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*  Cellular senescence
Senescence-associated beta-galactosidase, along with p16Ink4A, is regarded to be a biomarker of cellular senescence. This ... "Physiological and pathological consequences of cellular senescence". Cellular and Molecular Life Sciences. 71 (22): 4373-4386. ... Cellular senescence is the phenomenon by which normal ploid cells cease to divide. In culture, fibroblasts can reach a maximum ... As such, cellular senescence represents a change in "cell state" rather than a cell becoming "aged" as the name misleadingly ...
*  Senolytic
Autophagy Geroprotector Venetoclax Childs BG, Durik M, Baker DJ, van Deursen JM (2015). "Cellular senescence in aging and age- ... Campisi J (2013). "Aging, cellular senescence, and cancer". Annual Review of Physiology. 75: 685-705. doi:10.1146/annurev- ... In basic research, senescence is a potential tumor suppressive mechanism and possible factor that accelerates the aging process ... A senolytic (from the words "senescence" and "lytic" - destroying) is among the class of small molecules under basic research ...
*  DNA-SCARS
Rodier, F.; Campisi, J. (14 February 2011). "Four faces of cellular senescence". The Journal of Cell Biology. 192 (4): 547-556 ... DNA-SCARS are one of the most prevalent nuclear markers of cellular senescence. DNA-SCARS were discovered by Judith Campisi and ... DNA-SCARS (short for DNA segments with chromatin alterations reinforcing senescence) are nuclear substructures with persistent ... distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion". Journal ...
*  Lipid signaling
"Role of ceramide in cellular senescence". J. Biol. Chem. 270 (51): 30701-30708. doi:10.1074/jbc.270.51.30701. PMID 8530509. ... Lee, J. Y.; Hannun, Y. A.; Obeid, L. M. (1996). "Ceramide inactivates cellular protein kinase Cα". J. Biol. Chem. 271 (22): ... Other factors that induce SK include cellular communication molecules called cytokines, such as tumor necrosis factor α (TNFα) ... Fourth, the second messenger activates a certain cellular process. The G-protein coupled receptors for the PIP2 messenger ...
*  DNA repair
2006). "How does cellular senescence prevent cancer?". DNA Cell Biol. 25 (2): 69-78. doi:10.1089/dna.2006.25.69. PMID 16460230 ... Campisi J, d'Adda di Fagagna F (2007). "Cellular senescence: when bad things happen to good cells". Rev Mol Cell Biol. 8 (9): ... quiescence is a reversible state of cellular dormancy that is unrelated to genome damage (see cell cycle). Senescence in cells ... Senescence, an irreversible process in which the cell no longer divides, is a protective response to the shortening of the ...
*  Marrow adipose tissue
... and cellular senescence". Aging Cell. 9 (5): 667-684. doi:10.1111/j.1474-9726.2010.00608.x. ISSN 1474-9726. PMC 2941545 . PMID ... Kassem, Moustapha; Marie, Pierre J. (2011-04-01). "Senescence-associated intrinsic mechanisms of osteoblast dysfunctions". ... Cellular and molecular life sciences: CMLS. 66 (2): 236-253. doi:10.1007/s00018-008-8429-z. ISSN 1420-9071. PMID 18854943. ... Journal of Cellular Biochemistry. 98 (2): 251-266. doi:10.1002/jcb.20777. ISSN 0730-2312. PMID 16479589. Cawthorn, William P.; ...
*  Epigenetic clock
It is unclear whether the three major types of cellular senescence, namely replicative senescence, oncogene-induced senescence ... cellular senescence, and the DNA damage response pathway. Although the uncoupling of senescence from cellular aging appears at ... Therefore, cellular senescence is a route by which cells exit prematurely from the natural course of cellular aging. Men age ... However, the epigenetic clock analysis of senescence suggests that cellular senescence is a state that cells are forced into as ...
*  Ageing
In the broader sense, ageing can refer to single cells within an organism which have ceased dividing (cellular senescence) or ... Pereira-Smith OM, Ning Y (1992). "Molecular genetic studies of cellular senescence". Exp Gerontol. 27 (5-6): 519-22. PMID ... cellular senescence has been attributed to the shortening of telomeres at each cell division; when telomeres become too short, ... cellular senescence (accumulation of no longer dividing cells in certain tissues, a process induced especially by p16INK4a/Rb ...
