"Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells". Circulation Research. 74 ( ... and over-activity can lead to oxidative stress and cell damage. Excessive production of ROS in vascular cells causes many forms ... Vascular NADPH oxidases are regulated by a variety of hormones and factors known to be important players in vascular remodeling ... while in vascular cells, the radical anion appears to be released mainly intracellularly. The isoform found in neutrophils is ...
... and T-cell conditioned media. In vascular smooth muscle cells, activation is responsible for arterial thickening in allografts ... "Overexpression of allograft inflammatory factor-1 promotes proliferation of vascular smooth muscle cells by cell cycle ... Higher presence of AIF-1/NF-κB/MCP-1/CCR-2-pathway was detected in calcifaied vascular smooth muscle cells. AIF-1 was also ... Autieri MV, Chen X (July 2005). "The ability of AIF-1 to activate human vascular smooth muscle cells is lost by mutations in ...
Zhang C (Nov 2009). "MicroRNA-145 in vascular smooth muscle cell biology: a new therapeutic target for vascular disease". Cell ... a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation". Circulation ... "miR-145 and miR-143 regulate smooth muscle cell fate and plasticity". Nature. 460 (7256): 705-10. doi:10.1038/nature08195. PMC ... "MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury". Genes & ...
Déglise S, Bechelli C, Allagnat F. Vascular smooth muscle cells in intimal hyperplasia, an update. Front Physiol. 2023 Jan 4;13 ... hyperplasia is due to a dysfunction of endothelial cells which results in a reprogramming of the vascular smooth muscle cells ( ... particularly in vein and synthetic vascular grafts.[citation needed] Intimal ...
Statins also inhibit PPARγ in human macrophages, vascular endothelial cells, and smooth muscle cells; this action may ... "Statins meditate anti-atherosclerotic action in smooth muscle cells by peroxisome proliferator-activated receptor-γ activation ... this receptor is highly expressed in mouse and human airway epithelial cells and in Beas 2B human airway epithelial cells and, ... rodent and human bronchial epithelial cells, and in model cells made to express rodent or human TRPV1. This stimulation appears ...
Another role is maintaining a vascular smooth muscle cells contractile under physiological or pathological stimuli. Since 2003 ... 2007). "Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild ... With this new model, they were able to demonstrate that reduced cell proliferation and increased apoptosis are significant ... These patients show increased skeletal muscle stress, as indicated by the increase in myofibers with central nuclei. Myopathy ...
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Vascular smooth muscle cells control the size of the vein lumens, and thereby help to regulate blood pressure. The post- ... "Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders". ... This layer is much thinner than that in arteries Vascular smooth muscle cells control the size of the vein lumens, and thereby ... The endothelial cells continuously produce nitric oxide a soluble gas, to the cells of the adjacent smooth muscle layer. This ...
"IGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype". Am. J. Pathol. 178 ...
In rats, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. The C-terminus of RCBTB1 ... type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells ... In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and ... a region commonly deleted in B-cell chronic lymphocytic leukemia". Cancer Res. 61 (7): 2870-7. PMID 11306461. "Entrez Gene: ...
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"Glomulin is predominantly expressed in vascular smooth muscle cells in the embryonic and adult mouse". Gene Expr. Patterns. 4 ( ... Brouillard P, Vikkula M (2003). "Vascular malformations: localized defects in vascular morphogenesis". Clin. Genet. 63 (5): 340 ... 2003). "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis". Proc. Natl. Acad. Sci. U.S.A. 100 ( ... "The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 ...
2003). "A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells". Eur. J. ... gene is a cytoplasmic protein that may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. ... Cell. Biochem. 229 (1-2): 35-44. doi:10.1023/A:1017934810825. PMID 11936845. S2CID 24226208. Ohki T, Hongo S, Nakada N, et al ... 2002). "Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells". Brain Res. Dev ...
SCARA1 or MSR1 (SR-A1): besides macrophages they can be found on smooth vascular muscle cells and endothelial tissues; ... it has been discovered in macrophages and vascular smooth muscle cells in artery vessels. The expression of LOX-1 is induced by ... CD36 can be found in many different cells, for example, insulin-responsive cells, hematopoietic cells like platelets, monocytes ... Scavenger receptors are mainly found on myeloid cells and other cells that bind to numerous ligands, primarily endogenous and ...
... synthesized or generated in and released from the vascular endothelium that hyperpolarize nearby vascular smooth muscle cells. ... They cause smooth muscle hyperpolarization by opening vascular smooth muscle large-conductance calcium-activated potassium ... Tca-8113 cells, HeLa uterine cervix cell lines, A549 cells, MDA-MB-435 breast cells, and HepG2 cells but they had no ... inhibit vascular smooth muscle cell proliferation thereby reducing blood vessel hypertrophy and narrowing. EETs, ...
Dilation occurs when nitric oxide (NO) is released from endothelial cells and diffuses into nearby vascular smooth muscle. ... Various cell types play a role in HR, including astrocytes, smooth muscle cells, endothelial cells of blood vessels, and ... These consist of endothelial cells and smooth muscle cells, and as these pial arteries further branch and run deeper into the ... A principal function of pericytes is to interact with astrocytes, smooth muscle cells, and other intracranial cells to form the ...
... being expressed in skeletal muscle near myotendinous junctions, and in vascular smooth muscle cells, as a downstream target of ... transcription of the cell type-restricted ankyrin repeat protein CARP gene through CAGA motif in vascular smooth muscle cells ... activin induces CARP in smooth muscle cells". Arteriosclerosis, Thrombosis, and Vascular Biology. 23 (1): 64-8. doi:10.1161/01. ... activin induces CARP in smooth muscle cells". Arterioscler. Thromb. Vasc. Biol. 23 (1): 64-8. doi:10.1161/01.ATV. ...
