been shown to localize to plus-ends and the outer kinetochore as well ... at the centromere. While these dynamic rearrangements are vitally important to ensure accurate and high-fidelity segregation of ... The microtubule-associated protein Augmin acts in conjunction with γ-TURC to nucleate new microtubules off of existing ... Microtubule-associated proteins (MAPs) associate with microtubules at the midzone and the spindle poles to regulate their ...

... lack a homologue of the Boule protein that appears to be ubiquitous and conserved in males of all species of other ... Three pairs are metacentric, meaning that the centromere, the attachment point for the spindle fibers in cell division, is ... Though Trichoplax has a small genome in comparison to other animals, nearly 87% of its 11,514 predicted protein-coding genes ... The Trichoplax genome contains about 98 million base pairs and 11,514 predicted protein-coding genes. All nuclei of placozoan ...

... is a poison that disrupts cell division by affecting the protein threads that connect the centromere regions of chromosomes, ... Its origin stems from kinetochores, proteins that aid in joining DNA and microtubules on the chromatids. Only one unattached ... The mitotic spindle is composed of microtubules (polymerized tubulin) that aid, along with regulatory proteins, each other in ... Even though numerous other spindle proteins exist that could be the target of novel chemotherapeutics, tubulin-binding agents ...

In biological samples this allows a scientist to directly make a protein of interest fluorescent. The protein location can then ... LIMON microscopy Human lymphocyte nucleus stained with DAPI with chromosome 13 (green) and 21 (red) centromere probes ... pioneer of fluorescence microscopy techniques for visualization of bacterial subcellular proteins Green fluorescent protein ( ... DNA is stained blue, a protein called INCENP is green, and the microtubules are red. Each fluorophore is imaged separately ...

2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a ... 2004). "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins". J. Biochem. 133 (6): 713-8. ... Serrate RNA effector molecule homolog (SRRT) also known as arsenite-resistance protein 2 (ARS2) is a protein that in humans is ... It enables the binding activity of the mRNA cap binding complex and the adaptor activity of certain protein molecules. It can ...

... brightfield tricolor visualization of HER2 protein, the HER2 gene, and chromosome 17 centromere (CEN17) in formalin-fixed, ... Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ... HER2 proteins have been shown to form clusters in cell membranes that may play a role in tumorigenesis. Evidence has also ... The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of ...

2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a ... The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, ... E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene. Polycomb group (PcG) of proteins ... This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and ...

2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a ... Zinc finger protein 91 homolog is a protein that in humans is encoded by the ZFP91 gene. The protein encoded by this gene is a ... "Entrez Gene: ZFP91 zinc finger protein 91 homolog (mouse)". Iuchi S (2001). "Three classes of C2H2 zinc finger proteins". Cell ... Tompkins V, Hagen J, Zediak VP, Quelle DE (2006). "Identification of novel ARF binding proteins by two-hybrid screening". Cell ...

The absence of a localized centromere prompted several studies to identify proteins that are involved in the sister chromatid ... elegans centromeres are not made by centromere-associated retrotransposons nor centromere-associated satellite DNAs, but cenH3 ... Nagaki K, Kashihara K, Murata M (July 2005). "Visualization of diffuse centromeres with centromere-specific histone H3 in the ... proteins seem to be associated with a centromere-specific chromatin folding rather than with specific centromeric DNA sequences ...

The protein EPG5 is expressed primarily in the central nervous system (CNS), skeletal muscle, heart, thymus, cells of the ... consists of 44 exons and is transcriptionally driven from the centromere toward the telomere. The messenger RNA (mRNA) is ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res 7(4): 273-281. Cullup ... the ectopic P-granules autophagy protein 5, involved in the formation of lysosomes. EPG5 is the human homolog of the C.elegans ...

Cai, Mingjie; Davis, Ronald W. (May 1990), "Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is ...

