... and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes". J. Cell Biol. 115 (3): 829-41. ... alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion". Eur J Cancer Prev. 16 (6): 517-27. doi: ... "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". J. Cell ... roles in the adhesion and migration of putative endocrine progenitor cells". J. Cell Biol. 150 (6): 1445-60. doi:10.1083/jcb. ...
9-HODE induces cultured normal human epidermal keratinocytes to stop growing by inhibiting their cell cycle at the G1 stage; it ... in HL-60 human leukemic cells. The mouse G2A receptor, encoded by Gpr132, has 67% amino acid identity to human G2A but does not ... movement from the cell interior to the cell surface and/or by preventing its movement away from the cell surface to the cell ... by transfecting the cells with the human oncogene (i.e., cancer causing) BCR-ABL or by treating the cells with DNA damaging ...
"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". ... 2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876- ... Wilton SD, Lim L, Dorosz SD, Gunn HC, Eyre HJ, Callen DF, Laing NG (Jul 1996). "Assignment of the human alpha-tropomyosin gene ... Cell. Biol. 24 (20): 9176-85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884. PMID 15456888. Gerhard DS, Wagner L, Feingold ...
Another approach has been the development of test methods that use cultured human cells. Human epidermal keratinocytes have ... Tumoroids-3D cell cultures derived from cells biopsied from human patients-can be used in studying the genomics and drug ... The modular immune in vitro construct (MIMIC) uses human cells to create a model of the human immune system on which the ... Organoids are derived from three kinds of human or animal stem cells-embryonic pluripotent stem cells (ESCs), adult somatic ...
"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". ... Loss of Uchl1 increases the susceptibility of pancreatic beta-cells to programmed cell death, indicating that this protein ... "The immunolocalization of PGP 9.5 in normal human kidney and renal cell carcinoma". Il Giornale di Chirurgia. 18 (10): 521-4. ... "The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells". Human Molecular Genetics. 17 (14): ...
A study conducted on T cell-driven IL-22 amplification of Il-1beta-driven inflammation in human adipose tissue shows how there ... "Rho kinase inhibition effect on epidermal keratinocyte in vitro". www.ncbi.nlm.nih.gov. Retrieved 2020-12-19. "RNAfold web ... An analysis of non-invasive NeuN cells and invasive NeuT cells treated with interstitial fluid flow resulted in higher ... "Human BLAT Search". genome.ucsc.edu. Retrieved 2020-12-19. (All articles with dead external links, Articles with dead external ...
... of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes". ... Cell. 154 (2): 452-64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131. Human ACER1 genome location and ACER1 gene ... Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. PMID ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 19, Human proteins, All ...
"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". ... International Review of Cell and Molecular Biology. Vol. 292. pp. 197-280. doi:10.1016/B978-0-12-386033-0.00005-0. ISBN ... Tjoelker LW, Seyfried CE, Eddy RL, Byers MG, Shows TB, Calderon J, Schreiber RB, Gray PW (Mar 1994). "Human, mouse, and rat ... This association prepares the MHC class I for binding an antigen for presentation on the cell surface. A prolonged association ...
"Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes". Mol. Cancer. 9: 45. doi:10.1186/1476-4598- ... FOXM1 gene is now known as a human proto-oncogene. Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell ... Aberrant upregulation of FOXM1 in primary human skin keratinocytes can directly induce genomic instability in the form of loss ... More recently a study using transgenic/knockout mouse embryonic fibroblasts and human osteosarcoma cells (U2OS) has shown that ...
4-NQO and TPA on gene expression in cultured human epidermal keratinocytes". Nucleic Acids Res. 15 (15): 5945-62. doi:10.1093/ ... Schön M, Benwood J, O'Connell-Willstaedt T, Rheinwald JG (1999). "Human sweat gland myoepithelial cells express a unique set of ... "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100-9. doi:10.1091/mbc.E02-05-0271. PMC 133617. ... Genes on human chromosome 17, Keratins, All stub articles, Human chromosome 17 gene stubs). ...
The high affinity of arsenic for sulfhydryl groups makes keratin-rich cells (e.g., epidermal keratinocytes) a sensitive target ... "Arsenate perturbation of human keratinocyte differentiation". Cell Growth Differ. 5 (11): 1235-41. PMID 7848924. Archived from ... Arsenic has been shown to alter epidermal keratinocyte differentiation processes, induce overexpression of growth factors, and ... November 1996). "Arsenic induces overexpression of growth factors in human keratinocytes". Toxicol. Appl. Pharmacol. 141 (1): ...
