1997). "Malignant transformation of nontrophoblastic cells is associated with the expression of chorionic gonadotropin beta ... 1995). "Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human ... Cell. Biol. 8 (12): 5100-7. doi:10.1128/MCB.8.12.5100. PMC 365611. PMID 2468994. Carlsen RB, Bahl OP, Swaminathan N (1973). " ... CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are ...
... with malignant transformation Dermoid cyst with malignant transformation or with secondary tumor M9085/3 mixed germ cell tumor ... not neoplastic) M9381/3 Gliomatosis cerebri M9382/3 Mixed glioma oligoastrocytoma Anaplastic oligoastrocytoma M9383/1 ... cell-large cell carcinoma Combined small cell-adenocarcinoma Combined small cell-squamous cell carcinoma M8046/3 Non-small cell ... M8550/0 Acinar cell adenoma Acinar adenoma Acinic cell adenoma M8550/1 Acinar cell tumor Acinic cell tumor M8550/3 Acinar cell ...
... is a rare type of glioma, a cancer of the brain that comes from glial, or supportive, brain cells, as opposed to ... and its sarcomatous transformation. Cancer 2:264-277 McComb R, Jones TR, Pizzo SV, Bigner DD (1982) Immunohistochemical ... reports claimed that the hyperplastic blood vessels that are frequently present in high grade gliomas underwent neoplastic ... Neurosurgery 26:261-267 Ehrenreich T, Devlin JF (1958) A complex of glioblastoma and spindle-cell sarcoma with pulmonary ...
... and mutant forms of p53 that appear during cell transformation. It appears that Hsp90 can act as a "protector" of less stable ... in signal transduction and neoplastic transformation". J. Biol. Chem. 277 (10): 8312-20. doi:10.1074/jbc.M109200200. PMID ... They account for 1-2% of total protein in unstressed cells. However, when cells are heated, the fraction of heat shock proteins ... Cell. 127 (2): 329-40. doi:10.1016/j.cell.2006.09.027. PMID 17055434. Ali MM, Roe SM, Vaughan CK, Meyer P, Panaretou B, Piper ...
... transformation, bacterial MeSH G05.760.865 - transformation, genetic MeSH G05.760.865.820 - transformation, bacterial MeSH ... alpha-chain t-cell antigen receptor MeSH G05.330.801.211 - gene rearrangement, beta-chain t-cell antigen receptor MeSH G05.330. ... neoplastic MeSH G05.315.370.500 - gene expression regulation, leukemic MeSH G05.315.375 - gene expression regulation, plant ... 801.261 - gene rearrangement, delta-chain t-cell antigen receptor MeSH G05.330.801.311 - gene rearrangement, gamma-chain t-cell ...
Patients with neoplastic transformation of the tumours require chemotherapy; doxorubicin is thought to be the most effective ... giant cells increase and activation of inflammatory cells becomes more prominent.8 Spondylitis, a typical sign ascribed to ... T If you are planning on performing surgery, or if there are questions about the aorta or neoplastic transformation, consider ... and you may need to check for neoplastic transformation (evidence as ulceration and necrosis of the mass). In this instance, ...
Cell. 130 (4): 624-637. doi:10.1016/j.cell.2007.06.013. PMC 2779720. PMID 17719541. "ACGT - Scientific Advisory Council - ... Aaronson's early research established the transformation-competent but replication-defective nature of mammalian sarcoma ... Aron Professor of Neoplastic Diseases and Chairman of Oncological Sciences at The Mount Sinai Hospital in New York City until ... "Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells". Journal of Cell Biology. 185 (1 ...
It may be either truly neoplastic or merely hamartomatous (an odontoma). In neoplastic cases, it may be labeled an ameloblastic ... cell-rich and myxoid (9). Rarely, it may contain granular cells. However, it should be noted this may also be observed in a ... This is done when the tumour is large or is deemed to have a high chance of malignant transformation. In some cases the fibroma ... It is a neoplasm, meaning it is a mass of abnormal growth of cells or tissue. If the mass contains hard dental tissues they are ...
... mRNA was discovered to be increased in precancerous lesions and neoplastic cells of pancreatic tumors and cancer cell ... cell migration, and cell transformation. However, there have been other observations that AGR2 can repress growth and ... AGR2 was determined to be involved in cell adhesion. Agr2-silenced prostate cancer cells had a large decrease in association ... Cell. Proteomics. 3 (6): 534-47. doi:10.1074/mcp.M300089-MCP200. PMID 14967811. Wang Z, Hao Y, Lowe AW (January 2008). "The ...
