"Cell-Surface Proteomics Identifies Lineage-Specific Markers of Embryo-Derived Stem Cells". Developmental Cell. 22 (4): 887-901 ... They then use this information to research how to change human iPS cells (induced pluripotent stem cells) into cell types that ... stem cell lineages. Stem Cell Research A notable segment of Rossant's research has been her work leading to the 1998 discovery ... Her work led to the ability to isolate permanent trophoblast stem cell lineages using fibroblast growth factor 4 (FGF4) in ...
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Epigenetic memory in iPS affects the cell lineage it can differentiate into. For instance, an iPS cell derived from a blood ... The second being a somatic cell, referring to the cells of the human body. Skin cells, fat cells, and liver cells are only a ... "Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer". Cell. 153 (6): 1228-38. doi:10.1016/j.cell.2013.05.006. ... The Scientist 19 June 2007 Human Somatic Cell Nuclear Transfer Using Adult Cells Cell Stem Cell. Retrieved 18 April 2014 Ariana ...
"Requirement of Math1 for secretory cell lineage commitment in the mouse intestine". Science. 294 (5549): 2155-2158. Bibcode: ... Cell. 178 (5): 1159-1175.e17. doi:10.1016/j.cell.2019.07.043. PMC 6726125. PMID 31442405 - via Elsevier Science Direct. Kavli ... The MECP2 protein binds methylated cytosine (5-methylcytosine) in CpG sites, and is indispensable for almost all brain cells. ... Zoghbi, Huda Y; Mehta, Arpan R (September 2021). "Purkinje cells and their trees". The Lancet Neurology. 20 (9): 706. doi: ...
Merritt SE, Mata M, Nihalani D, Zhu C, Hu X, Holzman LB (April 1999). "The mixed lineage kinase DLK utilizes MKK7 and not MKK4 ... Conditional deletion of Map2k7 in neural stem cells and postmitotic neurons identified a role for MKK7 in axonal elongation. ... February 2004). "Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2". Nature Cell ... European Journal of Cell Biology. 90 (6-7): 536-44. doi:10.1016/j.ejcb.2010.11.008. PMID 21333379. Gantert C, Honerkamp J, ...
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"MicroRNA-25 promotes cell migration and invasion in esophageal squamous cell carcinoma". Biochemical and Biophysical Research ... Wang Y, Li Z, He C, Wang D, Yuan X, Chen J, Jin J (March 2010). "MicroRNAs expression signatures are associated with lineage ... suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer". Nucleic Acids Research. 37 (5): 1672-81. doi: ... "MicroRNA expression in human airway smooth muscle cells: role of miR-25 in regulation of airway smooth muscle phenotype". ...
Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine. Dev Biol. 2008 Jan 1;313(1):58-66. ... "Fibroblast growth factor receptor-3 regulates Paneth cell lineage allocation and accrual of epithelial stem cells during murine ... Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium. J. Cell Biol. ... Yang, Q.; Bermingham, N. A.; Finegold, M. J.; Zoghbi, H. Y. (2001). "Requirement of Math1 for Secretory Cell Lineage Commitment ...
In AML-M5 >80% of the leukemic cells are of monocytic lineage. This cancer is characterized by a dominance of monocytes in the ... must be of the monocytic lineage. A further subclassification (M5a versus M5b) is made depending on whether the monocytic cells ... The pathology of AML involves abnormal proliferation and differentiation of a population of myeloid stem cells. Genetic ... These overproduced monocytes interfere with normal immune cell production which causes many health complications for the ...
... positive cells originating from the proximal posterior epiblast cells are indeed the lineage-restricted primordial germ cell ... During B cell development, a B cell can either differentiate into a short-lived plasma cell or into a germinal center B cell ... The premature expression of BLIMP-1 in primary B cells results in cell death, so only cells that are ready to initiate ... and plays a critical role in the development of plasma B cells, T cells, dendritic cells (DCs), macrophages, and osteoclasts. ...
