The naturally occurring (wild type) p53 is widely involved in cellular processes, including autophagy, response to DNA damage, ... cell cycle regulation and senescence, apoptosis and the generation of adenosine triphosphate (ATP) through oxidative ... 20 December 2010). "Correlation of Cellular Immunity With Human Papillomavirus 16 Status and Outcome in Patients With Advanced ... OPC may include differences in the extent and manner in which cellular growth-regulatory pathways are altered in the two forms ...
It has been suggested that mega-teleomeres may serve as protective mechanism against senescence in long-lived organisms. ... cellular aging, and oncogenesis. ... progress towards a non-human model for replicative senescence ...
Zupanc, G.K.H.; Zupanc, F.B. (2019). "Stochastic cellular automata model of tumorous neurosphere growth: roles of developmental ... The availability of this first vertebrate model of 'negligible senescence' provides unprecedented opportunities for a better ... Sipahi, R.; Zupanc, G.K.H. (2018). "Stochastic cellular automata model of neurosphere growth: roles of proliferative potential ... the laboratory of Zupanc discovered the first vertebrate organism that lacks any of the hallmarks of brain senescence common to ...
Senescence can be induced by un-repaired DNA damage (e.g., from radiation, old age, etc.) or other cellular stress and also is ... "Senescence - Latest research and news , Nature". www.nature.com. Retrieved 28 April 2022. "Definition of SENESCENCE". www. ... Senescence is when cells stop dividing but don't die, but these cells can build up and cause problems in the body. These cells ... "senescence". NCI's Dictionary of Cancer Terms. National Cancer Institute. 2 February 2011. Retrieved 28 April 2022. Borrego- ...
The lower cellular density and proliferation in the mutant tendons, as well as the reduced self-renewal and earlier senescence ... Tnmd exerts a positive effect on tendon-derived stem/progenitor cells by supporting self-renewal and preventing senescence, ... Molecular and Cellular Biology. 30 (20): 4797-807. doi:10.1128/mcb.00207-10. PMC 2950547. PMID 20696843. Miyabara S, Yuda Y, ... Molecular and Cellular Biology. 25 (2): 699-705. doi:10.1128/mcb.25.2.699-705.2005. PMC 543433. PMID 15632070. Kimura N, ...
When the HPG axis becomes unbalanced, cellular growth and development is dysregulated, and cell death and dysfunction can occur ... become dysregulated and drive senescence. Rather than seeing aging as a loss of functionality as we get older, this theory ... The theory argues that these cellular changes are directed by reproductive hormones of the hypothalamic-pituitary-gonadal axis ... both of which can initiate senescence, the accumulated damage to cells, tissues, and organs that occurs with the passage of ...
The climacteric stage of fruit ripening is associated with increased ethylene production and a rise in cellular respiration and ... is the final physiological process that marks the end of fruit maturation and the beginning of fruit senescence. Its defining ...
Intra-cellular features are characteristic of a synthetically active cell. The cell density of full-thickness, human, adult, ... Although chondrocyte senescence occurs with aging, mitotic figures are not seen in normal adult articular cartilage. The ...
Reproductive senescence was measured as the decline in the number of progeny produced over time. On the basis of experimental ... The rate of progression of the cell cycle is further adjusted by additional signals arising from cellular sensors that monitor ... suggested that aging is probably a fundamental property of all cellular organisms. A similar phenomenon has since been ... Ackermann, Martin; Stephen C. Stearns; Urs Jenal (2003). "Senescence in a bacterium with asymmetric division". Science. 300 ( ...
The biologically relevant cellular partners can easily distinguish functional motifs, however computational tools have yet to ... Nutlin-3 antagonises the interaction of MDM2's SWIB domain with p53 thus stabilising p53 and inducing senescence in cancer ... Viruses often mimic human SLiMs to hijack and disrupt a host's cellular machinery, thereby adding functionality to their ... Eudy JD, Sumegi J (October 1999). "Molecular genetics of Usher syndrome". Cellular and Molecular Life Sciences. 56 (3-4): 258- ...
