... increases transmembrane influx of Na+ in vascular smooth muscle (VSM) cells through increased synthesis of Na+ channels". ... Dumitrescu A, Aberdeen GW, Pepe GJ, Albrecht ED (2007). "Developmental expression of cell cycle regulators in the baboon fetal ... Perusquía M (2003). "Androgen-induced vasorelaxation: a potential vascular protective effect". Exp. Clin. Endocrinol. Diabetes ... "Progestin is an essential factor for the initiation of the meiosis in spermatogenetic cells of the eel". Proc. Natl. Acad. Sci ...

... development of a smooth muscle cell in vitro system and identification of a vascular variant". Cell Struct. Funct. 22 (1): 65- ... a novel cytoskeletal protein specific for smooth muscle cells". J Cell Biol. 134 (2): 401-11. doi:10.1083/jcb.134.2.401. PMC ... This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress ... 1999). "A novel isoform of the smooth muscle cell differentiation marker smoothelin". J. Mol. Med. 77 (2): 294-8. doi:10.1007/ ...

... regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin". Circulation Research ... "Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells". The ... 25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene. 22 (26): 4035-46. doi:10.1038/ ... 25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene. 22 (26): 4035-46. doi:10.1038/ ...

Aortic vascular smooth muscle cells failed to organize into a normal tunica media, and pericytes were low in number. These KLF2 ... T-cells are activated and more prone to apoptosis without KLF2, suggesting that KLF2 regulates T-cell quiescence and survival. ... These KLF2-deficient embryonic stem cells contribute significantly to development of skeletal muscle, spleen, heart, liver, ... but it is also expressed temporally during embryogenesis in erythroid cells, endothelium, lymphoid cells, the spleen, and white ...

In healthy individuals nitric oxide (NO) acts as a signalling molecule on vascular smooth muscle cells to induce vasodilation. ... This results in overall lower levels of endothelial cell-derived NO and reduced vasodilation of smooth muscle cells. NO also ... reduces pulmonary smooth muscle cell growth and antagonises platelet inhibition, factors which play a key role in the ... and also significantly improved exercise capacity and hemodynamic parameters such as pulmonary vascular resistance, cardiac ...

Nitric oxide (NO) suppresses platelet aggregation, inflammation, oxidative stress, vascular smooth muscle cell migration and ... In vascular diseases, endothelial dysfunction is a systemic pathological state of the endothelium. Along with acting as a semi- ... Kuvin JT, Mammen A, Mooney P, Alsheikh-Ali AA, Karas RH (Feb 2007). "Assessment of peripheral vascular endothelial function in ... Botts SR, Fish JE, Howe KL (December 2021). "Dysfunctional Vascular Endothelium as a Driver of Atherosclerosis: Emerging ...

... cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell ... cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell ... and stem cell factor, it was therefore named "pre-B cell colony-enhancing factor" (PBEF). When the gene encoding the bacterial ... Rongvaux A, Shea RJ, Mulks MH, Gigot D, Urbain J, Leo O, Andris F (November 2002). "Pre-B-cell colony-enhancing factor, whose ...

... vascular smooth muscle, and skeletal muscle. β3-adrenergic receptors are located in fat cells. Beta receptors are found on ... cells of the heart muscles, smooth muscles, airways, arteries, kidneys, and other tissues that are part of the sympathetic ... Since β2 adrenergic receptors can cause vascular smooth muscle dilation, beta blockers may cause some vasoconstriction. However ... Stimulation of β2 receptors induces smooth muscle relaxation, induces tremor in skeletal muscle, and increases glycogenolysis ...

"Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor ... "Human fibroblast growth factor 1 gene expression in vascular smooth muscle cells is modulated via an alternate promoter in ... cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell ... but it does appear to form a disulfide linked dimer inside cells that associate with a complex of proteins at the cell membrane ...

It is expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system. The H1 ... Mitsuchashi M, Payan DG (June 1989). "Molecular and cellular analysis of histamine H1 receptors on cultured smooth muscle cells ... These cells project throughout the brain and spinal cord. Areas that receive especially dense projections include the cerebral ... Histamine H1 receptors are activated by endogenous histamine, which is released by neurons that have their cell bodies in the ...

The smooth muscle cells are relaxed to increase the diameter of flow, decreasing the vascular resistance. This is possible due ... the body attempts to capture heat in the blood by constricting the smooth muscle cells around the microvasculature. The muscle ... The smooth muscle cells are able to constrict from both external and internal stimuli. This mechanism can be triggered by the ... Vasoconstriction affects flow rate and surface properties of the microvasculature by constricting the smooth muscle cells and ...