2008). "S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells". Mol Cancer ... This in particular applies to keratinocytes while fibroblasts are not addressed in this way, apart from cell growth and ... Due to the hyperproliferative action against epidermal cells, S1P has been considered as an active pharmaceutical ingredient ... 2013). "Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells". J Leukoc Biol. 93 (4): 521-528. doi ...
If the mosquito's saliva is inoculated into human skin, the virus can infect epidermal keratinocytes, skin fibroblasts in the ... where it infects several cell types including testicular macrophages, peritubular cells and germ cells, the spermatozoa ... Dhiman G, Abraham R, Griffin DE (July 2019). "Human Schwann cells are susceptible to infection with Zika and yellow fever ... Cells are most susceptible to Zika infection when levels of IFITM3 are low. Once the cell has been infected, the virus ...
Characteristics Physical barrier: Epidermal keratinocytes are tightly linked by cell-cell junctions associated to cytoskeletal ... composed of columnar cells arranged perpendicularly. The layers of cells develop from stem cells in the basal layer. The human ... of its cells, but also contains melanocytes, Langerhans cells, Merkel cells,: 2-3 and inflammatory cells. Epidermal thickenings ... The skin contains specialized epidermal touch receptor cells called Merkel cells. Historically, the role of Merkel cells in ...
However it was later discovered that it was expressed in skin keratinocytes. Clinical literature that describes human elastase ... Elafin is expressed by epidermal keratinocytes under hyperproliferative conditions such as psoriasis and wound healing. It has ... Pancreatic elastase is a form of elastase that is produced in the acinar cells of the pancreas, initially produced as an ... Studies of human pancreatic elastase 1 have shown that this serine protease maps to the chromosomal region 12q13 and it is ...
... and CFTR in the human epidermis and epidermal appendages". Histochemistry and Cell Biology. 147 (6): 733-748. doi:10.1007/ ... they found a widespread distribution of ENaC in keratinocytes in the epidermal layers. Yet, in the eccrine sweat glands, ENaC ... Hanukoglu I, Fuchs E (Nov 1982). "The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of ... These studies establish that ENaC is an important regulator of fluid level in the luminal side of cells with motile cilia in ...
... activity to formation of the cross-linked envelope during terminal differentiation of the cultured human epidermal keratinocyte ... 1994). "HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' ... 2004). "Analysis of epidermal-type transglutaminase (transglutaminase 3) in human stratified epithelia and cultured ... "Isolation of a cDNA encoding a novel member of the transglutaminase gene family from human keratinocytes. Detection and ...
"Human trichohyalin gene is clustered with the genes for other epidermal structural proteins and calcium-binding proteins at ... well-differentiated squamous cell carcinoma) and follicular tumours (trichoepithelioma, keratotic basal cell epithelioma, ... since it harbors over fifty other genes involved in keratinocyte differentiation. Gene coding sequence contains 5829 ... The human TCHH is located on the long (q) arm of chromosome 1 at region 2 band 1 sub-band 3 (1q21.3), from base pair ...
"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". ... "Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens". ... "Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells ... Cell. Biol. 14 (5): 3459-68. doi:10.1128/mcb.14.5.3459. PMC 358710. PMID 7513052. Nishimura N, Goji J, Nakamura H, Orita S, ...
... epidermal cell maturation and epithelial tumorigenesis. Additionally, it can serve as surrogate model to study hS100A7 and ... The S100 calcium-binding protein mS100a7a15 is the murine ortholog of human S100A7 (Psoriasin) and human S100A15 (Koebnerisin ... In maturing keratinocytes, mS100a7a15 is induced by calcium mediated differentiation dependent on protein kinase C (PKC). It is ... and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation". The Journal of Investigative ...
"Di-rhamnolipid from Pseudomonas aeruginosa displays differential effects on human keratinocyte and fibroblast cultures". J. ... Red blood cells are rich in iron-containing heme. Lysis of these cells releases heme into the surroundings, allowing the ... Activated protein kinase C inhibits the tyrosine kinase activity of epidermal growth factor receptor (EGFR), the rational ... It regulates cell proliferation in colon carcinoma cells. TDH induces Ca2+ influx from an extracellular environment accompanied ...
