Soucek, Laura (2019). "Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy". ... Whitfield, Jonathan; Soucek, Laura (2019-08-01). "Editorial overview: Peptides in cancer". Current Opinion in Pharmacology. 47 ... Her research considers the Myc oncoprotein, a protein that cancer cells appear to depend on, which had long been considered too ... Peptomyc have demonstrated that Omomyc can be used against non-small-cell lung carcinoma and potentially be used for other ...
"Rapid microwave fixation of cell monolayers preserves microtubule-associated cell structures". The Journal of Histochemistry ... Picrates penetrate tissue well to react with histones and basic proteins to form crystalline picrates with amino acids and ... "Antibacterial action of structurally diverse cationic peptides on gram-positive bacteria". Antimicrobial Agents and ... Immersion can be used to fix histological samples from a single cell to an entire organism. The sample of tissue is immersed in ...
"Once the mutant K10 allele is activated in epidermal stem cells by topical application of an inducer, these stem cells ... freely penetrate almost 100% of keratinocytes in vitro, mouse skin, and human epidermis within hours after application." This ... peptides, or viruses. "Topical application of nucleic acids offers many potential therapeutic advantages for suppressing genes ... When cells make a protein from a gene on a chromosome sitting in the nucleus, the gene is first transcribed as a piece of RNA. ...
The mature SHP pheromone can then be taken into nearby cells and the cell it originated from via a transmembrane protein, ... Zakeri B, Fierer JO, Celik E, Chittock EC, Schwarz-Linek U, Moy VT, Howarth M (2012). "Peptide tag forming a rapid covalent ... and spread by penetrating host tissue layers. A carbohydrate-based bacterial capsule composed of hyaluronic acid surrounds the ... Four of the 20 T-antigens have been revealed to be pili, which are used by bacteria to attach to host cells. As of 2016, a ...
Penetrates Human Cells, and Stabilizes HDM2 in Cell Culture" PLOSOne (2012), 7(10), doi:10.1371/journal.pone.0045948 Shivaiah ... Spiroligomer molecules (also known as bis-peptides) are synthetic oligomers made by coupling pairs of bis-amino acids into a ... The molecule enters cells through passive diffusion, and this mimic was shown to stabilize HDM2 in cell culture. Binuclear ... "Solid-Phase Synthesis of Functionalized Bis-Peptides" Biopolymers, (2011), 96(5), 578-585 doi:10.1002/bip.21591 Christopher G. ...
The stinger usually breaks off in the wound, and as it is barbed it can easily penetrate the skin but is difficult to remove ... Knowing how these peptides are structured could lead to the development of a neutralization technique that could effectively ... These changes stimulate the release of nitric oxide from the endothelial cells, smooth muscle contractions, and other effects ... Two peptides were isolated from the stingray venom, orpotrin, which causes vasoconstriction, and porflan, which causes ...
Movement of cells is vital for the function of the immune system, and especially for antigen presenting cells. Dendritic cells ... The introduction of haptotactic peptides may help in healing several diseases such as diabetes mellitus, hemophilia A and B ... "Role of Thrombospondin-1 in Repair of Penetrating Corneal Wounds". Investigative Ophthalmology & Visual Science. 54 (9): 6262- ... which is highly influenced by the cell's velocity, which is in turn influenced by direction of cell motility. Cells migrate ...
October 2014). "Cell factories for insulin production". Microbial Cell Factories. 13 (1): 141. doi:10.1186/s12934-014-0141-0. ... However, insulin is a peptide hormone, which is digested in the stomach and gut and in order to be effective at controlling ... A similar device, but relying on skin-penetrating "microneedles", was in the animal testing stage in 2015. In the last couple ... Beta cell transplant may become practical in the near future. Additionally, some researchers have explored the possibility of ...
... exhibits the same toxicity to hepatocytes (liver cells) in vivo as in vitro. It penetrates the hepatocytes and damages ... Olsnes S, Pihl A (July 1973). "Different biological properties of the two constituent peptide chains of ricin, a toxic protein ... Modeccin requires a low pH for entry into the cell. Below pH of 6.0, modeccin can't enter the cell via endocytosis. It is also ... Reduced, dissociated toxin subunits inhibit ribosomal activity in cell-free systems, but they have no effect on intact cells. ...
... it penetrates the cells of muscles and promotes necrosis. Crotamine is homologous with other venom myotoxins and is similar to ... Exon 1 codes for the first 19 amino acids of the signal peptide and includes the 5'-untranslated region. Exon 2 codes 39 amino ... "Crotamine is a novel cell-penetrating protein from the venom of rattlesnake Crotalus durissus terrificus". FASEB Journal. 18 ( ... Crotamine has a number of biological actions: it acts on cell membrane's sodium channels, is slightly analgesic and is myotoxic ...