The SENS program aims to prevent or reverse seven forms of molecular or cellular damage associated with aging. During that time ... Methuselah Foundation served as the backbone organization for the strategies for engineered negligible senescence (SENS) ... Get the crud out acknowledges that cellular processes can result in harmful byproducts over time. The strategy promotes ...
Cellular and Molecular Neurobiology. 36 (2): 259-279. doi:10.1007/s10571-015-0327-y. PMID 26993513. S2CID 254384149. Elkahloun ... "Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis ... show that candesartan may have neuroprotective benefits that ameliorate certain central mechanisms of ageing and senescence. ...
Florez-Duquet, M.; Horwitz, B. A.; McDonald, R. B. (1998). "Cellular proliferation and UCP content in brown adipose tissue of ... McDonald, R. B.; Horwitz, B. A. (1999). "Brown adipose tissue thermogenesis during aging and senescence". Journal of ... Barbara A. Horwitz is an American cellular physiologist whose work focuses on metabolism. In particular, her research has ... In addition, Horwitz and collaborators have conducted studies on the cellular mechanisms involved in obesity, neuroplasticity, ...
Similar to the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, ... Anerillas C, Abdelmohsen K, Gorospe M (2020). "Regulation of senescence traits by MAPKs". GeroScience. 42 (2): 397-408. doi: ... which participates in a signaling cascade controlling cellular responses to cytokines and stress. Four p38 MAP kinases, p38-α ( ... a progression factor for amyloid-beta-induced cellular perturbation?". Journal of Alzheimer's Disease. 16 (4): 833-43. doi: ...
... cell senescence and genome stability. His studies on chromosome synapsis, genetic recombination and telomere dynamics attempted ... to widen the understanding of cellular recombination and Holliday junction and he is credited with the discovery of a negative ...
Fujita T, Shirasawa T, Uchida K, Maruyama N (October 1992). "Isolation of cDNA clone encoding rat senescence marker protein-30 ... Yamaguchi M (June 2014). "Regucalcin as a potential biomarker for metabolic and neuronal diseases". Molecular and Cellular ... Fujita T, Shirasawa T, Inoue H, Kitamura T, Maruyama N (September 1998). "Hepatic and renal expression of senescence marker ... Fujita T, Shirasawa T, Maruyama N (March 1999). "Expression and structure of senescence marker protein-30 (SMP30) and its ...
Consistent with the profiling results, ectopic apoptosis was observed in the cellular derivatives of the FoxD1 derived ... "MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer". The ... Williams AE (February 2008). "Functional aspects of animal microRNAs". Cellular and Molecular Life Sciences. 65 (4): 545-62. ... Journal of Cellular Physiology. 233 (8): 5574-5588. doi:10.1002/jcp.26514. PMID 29521426. S2CID 3766576. Liu G, Sun Y, Ji P, Li ...
Hof PR, Morrison JH (October 2004). "The aging brain: morphomolecular senescence of cortical circuits". Trends in Neurosciences ... Cellular and Molecular Life Sciences. 80 (7): 190. doi:10.1007/s00018-023-04832-6. PMC 10290611. PMID 37354261. Cummings, ... Aging movement control Hallmarks of aging Life extension Lifelong learning Timeline of senescence research List of life ...
In parallel, he has extensively investigated p53 functions in the regulation of DNA repair, apoptosis, senescence, and ... 36: 1003-1010, 1976, Nature 252: 68-69, 1974). This work was pivotal to the investigation of cellular transformation, and these ... He has successfully intertwined cancer epidemiology with pioneering studies of chemical carcinogenesis, mutagenesis, cellular ... International Cell Senescence Association, Athens, Greece (2019) State-of-the-Art Lecture, 36th Annual Meeting of the Germany ...
Setbacks such as low replication rates and early senescence have also been encountered when making iPSCs, hindering their use ... This result challenges the terminal nature of cellular differentiation and the integrity of lineage commitment; and implies ... "complex cellular variation" of totipotency. Stem cells resembling totipotent blastomeres from 2-cell stage embryos can arise ...