Serotonin stimulates the proliferation of pulmonary artery smooth muscle cells, and induces fibrosis in the wall of pulmonary ... Together, this causes vascular remodeling and narrowing of the pulmonary arteries. These changes result in increased vascular ... this potential medicine could offer the hope of achieving reversal of pulmonary artery vascular remodeling and attenuation of ...
Ruchoux MM, Guerouaou D, Vandenhaute B, Pruvo JP, Vermersch P, Leys D (1995). "Systemic vascular smooth muscle cell impairment ... cause an abnormal accumulation of Notch 3 at the cytoplasmic membrane of vascular smooth muscle cells both in cerebral and ... The underlying pathology of CADASIL is progressive hypertrophy of the smooth muscle cells in blood vessels. Autosomal dominant ... Fisher, Christopher (14 March 2011). "CADASIL, A Vascular Brain Disorder, Is Often Misdiagnosed As Multiple Sclerosis". BMED ...
Shofuda T, Shofuda K, Ferri N (2004). "Cleavage of focal adhesion kinase in vascular smooth muscle cells overexpressing ... in rat vascular smooth muscle cells and characterization of MT3-MMPs with and without transmembrane domain". J. Biol. Chem. 272 ... Cancer Cell. 6 (3): 251-61. doi:10.1016/j.ccr.2004.07.012. PMID 15380516. Gerhard DS, Wagner L, Feingold EA, et al. (2004). " ... proteolysis in malignant cells". J. Biol. Chem. 279 (6): 4260-8. doi:10.1074/jbc.M311569200. PMID 14645246. Lang R, Braun M, ...
... exhibits vasculoprotective effects by lowering vascular smooth muscle cell proliferation and endothelial ... cells inflammation. 3-Hydroxybenzaldehyde is used in the synthesis of monastrol. Salicylaldehyde (2-hydroxybenzaldehyde) 4- ...
... which will then induce smooth muscle relaxation. This is particularly important in the vasculature, where vascular smooth ... Instead, vascular endothelial cells will use L-arginine to make nitric oxide via nitric oxide synthase. The nitric oxide will ... then diffuse into the vascular smooth muscle and will activate the soluble guanylyl cyclase. The subsequent increase in cGMP ... muscle will bind ANP released as a result of increasing right atrial pressure and will cause the walls of the vasculature to ...
p. 174 in: The vascular smooth muscle cell: molecular and biological responses to the extracellular matrix. Authors: Stephen M ... single-unit smooth muscle, also known as visceral smooth muscle, and multiunit smooth muscle. Most smooth muscle is of the ... Within single-unit muscle, the whole bundle or sheet of smooth muscle cells contracts as a syncytium. Smooth muscle is found in ... Smooth muscle in the gastrointestinal tract is activated by a composite of three types of cells - smooth muscle cells (SMCs), ...
... vascular smooth muscle and endothelial cells". Regulatory Peptides. 126 (3): 233-40. doi:10.1016/j.regpep.2004.10.019. PMID ... Zhou N, Fan X, Mukhtar M, Fang J, Patel CA, DuBois GC, Pomerantz RJ (March 2003). "Cell-cell fusion and internalization of the ... February 2014). "Toddler: an embryonic signal that promotes cell movement via Apelin receptors". Science. 343 (6172): 1248636. ... Developmental Cell. 27 (6): 672-80. doi:10.1016/j.devcel.2013.11.002. PMID 24316148. Pauli A, Norris ML, Valen E, Chew GL, ...
"Sesquiterpene lactone suppresses vascular smooth muscle cell proliferation and migration via inhibition of cell cycle ...
"Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation". ...
Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proc. Natl. Acad. Sci ... Role of p42/p44 mitogen-activated protein kinase and p21waf1/cip1 in the regulation of vascular smooth muscle cell ... Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: Evidence for the ... Ignarro then speculated that nitric oxide could be the key to relaxing vascular smooth muscles. In turn, this led to his ...
Torella D (2011). "MicroRNA-133 Controls Vascular Smooth Muscle Cell Phenotypic Switch In Vitro and Vascular Remodeling In Vivo ... "MicroRNA regulation of cell lineages in mouse and human embryonic stem cells". Cell Stem Cell. 2 (3): 219-29. doi:10.1016/j. ... miR-133 suppresses Prdm16 expression in skeletal muscle stem cells (satellite cells), which controls myogenic vs. brown ... "MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16". Cell Metabolism. 17 ...
"TWIST1 induces phenotypic switching of vascular smooth muscle cells by downregulating p68 and microRNA-143/145". FEBS Open Bio ... January 2020). "Genomic profiling of human vascular cells identifies TWIST1 as a causal gene for common vascular diseases". ... Twist also protects cancer cells from apoptotic cell death. In addition, Twist is responsible for the maintenance of cancer ... Here and in epithelial ovarian cancer, Twist1 has been shown to be involved in evading apoptosis, making the tumour cells ...
Depletion of NAD+ can lead to DNA damage and cellular senescence in vascular smooth muscle cells. Although senescent cells can ... Natural killer cells (NK cells) and macrophages play a major role in clearance of senescent cells. Natural killer cells ... Immune system cells can be recruited by SASP to senescent cells, after which the SASP from the senescent cells can induce the ... T cells, B cells, and NK cells have all been reported to become senescent themselves. Senescent-like aging CD8+ cytotoxic T- ...
They mainly control smooth and vascular muscle dilation. Strength of response is dependent upon the concentration of receptors ... Local hormones are produced by nerve and gland cells and bind to either neighboring cells or the same type of cell that ... are local hormones that require close contact and act on either the cell which emitted them or on adjacent cells. According to ... These local hormones are formed by a chain of 20 amino acids and fatty acids from phospholipids in the cell membrane. ...