... the principal cell), odontoblasts, defence cells like histiocytes, macrophages, granulocytes, mast cells, and plasma cells. The ... By virtue of their peptide content, they also play important functions in inflammatory events and subsequent tissue repair. ... with some nerves penetrating the dentinal tubules. The dental pulp is also innervated by the sympathetic division of the ... Cell-rich zone, which contains fibroblasts and undifferentiated mesenchymal cells. Cell-free zone (zone of Weil, which is rich ...
An extension of this method used three different sized gold particles to track the localisation of regulatory peptides. A more ... Thin sections are required for immunogold labeling and these can produce misleading images; a thin slice of a cell component ... A further limitation is that antibodies and gold particles cannot penetrate the resin used to embed samples for imaging. Thus, ... 2008). Molecular biology of the cell (5th ed.). New York: Garland Science. ISBN 978-0-8153-4106-2. Faulk WP, Taylor GM ( ...
Then, The tube goes through a centrifugation to filter cell debris and non motile cells. After the centrifugation, healthy ... Capacitation has two effects: destabilisation of the acrosomal sperm head membrane which allows it to penetrate the outer layer ... The tripeptide fertilization promoting peptide (FPP) is essential for controlling capacitation. FPP is produced in the prostate ... numerous methods have been developed to induce this process in mammalian sperm cells. Sperm cells are harvested through ...
... contained in the central cell) in the centre of the gametophyte. The resulting cell is triploid (3n). This triploid cell ... The pollen tube penetrates the stigma and elongates through the extracellular matrix of the style before reaching the ovary. ... Resact is a 14 amino acid peptide purified from the jelly coat of A. punctulata that attracts the migration of sperm. After ... Two daughter cells are produced by one parent cell. It involves the process of mitosis. Algae, like some land plants, undergo ...
The sequence of nesting behavior is: cell construction, provisioning, egg-laying, and sealing the cell. Cells containing ... bicornis venom does not penetrate human skin like that of the honeybee. Protein components in the venom, such as osmin, have ... "Structural identification by mass spectrometry of a novel antimicrobial peptide from the venom of the solitary bee Osmia rufa ( ... Between the cells and the terminal plug is a space known as the vestibular cell. The vestibule acts as a form of protection ...
However, targeting an HLA-A*0201-restricted peptide in MAGE-A3 caused severe damage to gray matter in the brain, because this ... difficult-to-penetrate tumor stroma, and factors in the tumor microenvironment that impede the activity of the immune system. ... CD4+ T cells can also promote tumor rejection. CD4+ T cells enhance CD8+ T cell function and can directly destroy tumor cells. ... CD8+ T cells can exist in a stem cell-like state, capable of clonal proliferation. Human T memory stem cells express a gene ...
Targeting peptides can be used to achieve site- or cell-specific delivery, and it has been shown that these peptides increase ... Hydrophobic drugs have a very difficult time penetrating the skin layer, as they partition heavily into skin oils. Recently, ... Peptide dendrimers may be employed in the future to precisely target cancer cells and deliver chemotherapeutic agents. The ... a cancer treatment which requires a large concentration of boron in cancerous cells and a low concentration in healthy cells. A ...
Some derivatives that were designed to penetrate mitochondrial cell membranes (SkQ1 (plastoquinonyl-decyl-triphenylphosphonium ... Peptide Science. 15 (4): 285-295. doi:10.2174/1389203715666140327104802. ISSN 1875-5550. PMC 4030317. PMID 24678671. F.F. ... SkQ1 has been shown to scavenge superoxides both within cells (in vivo) and outside of cells (in vitro). SkQR1 and SkQ1 have ... The prefix plasto- means either plastid or chloroplast, alluding to its location within the cell. The role that plastoquinone ...
Its mode of action is also unrelated to the cell wall, instead causing DNA damage in tumor cells. Due to their toxicity, use of ... Some tissues are not penetrated very well by glycopeptides, and they do not penetrate into the cerebrospinal fluid. The second- ... are a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic nonribosomal peptides. ... Some members of this class of drugs inhibit the synthesis of cell walls in susceptible microbes by inhibiting peptidoglycan ...
Brain oedema formation is due to the breakdown of red blood cells, where haemoglobin and other contents of red blood cells are ... "Penetrating Head Trauma." Archived 2005-09-13 at the Wayback Machine Emedicine.com. Sheth KN (October 2022). "Spontaneous ... Cerebral amyloid angiopathy, a disease characterized by deposition of amyloid beta peptides in the walls of the small blood ... A new area of interest is the role of mast cells in ICH. Hemphill JC, Greenberg SM, Anderson CS, Becker K, Bendok BR, Cushman M ...