2011). "MicroRNA-26a is a novel regulator of vascular smooth muscle cell function". J Cell Physiol. 226 (4): 1035-43. doi: ... Smooth muscle cell (SMC) differentiation miRNA-26a is found to be significantly upregulated during SMC differentiation and ... miR-26 expression is induced in response to hypoxia and upregulated during smooth muscle cell (SMC) differentiation and ... cell line LoVo cells, compared with other three colorectal cell lines SW480, HT29 and Caco-2. Overexpression of miR-26b ...

Normally endothelial cells release prostacyclin and nitric oxide (NO) which induce relaxation of the smooth muscle cells, and ... In angiography, vascular access through femoral and axillary arteries are preferred because they are less prone to vasospasm. ... Aggregating platelets stimulate ADP to act on endothelial cells and help them induce relaxation of the smooth muscle cells. ... It does not stimulate as much prostacyclin and NO to induce relaxation on smooth muscle cells. Also there is not as much ...

... reach underlying vascular smooth muscle cells at a concentration sufficient to activate ion channels, and initiate smooth ... its action is to hyperpolarize vascular smooth muscle cells, causing these cells to relax, thus allowing the blood vessel to ... has been shown to activate an ouabain-sensitive electrogenic Na+-K+-ATPase followed by hyperpolarization and smooth muscle cell ... Contact-mediated mechanisms bestow endothelial hyperpolarization that passively spreads to the smooth muscle through inter- ...

... interstitial cells of the nasal mucosa, airway smooth muscle cells, bronchial fibroblasts and vascular endothelial cells. ... smooth muscle proliferation, collagen deposition, and fibrosis in various tissue sites; and mucin secretion by goblet cells, ... "CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to ... T cells, B lymphocytes, pluripotent hematopoietic stem cells (CD34+), mast cells, pancreas, small intestine, prostate, ...

... but not to vascular smooth muscle and endothelial cells. One project seeded decellularized mouse hearts with human iPSC-derived ... Stem cells extracted from fat tissue after liposuction may be coaxed into becoming progenitor smooth muscle cells (iPVSMCs) ... The introduced cells migrated, proliferated and differentiated in situ into cardiomyocytes, smooth muscle cells and endothelial ... In newts, muscle tissue is regenerated from specialized muscle cells that dedifferentiate and forget the type of cell they had ...

Examples of progenitor cells are vascular stem cells that have the capacity to become both endothelial or smooth muscle cells. ... Cell potency is a cell's ability to differentiate into other cell types. The more cell types a cell can differentiate into, the ... In cell biology, a unipotent cell is the concept that one stem cell has the capacity to differentiate into only one cell type. ... A close synonym for unipotent cell is precursor cell. Biology portal Induced stem cells Cell totipotency was discovered by ...

Khachigian, L.M. et al (2002) c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury ... Induces Off-Target Cytotoxicity in Endothelial Cells with Features of Nonapoptotic Programmed Cell Death. Oligonucleotides 18(3 ... Cancer Cell Int. 10: 9. Xie, J. et al (2014) Regulatory roles of c-jun in H5N1 influenza virus replication and host ... Zhang, G. et al (2006) Squamous cell carcinoma growth in mice and in culture is regulated by c-Jun and its control of matrix ...

"Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/ ... Endogenous sulfur dioxide also has been shown to lower the proliferation rate of endothelial smooth muscle cells in blood ... Smooth muscle cell proliferation is one of important mechanisms of hypertensive remodeling of blood vessels and their stenosis ... tissue or cell or are received by the organism, tissue or cell from outside (say, from the atmosphere or hydrosphere, as in the ...

... kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells ... Cell. 12 (4): 971-82. doi:10.1016/S1097-2765(03)00388-5. PMID 14580347. Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR ( ... Cell. Biol. 24 (12): 5094-105. doi:10.1128/MCB.24.12.5094-5105.2004. PMC 419863. PMID 15169877. Michels AA, Fraldi A, Li Q, ... Wittmann BM, Wang N, Montano MM (2003). "Identification of a novel inhibitor of breast cell growth that is down-regulated by ...

... contraction of smooth muscle, and increased vascular permeability. C5a des-Arg is a much less potent anaphylatoxin. Both C5a ... initiating accumulation of complement and phagocytic cells at sites of infection or recruitment of antigen-presenting cells to ... White blood cells are activated by upregulation of integrin avidity, the lipoxygenase pathway and arachidonic acid metabolism. ... May 2018). "Cell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study". Intensive Care ...

