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*  Wnt signaling pathway
The noncanonical planar cell polarity pathway regulates the cytoskeleton that is responsible for the shape of the cell. The ... Cell fate specification or cell differentiation is a process where undifferentiated cells can become a more specialized cell ... The biochemistry of cancer stem cells is subtly different than that of other tumor cells. These so-called Wnt-addicted cells ... Wnt signaling functions can be divided into axis patterning, cell fate specification, cell proliferation and cell migration. In ...
*  Cell polarity
Epithelial polarity Cell migration Embryogenesis Embryonic development Asymmetric cell division 3D cell culture Cell culture ... cell migration, cell-cell signalling and fertilization. Cell polarity is an example of the self-organization property that all ... Cell polarity refers to spatial differences in shape, structure, and function within a cell. Almost all cell types exhibit some ... "Cell Polarity in Eggs and Epithelia: Parallels and Diversity". Cell. 141 (5): 757-774. doi:10.1016/j.cell.2010.05.011. PMID ...
*  Wd repeat containing planar cell polarity effector
A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ... WD repeat containing planar cell polarity effector is a protein that in humans is encoded by the WDPCP gene. This gene encodes ... WD repeat containing planar cell polarity effector". Retrieved 2017-06-07. Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, ...
*  Neuroepithelial cell
In the absence of occludin some polarity is still lost and the neuroepithelial cell gives rise to the radial glial cell. In the ... Neuroepithelial cells undergo mitosis generating more neuroepithelial cells, radial glial cells or progenitor cells, the latter ... The asymmetric cell division results in two different varieties of daughter cells (i.e. a neuroepithelial cell divides into a ... Neuroepithelial cells are the "stem cells" of the nervous system, deriving from actual stem cells in several different stages ...
*  Torsin A
Ferrari Toninelli G, Spano P, Memo M (2003). "TorsinA, microtubules and cell polarity". Funct. Neurol. 18 (1): 7-10. PMID ... 2000). "Mutant torsinA, responsible for early-onset torsion dystonia, forms membrane inclusions in cultured neural cells". Hum ...
*  Symmetry breaking and cortical rotation
In fact, the origin of asymmetry in cell division, cell polarity and the mechanism that breaks the symmetry continue to be ... Cells first need to establish a polarity through a symmetry-breaking event before tissues and organs themselves can be polar. ... Wong, Fei (2009). "The Signaling Mechanisms Underlying Cell Polarity and Chemotaxis". Cold Spring Harbor Perspectives in ... Nelson, James W. (2009). "Remodeling epithelial cell organization: Transitions between front-rear and apical-basal polarity". ...
*  Arp2/3 complex
The complex has also been shown to be involved in the establishment of cell polarity and the migration of fibroblast monolayers ... pavement cells, hypocotyl cells, and root hair cells. The Arp2/3 complex is composed of seven subunits: Arp2, Arp3, p41/ARPC1, ... Xu J, Scheres B (December 2005). "Cell polarity: ROPing the ends together". Current Opinion in Plant Biology. 8 (6): 613-8. doi ... "Involvement of the Arp2/3 complex and Scar2 in Golgi polarity in scratch wound models". Molecular Biology of the Cell. 14 (2): ...
*  CAB39
Baas AF, Smit L, Clevers H (2004). "LKB1 tumor suppressor protein: PARtaker in cell polarity". Trends Cell Biol. 14 (6): 312-9 ... 2005). "Analysis of the LKB1-STRAD-MO25 complex". J. Cell Sci. 117 (Pt 26): 6365-75. doi:10.1242/jcs.01571. PMID 15561763. ...
*  LYK5
Baas AF, Smit L, Clevers H (2004). "LKB1 tumor suppressor protein: PARtaker in cell polarity". Trends Cell Biol. 14 (6): 312-9 ... Cell Sci. 117 (Pt 26): 6365-75. doi:10.1242/jcs.01571. PMID 15561763. Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, ... Cell Sci. 117 (Pt 26): 6365-75. doi:10.1242/jcs.01571. PMID 15561763. ...
