Some interesting effects of glycitin include human dermal fibroblast cell proliferation and migration via TGF‐β signaling, ... reorganization and wound fibrosis inhibition) were significantly and synergistically boosted in both in vivo mice and in vitro ... Promotes Human Dermal Fibroblast Cell Proliferation and Migration via TGF-β Signaling". Phytotherapy Research. 29 (5): 757-769 ... In conjunction with 4′,6,7-trimethoxyisoflavone (TMF), an isoflavone that promotes fibroblast migration but not proliferation, ...

... kidney and epithelial cells ). In vitro, VEGF-A has been shown to stimulate endothelial cell mitogenesis and cell migration. ... and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1". Nat. Med. 8 (8): 831-40. doi:10.1038/nm731. ... Angiogenesis ↑ Migration of endothelial cells ↑ mitosis of endothelial cells ↑ Matrix metalloproteinase activity ↑ αvβ3 ... and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively, spliced transcript variants, ...

Upregulation of AIF-1 is connected with increased migration of mononuclear peripheral blood cell. In the CD14 positive cells, ... It has also been shown that AIF-1 expression can contribute to progression of cancer by inhibition of apoptosis in cells. The ... It is currently theorized that AIF1 works to control endothelial cell proliferation and migration through action in signal ... It was also shown that AIF-1 promote cell proliferation in the brest cancer cells line. This effect was dependent on time and ...

Biology portal Epithelial polarity Cell migration Embryogenesis Embryonic development Asymmetric cell division 3D cell culture ... differential expression of membrane receptors and ligands that cause lateral inhibition, in which the receptor-expressing cell ... Many cell types are capable of migration, such as leukocytes and fibroblasts, and in order for these cells to move in one ... Here, actin polymerization in the direction of migration allows cells to extend the leading edge of the cell and to attach to ...

... and migration. Forced expression of TRPV6 in gastric cancer cells increases their sensitivity to capsaicin-induced apoptosis ... Among different inhibition strategies tested so far, the 13-amino acid peptide SOR-C13 has shown the most promise. This 13- ... TRPV6 expression has been reported multiple breast cancer cell lines and prostate cancer cell lines. The prostate cancer cell ... Silencing of TRPV6 induces apoptosis and cell cycle arrest in pancreatic cancer cells and inhibits their invasion, ...

"P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration". J. Biol. Chem. 282 (32): 23708-15. ... Leslie NR (2009). "P-REX2a driving tumorigenesis by PTEN inhibition". Sci Signal. 2 (94): pe68. doi:10.1126/scisignal.294pe68. ... "Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a". Science. 325 (5945): 1261-5. ...

Lehmann, Ruth (August 2001). "Cell migration in invertebrates: clues from border and distal tip cells". Current Opinion in ... "miRNA-mediated feedback inhibition of JAK/STAT morphogen signalling establishes a cell fate threshold". Nature Cell Biology. 13 ... "MiRNA-mediated feedback inhibition of JAK/STAT morphogen signalling establishes a cell fate threshold". Nature Cell Biology. 13 ... Border cells in the ovary of Drosophila melanogaster are set of ~8 migratory cells that support the oocyte during oogenesis. ...

Trans interactions between CD22 and its ligands are important for B cell adhesion and migration. Specifically, CD22-deficient ... That means that association of CD22 with SHP-1 leads to the inhibition of BCR signaling. After CD22 is phosphorylated, the ITAM ... It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a ... CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to ...

"RAC1 activation mediates Twist1-induced cancer cell migration". Nature Cell Biology. 14 (4): 366-74. doi:10.1038/ncb2455. PMID ... For example, Rac1-dependent pathway inhibition resulted in the reversal of tumour cell phenotypes, suggesting Rac1 as a ... Rac1 is a pleiotropic regulator of many cellular processes, including the cell cycle, cell-cell adhesion, motility (through the ... "Rac activation and inactivation control plasticity of tumor cell movement". Cell. 135 (3): 510-23. doi:10.1016/j.cell.2008.09. ...

NOV regulates multiple cellular activities including cell adhesion, migration, proliferation, differentiation, and survival. It ... "Inhibition of glioma cell growth and tumorigenic potential by CCN3 (NOV)". Molecular Pathology. 54 (5): 293-9. doi:10.1136/mp. ... inhibits proliferation while promoting migration and invasion of the same cell type". Oncogene. 24 (27): 4349-61. doi:10.1038/ ... "CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration". Arteriosclerosis, ...