These cells respond by increasing production of nitric oxide, which signals the surrounding smooth muscle to relax, leading to ... Acetylcholine in the serum exerts a direct effect on vascular tone by binding to muscarinic receptors present on vascular ... a kind of striated muscle. These are the muscles used for all types of voluntary movement, in contrast to smooth muscle tissue ... The main location of muscle-type receptors is on muscle cells, as described in more detail below. Neuronal-type receptors are ...

"Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/ ... Endogenous sulfur dioxide also has been shown to lower the proliferation rate of endothelial smooth muscle cells in blood ... Smooth muscle cell proliferation is one of important mechanisms of hypertensive remodeling of blood vessels and their stenosis ... PKA signaling". Cell Death Dis. 5 (5): e1251. doi:10.1038/cddis.2014.229. PMC 4047873. PMID 24853429. Wang XB, Jin HF, Tang CS ...

The morphologic features of mild and moderate HDV include: Perivascular inflammatory cells, +/-Vascular thrombosis, Smooth ... the smooth muscle of the decidual (or maternal) blood vessels is hypertrophic, i.e. the muscle part of the blood vessels ... muscle hypertrophy, and Endothelial hyperplasia. Severe HDV is characterized by: Atherosis - foamy macrophages within vascular ...

... within vascular smooth muscle cells. However, the specific mechanisms for generating an increased intracellular concentration ... Smooth muscle cells are capable of generating action potentials, but this mechanism is rarely utilized for contraction in the ... These results suggest that U-46619 elicits contraction of rat caudal arterial smooth muscle by activating Ca2+ entry from the ... 2005-08-01) [Published on Journal website 2005-07-26]. "Thromboxane A2-induced contraction of rat caudal arterial smooth muscle ...

... their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells". Growth Factors. 23 (2): 87-95. ...

"Resveratrol Inhibits AGEs-Induced Proliferation and Collagen Synthesis Activity in Vascular Smooth Muscle Cells from Stroke- ... is found on many cells, including endothelial cells, smooth muscle, cells of the immune system[which?] from tissue such as lung ... Reduced muscle function is also associated with AGEs. AGEs have a range of pathological effects, such as: Increased vascular ... Increased arterial stiffness Inhibition of vascular dilation by interfering with nitric oxide. Oxidizing LDL. Binding cells- ...

have looked into ethanol effects on voltage-gated calcium channels on detrusor smooth muscle cells in guinea pigs. Perforated ... CCBs used as medications primarily have four effects: By acting on vascular smooth muscle, they reduce contraction of the ... The class of CCBs known as dihydropyridines mainly affect arterial vascular smooth muscle and lower blood pressure by causing ... CCBs do not work on venous smooth muscle). By acting on cardiac muscles (myocardium), they reduce the force of contraction of ...

... and KGF receptor genes in human vascular smooth muscle cells and arteries". Journal of Cellular Physiology. 173 (3): 380-6. doi ... cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth ... A fibroblast growth factor family member with unusual target cell specificity". Annals of the New York Academy of Sciences. 638 ... FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes ...

Antagonist of alpha-1 adrenoceptors on vascular smooth muscle, thereby inhibiting the vasoconstrictor effect of circulating and ... α1-Adrenergic receptors have additionally been found on immune cells, where catecholamine binding can stimulate and enhance ... The α1-adrenergic receptors are found in vascular smooth muscle, where they are responsible for the vasoconstrictive action of ... The nasal congestion is exacerbated by changing body positions, because α1-adrenergic receptors also control nasal vascular ...

Hyperpolarisation of smooth muscle cell membranes pulls their membrane potential away from the threshold, so making it more ... It can be used to treat hypertension as it will relax vascular smooth muscle to lower blood pressure. ...

Jones FS, Meech R, Edelman DB, Oakey RJ, Jones PL (July 2001). "Prx1 controls vascular smooth muscle cell proliferation and ... The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. ... "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 ( ... Cell. Biol. 15 (6): 3318-26. doi:10.1128/MCB.15.6.3318. PMC 230565. PMID 7760827. Maruyama K, Sugano S (1994). "Oligo-capping: ...

... and cytokine-stimulated human vascular smooth muscle cells". Cell Growth & Differentiation. 7 (11): 1453-60. PMID 8930394. Ku ... It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart ... with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells". DNA ... Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (September 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast ( ...