Since assembly of kinetochore proteins at centromeres is affected by the methylation of cytosine and histone proteins, a ... irregularities in kinetochore proteins or their assembly, dysfunctional spindle apparatus, or flawed anaphase checkpoint genes ... centromere instability, and facial anomalies syndrome) or after treatment by DNA methyl transferase inhibitors. ...

Yeast mating Saccharomyces cerevisiae Centromere Computational epigenetics DNA methylation Epigenomics Histone code Human ... Instead, it relies on other SIR proteins to find its appropriate silencing target. In the SIR protein complex, SIR2 removes ... Silent Information Regulator (SIR) proteins are involved in regulating gene expression. SIR proteins organize heterochromatin ... "Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1". Genes & Development. 8 ...

The protein encoded by this gene is a member of the ISWI family of proteins. Members of this family have helicase and ATPase ... Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa ... The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. SMARCA5 has been shown to ... The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the ...

2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a ... Zinc finger protein 91 homolog (mouse), ciliary neurotrophic factor transcription unit, also known as ZFP91-CNTF, is a human ... The co-transcribed mRNA encodes an isoform of ZFP91 but does not appear to encode a CNTF protein. "Human PubMed Reference:". ... Tompkins V, Hagen J, Zediak VP, Quelle DE (2006). "Identification of novel ARF binding proteins by two-hybrid screening". Cell ...

SHC SH2 domain-binding protein 1 is a protein that in humans is encoded by the SHCBP1 gene. SHCBP1 has been shown to interact ... Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi: ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-1178. Bibcode: ...

2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a ... Zinc finger CCCH domain-containing protein 13 is a protein that in humans is encoded by the ZC3H13 gene. GRCh38: Ensembl ... 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355-64. doi: ...

... the cohesin from the chromosome arms is degraded while the cohesin surrounding the centromere remains protected by a protein ... the cell synthesizes its vast array of proteins, including the enzymes and structural proteins it will need for growth. In G1, ... The protein complex cohesin holds sister chromatids together from the time of their replication until anaphase. In mitosis, the ... there is a role of MeiRNA binding protein for entry to meiotic cell division. It has been suggested that Yeast CEP1 gene ...

2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a ... The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated ...

... protein is a CRL4A substrate only when directed by viral proteins §protein is a CRL4A substrate only when directed by IMiDs ... Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa ... DDB2 is a DCAF protein and is both a ubiquitination substrate of the CRL4 complex and also serves as an E3 ligase protein for ... CUL4A belongs to the cullin family of ubiquitin ligase proteins and is highly homologous to the CUL4B protein. CUL4A regulates ...

Centromere protein U MMAA: methylmalonic aciduria (cobalamin deficiency) cblA type MTHFD2L: NAD-dependent ... encoding protein Transmembrane protein 155 TMEM165: encoding protein Transmembrane protein 165 TMEM175: encoding protein ... Serine/threonine-protein kinase PLK4 PPEF2: encoding protein Protein phosphatase with ef-hand domain 2 PSAPL1: encoding protein ... encoding protein B cell scaffold protein with ankyrin repeats 1 BEND4: encoding protein BEN domain containing 4 CCDC109B: ...

The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large ... Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa ... "The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2". FEBS Letters. 579 (5): 1220- ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...

For example, the transcription of a gene located very close to a nucleosome, centromere, or telomere is often repressed or ... Often, the dominant allele codes for a functional protein while its recessive counterpart does not. Dominance is not an ... Mutators are often transposable elements, or may be mutant housekeeping genes such as those that encode helicases or proteins ... pericentric (of a gene or region of a chromosome) Positioned near the centromere of the chromosome. pericentric inversion A ...

They are formed of DNA, RNA and a few proteins. As they are the site of transcription, transcription mechanisms such as RNA ... Another example within the fly itself is the tandem duplication of various polytene bands located near the centromere of the X ... The interbands are involved in the interaction with the active chromatin proteins, nucleosome remodeling, and origin ... "Banding patterns in Drosophila melanogaster polytene chromosomes correlate with DNA-binding protein occupancy". BioEssays. 34 ( ...