They concluded a 15% cell viability and dose dependent cell damage. Reduction in cell viability was detected in vivo ... Through the inhibition of angiogenesis, the reduction of rheumatoid arthritis is prevalent. In addition, angiogenic inhibitors ... It involves the degradation of the extracellular matrix, activation, migration, proliferation, and differentiation of ... Studies in human leukemia cells revealed that prolonged exposure in AuNPs did not harm the cells, even at ~100 μM of Au. Rather ...

May 2013). "Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation". Science. 340 (6132): 622- ... could be an effective therapy to repress the migration capacities of SDHB-mutant cells, IHC staining for FH is used to detect ... Cancer cells rely on aerobic glycolysis, which is reached through defects in enzymes involved in normal cell metabolism, this ... Cells with increased growth and survivability differ from non-tumorigenic cells in terms of metabolism. The Warburg Effect, ...

... was described to be the main cause of the inhibition of cell division and of tumor cell death in paclitaxel treated cells. ... the cytoskeleton of eukaryotic cells and have an important role in various cellular functions such as intracellular migration ... Hemiasterlin A and hemiasterlin B show potent activity against the P388 cell line and inhibit cell division by binding to the ... Cancer can develop the resistance by mutations to their cells which result in alterations in the surface of cells or in ...

CLU promotes cell survival by a number of means, including inhibition of BAX on the mitochondrial membrane, activation of the ... CLU functions to regulate ERK 1/2 signaling and matrix metallopeptidase-9 expression to promote tumor cell migration, invasion ... programmed cell death, and complement-mediated cell lysis. Overexpression of the secretory CLU isoform protects the cell from ... Studies revealed that inhibition of CLU resulted in increased effectiveness of chemotherapeutic agents to kill tumor cells. In ...

It regulates differentiation and migration of neural crest cells along with other genes (e.g. FOXD3, SOX9 and SOX10, BMPs) in ... A knockout model using chick embryos has also showed inhibition of mesodermal and neural crest delamination; chick embryo Slug ... It promotes the differentiation and migration of certain cells and has roles in initiating gastrulation. This gene encodes a ... "Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells". The Journal ...

... 's normal role in cell migration and adhesion enables it to utilize the normal cell biology of integrin and FAK for cancer ... The inhibition of Fyn (like other SFKs) results in decreased cell growth. Furthermore, "expression of kinase-dead-Fyn (KD-Fyn ... interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells". Exp. Cell Res. 256 ... Normal integrin is a cell surface receptor that interacts with the extracellular matrix to send signals influencing cell shape ...

... migration and proliferation. In the recognition of immune cells during inflammation, the function of CX3CL1-CX3CR1 axis in the ... Imai T, Yasuda N (December 2016). "Therapeutic intervention of inflammatory/immune diseases by inhibition of the fractalkine ( ... cells, dendritic cells, B lymphocytes, mast cells, monocytes, macrophages, neutrophils, microglia, osteoclasts and thrombocytes ... CX3CR1 and immune cells are strongly connected due to its abundant cell surface expression. Therefore, clinical meaning of ...

... porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro". Cancer ... Che, Chi-Ming; Siu, Fung-Ming (April 2010). "Metal complexes in medicine with a focus on enzyme inhibition". Current Opinion in ... Importantly, some of these compounds do not exhibit harmful cytotoxicity to normal cells, as many Pt-based anti-cancer agents ...

However, other studies have noted that tTG transamidation activity could be linked to the inhibition of tumor cell invasiveness ... differentiation and migration and adhesion . Such neurological diseases are characterized in part by the abnormal aggregation ... In its GTP bound form, tTG contributes to cancer cell survival and appears to be a cancer driver. tTG is upregulated in cancer ... International Review of Cell and Molecular Biology. Vol. 294. pp. 1-97. doi:10.1016/B978-0-12-394305-7.00001-X. ISBN ...

In mast cells, FYB regulates cell adhesion as well as degranulation. In T cells, FYB allows for cell adhesion and migration ... leading to a decrease in integrin activity that results in an inhibition of adhesion, phagocytosis, and cytotoxicity. FYB is ... The protein is expressed in T cells, monocytes, mast cells, macrophages, NK cells, but not B cells. FYB is a multifunctional ... FYB regulates cytokine production in T cells as well as in activated NK cells through the FYN-ADAP axis. In T cells, after TCR ...