Frontiers in Cellular and Infection Microbiology. 11: 786994. doi:10.3389/fcimb.2021.786994. PMC 8777051. PMID 35071039. This ... "Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and ...
They are not needed for the procession of mitosis and meiosis yet, subtelomeres take advantage of cellular DNA recombination. ... while the removal of the last 15kb increased chromosome senescence. The knockout of subtelomeres in fission yeast, ... Cellular Microbiology. 15 (5): 718-726. doi:10.1111/cmi.12115. PMC 3654561. PMID 23351305. Cross, George A. M. (April 1996). " ... "A subtelomeric region affects telomerase-negative replicative senescence in Saccharomyces cerevisiae". Scientific Reports. 9 (1 ...
... it can be used as an informative model system for understanding cumulative age-related cellular alterations. Oxidative DNA ... with age and reduce life expectancy supporting the hypothesis that oxidative molecular damage is a causal factor in senescence ...
Senescence Anthony Joonkyoo Yun, MD (2014). Hiding in Plain Sight: Essays by Joon Yun, MD, Second Edition. p. 130. ISBN ... cellular, physiological, and organismal. In the context of human beings, homeostatic capacity refers to the inherent ability of ...
Moh MC, Zhang T, Lee LH, Shen S (December 2008). "Expression of hepaCAM is downregulated in cancers and induces senescence-like ... Journal of Cellular Physiology. 219 (2): 382-91. doi:10.1002/jcp.21685. PMID 19142852. S2CID 206047365. Moh MC, Lee LH, Zhang T ... In cell signaling, hepaCAM directly interacts with F-actin and calveolin 1, and is capable of inducing senescence-like growth ... Journal of Cellular Biochemistry. 107 (6): 1129-38. doi:10.1002/jcb.22215. PMID 19507233. S2CID 21271941. Moh MC, Tian Q, Zhang ...
Molecular and Cellular Biology. 2010 Nov;30(21):5071-85. Hou Z, Peng H, White DE, Wang P, Lieberman PM, Halazonetis T, Rauscher ... accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell ... Molecular and Cellular Biology. 2011 May;31(9):1833-47. Mellert HSA, Stanek TJ, Sykes SM, Rauscher FJ, Schultz DC, McMahon SB ...
senescence 1. Growing old. From Latin senescere, to grow old. 2. The degeneration over time that makes indefinite propagation ... Has both ameba (cellular slime molds) and plasmoidial (multi-nucleate) varieties. No longer categorized as fungi, but were ... Cellular slime molds are part of Acrasiomycota or Dictyosteliomycota; plasmodial slime molds were traditionally part of the ... budding A type of asexual cellular multiplication. A small outgrowth or bud from a parent cell enlarges and eventually ...
Molecular and Cellular Biology. 26 (7): 2560-9. doi:10.1128/MCB.26.7.2560-2569.2006. PMC 1430336. PMID 16537902. Cao R, Wang L ... regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins". Molecular Biology ... Molecular and Cellular Biology. 27 (13): 4968-79. doi:10.1128/MCB.02244-06. PMC 1951487. PMID 17452456. Guo WJ, Zeng MS, Yadav ... Molecular and Cellular Biology. 22 (17): 6070-8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701. Suzuki M, ...
... and induces rapid senescence". The Plant Cell. 11 (7): 1253-66. doi:10.1105/tpc.11.7.1253. PMC 144264. PMID 10402427. McKnight ... Molecular and Cellular Biochemistry. 187 (1/2): 113-120. doi:10.1023/A:1006812300200. PMID 9788748. S2CID 28158640. Dai, N; ...
They are involved in modulating senescence of organs in plants and are therefore considered as a plant hormone. In addition, ... thereby the cellular energy, i.e. K+ ion gradient across the cell membrane, is conserved. In addition, polyamine participate in ... Pandey S, Ranade SA, Nagar PK, Kumar N (September 2000). "Role of polyamines and ethylene as modulators of plant senescence". J ...