*  Aprataxin
These mice showed accelerated cellular senescence. This study also demonstrated a protective role of Aptx in vivo and suggested ... Hannan MA, Sigut D, Waghray M, Gascon GG (1995). "Ataxia-ocular motor apraxia syndrome: an investigation of cellular ...
*  Sphingolipid
Venable ME, Lee JY, Smyth MJ, Bielawska A, Obeid LM (December 1995). "Role of ceramide in cellular senescence". The Journal of ... These sphingolipid-based microdomains, or "lipid rafts" were originally proposed to sort membrane proteins along the cellular ... senescence, and differentiation. Ceramide-based lipids self-aggregate in cell membranes and form separate phases less fluid ...
*  P16
... INK4a, along with senescence-associated beta-galactosidase, is regarded to be a biomarker of cellular senescence. Therefore ... Notably, a recent survey of cellular senescence induced by multiple treatments to several cell lines does not identify p16 as ... Rayess H, Wang MB, Srivatsan ES (April 2012). "Cellular senescence and tumor suppressor gene p16". International Journal of ... These pathways are activated in cellular response to reduce senescence. Mutations resulting in deletion or reduction of ...
*  CYR61
Jun JI, Lau LF (2010). "Cellular senescence controls fibrosis in wound healing". Aging. 2 (9): 627-631. doi:10.18632/aging. ... However, CYR61 can also induce apoptosis and cellular senescence, two well-established mechanisms of tumor suppression Thus, ... and induce cellular senescence in fibroblasts. During embryo development in mice, Cyr61 is highly expressed in the ... and in fibroblasts promotes cellular senescence and enables TNFα to induce apoptosis through binding to α6β1-HSPGs. However, ...
*  Mir-598 microRNA precursor family
miR-598 acts to modulate cellular senescence. More specifically, its overexpression induces senescence in early-passage cells ... MicroRNA Shin KK, Kim YJ, Hong CP, Yang JW, Bae YC, Jung JS (2012). "miR-598 induces replicative senescence in human adipose ... in the senescence of human adipose-tissue-derived mesenchymal stem cells. Increased miR-598 expression during the senescent ... whilst inhibition conversely sees a partial recovery of the ageing phenotype through increased cellular differentiation. ...
*  CDKN2A
Thus P16 participates not only in the initiation but also in the maintenance of cellular senescence, as well in tumor ... Notably, a recent survey of cellular senescence induced by multiple treatments to several cell lines does not identify CDKN2A ... Activation of the CDKN2A locus promotes the cellular senescence tumor suppressor mechanism, which is a permanent form of growth ... Rayess H, Wang MB, Srivatsan ES (April 2012). "Cellular senescence and tumor suppressor gene p16". International Journal of ...
*  Senotherapeutics
Burton, D. G. A.; Faragher, R. G. A. (2015). "Cellular senescence: From growth arrest to immunogenic conversion". AGE. 37 (2). ... Soto-Gamez A, Demaria M (2017). "Therapeutic interventions for aging: the case of cellular senescence". Drug Discovery Today. ... "Cellular senescence in aging and age-related disease: from mechanisms to therapy". Nature Medicine. 21 (12): 1424-35. doi: ... agents/strategies which prevent or reverse the senescent state by preventing triggers of cellular senescence, such as DNA ...
*  Norman Sharpless
Cellular Senescence Limits Regenerative Capacity and Allograft Survival. Journal of the American Society of Nephrology : JASN. ... doi:10.1371/journal.pone.0068133 Koppelstaetter, C., Schratzberger, G., Perco, P., et al (2008), Markers of cellular senescence ... "Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse". Cancer Discovery. 7 (2): 165-176. doi:10.1158 ... and colleagues demonstrated In 2016 how chemotherapy triggers cellular senescence, a pro-inflammatory stress response, which ...