... particularly the inhibition of vasodilation, vascular permeability, and migration of leukocytes. Neither loteprednol etabonate ... They also reduce synthesis of histamine, stabilize cell membranes, and inhibit degranulation of mast cells. Recent work ...

Saxena M, Williams S, Brockdorff J, Gilman J, Mustelin T (Apr 1999). "Inhibition of T cell signaling by mitogen-activated ... p38α MAPK is implicated in cell survival/apoptosis, proliferation, differentiation, migration, mRNA stability, and inflammatory ... Therefore, p38 MAPK is associated with cell-cycle arrest in mammalian cardiomyocytes and its inhibition may represent a ... Janknecht R (Nov 2001). "Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase ...

2016). "Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells". Nature Cell ... Inhibition of Arp2/3 increased the speed and decreased the accumulation of F-actin at the front of iDCs. As a result of the ... "Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells". Nature Cell Biology. 18 (1 ... Arpc2KO iDCs saw a similar increase in cell velocity and moved as swiftly as LPS-DCs. Additionally, in under-agarose migration ...

"Macrophage Migration Inhibitory Factor Is Induced by Thrombin and Factor Xa in Endothelial Cells". Journal of Biological ... Ashcroft, Gillian S.; Mills, Stuart J. (1 September 2002). "Androgen receptor-mediated inhibition of cutaneous wound healing". ... "Red cell, plasma and blood volume in healthy men measured by radiochromium (Cr51) cell tagging and hematocrit: influence of age ... Sex hormones may influence female hippocampal cells to tolerate brain damage better than the same cells in males. The studies ...

"Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2". The Journal of Cell ... and kinetochore-microtubule interactions that facilitate chromosome migration and alignment. BubR1 promotes mitotic fidelity ... "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". The Journal of Cell ... CRT acts by inducing damage in the DNA of the cancer cells. Bladder cancer tumor samples were taken from patients before ...

"MicroRNA-25 promotes cell migration and invasion in esophageal squamous cell carcinoma". Biochemical and Biophysical Research ... "Inhibition of miR-25 improves cardiac contractility in the failing heart". Nature. 508 (7497): 531-5. doi:10.1038/nature13073. ... Blood Cells, Molecules & Diseases. 44 (3): 191-7. doi:10.1016/j.bcmd.2009.12.010. PMC 2829339. PMID 20110180. Zhu Z, He J, Jia ... suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer". Nucleic Acids Research. 37 (5): 1672-81. doi: ...

EFs have also experimentally been found to influence cell migration in human umbilical vein cells, dermal fibroblasts, and ... Additionally, calcium channel inhibition using Co2+ or D600 was observed to prevent electotaxis in most cases. Cells that ... "Electrical fields in wound healing-An overriding signal that directs cell migration". Seminars in Cell & Developmental Biology ... Cancer cells and tumors have been known to produce and respond to electrical currents within the body. Cancer cells isolated ...

... and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function". Mol. Cell. ... Parada NA, Cruikshank WW, Danis HL, Ryan TC, Center DM (1996). "IL-16- and other CD4 ligand-induced migration is dependent upon ... without diminishing the ability of T cells to get rid of viral-infected cells. Inhibitors could be used in T-cell mediated ... Ruegg CL, Strand M (1990). "Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic ...

... and bone marrow cells. These receptors have also been implicated in the migration of B cells into the marginal zone and the ... Good CH (2007). "Endocannabinoid-dependent regulation of feedforward inhibition in cerebellar Purkinje cells". Journal of ... A related study found that endocannabinoids affect taste perception in taste cells. In taste cells, endocannabinoids were shown ... inhibition, or the initiation of second messenger cascades. Based on the cell, these effects may result in the on-site ...

"The homeobox gene goosecoid controls cell migration in Xenopus embryos". Cell. 72 (4): 491-503. doi:10.1016/0092-8674(93)90069- ... GSC directly represses the expression of Xwnt-8 while indirectly repressing BMP-4. The inhibition of Xwnt-8 and BMP-4 ensures ... Due to its role as a transcription factor in cell migration during embryonic development, GSC has been looked into as a ... Over activation in Xenopus promotes dorso-anterior migration and dorsalization of mesodermal tissue of the cells along with BMP ...