The exact point of failure, in terms of the minimal percentage of neoplastic cells, will depend on the particular platform and ... Columbia University Press N.Y. Shaffer LG, Bejjani B (2006). "Medical applications of array CGH and the transformation of ... Clear cell renal carcinoma: del 9p and del 14q are poor prognostic indicators. Papillary renal cell carcinoma: duplication of ... van den Berg, E; Störkel, S (2003). "Kidney: Clear cell renal cell carcinoma". Atlas Genet Cytogenet Oncol Haematol. 7 (3): 424 ...
... but the neoplastic cells have a distinct morphology under the microscope (hairy cell leukemia cells have delicate, hair-like ... Liu H, Miao Y, Ferrajoli A, Tang G, McDonnell T, Medeiros LJ, Hu S (March 2020). "Leukemic phase of Richter transformation: A ... These B-cells are abnormal: they are monoclonal, i.e. produced by a single ancestral B-cell, and have some of the same cell ... The T cells had been modified to express genes that would allow the cells to proliferate in the body and destroy B cells ...
"Purification of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian ... Bursa cells were termed B-cells for Bursa to differentiate them from thymus derived T-cells. The chicken embryo is a unique ... Discoveries in the chicken ultimately divided the adaptive immune response into antibody (B-cell) and cell-mediated (T-cell) ... Easty, G. C.; Easty, D. M.; Tchao, R. (1969). "The growth of heterologous tumour cells in chick embryos". European Journal of ...
It is currently unclear as to whether cancer stem cells arise from adult stem cell transformation, a maturation arrest of ... "Cancer prevention strategies that address the evolutionary dynamics of neoplastic cells: simulating benign cell boosters and ... The first malignant cell, that gives rise to the tumor, is often labeled a cancer stem cell. The cancer stem-cell hypothesis ... When a cancer cell divides, both daughter cells inherit the genetic and epigenetic abnormalities of the parent cell, and may ...
Cancer stem cells may arise from transformation of adult stem cells or differentiated cells within a body. These cells persist ... result in cancer through their effects on the population of neoplastic cells and their microenvironment. Mutant cells in ... and stem cells are the only cells that can transmit DNA from the zygote to cells late in life. Other cells, derived from stem ... The cancer stem cell hypothesis proposes that the different kinds of cells in a heterogeneous tumor arise from a single cell, ...
J. Cell Biol. 79 (4): 283-293. doi:10.1078/S0171-9335(04)70031-X. PMID 10826496. Erdmann KS, Kuhlmann J, Lessmann V, et al. ( ... 2000). "Immunohistochemical localization of FAP-1, an inhibitor of Fas-mediated apoptosis, in normal and neoplastic human ... and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic ... PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, ...
"Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins". Oncogene. ... Buck, Genna (14 August 2013). "Anthony Pawson helped discover how cells communicate with each other". The Globe and Mail. ... Pawson, T.; Nash, P. (2003). "Assembly of Cell Regulatory Systems Through Protein Interaction Domains". Science. 300 (5618): ... Bernstein, Alan; Rossant, Janet (2013). "Anthony James Pawson (1952-2013) Biochemist whose vision of cell signalling ...
The molecular mechanisms underlying the malignant transformation of normal mesothelial cells by asbestos fibers remain unclear ... studies play an important role for the pathologist in differentiating malignant mesothelioma from neoplastic mimics, such as ... Also, heating itself damages the malignant cells more than the normal cells.[citation needed] Multimodal therapy, which ... complete in vitro transformation of normal human mesothelial cells to a malignant phenotype following exposure to asbestos ...
... that last more than 2 weeks or over one year and does not develop progression of cancer cells have a low chance of neoplastic ... Other related causes such as lymphoproliferative conditions known as Castleman disease, or progressive transformation of ... It is known, however, that a stimulation of the B cell compartment and by abnormal cell growth of secondary follicles are key ... It is caused by a stimulation of the B cell compartment and by abnormal cell growth of secondary follicles. This typically ...
Carcinomas are tumors derived from epithelial cells and SCC results from transformation and proliferation of squames, epidermal ... Knottenbelt, Derek C.; John W. McGarry (2009). "Chapter 18: Neoplastic conditions". Pascoe's principles and practice of equine ... Squamous-cell carcinoma is the second-most prevalent skin cancer, followed by melanoma. Squamous-cell carcinoma and melanoma ... 694 Knottenbelt and McGarry, Squamous cell carcinoma, pg. 427 Knottenbelt and McGarry. Squamous cell carcinoma., pg. 433. ...
This activates the catenin pathway and leads to inappropriate cell division. The diagnosis of salivary gland tumors utilize ... Pleomorphic adenoma (or benign mixed tumor) is a common benign salivary gland neoplasm characterised by neoplastic ... pleomorphic adenomas have the capacity to grow to large proportions and may undergo malignant transformation, to form carcinoma ... spindle or stellate-shaped cells (hence pleiomorphism). Areas of squamous metaplasia and epithelial pearls may be present. The ...