... in the Human Keratinocyte Cell Line HaCaT". Journal of Investigative Dermatology. 105 (4): 602-607. doi:10.1111/1523-1747. ... Wraight, Christopher J.; Werther, George A. (1995-10-01). "Insulin-Like Growth Factor-I and Epidermal Growth Factor Regulate ... One example of a null allele is the 'O' blood type allele in the human A, B and O blood type system. The alleles for the A- ... Cell. 75 (1): 59-72. doi:10.1016/s0092-8674(05)80084-4. ISSN 0092-8674. PMID 8402901. S2CID 42023430. Clayton, J. W.; Tretiak, ...
"A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of ... Moreover, Tregs that express amphiregulin, along with keratinocyte growth factor (KGF), CD39 and CD73, act on parenchymal cells ... "Production of epidermal growth factor related ligands in tumorigenic and benign human lung epithelial cells". Cancer Letters. ... in humans. The protein encoded by this gene is a member of the epidermal growth factor (EGF) family. It is a critical autocrine ...
"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". ... and can be found within the cell or secreted by the cell. PPIB is the second of 18 cyclophilins to be identified in humans, ... "Somatic cell mapping of the human cyclophilin B gene (PPIB) to chromosome 15". Cytogenet. Cell Genet. 60 (3-4): 219-21. doi: ... Allain F, Denys A, Spik G (1994). "Characterization of surface binding sites for cyclophilin B on a human tumor T-cell line". J ...
"Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes ... Serine palmitoyltransferase, long chain base subunit 2, also known as SPTLC2, is a protein which in humans is encoded by the ... Cell. 127 (3): 635-648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. Chen M, Han G, Dietrich CR, Dunn TM, Cahoon EB (December ... Epidermal ceramides are critical for normal skin barrier function and SPTLC2 is differentially expressed across body sites to ...
... keratinocytes, melanocytes, Merkel cells, and Langerhans cells. The predominant cell keratinocyte, which produces keratin, a ... The human epidermis is composed of stratified squamous epithelial cells, which further break down into four to five layers: the ... Non-keratinized cells allow water to "stay" atop the structure. The protein keratin stiffens epidermal tissue to form ... Human Anatomy & Physiology (7th ed.). Pearson Benjamin Cummings. p. 142. ISBN 9780805359107. The Wikibook Human Physiology has ...
... and keratinocytes. For numerous cell types such as breast and ovarian tumor cells, human epithelial cells and keratinocytes HB- ... 1994). "Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes". J. ... 2001). "Heparin-binding epidermal growth factor-like growth factor is an autocrine mediator of human prostate stromal cell ... HB-EGF can bind two locations on cell surfaces: heparan sulfate proteoglycans and EGF-receptor effecting cell to cell ...
Ulcers treated with human Muse cells heal faster with a thick epidermal layer than those treated with non-Muse cells, with a ... Human adipose tissue-derived Muse cells differentiate into keratinocytes by spontaneous differentiation on a gelatin culture ... Muse cells are identified as cells positive for SSEA-3+, a well-known marker for undifferentiated human ES cells. They are also ... When mesenchymal cells (sometimes called mesenchymal stem cells) are separated into Muse and non-Muse cells by SSEA-3 cell ...
... the primary cell type of the epidermis. In humans, the complex is located on a 1.9 Mbp stretch within chromosome 1q21. The ... The CE is a cross-linked matrix that surrounds terminally differentiated squamous keratinocytes after a process known as ... The epidermal differentiation complex (EDC) is a gene complex comprising over fifty genes encoding proteins involved in the ... The epidermal differentiation complex was first described in 1993, and further characterized in 1996, when Dietmar Mischke and ...
It is found in substantial amounts in normal human epidermis and is distributed in a 1:1 ratio between living epidermal cells ... With the exception of skin keratinocytes, some epithelial cells and certain cells in central nervous system, the mRNA coding ... lymph node cells, maternal placental cells and several other cell types. IL1A is found on the surface of senescent cells, where ... kidney mesangial cells, Langerhans cells, dermal dendritic cells, natural killer cells, large granular lymphocytes, microglia, ...