*  YPEL3
... replicative senescence). Recognized hallmarks of cellular senescence include senescence associated(SA)beta galactosidase ... As a part of the p53 pathway response and its anti-proliferation role, cellular senescence has gained attention for its working ... Studies in U2OS osteosarcoma cells and MCF7 breast cancer cells have also demonstrated increased cellular senescence upon YPEL3 ... cellular senescence and apoptosis. The importance of functioning p53 in the regulation of the cell cycle is evident in that 55 ...
*  TP53
... a p53-regulated gene that induces cellular senescence". Cancer Research. 70 (9): 3566-75. doi:10.1158/0008-5472.CAN-09-3219. ... Zakut-Houri R, Oren M, Bienz B, Lavie V, Hazum S, Givol D (1983). "A single gene and a pseudogene for the cellular tumour ... Iwabuchi K, Bartel PL, Li B, Marraccino R, Fields S (June 1994). "Two cellular proteins that bind to wild-type but not mutant ... Zakut-Houri R, Bienz-Tadmor B, Givol D, Oren M (May 1985). "Human p53 cellular tumor antigen: cDNA sequence and expression in ...
*  GNG11
Hossain MN, Sakemura R, Fujii M, Ayusawa D (2007). "G-protein gamma subunit GNG11 strongly regulates cellular senescence". ...
*  Germinal center B-cell like diffuse large B-cell lymphoma
BCL-6 is also an inhibitor of cellular senescence. Cellular senescence is a programmed response that prevents a cell from ... Cell death does not appear to be mediated by complement, but modest antibody-dependent cellular cytotoxicity and direct killing ... but studies suggest that rituximab modulates cellular and molecular signal transduction pathways that regulate bcl-2-expression ...
*  Inhibitor of DNA-binding protein
Zebedee Z, Hara E (December 2001). "Id proteins in cell cycle control and cellular senescence". Oncogene. 20 (58): 8317-25. doi ... ID proteins also promote cell cycle progression, delaying senescence, and help facilitate cell migration. In contrast, ...
*  Judith Campisi
Cellular senescence was first formally observed cellular in 1965 by Leonard Hayflick, who demonstrated that certain cells have ... "Four faces of cellular senescence." The Journal of cell biology (2011): jcb-201009094. SENS Research Foundation interview with ... These phenomena became known as cellular senescence, and could be viewed as both helpful and harmful to an organism; It could ... Much less is known about the relationship between cellular senescence and aging. However, it has been shown that the number of ...
*  Senescence
The word senescence can refer either to cellular senescence or to senescence of the whole organism. It is commonly believed ... cellular senescence, and the DNA damage response pathway. Although the uncoupling of senescence from cellular aging appears at ... the three major types of cellular senescence, namely replicative senescence, oncogene-induced senescence and DNA damage-induced ... Hence senescence is a route by which cells exit prematurely from the natural course of cellular ageing. Organismal senescence ...
*  SKP2
... inactivation profoundly restricts cancer development by triggering a massive cellular senescence and/or apoptosis response ... "Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence". Nature. 464 (7287): 374-9. doi:10.1038/ ... that Skp2 deficiency inhibits cancer development in multiple mouse models by inducing p53-independent cellular senescence and ... Molecular and Cellular Biology. 19 (1): 635-45. doi:10.1128/mcb.19.1.635. PMC 83921 . PMID 9858587. Bornstein G, Bloom J, Sitry ...
*  Pathogenic Escherichia coli
Colibactin can cause cellular senescence or cancer by damaging DNA. However, the mucosal barrier prevents E. coli from reaching ... There, the Dr adhesins induce the development of long cellular extensions that wrap around the bacteria, accompanied by the ... "Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells". PLOS ONE. 8 (10): ...
*  Interferon
Another cellular enzyme, RNAse L-also induced by interferon action-destroys RNA within the cells to further reduce protein ... Moiseeva O, Mallette FA, Mukhopadhyay UK, Moores A, Ferbeyre G (2006). "DNA Damage Signaling and p53-dependent Senescence after ... ISBN 978-981-02-3148-4. Tan YH, Armstrong JA, Ke YH, Ho M (1970). "Regulation of cellular interferon production: enhancement by ... IFN receptor homologs-like the B18R protein of the vaccinia virus-that bind to and prevent IFN interacting with its cellular ...