The virus is injected along with the wasp egg into the body cavity of a lepidopteran host caterpillar and infects cells of the ... The wasp Leptopilina heterotoma secrete VLPs that are able to penetrate into the lamellocytes, thanks to specific receptors, ... Finally, insects can also respond with production of antiviral peptides. PolyDNAvirus protect the hymenopteran larvae from the ... VLPs allow the larvae to escape the immune system: the larva is not recognised as harmful by its host, or the immune cells ...
... endothelial cell junctions are reorganized and the vessel bilayer is perforated to allow growth factors and cells to penetrate ... Most are single-chain peptides of 16-18 kDa and display high affinity to heparin and heparan sulfate. In general, FGFs ... The cells that are proliferating are located behind the tip cells and are known as stalk cells. The proliferation of these ... with many open questions regarding best cell types and dosages to use. Cancer cells are cells that have lost their ability to ...
Cell. 181 (5): 1004-1015.e15. doi:10.1016/j.cell.2020.04.031. PMC 7199733. PMID 32375025. Konwarh, Rocktotpal (23 June 2020). " ... These peptides have similar affinity to antigens as whole antibodies, but are more heat-resistant and stable towards detergents ... This property has been shown to result from their extended CDR3 loop, which is able to penetrate such buried sites. A single- ... Nanobodies targeting the cell receptor binding domain of the virulence factors toxin A and toxin B of Clostridium difficile ...
Using a structure called an appressorium, the pathogen penetrates the plant. The appressorium cell wall is chitinous and its ... small RNAs and short peptides". Trends in Biotechnology. Cell Press. 40 (3): 1-18. doi:10.1016/j.tibtech.2021.07.003. ISSN 0167 ... "A single fungal MAP kinase controls plant cell-to-cell invasion by the rice blast fungus". Science. 359 (6382): 1399-1403. ... SNP-D4 is a short peptide located by an in vitro library screen against the M. oryzae calmodulin. It binds to calmodulin, ...
Because the stain only penetrates cells with compromised plasma membranes, it can be used to investigate antibacterial ... "Nonperturbative imaging of nucleoid morphology in live bacterial cells during an antimicrobial peptide attack". Applied and ... There have, however, been studies which confirm the use of SYTOX dyes for live cell imaging of bacteria. Lee H, Woo ER, Lee DG ...
The translated protein contains 629 amino acids; it is a type I penetrating protein and includes a signal peptide, an N- ... Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. PMID ... doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131. "Infection and Immunity Immunophenotyping (3i) Consortium". Parham ... "Figure 8. with two source data miR-34a regulates Th17 cell-mediated proliferation". doi:10.7554/elife.39479.025. {{cite journal ...
Podocytes, Endothelial cells, and Glomerular mesangial cell are present. Nephrology Urology Lote CJ (2012). Principles of Renal ... atrial natriuretic peptide (sodium) and brain natriuretic peptide (sodium). A countercurrent system in the renal medulla ... Cortical nephrons (the majority of nephrons) start high in the cortex and have a short loop of Henle which does not penetrate ... It contains three components: the macula densa, juxtaglomerular cells, and extraglomerular mesangial cells.: 404 Patients in ...
Poly‐ε‐lysine penetrates the cell wall, causing physiological damage to the cell and death. In comparison to a similar ... The antimicrobial activity is a product of the peptides' structure, including its highly rigid backbone. These peptides have ... Antimicrobial agents that are released from polymers induce cell death through binding to or penetrating the cell wall. When ... Antimicrobial polymers inhibit cell growth and initiate cell death through two primary mechanisms. The first mechanism is ...
Once these cells penetrate through the first few layers of cells of the decidua, they lose their ability to proliferate and ... peptide hormone production and differentiation of human term trophoblast." Trophobl. Res., 11, 35-49. Yang, M., Lei, Z. M., & ... Multinucleated giant cells (small syncytia) are found in the placental bed and myometrium as a result of the fusion of ... Cytotrophoblastic cells play an important role in the implantation of an embryo in the uterus. The formation of all ...
De Kloet ER (October 1997). "Why Dexamethasone Poorly Penetrates in Brain". Stress. 2 (1): 13-20. doi:10.3109/10253899709014734 ... which prevent drug permeation through the lipid bilayer cell membranes of the blood-brain barrier, and efflux out of the brain ... opioid peptides, growth factors, many others) Pirenzepine - an anticholinergic Pyridostigmine - an acetylcholinesterase ... a 5-HT3 receptor antagonist with some peripheral selectivity Peptides and proteins (e.g., insulin, oxytocin, vasopressin, ...