*  PRICKLE1
Prickle planar cell polarity protein 1 is a protein that in humans is encoded by the PRICKLE1 gene. This gene encodes a nuclear ... Prickle planar cell polarity protein 1". Retrieved 2017-08-08. Katoh M, Katoh M (2003). "Identification and characterization of ... "Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling". EMBO J. 22 ... Cell. Biol. 23 (24): 9025-31. PMC 309669 . PMID 14645515. Kim SM, Yang JW, Park MJ, Lee JK, Kim SU, Lee YS, Lee MA (2006). " ...
*  PDZ domain
Liu, Jie; Li, Juan; Ren, Yu; Liu, Peijun (2014-01-01). "DLG5 in cell polarity maintenance and cancer development". ... Cell. 131 (1): 80-92. doi:10.1016/j.cell.2007.07.037. ISSN 0092-8674. PMID 17923089. van den Berk, Lieke C. J.; Landi, Elena; ... both play an important role at cell junctions and in cell signaling complexes. Since the discovery of PDZ domains more than 20 ... For cells to function properly it is important for components-proteins and other molecules- to be in the right place at the ...
*  STK11
Baas AF, Smit L, Clevers H (2004). "LKB1 tumor suppressor protein: PARtaker in cell polarity". Trends Cell Biol. 14 (6): 312-9 ... The STK11/LKB1 gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a ... A picture from current research is emerging that loss of LKB1 leads to disorganization of cell polarity and facilitates tumour ... Activation of AMPK-related kinases by LKB1 plays vital roles maintaining cell polarity thereby inhibiting inappropriate ...
*  Weill Institute for Cell and Molecular Biology
His research focuses on microfilaments and cell polarity. "Institute for Cell and Molecular Biology benefits from $25 million ... "Cornell's Weill Institute for Cell and Molecular Biology". ASBMB Today (September 2008): 30-33. Weill Institute for Cell and ... It has also been found to play a vital role in cell division and the viral budding of HIV. His work on the ESCRT complexes has ... In May 2006, Scott D. Emr was named the Frank H.T. Rhodes Class of '56 Director of the Weill Institute for Cell and Molecular ...
*  Epithelial polarity
Cell polarity is a fundamental feature of many types of cells. Epithelial cells are one example of a polarized cell type, ... In at least one cultured cell line, the MDCK cell, this system is required for epithelial polarity. The relationship between ... How epithelial cells generate and maintain polarity remains unclear, but certain molecules have been found to play a key role. ... How epithelial cells polarize is still not fully understood. Some key principles have been proposed to maintain polarity, but ...
*  Strabismus (protein)
Prickle is another protein in the planar cell polarity signaling pathway. Prickle is recruited to the cell surface membrane by ... Fanto M, McNeill H (February 2004). "Planar polarity from flies to vertebrates". J. Cell Sci. 117 (Pt 4): 527-33. doi:10.1242/ ... Wolff T, Rubin GM (March 1998). "Strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila ... Strabismus was originally identified as a Drosophila protein involved in planar cell polarity. Flies with mutated strabismus ...
*  Allomyces macrogynus
39 233 - 240 Youatt, J.; Gow, N. A. R.; Gooday, G. W. (1988). "Bioelectric and biosynthetic aspects of cell polarity ...
*  MAPRE2
Tirnauer JS, Bierer BE (2000). "EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability". J. Cell ... "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex". J. Cell Biol. 168 (1): 141-53. ... Cell. 13 (10): 3627-45. doi:10.1091/mbc.E02-01-0061. PMC 129971 . PMID 12388762. Bu W, Su LK (2004). "Characterization of ... Xu H, Hebert MD (2006). "A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin". BMC Cell Biol. 6 ...
*  Dactylellina haptotyla
Some of those genes are responsible for cell polarity regulation. For example, profilin and cofilin are downregulated in knobs ... The adhesive knob is a globose adhesive cell locates at the end of non-adhesive stalk which is composed by one to three cells. ... The other trapping structure, non-constricting loop, is constructed by three cells which elongate from stalk and fuse back to ... The electron-dense vesicles are rarely seen in stalk cells' cytoplasm. When sticky knob adheres a nematode, electron-dense ...
