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*  Radiobiology evidence for protons and HZE nuclei
Tracy Chui-hsu Yang; Laurie M. Craise; Man-Tong Mei; Cornelius A. Tobias (1985). "Neoplastic Cell Transformation by Heavy ... The fate of normal cells that contain a single terminal deletion is unknown, but it has been shown that the loss of a single ... Genomic instability has been observed both in vitro and in vivo in the progeny of cells that are irradiated with heavy ions in ... Cells containing telomere-deficient chromosomes will either senesce or undergo breakage-fusion-bridge (B/F/B) cycles, thereby ...
*  Cherry hemangioma
2007). "Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1". Carcinogenesis. 28 (9): 1918-27. ... induced cell proliferation of the endothelial cells. They also found that targeting MEK1 and cyclin E1 with small interfering ... A significant increase in the density of mast cells has been seen in cherry hemangiomas compared with normal skin. These ... By inhibiting mir-424 in normal endothelial cells they could observe the same increased protein expression of MEK1 and cyclin ...
*  ZAK
"A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and ... The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell ... interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle". Biochem. Biophys. Res. Commun. United ... interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle". Biochem. Biophys. Res. Commun. 301 (1 ...
*  Health threat from cosmic rays
"Split-dose exposures versus dual ion exposure in human cell neoplastic transformation". Radiat Environ Biophys. 46 (2): 119-23 ... With respect to cells in critical brain regions, as many as 13% of such cells may be traversed at least once by an iron ion ... 0.1 Gy). At larger doses (>~0.1 Gy) critical cells and cell components could receive more than one particle traversal, which is ... whereby a particle traversal to some cells modifies the response of other cells not traversed by particles. There is limited ...
*  List of MeSH codes (C23)
... cell transformation, neoplastic MeSH C23.550.727.152.110 --- blast crisis MeSH C23.550.727.152.160 --- cell transformation, ... plasma cell MeSH C23.550.382.875.500 --- granuloma, plasma cell, orbital MeSH C23.550.382.875.750 --- granuloma, plasma cell, ... neoplasm circulating cells MeSH C23.550.727.650.830 --- neoplasm seeding MeSH C23.550.727.650.895 --- neoplasms, unknown ... giant cell MeSH C23.550.382.750 --- granuloma, lethal midline MeSH C23.550.382.875 --- granuloma, ...
*  Nodular lymphocyte predominant Hodgkin's lymphoma
After transformation, neoplastic cells carry monoclonal immunoglobulin gene rearrangements. Histological transformation may ... cells are present embedded in nodules consisting of B cells and other reactive cells (mainly reactive T cells). Reed-Sternberg ... RSH cells typically express CD15 and CD30, whereas LP cells lack expression of these markers, but express B cell markers like ... Histologic transformation to diffuse large B-cell lymphoma (DLBCL) can occur in up to 12% of cases. ...
*  Small tumor antigen
Some, but not all, polyomaviruses are oncoviruses capable of inducing neoplastic transformation in some cells. In oncogenic ... STag is unable to induce neoplastic transformation in the host cell on its own, but its presence may increase the transforming ... the cell must be in S phase (the part of the cell cycle in which the host cell's genome is normally replicated) in order to ... In SV40, STag has a similar role in cellular transformation. In Merkel cell polyomavirus, it appears to play a significant role ...
*  Lactotropic cell
... of all cells in the anterior pituitary gland. If these cells undergo neoplastic transformation, they will give rise to a ... A lactotropic cell (also known as prolactin cell, epsilon acidophil, lactotrope, lactotroph, mammatroph, mammotroph) is a cell ... Prolactin cells are acidophilic by hematoxylin & eosin stains and comprise about 20% ...
*  Dense Inert Metal Explosive
These alloys were found to cause neoplastic transformations of human osteoblast cells. A more recent U.S. Department of Health ... "Neoplastic transformation of human osteoblast cells to the tumorigenic phenotype by heavy metal-tungsten alloy particles: ...
*  Middle tumor antigen
It has the ability to induce neoplastic transformation in a variety of cell types and can immortalize cells in culture. Its ... In MPyV, MTag is an efficient oncoprotein that can be sufficient to induce neoplastic transformation in some cells. The genes ... role in viral life cycle and cell transformation". Journal of cellular physiology. 215 (2): 309-19. doi:10.1002/jcp.21326. PMC ... The transformation capacity of MTag can be eliminated by mutations that remove the membrane anchor, and reduced or eliminated ...
*  Sialyltransferase
... the expression of sialyltransferases undergoes profound modifications during cell differentiation and neoplastic transformation ...
*  Large tumor antigen
Some, but not all, polyomaviruses are oncoviruses capable of inducing neoplastic transformation in some cells. In oncogenic ... are oncoproteins that can induce neoplastic transformation in the host cell. Polyomavirus LTag proteins contain four well- ... the cell must be in S phase (the part of the cell cycle in which the host cell's genome is normally replicated) in order to ... Of these, LTag is primarily responsible for cellular transformation. STag alone cannot transform cells, but improves the ...
*  Oncogenomics
This suggests that when a healthy cell transforms into a tumor cell (a neoplastic transformation) the mitochondria seem to ... not only cancer cells). Thus, drugs that knock out these oncogenes (and thereby kill cancer cells) may also damage normal cells ... If the knockout of an otherwise nonessential gene has little or no effect on healthy cells, but is lethal to cancerous cells ... However, other genes may be essential to cancer cells but not to healthy cells. Treatments based on the principle of synthetic ...