Origin of the Vertebrate Endothelial Cell Lineage: Ontogeny and Phylogeny". Heart Development and Regeneration. Academic Press ... Angioblasts (or vasoformative cells) are embryonic cells from which the endothelium of blood vessels arises. They are derived ... Here a new type of cell, the angioblast, is differentiated from the mesoderm. These cells as they divide form small, dense ... Angioblasts are one of the two products formed from hemangioblasts (the other being multipotential hemopoietic stem cells). ...
The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B ... "Entrez Gene: PAX5 paired box gene 5 (B-cell lineage specific activator)". Torlakovic E, Torlakovic G, Nguyen PL, Brunning RD, ... cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter". The ... "Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors". Nature. 401 (6753): 603-6. ...
bHLH transcription factors have been implicated in cell lineage determination and differentiation. It is thought that during ... osteoblast development, this protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype. TWIST2 ...
Due to the NK lineage, clonal rearrangements of lymphoid (T cell receptor; B cell receptor) genes are not seen. The genome of ... The cell of origin is believed to be an NK cell. Blastoid NK cell lymphoma appears to be a different entity and shows no ... Aggressive NK-cell leukemia is a disease with an aggressive, systemic proliferation of natural killer cells (NK cells) and a ... Possible existence of a new clinical entity originating from the third lineage of lymphoid cells". Br. J. Haematol. 75 (1): 49- ...
Otto SP (November 2007). "The evolutionary consequences of polyploidy". Cell. 131 (3): 452-462. doi:10.1016/j.cell.2007.10.022 ... Duplication events that occurred long ago in the history of various evolutionary lineages can be difficult to detect because of ... these tetraploid cells simply tend to arise during in vitro cell culture or whether they are also present in placental cells in ... Species whose cells do not have nuclei, that is, prokaryotes, may be polyploid, as seen in the large bacterium Epulopiscium ...
"Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells". J. Histochem. Cytochem. 47 (10 ... Cell. 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923. Portal ... Cell. Biol. 19 (10): 7245-54. doi:10.1128/mcb.19.10.7245. PMC 84717. PMID 10490659. Merritt SE, Mata M, Nihalani D, Zhu C, Hu X ... Merritt SE, Mata M, Nihalani D, Zhu C, Hu X, Holzman LB (1999). "The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as ...
"Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development". Immunity. 18 ( ... "Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1". Immunity. 16 (2): 231-43. doi:10.1016/ ... Cell. 90 (2): 281-91. doi:10.1016/S0092-8674(00)80336-0. PMID 9244302. S2CID 16544864. Matsuno K, Diederich RJ, Go MJ, ... "Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells". Molecular Immunology. 39 (13 ...
They have a preoral chamber formed by epidermal gland cells. The medusae bud off at the base of the hydrants, though where ... Several members of this lineage were formerly considered a separate family Eleutheriidae. The hydranths have a circular mouth ...
... cell pathway by repressing lineage-inappropriate genes and that simultaneously promotes B cell development by activating B-cell ... To date, Pax5 is known to function as a guardian of B cell identity for early to late B cell development and to function as an ... and his lab described the first molecular definition of a lineage commitment process by identifying Pax5 as the B cell lineage ... "Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development ...
"Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines". Proceedings of the National ... which are the precursor cells to all types of blood cells, or primordial germ cells (PGCs), the precursor to cells passed on in ... HOX B6 gene is only expressed in erythoid progenitor cells, which are the precursor to red blood cells used for transport of ... An oncoprotein can cause the transformation of a normal cell into a tumor cell. Overexpression of HOXB6, along with the ...
It also is a marker of cells from the monocyte/macrophage lineage. CD163 functions as innate immune sensor for gram-positive ... to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis". Cytogenetics and Cell Genetics. 90 (3-4 ... Cell Biology. 34 (4): 309-14. doi:10.1016/S1357-2725(01)00144-3. PMID 11854028. Madsen M, Graversen JH, Moestrup SK (2002). " ... a Jack-of-all-trades and potential target for cell-directed therapy". Molecular Immunology. 47 (7-8): 1650-60. doi:10.1016/j. ...
