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*  Cell survival curve
A cell survival curve is a curve used in radiobiology. It depicts the relationship between the fraction of cells retaining ... Cell survival fractions are exponential functions with a dose-dependent term in the exponent due to the Poisson statistics ... The linear quadratic model is now most often used to describe the cell survival curve, assuming that there are two mechanisms ... Dose fractionation Dose-response relationship Chronic radiation syndrome "Cell Survival Curves" (PDF). Massachusetts Institute ...
*  Shimon Schuldiner
A common theme of cell survival. Ann. N. Y. Acad. Sci. 733, 174-184 Yaffe, D., Radestock, S., Shuster, Y., Forrest, L. R., and ... Woodall, N. B., Yin, Y., and Bowie, J. U. (2015) Nat Commun 6 "The Up And Down Side Of 'Traffic' In Our Cells". Medical News ... Traffic' in our cells works both for and against us , EurekAlert! Science News". Eurekalert.org. 2013-05-01. Retrieved 2016-08- ...
*  TGF beta signaling pathway
They are also nerve cell survival factors. The BMPs bind to the bone morphogenetic protein receptor type-2 (BMPR2). They are ... It is also involved in G1 arrest in the cell cycle. Activin causes the transcription of mRNAs involved in gonadal growth, ... Like the BMPs, TGF betas are involved in embryogenesis and cell differentiation, but they are also involved in apoptosis, as ... December 1992). "TGF beta signals through a heteromeric protein kinase receptor complex". Cell. 71 (6): 1003-14. doi:10.1016/ ...
*  Low-affinity nerve growth factor receptor
NGF is critical for the survival and maintenance of sympathetic and sensory neurons. NGF is released from the target cells, ... Lee R, Kermani P, Teng KK, Hempstead BL (Nov 2001). "Regulation of cell survival by secreted proneurotrophins". Science. 294 ( ... Gene knockdown of CD271 has also been shown to abolish neural crest stem cell properties of melanoma cells. Low-affinity nerve ... "TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor". Cell. 66 (2 ...
*  Spermidine
They serve vital roles in cell survival. Spermidine synthase (SPDS) catalyzes the formation of spermidine from putrescine. ... It also was found to reduce the amount of aging in yeast, flies, worms, and human immune cells by inducing autophagy. Recently ... T.M. Klein; T. Gradziel; M.E. Fromm; J.C. Sanford (1988). "Factors influencing gene delivery into Zea mays cells by high- ... Spermidine has also been found to "upregulate expression of the epithelial stem cell-associated keratins K15 and K19, and dose- ...
*  Nerve growth factor
NF-κB regulates nuclear gene transcription to promote cell survival. Alternatively, programmed cell death occurs when TRAF6 and ... and survival of nerve cells (neurons). In fact, NGF is critical for the survival and maintenance of sympathetic and sensory ... High affinity binding between proNGF, sortilin, and p75NTR can result in either survival or programmed cell death. Study ... Lee R, Kermani P, Teng KK, Hempstead BL (Nov 2001). "Regulation of cell survival by secreted proneurotrophins". Science. 294 ( ...
*  Tropomyosin receptor kinase A
Lee R, Kermani P, Teng KK, Hempstead BL (November 2001). "Regulation of cell survival by secreted proneurotrophins". Science. ... Cells which express both the LNGFR and the Trk receptors might therefore have a greater activity - since they have a higher " ... It has also been shown, however, that in the absence of a co-expressed TrkA, the LNGFR may signal a cell to die via apoptosis ... Cell. Neurosci. 31 (2): 179-92. doi:10.1016/j.mcn.2005.09.007. PMID 16253518. Lambiase A, Merlo D, Mollinari C, Bonini P, ...
*  CD40 (protein)
Dallman C, Johnson PW, Packham G (Jan 2003). "Differential regulation of cell survival by CD40". Apoptosis. 8 (1): 45-53. doi: ... The B cell can present antigens to helper T cells. If an activated T cell recognizes the peptide presented by the B cell, the ... B cells and macrophages. It can also be expressed by endothelial cells, smooth muscle cells, fibroblasts and epithelial cells. ... The T cell also produces IL-2, which directly influences B cells. As a result of this net stimulation, the B cell can undergo ...