*  Polycomb Group Proteins and Cancer
"EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells". Proceedings of ... Its roles in the cell cycle and apoptosis help cells maintain an immature state, and its expression wanes as cells begin to ... modulation of these cell cycle inhibitor genes also allows Bmi-1 to malignantly transform cells (both mature and stem cells) ... Maintenance of adult stem cells PcG proteins are also key players in the maintenance of adult stem cell populations. Several ...
*  XRCC2
"EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells". Proc. Natl. ... Cell. Biol. 33 (2): 387-95. doi:10.1128/MCB.00465-12. PMC 3554112 . PMID 23149936. Schild D, Lio YC, Collins DW, Tsomondo T, ... "Entrez Gene: XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2". Miller KA, Sawicka D, Barsky D, ... Molecular Cell. 1 (6): 783-93. doi:10.1016/S1097-2765(00)80078-7. PMID 9660962. Johnson RD, Liu N, Jasin M (Sep 1999). " ...
*  EZH2
"EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells". Proceedings of ... In breast cancer cells, EZH2 activates genes that promote cell proliferation and survival. It can also activate regulatory ... Further, EZH2 has been identified as an essential protein involved in development and differentiation of B-cells and T-cells. ... It and its homologs play essential roles in development, cell differentiation, and cell division in plants, insects, fish, and ...
*  XRCC3
"EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells". Proc. Natl. ... Cell Mol. Genet. 23 (4): 237-247. doi:10.1007/BF02674415. PMID 9542526. Liu N, Lamerdin JE, Tebbs RS, Schild D, Tucker JD, Shen ... Cell. Biol. 33 (2): 387-95. doi:10.1128/MCB.00465-12. PMC 3554112 . PMID 23149936. Hussain S, Wilson JB, Medhurst AL, Hejna J, ... Cell. 1 (6): 783-793. doi:10.1016/S1097-2765(00)80078-7. PMID 9660962. Pierce AJ, Johnson RD, Thompson LH, Jasin M (1999). " ...
*  RAD51C
"EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells". Proc. Natl. ... A characteristic of many cancer cells is that parts of some genes contained within these cells have been recombined with other ... Cell. Biol. 33 (2): 387-95. doi:10.1128/MCB.00465-12. PMC 3554112 . PMID 23149936. Wu GJ, Sinclair CS, Paape J, Ingle JN, Roche ... One such gene fusion that has been identified in a MCF-7 breast cancer cell line is a chimera between the RAD51C and ATXN7 ...
*  Mycoplasma haemofelis
Interestingly, chronic M. haemofelis infection may promote neoplastic transformation of white blood cells in FeLV-infected ... Once in the blood stream, M. haemofelis individuals adhere to the cell membranes of red blood cells and eventually become ... It has shed many biosynthetic systems found in related gram-positive bacteria as well as the ability to secrete a cell wall ( ... Parasitized red blood cells often lose their biconcave shape. This decreases surface area, increases osmotic fragility, and ...
*  Risk factors for breast cancer
This data indicates that BPA is able to induce neoplastic transformation of human breast epithelial cells. Epigenetic changes ... BPA was able to induce transformation of human breast MCF-10F epithelial cells. After treatment with BPA, the cells produced ... The cells treated with 10-3 M BPA died on the second day of treatment. The concentration of 10-4 M BPA was also toxic for the ... Also, human breast cells put into contact with small amounts of ethylene oxide in a laboratory can lead to DNA damage of the ...
*  Radiation hormesis
Cao, J.; Wells, R.L.; Elkind, M.M. (1992). "Enhanced Sensitivity to Neoplastic Transformation by137Cs γ-rays of Cells in the G2 ... Dobrzyński, L.; Fornalski, K. W.; Socol, Y.; Reszczyńska, J. M. (2016). "Modeling of Irradiated Cell Transformation: Dose- and ... Adaptive Response for Protection against Micronucleus Formation and Neoplastic Transformation in C3H 10T1/2 Mouse Embryo Cells ... "Multifractionation of 60Co gamma-rays reduces neoplastic transformation in vitro". Carcinogenesis. 5 (2): 193-97. doi:10.1093/ ...
*  SPEN
... ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... doi:10.1016/j.cell.2006.03.032. PMID 16713569. Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach ... Cell. Biochem. 288 (1-2): 151-7. doi:10.1007/s11010-006-9131-9. PMID 16583136. Gregory SG, Barlow KF, McLay KE, et al. (2006 ...
*  MRN complex
"Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer ... Since tumor cells have increased mitotic rates compared to non-malignant cells this is not entirely unexpected, as it is ... arresting tumor cell proliferation both in vitro and in vivo via mouse models grafted with various HNSCC cell lines. While ... Cell. 135 (1): 97-109. doi:10.1016/j.cell.2008.08.017. PMC 2681233 . PMID 18854158. Zhu, XD; Küster, B; Mann, M; Petrini, JH; ...
*  List of intestinal stem cell marker genes
"Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation". Nature. 457 (7229): 603-607. doi: ... these cells are also called quiescent stem cells. The stem cell zone model states that the CBC stem cells reside in a stem-cell ... "The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse". Cell Stem Cell. 8 (5 ... "Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls". Cell Stem Cell. 11 (4): 452-460. doi:10.1016/j. ...
*  FYN
When this normal biology is compromised, the altered Fyn becomes involved in the neoplastic transformation of normal cells to ... interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells". Exp. Cell Res. 256 ... Overexpression of Fyn has been found to drive morphologic transformation in normal cells and increase "anchorage-independent ... Fyn's normal role in cell migration and adhesion enables it to utilize the normal cell biology of integrin and FAK for cancer ...
*  Fusion transcript
Li; Wang, J; Mor, G; Sklar, J (2008). "A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells". Science. ... 2009). "SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer". Cancer ... Certain fusion transcripts are commonly produced by cancer cells, and detection of fusion transcripts is part of routine ...