They are present in the guard cell. Veetil, S.K; Mittal, C; Ranjan, P; Kateriya, S (July 2011). "A conserved isoleucine in the ... These blue light receptors are seen across the entire green plant lineage. When Phototropins are hit with blue light, they ... Phototropins have been shown to impact the movement of chloroplast inside the cell. In addition phototropins mediate the first ... Phototropin is also required for blue light mediated transcript destabilization of specific mRNAs in the cell. ...
Target cell are therefore myeloid lineage cells, mainly phagocytes, such as neutrophils. Binding to cells without the CR3 also ... IL-12 is important for T-cell response polarization. Other effects of cAMP on dendritic cell interaction with T-cells are also ... Translocation of the AC domain into the cell starts the main process by which this toxin influences target cells: the AC domain ... Although cAMP induces dendritic cell migration into lymph nodes, it lowers their capacity to interact with T-cells and present ...
August 2021). "Polyamine metabolism is a central determinant of helper T cell lineage fidelity". Cell. 184 (16): 4186-4202.e20 ... showed that TH1 and TH2 cells express higher levels of ODC than regulatory T (Treg) cells and TH17 cells, which corresponded to ... using T-cell specific ODC cKO mice showed that T cells can function and proliferate normally in vivo and other polyamine ... Shi H, Chi H (August 2021). "Polyamine: A metabolic compass for T helper cell fate direction". Cell. 184 (16): 4109-4112. doi: ...
Blood cell lineage Hematopoiesis Erythropoiesis Haematopoiesis Hematopoietic stem cell Hartenstein, V (2006). "Blood cells and ... A nucleated red blood cell (NRBC), also known by several other names, is a red blood cell that contains a cell nucleus. Almost ... Because RNA and cytoplasmic elements are synthesized at a constant rate despite the cells' impaired DNA synthesis, the cells ... After infancy, RBCs normally contain a nucleus only during the very early stages of the cell's life, and the nucleus is ejected ...
... is expressed highly in the red blood cell or erythroid lineage. Here it is driven by another KLF, Erythroid KLF or KLF1, ... a Major CACCC-Box-Binding Protein in Erythroid Cells and Selected Other Cells". Mol. Cell. Biol. 16 (4): 1695-705. doi:10.1128/ ... As well as being expressed in erythroid cells, KLF3 is present in other cell types and analysis of the knockout mice has ... Cell. 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573. KLF3 protein, human at the U.S. National ...
Fraser S, Keynes R, Lumsden A (March 1990). "Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions ... Lumsden A, Sprawson N, Graham A (December 1991). "Segmental origin and migration of neural crest cells in the hindbrain region ... Lumsden A (March 1989). "Multipotent cells in the avian neural crest". Trends Neurosci. 12 (3): 81-3. doi:10.1016/0166-2236(89) ... where he discovered signalling properties in a small set of cells that pattern the large surrounding region of the thalamus. ...
"Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines". Proceedings of the National ... and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells". Experimental ... Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551-3. doi:10.1016/0092-8674(92)90588-4. PMID ... More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. ...
"Mixed-Lineage Kinase 3 Delivers CD3/CD28-Derived Signals into the IκB Kinase Complex". Mol. Cell. Biol. 20 (7): 2556-68. doi: ... "Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival". J. Biol. Chem. 278 (6): 3897-902 ... Cell. Biol. 19 (10): 7245-54. doi:10.1128/mcb.19.10.7245. PMC 84717. PMID 10490659. Figueroa C, Tarras S, Taylor J, Vojtek AB ( ... Cell. Biol. 19 (10): 7245-54. doi:10.1128/mcb.19.10.7245. PMC 84717. PMID 10490659. Kelkar N, Gupta S, Dickens M, Davis RJ ( ...
"A transcription factor collective defines cardiac cell fate and reflects lineage history". Cell. 148 (3): 473-86. doi:10.1016/j ... "Editorial Board: Developmental Cell". cell.com. "Editors and Board , Development". dev.biologists.org. "Editors & Board , ... "Flyer Online Symposium Minerva-Gentner Symposium 2020" (PDF). "Speaker - Cell Symposia: Transcriptional Regulation". cell- ... "Lineage-Resolved Enhancer and Promoter Usage during a Time Course of Embryogenesis". Developmental Cell. 55 (5): 648-664.e9. ...