*  Carmofur
Ceramide influences cancer cell survival, growth and death. Inhibition of AC activity sensitizes tumor cells to the effects of ... Once inside a cell, carmofur prodrug is converted into 5-FU. The mechanism of action of carmofur prodrug is traditionally ... Moreover, the treatment had no survival advantage for stage 1 and 2 cancer patients. This may be a reason why carmofur was ... extending their survival. Mifurol, Bayer, China; Carmofur, Japan As fluorouracil, carmofur has been known to induce ...
*  Ashby technique
The number of remaining nonagglutinated Type O cells as a function of time defines the survival rate of blood cells. This ... Franco RS (February 2009). "The measurement and importance of red cell survival". Am. J. Hematol. 84 (2): 109-14. doi:10.1002/ ... Differential agglutination of the red cells is then used to determine the number of remaining donor cells, allowing the ... The Ashby technique is a method for determining the volume and life span of red blood cells in humans, first published by Dr. ...
*  PAWR
Ranganathan P, Rangnekar VM (Nov 2005). "Regulation of cancer cell survival by Par-4". Annals of the New York Academy of ... Bieberich E, MacKinnon S, Silva J, Noggle S, Condie BG (Aug 2003). "Regulation of cell death in mitotic neural progenitor cells ... is a human gene coding for a tumor-suppressor protein that induces apoptosis in cancer cells, but not in normal cells. The ... This protein is specifically upregulated during apoptosis of prostate cells. The active domain of the Par-4 protein has been ...
*  Protein kinase B
ISBN 0-87893-106-6. Song G, Ouyang G, Bao S (2005). "The activation of Akt/PKB signaling pathway and cell survival". J. Cell. ... cell proliferation, transcription and cell migration. Akt1 is involved in cellular survival pathways, by inhibiting apoptotic ... Tumor cells that have constantly active Akt may depend on Akt for survival. Therefore, understanding Akt and its pathways is ... Since it can block apoptosis, and thereby promote cell survival, Akt1 has been implicated as a major factor in many types of ...
*  Sulfiredoxin
Identification of novel gene clusters for cell survival. J. Biol. Chem. 278, 8135-8145 Wimmer, U., Wang, Y., Georgiev, O. and ... Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one ...
*  Laminin, alpha 4
"The alpha4 laminin subunit regulates endothelial cell survival". Experimental Cell Research. 294 (1): 281-9. doi:10.1016/j. ... Mrowiec T, Melchar C, Górski A (1998). "HIV-protein-mediated alterations in T cell interactions with the extracellular matrix ... They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, ... "Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of ...
*  GSK3B
Jope RS, Bijur GN (2002). "Mood stabilizers, glycogen synthase kinase-3beta and cell survival". Molecular Psychiatry. 7 Suppl 1 ... Cell. 144 (3): 341-52. doi:10.1016/j.cell.2010.12.033. PMC 3050560 . PMID 21295697. Li Y, Bharti A, Chen D, Gong J, Kufe D (Dec ... "Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation". Nature. 406 (6791): 86-90. doi: ... Cell. 126 (5): 955-68. doi:10.1016/j.cell.2006.06.055. PMID 16959574. Turenne GA, Price BD (2001). "Glycogen synthase kinase3 ...
*  Sda protein domain
This protein domain is highly important to cell survival. When starved of nutrients, the cell is under extreme stress so ... It prevents the cell communicating the stress that it is under, which is crucial if the cell is to survive. All cells ... This signal transduction mechanism is switched on when the cell is under stress, such as nutrient deprivation. It works through ... Mol Cell. 13 (5): 689-701. doi:10.1016/S1097-2765(04)00084-X. PMID 15023339. Jacques DA, Streamer M, Rowland SL, King GF, Guss ...
*  PANX1
"Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival". Nature Cell Biology (17): 943-952. doi: ... Truncating mutations in this gene have been shown to promote breast cancer metastasis to the lungs by allowing cancer cells to ... Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap ... Bhalla-Gehi R, Penuela S, Churko JM, Shao Q, Laird DW (Mar 2010). "Pannexin1 and pannexin3 delivery, cell surface dynamics, and ...
*  Dengue virus
Ghosh Roy S, Sadigh B, Datan E, Lockshin RA, Zakeri Z (2014). "Regulation of cell survival and death during Flavivirus ... virus replication and protection from cell death require ER stress (PERK) pathway activation". Cell Death and Disease. 7 (e2127 ... "Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by ... However, a current study has found that the protein D7 hinders the virus transmission into the host cells. The immune responses ...