... transformation, and metastatic spread of the triple negative human BCa cell line MDA-MB-231. Elevated levels of RHAMM and ... hyperplasic and neoplastic prostate tissue". BJU International. 113 (5): 822-829. doi:10.1111/bju.12339. PMID 24053431. S2CID ... RHAMM is localized inside the cell and is unconventionally exported to the cell surface in response to certain defined stimuli ... "Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation". Cell. 82 (1): ...
Grb2-associated binder-1-SHP-2 complex formation and its functional loss during neoplastic cell progression". Cell Growth ... Fixman ED, Holgado-Madruga M, Nguyen L, Kamikura DM, Fournier TM, Wong AJ, Park M (1997). "Efficient cellular transformation by ... "The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream ... Cell. Biol. 19 (3): 1784-99. doi:10.1128/MCB.19.3.1784. PMC 83972. PMID 10022866. Nishida K, Yoshida Y, Itoh M, Fukada T, ...
In the tumour stage, the cancer cells move into the dermis (the deeper layer of skin) Large cell transformation, where clonally ... Knowles DM (2000). Neoplastic Hematopathology. Lippincott Williams Wilkins. p. 1957. ISBN 978-0-683-30246-2. Hwang ST, Janik JE ... SS cells are found mainly in the blood, whereas MF typically involves the skin. In advanced stages of MF, the cancer cells move ... Additionally, the disease is an unusual expression of CD4 T cells, a part of the immune system. These T cells are skin- ...
"Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2". Nature Communications. 5 ... Qualtrough D, Hinoi T, Fearon E, Paraskeva C (Aug 2002). "Expression of CDX2 in normal and neoplastic human colon tissue and ... Later in development, CDX2 is expressed in intestinal epithelial stem cells, which are cells that continuously differentiate ... specifically marking the trophectoderm lineage of cells in the blastocyst of mouse and human. Trophectoderm cells contribute to ...
... a technique that can isolate individual cell types individual cells, which gave rise to cDNA libraries of specific cell types. ... an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus". Proceedings of ... used for defining chromosome structure and to characterize rearrangements that are associated with malignant transformation. It ... An example is prostate cancer tissue where epithelial cells, which have been shown to be the only cell type give rise to cancer ...
... deep muscle tissue as a neoplastic transformation of a larger existing benign cavernous hemangioma, bone and spleen, and has ... Weiss in 1996 as "spindle cell hemangioma", rather than hemangioendothelioma, due to the excellent prognosis observed in a ... These tumors are so named because their histologic appearance resembles a proliferation of epithelioid cells, with polygonal ... Perkins P, Weiss SW (October 1996). "Spindle cell hemangioendothelioma. An analysis of 78 cases with reassessment of its ...
"Metabolic Alterations in Cancer Cells and the Emerging Role of Oncometabolites as Drivers of Neoplastic Change". Antioxidants. ... Today, mutations in oncogenes and tumor suppressor genes are thought to be responsible for malignant transformation, and the ... where nuclei from cancer cells are placed in normal cytoplasm and where nuclei from normal cells are placed in cancer cytoplasm ... Warburg investigated the metabolism of tumors and the respiration of cells, particularly cancer cells, and in 1931 was awarded ...
Malignant transformation of polyps requires surgical colectomy. Most juvenile polyps are benign; however, malignancy can occur ... While the majority of the polyps found in juvenile polyposis syndrome are non-neoplastic, hamartomatous, self-limiting and ... Cell surface receptor deficiencies, Pediatric cancers, Hereditary cancers, Gastrointestinal cancer, Syndromes affecting the ...
It is expressed at much lower levels in most mammalian cells. When present in the same cell, different isozymes readily form ... More recently, a derivative of SF2312, termed HEX, and a prodrug thereoff, POMHEX, were shown to exert anti-neoplastic activity ... Enzymatic transformation of phosphoglyceric acid into pyruvic and phosphoric acid]. Biochemische Zeitschrift (in German). 273: ... It is present at some level in all normal human cells. ββ or muscle-specific enolase (MSE). Also known as enolase 3. This ...
Schrek R, Donnelly WJ (February 1966). ""Hairy" cells in blood in lymphoreticular neoplastic disease and "flagellated" cells of ... A typical transformation rate of 5-6% has been postulated in the UK, similar to the Richter's transformation rate for splenic ... Hairy cells are nearly mature B cells, which are activated clonal cells with signs of VH gene differentiation. They may be ... This cytokine also suppresses normal production of healthy blood cells in the bone marrow. Unlike healthy B cells, hairy cells ...