*  Multi-state modeling of biomolecules
Mogilner, A; Allard, J; Wollman, R (2012). "Cell polarity: Quantitative modeling as a tool in cell biology". Science. 336 (6078 ... This allows for simulations of biomolecules in realistic reconstructions of living cells, including cells with complex ... cell division and movement of cells. Models specified in ML-Rules can be simulated using the James II simulation framework. A ... Cell. 123 (5): 849-60. doi:10.1016/j.cell.2005.10.029. PMID 16325579. Stefan, M. I.; Marshall, D. P.; Le Novère, N (2012). " ...
*  MAPRE1
Tirnauer JS, Bierer BE (2000). "EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability". J. Cell ... Cell. 149 (2): 371-82. doi:10.1016/j.cell.2012.02.049. PMC 3368265 . PMID 22500803. Nakamura S, Grigoriev I, Nogi T, Hamaji T, ... Cell. 13 (12): 4308-16. doi:10.1091/mbc.E02-04-0236. PMC 138635 . PMID 12475954. Ligon LA, Shelly SS, Tokito M, Holzbaur EL ( ... Cell. 13 (10): 3627-45. doi:10.1091/mbc.E02-01-0061. PMC 129971 . PMID 12388762. Tirnauer JS, Canman JC, Salmon ED, Mitchison ...
*  Prickle (protein)
In epithelial cells, Prickle2 establishes and maintains cell apical/basal polarity. Prickle1 plays an important role in the ... Prickle is recruited to the cell surface membrane by strabismus, another planar cell polarity protein. In the developing ... "Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding". Nat. Cell Biol. 7 (7 ... Prickle is part of the non-canonical Wnt signaling pathway that establishes planar cell polarity. A gain or loss of function of ...
*  DLG1
Humbert P, Russell S, Richardson H (Jun 2003). "Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer". ... There is some evidence that SAP97 regulates cell-to-cell adhesion during cell death, and may interact with HPV. In the brain, ... Reuver SM, Garner CC (Apr 1998). "E-cadherin mediated cell adhesion recruits SAP97 into the cortical cytoskeleton". Journal of ... SAP97 is expressed throughout the body in epithelial cells, including the kidney and brain. ...
*  FAM203B
"Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy". Nature Cell Biology. 15 (1 ...
*  DVL1
"Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1-3): 167-73. doi:10.1016/s0014 ... Segment polarity protein dishevelled homolog DVL-1 is a protein that in humans is encoded by the DVL1 gene. DVL1, the human ... Cell. Biol. 19 (6): 4414-22. doi:10.1128/mcb.19.6.4414. PMC 104400 . PMID 10330181. Fagotto F, Jho Eh, Zeng L, Kurth T, Joos T ... Cell. Biol. 19 (6): 4414-22. doi:10.1128/mcb.19.6.4414. PMC 104400 . PMID 10330181. Inobe M, Katsube Ki, Miyagoe Y, Nabeshima ...
*  PARD3B
Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity ... a human Par3-related cell polarity protein". Biochem. Biophys. Res. Commun. 329 (1): 211-8. doi:10.1016/j.bbrc.2005.01.115. ... "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1-3): 167-73. doi:10.1016/S0014 ... "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. Netherlands. 539 (1-3): 167-73. doi: ...
*  Catenin
Cell-cell adhesion complexes are required for simple epithelia in higher organisms to maintain structure, function and polarity ... F9 embryonal carcinoma cells are similar to the P19 cells shown in Figure 1 and normally have cell-to-cell adhesion mediated by ... A tumor cell line with defective δ-catenin, low levels of E-cadherin and poor cell-to-cell adhesion could be restored to normal ... providing the cell with a means of stable cell adhesion. However, decreases in this adhesion ability of the cell has been ...
*  Erbin (protein)
"Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1-3): 167-73. doi:10.1016/s0014 ... at cell-cell junctions of epithelial cells". Genes Cells. 7 (5): 475-85. doi:10.1046/j.1365-2443.2002.00533.x. PMID 12047349. ... at cell-cell junctions of epithelial cells". Genes Cells. 7 (5): 475-85. doi:10.1046/j.1365-2443.2002.00533.x. PMID 12047349. ... "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1-3): 167-73. doi:10.1016/S0014 ...