*  NUAK1
ARK5 is often overexpressed in multiple myeloma cell lines. ARK5 promotes tumor cell survival under regulation by Akt. ARK5 ... also inhibits ARK5 and reduces proliferation of multiple myeloma and mantle cell lymphoma cell lines. NUAK1 has been shown to ... Cell. Biol. 24 (8): 3526-35. doi:10.1128/MCB.24.8.3526-3535.2004. PMC 381626 . PMID 15060171. CS1 maint: Uses authors parameter ... Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Esumi H (Sep 2003). "ARK5 suppresses the cell death induced by nutrient ...
*  Pannexin
"Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival". Nature Cell Biology (17): 943-952. doi: ... J. Physiol., Cell Physiol. 295 (3): C761-7. doi:10.1152/ajpcell.00227.2008. PMC 2544448 . PMID 18596212. Andrew L Harris & ... Calcium waves are supported by glial cells, which help maintain and modulate neuronal metabolism. According to one of the ... Pannexin 1 channels are pathways for release of ATP from cells. Intercellular gap junctions in vertebrates, including humans, ...
*  Jerry Adams
... arbiters of cell survival". Science. 281 (5381): 1322-6. doi:10.1126/science.281.5381.1322. PMID 9735050. ... programmed cell death) and cancer, while studying the bcl-2 gene in follicular lymphoma, the most common human lymphoma. He ... a malignancy of antibody-producing cells, called "B lymphocytes". It was in Adams' lab that his PhD student, David Vaux, made ...
*  Retinal degeneration (rhodopsin mutation)
Satoh AK, Ready DF; Ready (2005). "Arrestin1 mediates light-dependent rhodopsin endocytosis and cell survival". Curr Biol. 15 ( ... Photoreceptor cell death is the eventual outcome of retinal degeneration. Without proper function of the photoreceptor cells, ... RP begins with death of rod photoreceptor cells, which are the only cells in the retina to express rhodopsin and which express ... Eventually, loss of rod cells leads to loss of cone cells (cone photoreceptors), the mainstay of human vision. Symptoms of RP ...
*  Calorie restriction
2004). "Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase". Science. 305 (5682): 390-2. ... "Short-term calorie restriction enhances skeletal muscle stem cell function". Cell Stem Cell. 10 (5): 515-9. doi:10.1016/j.stem. ... Guarente L, Picard F (February 2005). "Calorie Restriction- the SIR2 Connection". Cell. 120 (4): 473-482. doi:10.1016/j.cell. ... One proponent of the view that the gene Sir2 may underlie the effect of calorie restriction in mammals by protecting cells from ...
*  Membrane progesterone receptor
Song G, Ouyang G, Bao S (2005-03-01). "The activation of Akt/PKB signaling pathway and cell survival". Journal of Cellular and ... granulosa cell apoptosis, immunosuppression of T cells, breast and ovarian cells. It has been found that allopregnanolone, an ... Experimental evidence also supports that mPRs are intermediaries in progestin-induced cell survival. MAP kinase and Akt are ... mPRs are cell surface receptors which rapidly alter cell signaling via modulation of intracellular signaling cascades. The mPRs ...
*  STUB1
"CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival". The Journal of Biological Chemistry. 279 (6): ... "X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility". Nature Cell Biology. 10 (12): 1447-55. ... Molecular Cell. 10 (1): 55-67. doi:10.1016/s1097-2765(02)00583-x. PMID 12150907. Li X, Huang M, Zheng H, Wang Y, Ren F, Shang Y ... Nature Cell Biology. 3 (1): 93-6. doi:10.1038/35050618. PMID 11146632. Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, ...
*  Cervical cancer
In medical research, the most famous immortalised cell line, known as HeLa, was developed from cervical cancer cells of a woman ... Survival rates decrease to 30-40% for women with stage III cancer and 15% or fewer of those with stage IV cancer five years ... adenosquamous carcinoma small cell carcinoma neuroendocrine tumour glassy cell carcinoma villoglandular adenocarcinoma ... Five year survival in the United States for White women is 69% and for Black women is 57%. Regular screening has meant that ...